Clinical trials: Articular Cartilage Disorder of Knee
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis
Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
The purpose of this two-part study is to assess the efficacy, safety and tolerability of multiple intra-articular (i.a.) injections of LNA043, in regenerating the articular surface in patients with cartilage lesions of the knee…
- Trial name
- NCT03275064
- Testing
- LNA043
- Where
- 19 sites in United States, Czechia and 1 more
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis
Effect of Metformin on Patients With Osteoarthritis
This randomized controlled trial aims to investigate if metformin has osteoarthritis protective effects among overweighted knee osteoarthritis patients.
- Trial name
- NCT05034029
- Testing
- Metformin hydrochloride sustained release tablets
- Where
- 5 sites in China
- Volunteers
- 262 people
- Sponsor
- Guangzhou First People's Hospital
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Other Articular Cartilage Disorders, Osteochondritis Dissecans
Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture
The Cartilage Autograft Implantation System (CAIS) is a single-stage procedure in which cartilage is harvested from non-critical regions of articular cartilage, but then immediately morcellated and loaded onto a polymer…
- Trial name
- CAIS (NCT01498029)
- Testing
- Microfracture, Cartilage Autograft Implantation System (CAIS)
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Singapore General Hospital
Knee Osteoarthritis
The Effect of Corrective Osteotomy on in Vivo Cartilage Mechanobiology in Patients With Knee Osteoarthritis
Our overall hypothesis is that a sudden ambulatory load reduction (caused by corrective osteotomy) leads to changes in cartilage biology that delay or reverse osteoarthritic processes determining the clinical outcome and…
- Trial name
- Osteotomy (NCT02622204)
- Testing
- Corrective osteotomy
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Knee Osteoarthritis, Cartilage Damage
Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration
The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis…
- Conditions
- Knee Osteoarthritis, Cartilage Damage, Meniscal Tear
- Trial name
- PRP-Bochum (NCT02189408)
- Testing
- Platelet rich plasma
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Ruhr University of Bochum
Knee Osteoarthritis, Low Level Laser Therapy
Low-Level Laser Therapy in Knee Osteoarthritis: Effects on Clinical Outcomes, Femoral Cartilage Thickness and Regional Sarcopenia
It was designed as a single-center, prospective, randomized controlled study. The study consists of two groups. Both groups of patients will receive a conventional home based exercise program.
- Conditions
- Knee Osteoarthritis, Low Level Laser Therapy, Regional Sarcopenia, Exercise Theraphy
- Trial name
- NCT07078877
- Testing
- home based exercise, Low Level Laser Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Ankara Etlik City Hospital
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Knee Osteoarthritis (OA)
A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)
This study is designed to evaluate, by MRI, knee cartilage and structure in all subjects. Half the subjects in this study will take collagen hydrolysate each day for 48 weeks and the other half of the subjects will take a placebo…
- Trial name
- NMR (NCT00536302)
- Testing
- Collagen Hydrolysate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- GELITA
Articular Cartilage Disorder of Knee, Osteoarthritis, Knee
Mesenchymal Stem Cells in Knee Cartilage Injuries
Induction of autologous repair chondrogenesis to regenerate injured articular cartilage using bone marrow mesenchymal stem cells (MSCs) after in vitro expansion under restricted culturing conditions.
- Trial name
- NCT02118519
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- Jordan
- Volunteers
- 13 people
- Sponsor
- University of Jordan
Osteoarthritis (OA) of the Knee
Total Osteo-Cartilage Replacement for the Treatment of Osteoarthritis of Knee
Young patients who require total knee arthroplasty with metallic and plastic implants will undergo femoral condyle cartilage and top of the tibia with meniscus replacement.
- Trial name
- NCT07769632
- Testing
- Total osteo-cartilage replacement of the distal femur and proximal tibia, including medial and lateral meniscus., allogenic bone and cartilage graft
- Where
- Bahrain
- Volunteers
- 10 people
- Sponsor
- AlSalam Hospital
Osteearthritis
Application of Autologous Stem Cells From Adipose Tissue in the Regeneration of Knee Joint Cartilage
This randomized, controlled clinical trial will evaluate the safety and effectiveness of autologous adipose-derived stromal vascular fraction (SVF) therapy in patients with knee osteoarthritis (OA) grades II-IV, compared with…
- Trial name
- NCT07405840
- Testing
- stromal vascular fraction (SVF), CP
- Where
- Serbia
- Volunteers
- 60 people
- Sponsor
- Clinical Center of Vojvodina