Clinical trials: Arthroplasty Complications
Total Knee Anthroplasty, Genicular Nerves Block
Efficacy of Genicular Block on Total Knee Arthroplasty Surgery
This prospective, randomized, double-blind, placebo-controlled trial evaluated the analgesic efficacy of preoperative ultrasound-guided genicular nerve block (GNB) in patients undergoing total knee arthroplasty.
- Trial name
- NCT06942702
- Testing
- Genicular blocks (bupivakain), Paracetamol (acetaminophen)+diclofenac, Patient Control Analgesia (PCA) Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Mersin University
Analgesia
Analgesia After Total Knee Arthroplasty
The recovery from knee replacement surgery often involves a significant amount of pain. The best way to prevent/treat this pain is unknown.
- Trial name
- NCT00869037
- Testing
- Periarticular Injection, CFNB + Posterior Capsular Injection
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Manitoba
Total Knee Arthroplasty (TKA)
Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia…
- Trial name
- NCT07672301
- Testing
- Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
Hip Arthroplasty
Effect of Spinal Ketorolac on Mechanical Hypersensitivity After a Total Hip Replacement
Chronic pain in patients following total hip replacement seems to be a significant problem. Previous research has shown that more effective pain management in the early postoperative period may decrease the incidence of the…
- Trial name
- NCT00621530
- Testing
- ketorolac tromethamine opthalmic solution
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Wake Forest University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty
This prospective, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of intraoperative ketamine and dexmedetomidine on the incidence of postoperative delirium (POD) and postoperative…
- Trial name
- NCT06963294
- Testing
- Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Inflammation, Postoperative Delirium
Propofol and Dexmedetomidine on Inflammation
Dexmedetomidine, was reported to prevent postoperative delirium in elderly patients following its use in intensive care units. Possible mechanisms included improved quality of sleep and an inhibitory effect on inflammation.
- Conditions
- Inflammation, Postoperative Delirium, Anesthesia
- Trial name
- NCT03600727
- Testing
- Propofol, Dexmedetomidine
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Femoral Neck Fractures
This is a Study to Verify if Periarticular Hip Injection of Corticosteroid After Hip Replacement Reduce the Pain and the Hospitalisation Time
The investigators are going to evaluate if periarticular corticosteroid injection during endoprothesis implantation can lead to any advantage to the patients, namely if it can reduce post-operative pain, lenght and cost of…
- Trial name
- NCT05023369
- Testing
- Dexamethasone is a steroid drug and will be administered as an injectable solution (4mg/ml)
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Total Hip and Knee Arthroplasties
Teicoplanin Prophylaxis for Total Hip or Knee Arthroplasty
This is a prospective, open-label, randomized clinical trial where patients were administered prophylaxis for total hip or knee arthroplasty either with teicoplanin or with other antibiotics.
- Trial name
- NCT00719056
- Testing
- Teicoplanin, β-lactams or ciprofloxacin
- Where
- 3 sites in Greece
- Volunteers
- 616 people
- Sponsor
- University of Athens
Postoperative Pain
Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
The primary purpose of this study is to evaluate postoperative pain. Secondary outcomes evaluated in this study will include range of motion (ROM), opioid consumption, and ambulation.
- Trial name
- NCT06479161
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Matthew Grosso, MD
Postoperative Pain
Deep Subgluteal Block vs PENG Combined With LFCN Block for Analgesia After Hip Arthroplasty
This randomized, prospective study aims to compare the clinical efficacy of ultrasound-guided Deep Subgluteal Block (DSGB) versus Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve (LFCN) block…
- Trial name
- DSG-PENG (NCT07770932)
- Testing
- 0.25% Bupivacaine for Deep Subgluteal Block, 0.25% and 0.125% Bupivacaine for PENG+LFCN Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Hip Arthroplasty, Hip Fracture Surgeries
Sacral ESPB vs. PENG Block for Hip Hemiarthroplasty Analgesia
Sacral erector spinae plane block(S-ESPB) has been recently described. Case reports are showing that it is useful in various types of surgery.
- Conditions
- Hip Arthroplasty, Hip Fracture Surgeries, Femoral Neck Fractures, Postoperative Pain
- Trial name
- NCT07442721
- Testing
- Sacral erector spinae plane block, PENG block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Fayoum University Hospital
Pain, Postoperative Pain
PENG Block Plus Lateral Femoral Cutaneous Nerve Block for Posterolateral-approached Total Hip Arthroplasty
This study aims to analyze the effect of Pericapsular Nerve Group (PENG) Block combined with lateral femoral cutaneous nerve block vs.
- Conditions
- Pain, Postoperative Pain, Acute Pain, Analgesia
- Trial name
- PENG-FLAT (NCT05432011)
- Testing
- PENG Block, Lateral Femoral Cutaneous Nerve Block, Wound Infiltration
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Campus Bio-Medico University
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital
Pain, Postoperative
Different Bupivacaine Volumes in Infiltration Between Popliteal Artery and Capsule of Knee Block
comparing between three different volumes; 15, 20 \& 25 ml of 0.25% bupivacaine to determine the best volume of Infiltration Between Popliteal Artery and Capsule of Knee (IPACK) block following adductor canal block (ACB) with the…
- Trial name
- NCT05438992
- Testing
- Bupivacaine 0.25% Preservative-Free Injectable Solution
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Cairo University
Orthostatic Intolerance, Orthostatic Hypotension
Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty (THA)
Incidence and pathophysiologic hemodynamics of orthostatic intolerance and orthostatic hypotension in patients undergoing unilateral THA
- Conditions
- Orthostatic Intolerance, Orthostatic Hypotension, Postoperative Complications
- Trial name
- NCT03759574
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Hvidovre University Hospital
Dysglycemia, Arthroplasty Complications
Recognition and Treatment of Dysglycemia. AGS - Acute Glucose Service
AGS (Acute Glucose Service ) is an inpatient glucose management service consisting of Nurse Practitioner and physician. Team manages not - consulted- based preoperative assessment, perioperative glucose control, patient education…
- Trial name
- AGS (NCT03306810)
- Testing
- AG service
- Where
- Finland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Total Knee Arthroplasty, Pain, Postoperative
Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
Patients undergoing Primary Total Knee Arthroplasty will be randomized to receive either multimodal single injection adductor canal block with sham infusion catheter or continuous infusion of local anesthetic (control) for…
- Conditions
- Total Knee Arthroplasty, Pain, Postoperative, Adductor Canal Block
- Trial name
- NCT02991404
- Testing
- Multimodal Peripheral Nerve Block Injection, Single Shot Adductor Canal Block, Initial Bolus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Frailty, Cognitive Impairment
Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic
This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total…
- Conditions
- Frailty, Cognitive Impairment, Older Adults, Hip Arthroplasty
- Trial name
- ORTOPODCZ (NCT07432009)
- Where
- 7 sites in Czechia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Hip Replacement Surgery, Hip Replacement, Total
OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study
Main indications for total hip arthroplasty (THA) are degenerative osteoarthritis of the coxofemoral joint, osteonecrosis of the hip, congenital disorders such as dysplasia and inflammatory arthritis.
- Conditions
- Hip Replacement Surgery, Hip Replacement, Total, Hip Pain, Hip Arthroplasty
- Trial name
- NCT07017192
- Testing
- SIFI Block, ESP block
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Surgical Wound Infection
A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)
The aim of this study is to assess the prevention of incision healing complications in patients undergoing revision TKA and THA treated with either Single-Use NPWT (PICO) compared to standard of care dressings (AQUACEL Ag…
- Trial name
- NCT02664168
- Testing
- Aquacel Ag Surgical Dressing, Single-Use Negative Pressure Wound Therapy (PICO)
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics