Clinical trials: Artificial Limbs
Hip Prosthesis Infection, Knee Prosthesis Infection
Proof of Concept Study to Assess Safety and Efficacy of Phage Therapy in Hip or Knee Prosthetic Joint Infections Due to Staphylococcus Aureus Treated by DAIR.
Total joint replacements are effective for chronic pain but can lead to Prosthetic Joint Infections (PJI), primarily caused by Staphylococcus aureus and resistant to antibiotics.
- Trial name
- GLORIA (NCT06605651)
- Testing
- Anti-Staphylococcus aureus Bacteriophages (PP1493 and PP1815) intra-articular injection with 0.9% NaCl solution, 0.9% NaCl solution
- Volunteers
- 100 people
- Sponsor
- Phagenix
Dental Prosthesis Failure, Frail Elderly Syndrome
Immediate Dental Prosthesis Functionalization Protocol in People Over 70 Years of Age
Sarcopenia and malnutrition are closely involved in frailty. To prevent them, it is essential to assess oral function. "Oral fragility" manifests with specific signs or symptoms, including occlusion loss due to tooth loss and…
- Trial name
- NCT05818436
- Testing
- Procedure: prosthetic functioning, Conventional dental prosthesis
- Where
- Chile
- Volunteers
- 124 people
- Sponsor
- University of Chile
Prosthesis Survival
PEEK Prostheses in the All-on-4 Concept Using Zygomatic Implants for Full-arch Rehabilitation.
The goal of this study is to evaluate the outcome of a Poly-ether-ether-ketone - acrylic resin prosthesis for full-arch rehabilitation of the atrophic maxillae through the All-on-4 Hybrid concept (standard and zygomatic implants)…
- Trial name
- PEEKPilotZyg (NCT05589545)
- Testing
- Prosthetic full-arch rehabilitation using a PEEK-acrylic resin prosthesis
- Where
- Portugal
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Malo Clinic
Atrophy of Edentulous Alveolar Ridge, Alveolar Ridge Augmentation
Evaluation of Ridge Dimensional Changes After Immediate Implantation and Efficacy of This Procedure
1. Evaluation of dimensional changes in alveolar ridge following immediate implantation compared to delayed implantation 2. evaluation of the effect of gap dimensions between socket walls and dental implant in implant stability
- Trial name
- NCT01399775
- Testing
- immediate implantation, Delayed implantation
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Osteo Arthritis Knee, Knee Pain Chronic
Anterior Knee Pain Between Unisex Knee Prosthesis VS Gender Specific Knee Prosthesis Following MIS TKA
Unisex knee prosthesis and patient specific knee prosthesis has the same anterior knee pain and patellar tracking
- Trial name
- NCT05045651
- Testing
- Gender Solution®posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA and standard posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Craniectomy, Trephined Syndrome
External Post-Operative Skull Prosthesis to Prevent Sunken Flap Syndrome in Craniectomy Patients
Patients that undergo decompressive craniectomy are at risk of delayed changes in brain function known as "Sunken Flap Syndrome" or "Syndrome of the Trephined." The goal of this clinical trial is to see if placing a prosthetic…
- Conditions
- Craniectomy, Trephined Syndrome, Traumatic Brain Injury (TBI) Patients, Ischemic Stroke
- Trial name
- ExO-Skull (NCT06899711)
- Testing
- External Cranial Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Johns Hopkins University
THA, Dislocation, Hip
The Q-REDUCE Study
The purpose of this study is to design a fast-track pathway for patients referred to the University Hospital of Southern Denmark, Esbjerg, with high probability of having a dislocated hip prosthesis with the primary aim to reduce…
- Conditions
- THA, Dislocation, Hip, PROM
- Trial name
- NCT06639334
- Testing
- Fasttrack pathway for THA/HE prosthesis reduction, Standard pathway for THA/HE prosthesis reduction
- Volunteers
- 120 people
- Sponsor
- University of Southern Denmark
Hearing Loss
CHANGE Feasibility Study
The purpose of the feasibility study is to examine audiological outcomes (audiometry and speech perception) and safety (adverse events and adverse device effects) with the Nucleus CI532 cochlear implant in group of adult subjects…
- Trial name
- CLTD5626 (NCT02671032)
- Testing
- Nucleus CI532 cochlear implant
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Cochlear
Radial Head Fractures
A Study of Participants Undergoing Radial Head Replacement Using the DePuy Synthes Radial Head Replacement System for Partial Replacement of the Elbow Joint
The purpose of this study is to establish survivorship defined by the cumulative incidence of revision over the first 6 months post-implantation.
- Trial name
- NCT05415592
- Testing
- DePuy Synthes Radial Head Replacement System
- Where
- 4 sites in United States, United Kingdom
- Sponsor
- DePuy Synthes Products, Inc.
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint Prosthesis
This study is a non-randomized, consecutive enrollment, one-year post-approval study of patients who are treated with the Ascension® MCP.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Osteoarthritis, Post-traumatic Arthritis
- Trial name
- MCP (NCT02408471)
- Testing
- Ascension® MCP Finger Implant
- Where
- 9 sites in United States
- Volunteers
- 97 people
- Sponsor
- Smith & Nephew, Inc.
Aseptic Loosening, Aseptic Loosening of Prosthetic Joint
DIGITAL-KNEE Study: Adequately Diagnosing Total Knee Arthroplasty Loosening by Evaluating the AtMoves Knee System in a Routine Clinical Setting
The goal of the clinical trial is to evaluate the efficacy of the AtMoves Knee System in the clinical diagnostic process of aseptic loosening in patients with a knee prosthesis.
- Conditions
- Aseptic Loosening, Aseptic Loosening of Prosthetic Joint, Aseptic Loosening of Orthopaedic Hardware, Knee Arthroplasty, Total
- Trial name
- DigitalKnee (NCT06839807)
- Testing
- AtMoves Knee System
- Where
- 7 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Prosthesis Durability
Management of Severely Atrophied Maxillary Ridge Using Quad Zygomatic Implants
This clinical study will aim to compare and evaluate zygomatic implant stability, occlusal contact, and bone level changes around dental implants
- Trial name
- NCT06031506
- Testing
- Implant supported hybrid maxillary prosthesis
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Lip, Prosthesis User
Facial Scanning for Lip Support Assessment in Full Arch Implant Rehabilitations
Lip support plays an important role in facial esthetics, being a relevant factor when realizing full arch implant supported rehabilitations.
- Conditions
- Lip, Prosthesis User, Soft Tissue
- Trial name
- NCT04753866
- Testing
- Facial scanner
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Avascular Necrosis of Hip, Osteoarthritis, Hip
Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral Component
The Zimmer Hip Resurfacing System Post-Market Clinical Follow-up study will examine the safety and efficacy of this device in the young and/or active patient with advanced hip disease.
- Conditions
- Avascular Necrosis of Hip, Osteoarthritis, Hip, Rheumatoid Arthritis, Inflammatory Arthritis
- Trial name
- MMC (NCT03681639)
- Testing
- Serum Metal ion levels determined to monitor changes in chromium and cobalt levels
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Zimmer Biomet
Lumbar Disc Disease
Postoperative Scar in the Control Excess of Mobility Induced by Annulus Removal on Inserting a Lumbar Disc Prosthesis
To implant a complete lumbar disc prosthesis removal of the anterior portion of the annulus fibrosus is required. As the anterior portion of the annulus limits the movement in extension and axial rotation, we would like to know…
- Trial name
- NCT04641039
- Testing
- Anterior lumbar disc annulus removal versus replacement
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- University of Valencia
Other and Unspecified Complications of Amputation Stump
Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis
The purpose of this study is to determine if transfemoral amputees of varied etiology will demonstrate increased function, safety and quality of life following accommodation with a new knee prosthesis as compared to their former…
- Trial name
- NCT01473992
- Testing
- Otto Bock C-Leg, Otto Bock Genium
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Jason Highsmith
Post Traumatic Arthritis, Osteoarthritis
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
The goal of this study is to demonstrate the safety and performance of the Incompass™ Total Ankle System after surgery over the standard follow-up period.
- Conditions
- Post Traumatic Arthritis, Osteoarthritis, Total Ankle Replacement, Total Ankle Prosthesis
- Trial name
- NCT07118501
- Testing
- Total Ankle Replacement
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stryker Trauma and Extremities
Surgical Wound, Revision Total Knee Arthroplasty
Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty
This study evaluates surgical site complications in subjects undergoing revision of a total knee arthroplasty when closed incision negative pressure therapy is used to manage the closed incision, as compared to a standard of care…
- Conditions
- Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease
- Trial name
- PROMISES (NCT03274466)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
- Where
- 17 sites in United States
- Volunteers
- 294 people
- Sponsor
- KCI USA, Inc
Amputation
Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis
People with lower extremity amputation (LEA) have persistent problems with balance, falls, residual limb pain, functional mobility, cognitive attention during gait, and satisfaction with participation in daily activities, despite…
- Trial name
- NCT06214026
- Testing
- META-Arc foot locked, META-Arc foot unlocked
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Washington
Knee Replacement
Survival Rates of Patients With Mobile Bearing Total Knee Arthroplasty After 10 Years
The total knee replacement has become a routine procedure. Survival rate of over 90% after 10 years are generally reported. However, complications and reoperation may still occur for many reasons, and some of them may be related…
- Trial name
- NCT02651571
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France