Clinical trials: Arthroplasty of Knee
Knee Arthroplasty
Rehabilitation After Fast-track Total Knee Arthroplasty
BACKGROUND In 2008 approximately 7,700 total knee arthroplasties (TKA) were performed in Denmark. The results after TKA is in general very good, the investigators have, however, discovered that patients following fast-track TKA…
- Trial name
- HOLEST (NCT01329081)
- Testing
- Postoperative rehabilitation after fast-track TKA
- Where
- Denmark
- Sponsor
- University of Aarhus
Bone Marrow Edema, Knee Pain Chronic
Subchondroplasty® Knee RCT
This is a multi-center, prospective, single-blinded, two-arm study, randomized to include approximately 134 subjects treated with Subchondroplasty (SCP) + Arthroscopy and 67 subjects with arthroscopy alone.
- Conditions
- Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee
- Trial name
- PRESERVE Knee (NCT03112200)
- Testing
- Subchondroplasty with Arthroscopy, Arthroscopy Alone
- Where
- 13 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Zimmer Biomet
Knee Arthroplasty, Total
Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block
The purpose of this study is to compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption, and pain scores) following total knee arthroplasty by either combined biceps femoris short…
- Trial name
- NCT07418307
- Testing
- Combined biceps femoris short head block and adductor canal block, Genicular nerve block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Zagazig University
Analgesia
Safety of F14 Following Total Knee Replacement
Open-label single-arm study in which all subjects receive F14 as part of a scheduled TKR and multimodal analgesia
- Trial name
- NCT04860635
- Testing
- F14 (sustained release celecoxib)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Arthritis Innovation Corporation
Knee Osteoarthritis, Arthropathy of Knee Joint
Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia
Previous retrospective database studies suggest that total knee arthroplasty (TKA) surgery under spinal anesthesia has less complications than when performed under general anesthesia.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee Joint, Knee Pain Chronic, Rheumatoid Arthritis
- Trial name
- NCT03364088
- Testing
- Spinal anesthesia with tourniquet, Spinal anesthesia without tourniquet, General anesthesia with tourniquet
- Where
- Finland
- Volunteers
- 402 people
- Sponsor
- Riku Antero Palanne
Osteoarthritis, Knee
Does Rehabilitation After Total Knee Arthroplasty Work? - Feasibility Trial
The aim of this feasibility trial is to investigate the feasibility of a trial intervention for a population of patients after total knee replacement for osteoarthritis.
- Trial name
- DRAW-TKA-Fea (NCT05935020)
- Testing
- Usual care - Municipal exercise-based rehabilitation, Return to Everyday life, Symptom guide and encouragement to follow DHA/WHO recommendations for physical activity
- Where
- 2 sites in Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Pain Management, Arthroplasty
Effect of Preoperative Pain Education on Anxiety, Pain, and Analgesic Use in Total Knee and Hip Replacement Patients
This randomized controlled trial evaluates whether a standardized preoperative pain education session delivered by a nurse reduces postoperative pain intensity and surgical anxiety among adult elective orthopedic surgery patients…
- Conditions
- Pain Management, Arthroplasty, Knee Replacement, Hip Replacement
- Trial name
- Pain-Anxiety (NCT07362589)
- Testing
- Pain education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Yeditepe University
Pain, Postoperative, Osteoarthritis, Knee
Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin
Evaluation of the analgesic efficacy of a pre-operative dose of ketorolac and gabapentin in reducing post-operative pain scores in patients undergoing TKA
- Trial name
- NCT07047040
- Testing
- Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Knee Osteoarthritis
Patellar Resurfacing in Total Knee Arthroplasty Leads to Better Isokinetic Performance and Higher Clinical Scores
For decades there have been concerns about patellar resurfacing (PR) in total knee arthroplasty (TKA) and the individual preference of the surgeon is still the main determinant of whether or not resurfacing is applied.
- Trial name
- NCT04637490
- Testing
- patellar component
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gulhane Training and Research Hospital
Postoperative Pain
Analgesic Effect of Escitalopram in Total Knee Arthroplasty (TKA)
Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect.
- Trial name
- NCT01430520
- Testing
- Escitalopram
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Hvidovre University Hospital
Arthroplasty, Replacement, Knee
Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee
Polyethylene wear and osteolysis remain a concern with the use of modular, fixed bearing total knee arthroplasty. A variety of highly cross-linked polyethylenes have been introduced to decrease this problem, but there is little…
- Trial name
- NCT02178020
- Testing
- knee arthroplasty, standard polyethylene, knee arthroplasty, XLP polyethylene
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Chapel Hill Orthopedics Surgery & Sports Medicine
Knee Osteoarthritis
Effects of Bandaging and Kinesiotaping® in Patients With Total Knee Arthroplasty
The study aimed to compare the effectiveness of elastic bandaging, Kinesio taping, and short stretch bandaging techniques on postoperative pain, edema, and functional level in the early stage after total knee arthroplasty.
- Trial name
- NCT05847725
- Testing
- Elastic bandaging, Short stretch bandaging, Kinesio taping
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Total Knee Arthroplasty
Personalized Information Before and After Total Knee Arthroplasty: PAK-study
Despite positive results following total knee arthroplasty (TKA), some patients are dissatisfied after recovery. Unfulfilled expectations is a key predictor of dissatisfaction.
- Trial name
- PAK (NCT05266482)
- Testing
- Personal report
- Where
- Netherlands
- Volunteers
- 461 people
- Sponsor
- Kliniek ViaSana
Healthy
Is Standard 3-degree of External Rotation for Posterior Femoral Cut Relevant for Turkish Population
The aim of this study is to evaluate the posterior condylar angle of the distal femur in Turkish population and its concordance with the current standard prosthesis designs used in total knee arthroplasty and to evaluate…
- Trial name
- NCT04355182
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty (Postoperative Pain)
Effects of tDCS Combined With CBI on Postsurgical Pain
The purpose of this study is to determine whether a new medical technology can help reduce post-operative total knee or hip pain when combined with a Cognitive-Behavioral intervention (CBI).
- Trial name
- tDCS-CBI (NCT04199780)
- Testing
- Transcranial Direct Current Stimulation, Cognitive-Behavioral (CB) intervention
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- VA Office of Research and Development
Acute Pain, Arthropathy of Knee
NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative
- Trial name
- NCT03834142
- Testing
- NSS-2 Bridge
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Osteoarthritis of the Knee
Genicular Radiofrequency Ablation for Unilateral Knee Arthroplasty Pain Management
Three primary reasons prolong hospital stays following unilateral knee arthroplasty. Pain is the primary reason followed by opioid drowsiness and nausea/vomiting side effects.
- Trial name
- RFA (NCT02925442)
- Testing
- t-RFA, C-RFA, Control
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lyman Medical Research Foundation, Inc.
Infection, Osteoarthritis of the Knee
The Effectiveness of Antibiotic Cement (ABC) Compared to Regular Cement in Reducing the Rate of Infection Following Total Knee Arthroplasty: The ABC Trial
Rationale: Infection following total knee replacement (TKA) is a devastating complication that usually requires prosthesis removal, hospitalization while the infection is eradicated, and a second surgery to implant a revision…
- Trial name
- ABC (NCT01079559)
- Testing
- Simplex™ P with Tobramycin, Simplex™ P
- Where
- Canada
- Sponsor
- University of Western Ontario, Canada
Total Knee Replacement
Knee4Life Project: Empowering Knee Recovery After Total Knee Replacement Through Digital Health
The research project will investigate the extent to which a smartphone camera sensor tool can help predict and measure knee stiffness and pain after Total Knee Replacement Surgery (TKR) and how a tool such as this could be…
- Trial name
- K4L (NCT06429462)
- Testing
- smartphone camera sensor tool
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Readiness to Discharge
Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade
There are 2 common ways to manage pain after total knee arthroplasty at our institution. Some patients receive an epidural analgesia, a femoral nerve block and pills for pain.
- Trial name
- PAI vs FNB (NCT01335542)
- Testing
- Peri-Articular Injection, Epidural Pathway (PCEA+FNB)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Hospital for Special Surgery, New York
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