Clinical trials: Articular Disease
Knee Osteoarthritis
Pain Compared Between the First and the Second Surgery in Staged BTKA
postoperative pain and analgesic consumption between the first and the second surgery would be compared in patients undergoing staged bilateral total knee arthroplasty (BTKA).
- Trial name
- NCT01457313
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Bundang Hospital
Spondylosis, Osteoarthritis
Medial Branch Radiofrequency Ablation and Lumbar Multifidi
The purpose of this study is to evaluate the effects of lumbar medial branch radiofrequency ablation (RFA) on lumbar multifidi muscle size and clinical spinal stability.
- Trial name
- NCT03744260
- Testing
- Patients undergo ultrasound and lumbar MRI
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Columbia University
Exercise, Ankylosing Spondylitis
Clinical Pilates and Aerobic Exercise in Patients With Ankylosing Spondylitis
The aim of our study is to investigate the effect of Clinical Pilates Exercises on functional status and quality of life when applied together with aerobic exercise in patients with ankylosing spondylitis (AS).
- Trial name
- NCT03211559
- Testing
- Exercise
- Where
- Cyprus
- Volunteers
- 36 people
- Sponsor
- Eastern Mediterranean University
SLE (Systemic Lupus), Systemic Sclerosis
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
This is an open clinical pharmacological translational Research Study, aiming to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of CD19 or CD19-BCMA CAR-T in patients with active SLE, SSc, AAV…
- Conditions
- SLE (Systemic Lupus), Systemic Sclerosis, ANCA Associated Vasculitis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT06548607
- Testing
- CD19 or CD19-BCMA CAR-T
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
Rheumatoid Arthritis
To Compare the Efficacy and Safety of Low-dose Glucocorticoids and Tofacitinib in Alleviating Moderate to High Disease Activity Rheumatoid Arthritis for 24 Weeks
Glucocorticoids are effective in the treatment of rheumatoid arthritis, but long-term use of glucocorticoids has many side effects. Tofacitinib is a new small-molecule drug targeting JAK, which has been found to act quickly.
- Trial name
- NCT05606107
- Testing
- Tofacitinib, Glucocorticoid
- Where
- 5 sites in China
- Volunteers
- 230 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Calcific Tendinitis of Shoulder
Ultrasound-Guided Extracorporeal Shock Wave Therapy for Calcific Tendinitis
Calcific tendinitis of the shoulder is a debilitating musculoskeletal condition that significantly impacts the working-age population, typically those between 30 and 60 years of age.
- Trial name
- ESWT (NCT07756307)
- Testing
- Ultrasound guide localization, Palpation localization
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University WanFang Hospital
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA)
Biomarkers in Ankylosing Spondylitis
In this study, we aimed to compare serum PGRN(progranulin) and TNF-α levels in AS patients with healthy controls and to determine the relationship between TNF-α inhibitor use and PGRN levels in AS patients.
- Trial name
- NCT07117344
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Arthritis, Rheumatoid
Safety, Efficacy and Pharmacokinetics Study of ALD518 in Patients With Active Rheumatoid Arthritis
The purpose of this study is to determine the safety and efficacy of ALD518 in three different doses in patients who have not had an adequate response to methotrexate.
- Trial name
- ALD518-003 (NCT00867516)
- Testing
- ALD518, Infusion without ALD518'
- Where
- 26 sites in Canada, Georgia and 4 more
- Volunteers
- 127 people
- Sponsor
- CSL Behring
Knee Osteoarthristis
Sleep TO Prevent Post-surgical Pain
This research study is being done to compare different methods of addressing sleep problems before total knee replacement surgery. These methods include Cognitive Behavioral Therapy and light exposure.
- Trial name
- STOPPP (NCT06976138)
- Testing
- Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- Johns Hopkins University
Rheumatoid Arthritis
Gonadotropin-Releasing Hormone (GnRH)-Antagonist Therapy in Rheumatoid Arthritis
The purpose of this study is to compare the safety and efficacy of gonadotropin-releasing hormone (GnRH) antagonist therapy versus placebo in patients with moderate to severe rheumatoid arthritis.
- Trial name
- AGRA (NCT00667758)
- Testing
- Cetrorelix
- Where
- Norway
- Volunteers
- 104 people
- Sponsor
- Betanien Hospital
Ankylosing Spondylitis
Study Evaluating Etanercept in Patients With Ankylosing Spondylitis
This study will assess the efficacy of etanercept for the treatment of Ankylosing Spondylitis (AS).
- Trial name
- NCT00458185
- Testing
- etanercept
- Volunteers
- 40 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Shoulder Impingement Syndrome, Shoulder Rotator Cuff Tendinopathy
Effectiveness of Supervised Motor Control Exercises on Rotator Cuff Tendinopathies
The shoulder is the most mobile joint in the body but still has the responsibility of ensuring a strong stability of our upper limbs during daily activities.
- Trial name
- NCT02926443
- Testing
- Upper Extremity Neuromuscular Training Program, Usual Physiotherapy Care
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Laval University
Rheumatoid Arthritis
Study To Assess The Efficacy And Safety Of Pf-06651600 In Subjects With Rheumatoid Arthritis With An Inadequate Response To Methotrexate
This is an 8 week study to assess the efficacy and safety profile of PF-06651600 in seropositive subjects with rheumatoid arthritis with an inadequate response to methotrexate (up to approximately 50% of subjects may also have…
- Trial name
- NCT02969044
- Testing
- PF-06651600
- Where
- 30 sites in United States, Bulgaria and 7 more
- Volunteers
- 70 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Effects of MWM Vs Sustained Mobilization on Knee Osteoarthritis
This article focused on people diagnosed with grade III Knee OA with sample size of 68 patients , who will randomly divided into two groups .
- Trial name
- MWM (NCT07315464)
- Testing
- mulligan moblization, kaltenborn moblization
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Anterior Cruciate Ligament Rupture
The Effect of Subtalar Joint Antipronation Taping on the Dynamic Knee Valgus in Female Volleyball Players with Low Medial Arch
This study aims to investigate the biomechanical mechanisms of dynamic knee valgus and the impact of subtalar pronation, particularly due to decreased medial longitudinal arch, on knee injury risk, highlighting the importance of…
- Trial name
- NCT06752109
- Testing
- Antipronation Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara Yildirim Beyazıt University
Osteoarthritis, Knee
A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee
To evaluate the safety and tolerability of single IV doses of PF-04383119 in Japanese patients with moderate to severe pain from OA of the knee (Part I).
- Trial name
- NCT00669409
- Testing
- PF-04383119 (tanezumab)
- Where
- 12 sites in Japan
- Volunteers
- 83 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy
This two part, multi-center, open-label, single-arm study will evaluate the efficacy and safety of tocilizumab as a monotherapy or in combination with methotrexate or other conventional synthetic disease modifying antirheumatic…
- Trial name
- TOSCA (NCT02001987)
- Testing
- Tocilizumab, Methotrexate, csDMARDs
- Where
- 32 sites in France
- Volunteers
- 139 people
- Sponsor
- Hoffmann-La Roche
Effusion Joint
Ultrasound Guided Versus Landmark Guided Small & Medium Joint Arthrocentesis
Arthrocentesis is the removal of synovial fluid for analysis of pathologic processes. Small \& medium joint arthrocentesis will be defined as the following joints: elbow, wrist, finger, ankle and toe.
- Trial name
- NCT03327584
- Testing
- Arthrocentesis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Temple University
Osteoarthritis
Comparison of Two Application Regimens for Viscosupplementation
Viscosupplementation by intra-articular injection of hyaluronate products has recently gained popularity as a treatment modality of gonarthritis.There is not, however, a consensus on the best method.Our objective is to evaluate…
- Trial name
- NCT01824485
- Testing
- viscosupplementation 1+1+1, viscosupplementation 3 at once
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- University of Sao Paulo General Hospital
Rheumatoid Arthritis, Psoriatic Arthritis
PBR28 PET and Inflammatory Arthritis
The importance of the detection of early inflammatory arthritis is recognised as being essential to the prevention of permanent joint damage.
- Trial name
- NCT02361385
- Testing
- this is not an interventional study
- Where
- 2 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Oxford
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.