Clinical trials: Artificial Respiration
Respiration, Artificial, Ventilator Weaning
Pediatric Ventilation Weaning
The hypothesis of the present study is that the use of Continuous Positive Airway Pressure (CPAP) plus PS can accelerate the weaning process and, consequently, shorten the MV.
- Trial name
- PROVENTUS (NCT04023643)
- Testing
- Ventilation Weaning
- Where
- 5 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- São Paulo State University
Respiration, Artificial, Critical Care
Weaning Algorithm for Mechanical VEntilation
To compare the duration of mechanical ventilation and the weaning period between two groups of patients managed with either Standard Care or with mechanical ventilation adjusted according to the Beacon Caresystem, in patients…
- Conditions
- Respiration, Artificial, Critical Care, Respiratory Insufficiency, Intensive Care (ICU) Myopathy
- Trial name
- WAVE (NCT03697785)
- Testing
- Beacon Care System
- Where
- 2 sites in United Kingdom
- Volunteers
- 286 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Respiration, Artificial, Critical Care
Pressure Support During Chest Wall Compression
The purpose of this study is to compare two physiotherapy techniques: chest wall compression versus chest wall compression plus increase of 10 cmH2O in inspiratory pressure.
- Trial name
- NCT01155648
- Testing
- Chest wall compression plus increase of 10 cmH2O in inspiratory pressure during Pressure Support Ventilation for ten minutes in chest., Chest wall compression for ten minutes in chest
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obesity, Reduced Lung Compliance.
Comparison Between Volume Controlled Ventilation and Pressure Controlled Ventilation
To assess the potential benefits on mechanical ventilation plateau pressure of pressure controlled mode versus volume controlled mode for laparoscopic bariatric surgery in obese patients (BMI > 35).
- Conditions
- Obesity, Reduced Lung Compliance., Anesthesia., Laparoscopy.
- Trial name
- NCT00224653
- Testing
- Mechanical Ventilation
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Respiration, Artificial, Critical Illness
Adjunctive Clonidine in the Sedation of Mechanically Ventilated Children
Almost all critically ill children who are mechanically ventilated require sedation and analgesia. Providing effective sedation for children in the PICU requires careful balancing of the need for sedation with the adverse effects…
- Conditions
- Respiration, Artificial, Critical Illness, Conscious Sedation, Deep Sedation
- Trial name
- NAPS Pilot (NCT00959062)
- Testing
- clonidine
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Hamilton Health Sciences Corporation
Respiration, Artificial, Postoperative Pain
Sedation Administration Timing: Intermittent Dosing Reduces Time to Extubation
SATIRE is a prospective, randomized control trial assessing two methods of administration of intravenous sedation and narcotics in surgical patients requiring mechanical ventilation.
- Conditions
- Respiration, Artificial, Postoperative Pain, Postoperative Complications
- Trial name
- SATIRE (NCT03181620)
- Testing
- Intermittent Dosing of Medication
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abington Memorial Hospital
Respiration, Artificial
A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospitals
Protocol directed weaning has been shown to reduce the duration of mechanical ventilation for patients admitted to the intensive care unit (ICU) of tertiary centres.
- Trial name
- NCT00157287
- Testing
- Evidence based weaning protocol
- Where
- 11 sites in Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mechanical Ventilation Complication
Impact of Inspiratory Muscle Pressure Curves on the Ability of Professionals to Identify Patient-ventilator Asynchronies
Patient-ventilator asynchronies can occur as a result of a mismatch between neural (patient) and ventilator inspiratory and expiratory phases.
- Trial name
- Pmus (NCT05144607)
- Testing
- Muscle Pressure curve (Pmus)
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
ARDS (Acute Respiratory Distress Syndrome)
Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.
Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia and diffuse alveolar collapse, often requiring invasive mechanical ventilation.
- Trial name
- RECRUIT-PEEP (NCT07603310)
- Testing
- Positive End-Expiratory Pressure (PEEP) Titration guided by Static Compliance, Positive End-Expiratory Pressure (PEEP) Titration guided by Transpulmonary Pressure
- Where
- Chile
- Volunteers
- 52 people
- Sponsor
- Hospital Dr. Franco Ravera Zunino
Chest Pain, Dyspnea
ER-VISION-AI Study
Prospective, multicenter, randomized, open-label, blinded-endpoint (PROBE-like) clinical trial evaluating whether physician-supervised Generative Pre-trained Transformer (GPT)-assisted multimodal diagnostic support improves…
- Conditions
- Chest Pain, Dyspnea, Acute Cardiopulmonary Disease, Emergency Department Patients
- Trial name
- ER-VISION-AI (NCT07727590)
- Testing
- Generative Pre-trained Transformer (GPT)-assisted multimodal visual language model (VLM) diagnostic support, Conventional emergency department diagnostic evaluation
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Intraoperative Hypotension
Hypotension Prediction Index (HPI) in Lung Resections
Perioperative hypotension is a risk factor for perioperative complications. Advances in machine learning and artificial intelligence have produced an algorithm that predicts the occurrence of hypotension episodes by analyzing an…
- Trial name
- NCT06202638
- Testing
- HemoSphere monitor with Acumen Hypotension Prediction Index Software
- Where
- 3 sites in Greece, Poland
- Volunteers
- 77 people
- Sponsor
- John Paul II Hospital, Krakow
Respiratory Distress Syndrome
Sustained Lung Inflation in the Delivery Room in Preterm Infants at High Risk of Respiratory Distress Syndrome
BACKGROUND. Sustained lung inflation (SLI) associated to an adequate PEEP may help the efficacy of the respiratory effort in lung of preterm infants at risk for respiratory distress syndrome (RDS) and reduce need of mechanical…
- Trial name
- SLIS (NCT01440868)
- Testing
- Sustained lung inflation
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- University of Florence
Respiration, Artificial, Sedated
Influence of Chronic Vascular Diseases on Transcranial Doppler Profiles in Critically Ill Patients
The primary objective of this study is to show that cardiovascular risk factors associated with the chronic elevation of arterial resistance may be associated with "false" profiles of intracranial hypertension during transcranial…
- Trial name
- CritiDop (NCT02898389)
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Respiration, Artificial
Practice of Mechanical Ventilation in Patients With Severe Brain Injury in China
The mechanical ventilation strategy has changed over years worldwide. Several international researches have been conducted to study the association of the use of mechanical ventilation with clinical outcomes.
- Trial name
- NCT02517073
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Capital Medical University
Coronary Artery Disease
Continued Ventilation During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.
- Trial name
- NCT01627756
- Testing
- Lung Ventilation, Non-ventilated Group
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Hypertension, Diabete Mellitus
Assessing the Effectiveness of Large Language Model (LLM)-Enabled Nurse Treatment Planning in 2 Indian Districts
The goal of this clinical trial is to learn whether AI-enabled, nurse-led treatment planning can improve the quality of clinical reasoning and management compared with standard physician-led care in adult primary care patients…
- Conditions
- Hypertension, Diabete Mellitus, Breathlessness, Fever
- Trial name
- NCT07432893
- Testing
- AI-enabled clinical decision support tool (software) used by nurses, Physician consultation
- Where
- 2 sites in India
- Volunteers
- 736 people
- Sponsor
- Sarah Nabia
Stress Disorders, Post-Traumatic, Depression
Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on PTSD
Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation.
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety
- Trial name
- NCT02040649
- Testing
- Non-sedation, Control, sedation (propofol, midazolam)
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Palle Toft
Acute Respiratory Distress Syndrome, Respiration, Artificial
Impact of Decreasing Respiratory Rate on Lung Injury Biomarkers in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a form of acute lung injury of inflammatory origin, which represents a public health problem worldwide due to its prevalence, and its high mortality rate, close to 40%.
- Conditions
- Acute Respiratory Distress Syndrome, Respiration, Artificial, Ventilator-Induced Lung Injury
- Trial name
- NCT04641897
- Testing
- Respiratory rate modification
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile