Clinical trials: Arthroplasty
Acute Blood Loss Anemia, Osteoarthritis, Knee
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.
- Trial name
- NCT01370460
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Henry Ford Health System
Osteoarthritis, Knee
Residual Pain After Successful Implant of Metaphyseal Sleeves in Total Knee Arthroplasty
: Total knee revision arthroplasty is increasing in daily practice and will become more relevant in the years to come. Bone loss is a significant challenge in total knee arthroplasty (TKA) especially in revision procedures.
- Trial name
- NCT04995679
- Testing
- Implant of metaphyseal sleeves in Total knee arthroplasty
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- University of Milan
Total Hip Arthroplasty (THA)
Impact of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Elective Hip Replacement
In the present project, the framework conditions of outpatient rehabilitation at the Bonn Center for Outpatient Rehabilitation will now be used to prove whether sports science-controlled strength and BFR training has a similar…
- Trial name
- NCT07043127
- Testing
- BFR
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Total Knee Arthroplasty, Ischemic Preconditioning
Ischemic Preconditioning in Total Knee Arthroplasty
The application of a tourniquet for 5 minutes and subsequent reperfusion before actual inflation of the tourniquet for total knee arthroplasty (ischemic preconditioning) decreases the level of local inflammation and therefore…
- Conditions
- Total Knee Arthroplasty, Ischemic Preconditioning, Postoperative Pain
- Trial name
- NCT01333969
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Deep Vein Thrombosis, Venous
Rosuvastatin for Preventing Deep Vein Thrombosis
Deep vein thrombosis (DVT)is devastating disease which influencing the mortality and morbidity of patients at-risk like those undergoing orthopedic surgery.
- Conditions
- Deep Vein Thrombosis, Venous, Thrombosis, Prevention
- Trial name
- STOP-DVT (NCT01021488)
- Testing
- Rosuvastatin 20mg/d for 14days, enoxaparin only
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Hallym University Medical Center
Total Knee Arthroplasty
Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA）
This is a randomized, double-blind, active-controlled, multicenter, phase II clinical study designed to evaluate the efficacy and safety of BT-114143 Injection in the perioperative treatment of unilateral total knee arthroplasty.
- Trial name
- TKA (NCT07127042)
- Testing
- Low-dose BT-114143, High-dose BT-14143, Tranexamic Acid (IV)
- Where
- China
- Volunteers
- 270 people
- Sponsor
- ScinnoHub Pharmaceutical Co., Ltd.
Thumb Osteoarthritis
Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb
Thumb carpometacarpal (CMC) osteoarthritis (OA) is common, seen frequently in middle-aged and elderly women. While a variety of surgical treatments have been described with none superior to any other, there is no consensus on the…
- Trial name
- NCT04828954
- Testing
- Immobilization for 2-weeks postoperative, Immobilization for 6-weeks postoperative
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Chicago
Total Knee Arthroplasty
Swelling Management After Total Knee Arthroplasty
The purpose of this feasibility study is to estimate the initial efficacy and feasibility of an inelastic compression garment donned immediately after TKA on peak swelling in 14 subjects.
- Trial name
- NCT04841356
- Testing
- Immediate Compression Garment
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Knee Arthroplasty, Knee Arthroplasty, Total
Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
To evaluate the progression on patients suffering from end stage OA whilst being on the waiting list for TKR
- Conditions
- Knee Arthroplasty, Knee Arthroplasty, Total, Knee Replacement, Total, Replacement, Total Knee
- Trial name
- TKA HRQoL (NCT03492320)
- Testing
- Health Quality of Life Questionnaire Assessment
- Volunteers
- 127 people
- Sponsor
- Dr. Ho Ki Wai
ARTHROPLASTY, REPLACEMENT; ANESTHESIA
Postspinal Hypotension and Cardiac Performance in the Elderly
Patients, scheduled for elective arthroplasty were monitored with Lithium Dilution Cardiac Output monitor (LiDCOplus™) before and 45 minutes after spinal anesthesia.
- Trial name
- NCT02978066
- Testing
- Spinal anaesthesia
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Knee Osteoarthritis, Osteoarthritis (Knee)
Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis
The goal of this clinical trial is to learn if the VELYS Robotic-Assisted Solution (VRAS) device helps to improve outcomes from total knee replacement, when compared to regular non-robotic-assisted total knee replacement in the…
- Conditions
- Knee Osteoarthritis, Osteoarthritis (Knee), Osteo Arthritis of the Knee, Osteo Arthritis
- Trial name
- MARVEL Project (NCT07551856)
- Testing
- Robot-Assisted Functionally Aligned Total Knee Replacement, Manual Total Knee Arthroplasty
- Where
- United Kingdom
- Volunteers
- 346 people
- Sponsor
- Golden Jubilee National Hospital
Anatomic Total Shoulder Arthroplasty
Comparison of Glenoid Position Using SmartBones
The investigators propose a randomized clinical trial to evaluate the accuracy of glenoid implant placement comparing four groups of patients.
- Trial name
- NCT03035318
- Testing
- DePuy Global® Anchor Peg Glenoid Instrumentation, DePuy Global® Anchor Peg Instrumentation with SmartBone™, IRI with SmartBone™
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- The Cleveland Clinic
Osteoarthritis, Knee
The Comparison of Anterior Knee Pain in Patella With or Without Denervation in Medial Unicompartmental Knee Arthroplasty
the present study will conduct to assess anterior knee pain and complications after medial UKA with or without patella denervation in medial compartment arthritis and severe lateral facet patellofemoral arthritis patients.
- Trial name
- NCT03676179
- Testing
- patella denervation, patella non-denervation
- Where
- Thailand
- Volunteers
- 66 people
- Sponsor
- Ramathibodi Hospital
Intraoperative Bleeding, Post-operative Bleeding
Study to Compare the Addition of Floseal to Our Standard of Care to Control Post Operative Bleeding in TKR
The purpose of this study is to compare Floseal to our standard of care (SOC) to decrease intraoperative and immediate post-operative bleeding.
- Trial name
- NCT01891461
- Testing
- Floseal
- Where
- Canada
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Arthroplasty, Replacement, Knee, Anesthesia, Conduction
Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery
This study will prospectively investigate the efficacy of Adductor canal block with periarticular infiltration Vs Adductor canal block, Periarticluar infiltration and Sensory posterior articular nerve of the knee block in…
- Conditions
- Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Acute Pain
- Trial name
- NCT04290442
- Testing
- adductor canal block, SPANK, Ropivacaine
- Where
- United States
- Sponsor
- Bruce Ben-David
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Shoulder Arthritis, Patient Education
Preoperative Rehabilitation and Education Program
Shoulder problems affect many Canadians yearly. While surgery is one of the best treatments for shoulder problems, patients are unaware about shoulder replacement surgeries, the exercises needed after surgery and how to safely…
- Conditions
- Shoulder Arthritis, Patient Education, Prehabilitation, Shoulder Arthroplasty
- Trial name
- PREPS (NCT05965986)
- Testing
- Experimental: PREPS only, Experimental: PREPS and therapy
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
Efficacy Study of Pre-emptive Etoricoxib for Postoperative Pain and Functional Outcome in Total Knee Arthroplasty
The purpose of this study is to study the efficacy of pre-emptive etoricoxib in reducing post-operative pain and improving function outcome after a total knee arthroplasty.
- Trial name
- NCT01246362
- Testing
- Control, Etoricoxib
- Where
- Singapore
- Volunteers
- 65 people
- Sponsor
- Singapore General Hospital
Arthritis Shoulder, Rotator Cuff Injuries
Onlay Versus Inlay Humeral Component in Reverse Total Shoulder Arthroplasty
The goal of this study is to compare the effect of different ways to place the component that goes at the top of the humerus (upper arm) in reverse total shoulder replacement.
- Trial name
- NCT05297305
- Testing
- Tornier Ascend Flex stem, Tornier Perform Stem Reverse+
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Corewell Health East
Metal Staple Removal After Total Knee Replacement
Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement
- Trial name
- NCT02812602
- Testing
- Lidocaine patch
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital