Clinical trials: Artificial Pancreas
Type 1 Diabetes Mellitus
Crossover Feasibility Study of Portable AP Device With Zone-MPC and HMS and Adapted I:C and Basal Insulin
The purpose of this trial is to assess the performance of an Artificial Pancreas (AP) device using the Portable Artificial Pancreas System (pAPS) platform for subjects with type 1 diabetes using an insulin pump and rapid acting…
- Trial name
- DP3 (NCT01929798)
- Testing
- portable Artificial Pancreas
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes Mellitus, Type 1
Closed-Loop Control in Young Children 5-8 Years Old Using DiAs Platform
The overall aim of this proposed research is to determine the safety, feasibility and efficacy (AP vs at home use of SAP) of the Diabetes Assistant (DiAs) controller in day and night closed-loop control in young children 5-8…
- Trial name
- NCT02750267
- Testing
- Diabetes Assistant (DiAs) with Closed-Loop
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Short Term Closed-loop Glucose Control in Adults With Type 1 Diabetes
The main objective of this study is to determine the feasibility, efficacy and safety of automated closed-loop glucose control in the home setting over a short term period.
- Trial name
- AP@home02 (NCT01666028)
- Testing
- FlorenceD or similar closed loop glucose control system, CSII with real-time CGM
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 18 people
- Sponsor
- University of Cambridge
Type 1 Diabetes, Autoimmune Diabetes
Is the Artificial Pancreas, Without Carbohydrate Counting, Efficient and Safe in an Outpatient Setting
This is a pilot, interventional clinical trial to assess the effectiveness and safety of artificial pancreas (AP) using the ARG algorithm closed-loop system in a monitored 3-day period outpatient study.
- Trial name
- NCT04793165
- Testing
- Non-hybrid closed-loop system with ARG algorithm
- Where
- Argentina
- Volunteers
- 5 people
- Sponsor
- Hospital Italiano de Buenos Aires
Type 1 Diabetes, Pregnancy
Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes With Extension Into Outpatient at Home
This clinical trial is a safety and feasibility study to assess the performance of an artificial pancreas (AP) system using the Zone Model Predictive control (Zone-MPC) and Health Monitoring System (HMS) algorithms embedded into…
- Trial name
- NCT04492566
- Testing
- Automated Insulin Delivery
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Sansum Diabetes Research Institute
Chronic Pancreatitis, Exocrine Pancreatic Insufficiency
AI Evaluation of Pancreatic Exocrine Insufficiency in CP Patients
Early assessment of pancreatic exocrine insufficiency (PEI) is crucial for determining appropriate chronic pancreatitis (CP) treatment plans, thereby avoiding unnecessary suffering and further complications in patients.
- Conditions
- Chronic Pancreatitis, Exocrine Pancreatic Insufficiency, Machine Learning, Deep Learning
- Trial name
- NCT06278272
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Changhai Hospital
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes
Postprandial meal glucose control with closed-loop systems (CLS) still needs some improvements. In the postprandial period, sensor delay in detecting blood glucose rise after a meal together with delays in insulin absorption…
- Trial name
- NCT02416765
- Testing
- 15-hour intervention, Insulin (Lispro, Aspart or guilisine), Glucagon (Eli Lilly)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Pancreatic Cancer, Diagnose Disease
AI-Powered Precision Decision-Making for Pancreatic Diseases
This multicenter clinical trial evaluates an artificial intelligence (AI) system designed to assist in the diagnosis and management of pancreatic diseases.
- Conditions
- Pancreatic Cancer, Diagnose Disease, IPMN, Pancreatic, Pancreatic Cystic Lesions
- Trial name
- NCT07439757
- Testing
- Diagnosis by Artificial Intelligence model
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Hypoglycemia
Post Bariatric Closed Loop Glucagon Trial
This study is to test our automated hypoglycemia prevention and treatment device (glucagon-only bionic pancreas) in subjects that have undergone post-bariatric surgery that are experiencing symptoms of hypoglycemia.
- Trial name
- NCT02966275
- Testing
- Glucagon-only bionic pancreas - glucagon
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes Under Free Living Conditions
The main objective of this study is to determine whether home use of day and night closed loop insulin delivery under free living conditions applying faster insulin aspart (FiAsp) is non-inferior to home use of closed-loop…
- Trial name
- AP@Home04_P3 (NCT04055480)
- Testing
- Closed-loop using standard rapid-acting insulin, Closed-loop using faster insulin aspart
- Where
- 4 sites in Austria, Switzerland and 1 more
- Volunteers
- 25 people
- Sponsor
- University of Cambridge
Type1diabetes
The OpenAPS_ShadowMode Study
The "Open Artificial Pancreas System (OpenAPS)" was designed to quickly spread technology and knowledge about the construction of artificial pancreas systems to patients with diabetes without awaiting clinical regulatory…
- Trial name
- NCT03720080
- Testing
- OpenAPS
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pancreatic Neoplasms, Pancreatic Ductal Adenocarcinoma (PDAC)
EUS-Based Artificial Intelligence to Predict Outcomes in Pancreatic Cancer
The EUS-AI-R study is an observational, single-center, two-phase (retrospective-prospective) study designed to develop and validate artificial intelligence (AI) models for predicting chemotherapy response and oncological outcomes…
- Conditions
- Pancreatic Neoplasms, Pancreatic Ductal Adenocarcinoma (PDAC), Artificial Intelligence (AI), Endoscopic Ultrasound (EUS)
- Trial name
- EUS-AI-R (NCT07803770)
- Testing
- Endoscopic ultrasound (EUS), with or without tissue acquisition (EUS-FNA/FNB), performed according to standard clinical practice. No study-specific intervention is introduced.
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type 1
Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format,
In previous studies, the investigators tested the feasibility of a bi-hormonal reactive closed loop system without mealtime announcement.
- Trial name
- APPEL5 (NCT03858062)
- Testing
- Insulin pump therapy (with or without glucose sensor), Artificial pancreas (Inreda Diabetic)
- Where
- 2 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- J.H. DeVries
Type 1 Diabetes Mellitus
A Study to Evaluate a Multiple Model Probabilistic Predictive Controller (MMPPC) for Closed Loop Insulin Delivery
You are invited to participate in a research study for the development of an artificial pancreas. An artificial pancreas uses a program which takes information from a continuous blood glucose monitor and uses that information to…
- Trial name
- NCT01492062
- Testing
- Multiple Model Predictive Controller
- Where
- 2 sites in United States
- Sponsor
- Stanford University
Type 1 Diabetes
The Summer Camp Study: Blood Glucose Control With a Bi-Hormonal Bionic Endocrine Pancreas
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers both insulin and glucagon can improved glycemic control vs.
- Trial name
- NCT01833988
- Testing
- Bi-hormonal Bionic Pancreas, Usual Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes Mellitus
Pramlintide and Fiasp Closed-Loop With a Simple Meal Announcement
The aim of this pilot study is to generate preliminary data of (i) Fiasp-plus-Pramlintide closed-loop system with a simple meal announcement, compared to (ii) Fiasp-alone closed-loop system with full carbohydrate counting, in…
- Trial name
- NCT03993366
- Testing
- Fiasp+Pramlintide Closed-Loop System, Fiasp Closed-Loop System
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University
Chronic Pancreatitis, Pancreatic Cancer
Immune Repertoire Decoding for Chronic Pancreatitis-to-Pancreatic Cancer Risk Stratification
This study will follow people with chronic pancreatitis, people with pancreatic cancer, and healthy volunteers. The goal is to better understand why some people with chronic pancreatitis may later develop pancreatic cancer.
- Trial name
- NCT07612566
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Diabetes Mellitus, Type 1, Type 1 Diabetes
Co-administration of Pramlintide and Insulin Via an Automated Dual-hormone Artificial Pancreas System in Adults With Type 1 Diabetes
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Postprandial Hyperglycemia
- Trial name
- NCT04243629
- Testing
- Rapid-Acting Insulin, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McGill University
Diabetes, Type I
Closing the Loop Between Glucose Sensor and Insulin Pump-developing an Algorithm
An open interventional data collection study in order to build a database to close the loop between glucose sensor and insulin pump.
- Trial name
- NCT00541515
- Testing
- continuous glucose sensors and insulin pump
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes Mellitus in Prepubertal Children
Efficacy of Closed-loop Insulin Therapy in Prepubertal Child in Free-life
The study is a randomized trial preceded by a run-in period and followed by a non-randomized study extension. After 3 weeks of outpatient use of study pump (1 week) and study pump+CGM (2weeks) as run-in period, patient and…
- Trial name
- FREELIFE-KID (NCT03739099)
- Testing
- Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Montpellier