Clinical trials: Articular Cartilage Disorder, active
Femoro-acetabular Impingement (FAI)
Comparison of Minced Cartilage Implantation Versus Microfracture for Acetabular Chondral Lesions Due to FAI (Femoro-acetabular Impingement)
A femoroacetabular impingement (FAI) is an abnormal contact between pelvis and the neck of femur. It occurs particularly when patient bends his hip and causes damage to the cartilage.
- Trial name
- CARTIFRAC (NCT07657871)
- Testing
- Minced cartilage implantation - MCI, Microfracture
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Degenerative Arthritis, Knee Arthritis
Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy
This clinical trial is conducted to assess the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous BS-JS-IIT1 investigator initiated trial.
- Trial name
- NCT04825730
- Testing
- JOINTSTEM
- Volunteers
- 14 people
- Sponsor
- R-Bio
Cartilage Injury, OA Knee
Tissue Engineered Cartilage to Repairing Articular Cartilage Defects
The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.
- Trial name
- NCT07094100
- Testing
- Tissue engineered cartilage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Platelet Rich Plasma Injection, Ultrasonography
The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis
The primary objective of this study is to evaluate and compare the effectiveness of ultrasound-guided combined intra-articular and peri-articular platelet-rich plasma (PRP) injections with intra-articular PRP injections alone in…
- Conditions
- Platelet Rich Plasma Injection, Ultrasonography, Gonarthrosis
- Trial name
- NCT07339137
- Testing
- Conservative Therapy, Intra-Articular PRP, Peri-Articular PRP
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Bone Diseases, Infectious, Musculoskeletal Diseases
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health.
- Conditions
- Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis
- Trial name
- MVMS_MRI (NCT04536103)
- Testing
- MRI
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Xiaojuan Li
Platelets-rich Plasma, Osteoarthritis Knees Both
Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis
To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for…
- Conditions
- Platelets-rich Plasma, Osteoarthritis Knees Both, Meniscus Disorder, Cartilage Injury
- Trial name
- NCT06082531
- Testing
- Sodium hyaluronate injection
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Osteoarthritis (OA)
Research on the Pathogenesis and Therapeutic Targets of Articular Cartilage Degeneration in Osteoarthritis
Before you are included in this study, you will undergo the following examinations to determine if you are eligible to participate: Before you are included in this study, your doctor will ask and record your medical history…
- Trial name
- NCT07796607
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yunnan University of Chinese Medicine
Knee Osteoarthritis
Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma
This is a prospective cohort clinical study. Due to logistic constraints at the sites of implementation, a randomized allocation will not be feasible (private clinic).
- Trial name
- OASIS-PRP (NCT06520059)
- Testing
- Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration
- Where
- 2 sites in Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Osteoarthritis of the Hip, Degenerative Joint Disease of Hip
Evaluate the Safety and Effectiveness of the Polymotion Hip Resurfacing (PHR) System Compared to Total Hip Arthroplasty
The goal of this clinical trial is to evaluate the safety and effectiveness of the Polymotion Hip Resurfacing (PHR) System compared to total hip arthroplasty, for adults who require hip resurfacing arthroplasty due to 1)…
- Conditions
- Osteoarthritis of the Hip, Degenerative Joint Disease of Hip, Dysplasia; Hip
- Trial name
- PHR (NCT06792539)
- Testing
- Polymotion Hip Resurfacing (PHR) System
- Where
- 9 sites in United States, Bermuda
- Volunteers
- 238 people
- Sponsor
- JointMedica Inc.
Joint Disease
Extracellular Vesicles in Fibrin Gel for Cartilage Repair
This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth…
- Trial name
- GelVex (NCT06713902)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Articular Cartilage Defect, Chondral Defect
Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee
The major objective of this study is to evaluate the efficacy of the MACT versus the AMT for the treatment of large cartilage defects in patellofemoral and femorotibial injuries.
- Conditions
- Articular Cartilage Defect, Chondral Defect, Osteochondritis
- Trial name
- NCT05651997
- Testing
- MACT, AMT
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Meniscus Tear
The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears.
- Trial name
- NCT06532851
- Testing
- Progressive Resistance Exercise (PRE), Aerobic Exercise, Control
- Where
- 2 sites in Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Osteoarthritis
Developing Allogeneic Musculoskeletal Therapies
The goal of this observational study is to analyse the cartilage and bone forming potential of cells isolated from the tissues of patients undergoing surgery for the treatment of polydactyly, hip dislocation and from other…
- Trial name
- NCT06167928
- Where
- United Kingdom
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Keele University
Knee Osteoarthritis
Serum COMP and MMP-3 in Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disease characterized by pain, stiffness, and functional limitation, significantly affecting quality of life.
- Trial name
- KOACOMP (NCT07528872)
- Testing
- Observational Study
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteearthritis, Joint Damage
Effect of Agar/Collagen-based Compounds on Osteoarticular Pain: Randomized Triple-blind Clinical Trial
Joints-comprising bone, cartilage, ligaments, and synovial fluid-enable stable daily movement but may deteriorate with age, excess body weight, overuse, injury, or disease.
- Conditions
- Osteearthritis, Joint Damage, Inflammation, Cartilage Damage
- Trial name
- AGARTROSIS (NCT07318896)
- Testing
- Agar-Agar, Agar-Agar and undenatured collagen type II, undenatured collagen type II
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundació Eurecat
Osteoarthritis, Knee, Articular Cartilage Defects of the Knee
Subchondral Drilling Diameter During CARTISTEM Implantation for Knee Cartilage Defects
This prospective, randomized study at Severance Hospital compares two subchondral drilling techniques during CARTISTEM implantation for symptomatic medial-compartment knee articular cartilage defects.
- Trial name
- NCT07881445
- Testing
- 2-mm subchondral drilling, Sequential 4-mm and 2-mm subchondral drilling
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Knee Pain Chronic, Knee Osteoarthritis
BioPoly® Partial Resurfacing Knee Implant IDE
The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients…
- Conditions
- Knee Pain Chronic, Knee Osteoarthritis, Cartilage Damage, Cartilage Defects of the Knee
- Trial name
- NCT06915363
- Testing
- BioPoly, surgical standard of care (SSOC)
- Where
- 5 sites in United States
- Volunteers
- 152 people
- Sponsor
- BioPoly LLC
Digital Osteoarthritis or Rheumatoid Arthritis
Functional Imaging of Digital Osteoarthritis and Rheumatoid Arthritis Using 99mTc-NTP 15-5 in Nuclear Medicine
This study is a phase Ii clinical trial aimed to evaluate the performance of 99mTc-NTP 15-5 to identify a pathological hand joint in each group ; digital osteoarthrosis and rheumatoid arthritis
- Trial name
- CARSPECT II (NCT07624994)
- Testing
- 99mTc-NTP 15-5 at a diagnostic activity of 15 MBq/kg
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Jean Perrin
Osteoarthritis, Pain
Efficacy of Exercise on Quality of Life and Physical Function in Patients With Knee Osteoarthritis
The overall contribution of this study is to increase the knowledge of the efficacy of strength and aerobic exercise on knee related quality of life, knee pain, and physical function in patients with knee osteoarthritis (OA).
- Trial name
- NCT01682980
- Testing
- Strength training, Aerobic exercise
- Where
- Norway
- Volunteers
- 207 people
- Sponsor
- Oslo University Hospital