Clinical trials: Articular Cartilage Disorder
Osteoarthritis, Knee
Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial
Phase I/II randomized, double-blind, placebo-controlled clinical trial to test the safety and efficacy of Fisetin for treating mild to moderate osteoarthritis
- Trial name
- NCT04210986
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Steadman Philippon Research Institute
Degeneration Articular Cartilage Knee
Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
The purpose of this study is to determine whether CARTISTEM, a cell therapeutic product, is safe and effective in the treatment of articular cartilage defects of the knee as a result of ageing, trauma, or degenerative diseases.
- Trial name
- NCT01733186
- Testing
- CARTISTEM®
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Medipost, Inc.
Osteoarthritis, Knee
Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
The MegaCarti® is the decellularized allogeneic cartilage and acts as a cover after bone marrow stimulation to prevent the loss of blood clots and induces cartilage regeneration by assisting in the location of stem cells derived…
- Trial name
- NCT05440370
- Testing
- MegaCarti®, Microfracture
- Where
- 4 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- L&C Bio
Knee Osteoarthritis
Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma
This is a prospective cohort clinical study. Due to logistic constraints at the sites of implementation, a randomized allocation will not be feasible (private clinic).
- Trial name
- OASIS-PRP (NCT06520059)
- Testing
- Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration
- Where
- 2 sites in Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Meniscus Tear, Chondropathy/Degenerative Joint Disease (DJD)
Post-op Treatment With Hyaluronic Acid Injections
This study will look at patients with post-operative treatment of a meniscal tear or degenerative joint disease (degenerative arthritis).
- Trial name
- NCT01256788
- Testing
- Euflexxa, Saline
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Hawkins Foundation
Knee Osteoarthristis
Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis
This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis.
- Trial name
- CaRE (NCT06857123)
- Testing
- Exercise with Rest, Exercise without Rest
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Knee Osteoarthritis
Is Pulsed Ultrasound Treatment Effective in Knee Osteoarthritis
Osteoarthritis is a progressive rheumatic disease which is the most common cause of musculoskeletal pain and functional impairment, particularly in the elderly group. The most common form is knee osteoarthritis.
- Trial name
- NCT03705039
- Testing
- Pulsed Ultrasound Treatment, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Dokuz Eylul University
Instability, Joint, Shoulder Dislocation
Quantitative MRI of Glenohumeral Cartilage & Labrum in Shoulder Instability
The purpose of this study is to assess cartilage strain and contact areas following glenohumeral instability compared to healthy individuals.
- Conditions
- Instability, Joint, Shoulder Dislocation, Shoulder Injuries, Shoulder Subluxation
- Trial name
- OREF (NCT05431114)
- Testing
- MRI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Disorders of Synovium, Multiple Sites, Disorders of Subchondral Bone, Multiple Sites
Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients
The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of…
- Conditions
- Disorders of Synovium, Multiple Sites, Disorders of Subchondral Bone, Multiple Sites, Disorders of Cartilage, Hand Joints, Arthritis, Rheumatoid
- Trial name
- NCT01476865
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Osteoarthritis (OA)
Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA
This study explored the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage.
- Trial name
- NCT04097379
- Testing
- LRX712
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Joint Disease
Extracellular Vesicles in Fibrin Gel for Cartilage Repair
This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth…
- Trial name
- GelVex (NCT06713902)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Knee Osteoarthritis (OA)
A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)
This study is designed to evaluate, by MRI, knee cartilage and structure in all subjects. Half the subjects in this study will take collagen hydrolysate each day for 48 weeks and the other half of the subjects will take a placebo…
- Trial name
- NMR (NCT00536302)
- Testing
- Collagen Hydrolysate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- GELITA
Osteoarthritis
Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
The purpose of this two-part study is to assess the efficacy, safety and tolerability of multiple intra-articular (i.a.) injections of LNA043, in regenerating the articular surface in patients with cartilage lesions of the knee…
- Trial name
- NCT03275064
- Testing
- LNA043
- Where
- 19 sites in United States, Czechia and 1 more
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis of Knee, Degenerative Osteoarthritis
Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis
In this study, our objective was to assess the correlation between serum human cartilage glycoprotein-39 (YKL-40) and nesfatin-1 values, the patient's clinical condition, ultrasonographic cartilage thickness measurements, and the…
- Trial name
- NCT06254976
- Testing
- exercise, intraarticular knee PRP injections
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kayseri City Hospital
Osteoarthritis, Knee, Cartilage Degeneration
Subchondral and Intra-articular Application of Bone Marrow Concentrate for Knee Unicompartmental OA
Unicompartmental knee osteoarthritis (OA) is a common finding especially in patients with lower limb malalignment and previous meniscectomy.
- Trial name
- MarrowMule (NCT03790189)
- Testing
- Subchondral and intra-articular injection of BMC
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Clinico Humanitas
Osteoarthritis
Resistive Exercise for Arthritic Cartilage Health (REACH)
Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group.
- Trial name
- NCT00465660
- Testing
- Progressive resistance training
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Osteoarthritis
Effect of Metformin on Patients With Osteoarthritis
This randomized controlled trial aims to investigate if metformin has osteoarthritis protective effects among overweighted knee osteoarthritis patients.
- Trial name
- NCT05034029
- Testing
- Metformin hydrochloride sustained release tablets
- Where
- 5 sites in China
- Volunteers
- 262 people
- Sponsor
- Guangzhou First People's Hospital
Osteearthritis, Joint Damage
Effect of Agar/Collagen-based Compounds on Osteoarticular Pain: Randomized Triple-blind Clinical Trial
Joints-comprising bone, cartilage, ligaments, and synovial fluid-enable stable daily movement but may deteriorate with age, excess body weight, overuse, injury, or disease.
- Conditions
- Osteearthritis, Joint Damage, Inflammation, Cartilage Damage
- Trial name
- AGARTROSIS (NCT07318896)
- Testing
- Agar-Agar, Agar-Agar and undenatured collagen type II, undenatured collagen type II
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundació Eurecat
Knee Osteoarthritis
To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection
The purpose of this study is to identify novel imaging markers for characterizing the biochemical profiles in synovial fluid and cartilage matrix in OA knee joints after intra-articular HA (Euflexxa) injection using high field…
- Trial name
- NCT01895959
- Testing
- Euflexxa, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Knee Osteoarthritis
Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis
The aim of the study is to compare the 6 months clinical outcome of the treatment with a single intra-articular collagen injection versus a single placebo (saline solution) infiltration in the infiltrative treatment of knee…
- Trial name
- NCT04998188
- Testing
- Collagen
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Istituto Ortopedico Rizzoli