Clinical trials: Ascites Hepatic
Cirrhosis, Liver, Portal Hypertension
A Pilot Trial to Test the Feasibility of Utilizing Home Blood Pressure Monitoring to Optimize the Administration of Midodrine Among Decompensated Cirrhosis Patients
This is a randomized single-blind feasibility trial to test the utilization of home blood pressure devices to improve the clinical management of decompensated cirrhosis patients.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Ascites Hepatic
- Trial name
- WATCH (NCT05928624)
- Testing
- Withings Home Blood Pressure Device and Scale, Standard of Care
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of California, San Francisco
Hypertension, Portal, Liver Cirrhosis
Outcome After TIPS
This clinical trial is a retrospective single-centre study. Research data will be acquired via patient histories stored in the hospital data system.
- Conditions
- Hypertension, Portal, Liver Cirrhosis, Variceal Hemorrhage, Ascites Hepatic
- Trial name
- NCT03459378
- Testing
- no intervention - retrospective analyses
- Where
- Austria
- Volunteers
- 158 people
- Sponsor
- Medical University of Graz
Cirrhosis, Ascites Hepatic
PEriToneal Catheter Versus Repeated Paracentesis for Ascites in Cirrhosis
Insertion of a tunnelated peritoneal catheter (PleurX) allows repeated intermittent small volume fluid drainage at home. The treatment may improve the management of ascites and have a beneficial effect on the quality of life.
- Conditions
- Cirrhosis, Ascites Hepatic, Ascites (Non-Malignant)
- Trial name
- PETRA (NCT03027635)
- Testing
- PleurX, peritoneal tunnelated catheter, Large Volume Paracentesis, Ciprofloxacin 500Mg Tablet
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Nina Kimer
Cirrhosis, Hepatic Encephalopathy
The Effect of a Large-volume Paracentesis on Fatigue, Sleep, and Quality of Life in Cirrhosis
Ascites is the accumulation of fluid within the peritoneal cavity of the abdomen. It is a frequent complication of cirrhosis that is associated with significant morbidity and poor quality of life.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Ascites, Fatigue
- Trial name
- NCT01777971
- Where
- United States
- Sponsor
- NYU Langone Health
Cirrhosis, Ascites
The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy.
This study is being completed for patients with cirrhosis, including patients with a prior history of hepatic encephalopathy (HE) to evaluate the feasibility and benefits of medically-tailored meals as an intervention.
- Conditions
- Cirrhosis, Ascites, Liver Diseases, Frailty
- Trial name
- NCT04675775
- Testing
- Medically-tailored meals (MTM), Protein supplements, Nutrition education handout
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Michigan
Liver Cirrhosis, Portal Hypertension
VICIS - Vienna Cirrhosis Study
Patients with advanced chronic liver diseases treated at the Vienna General Hospital of the Medical University of Vienna will be offered to participate in this prospective observational trial - including an optional participation…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Ascites, Variceal Hemorrhage
- Trial name
- VICIS (NCT03267615)
- Where
- Austria
- Volunteers
- 10,000 people
- Sponsor
- Medical University of Vienna
End-stage Liver Disease (ESLD), Cirrhosis, Liver
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
The purpose of this study is to assess the safety and efficacy of RTX001 in patients with end-stage liver disease. This study is the first time RTX001, a macrophage cell therapy engineered to have an anti-inflammatory and…
- Conditions
- End-stage Liver Disease (ESLD), Cirrhosis, Liver, Cirrhosis, Decompensated, Liver Diseases
- Trial name
- EMERALD (NCT06823713)
- Testing
- RTX001
- Where
- 15 sites in Spain, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Resolution Therapeutics Limited
Cirrhosis, Ascites Hepatic
Using Bedside Ultrasound to Understand Fluid Management in Patients With Chronic Liver Disease
The goal of this observational study is to see if repeated bedside ultrasound measurements of the lungs and abdomen as well as a blood vessel in the neck can be done in patients with advanced liver disease and ascites (fluid in…
- Conditions
- Cirrhosis, Ascites Hepatic, Fluid Balance
- Trial name
- POCUS-C (NCT07810855)
- Testing
- Ultrasound measurement, Blood draw for the laboratory assessment
- Volunteers
- 100 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Refractory Ascites, Hepatic Hydrothorax
Glutamine Challenge as Predictor of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Transjugular intrahepatic portosystemic shunt (TIPS) is the first-line therapy for patients with cirrhosis and refractory ascites. However, mental changes known as hepatic encephalopathy (HE) frequently occur after TIPS.
- Conditions
- Refractory Ascites, Hepatic Hydrothorax, Hepatic Encephalopathy, Cirrhosis
- Trial name
- NCT02026609
- Testing
- Oral glutamine challenge, Psychometric Tests
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 3 people
- Sponsor
- University of Arkansas
Hepatic Ascites
Recombinant Human Serum Albumin in Patients With Liver Cirrhosis and Ascites Subjects
This trial adopts a randomized, double-blind, positive drug-controlled, dose-escalated phase Ib clinical study evaluating the safety, tolerability, pharmacokinetic characteristics and preliminary effectiveness of recombinant…
- Trial name
- NCT05249374
- Testing
- Recombinant Human Serum Albumin, Human serum albumin
- Where
- 8 sites in China
- Volunteers
- 36 people
- Sponsor
- Beijing Protgen Biotechnology Development Co., Ltd.
Liver Cirrhosis
Study in Patients With Decompensated Liver Cirrhosis
OPAL is a multicenter observational study, following the natural disease trajectory of participants who have permanent damage to their liver caused by scarring, sometimes also referred to as liver cirrhosis.
- Trial name
- OPAL (NCT06380335)
- Where
- 12 sites in Spain, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Resolution Therapeutics Limited
Ascites, Hepatic Cirrhosis
Dose Exploring and Setting Study for Tolvaptan to Treat Hepatic Cirrhosis With Ascites
To observe the safety/efficacy of tolvaptan for treatment of patients with hepatic cirrhosis with ascites and exploring the dosage-effect relations of the drug.
- Trial name
- NCT01349335
- Testing
- Tolvaptan
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Otsuka Beijing Research Institute
Caregivers
CAREGIVER: A Trial to Improve the Burden and Distress of Caring for Persons With Decompensated Cirrhosis
The goal of this study is to enroll caretakers of patients with decompensated cirrhosis to determine if written emotional disclosure or resilience training interventions reduce distress and burden among primary informal…
- Trial name
- NCT04205396
- Testing
- Written emotional disclosure, Resilience training, No treatment
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Michigan
Hepatic Encephalopathy, Ascites
Tackling 30-day Readmissions in Patients With Cirrhosis: The SALTYFOOD Trial
The purpose of this study is to determine the feasibility of a home meal delivery program for patients with cirrhosis and ascites and to determine the effectiveness of a salt-restricted (2 gram sodium) meal delivery program in…
- Conditions
- Hepatic Encephalopathy, Ascites, Liver Diseases, Cirrhosis
- Trial name
- NCT03493204
- Testing
- Meal delivery, Standard pamphlet with Dietary Advice
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Cirrhosis, End Stage Liver Disease
Mechanism and the Effect of Midodrine on Portal Pressures in Patients With Cirrhosis
Ascites is a frequent complication of patients with portal hypertension. As portal hypertension progresses, a percentage of these patients develop refractory ascites.
- Conditions
- Cirrhosis, End Stage Liver Disease, Ascites, Hypotension
- Trial name
- NCT01331785
- Testing
- Midodrine
- Where
- United States
- Sponsor
- The Cleveland Clinic
Cirrhosis, Liver, Liver Diseases
Telehealth Intervention in Cirrhotics
This study is a randomized controlled trial comparing a simple telehealth intervention implemented after hospital discharge to standard of care, specifically looking at the number of hospital readmissions throughout the course of…
- Trial name
- NCT03969186
- Testing
- Intervention
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- University of Pennsylvania
Cirrhosis, Liver, Hepatorenal Syndrome
HRS-AKI Treatment With TIPS in Patients With Cirrhosis
The study compares the effectiveness and safety of TIPS implantation in patients with HRS-AKI (stage1, 2 and 3) and liver cirrhosis with standard therapy (drug therapy with terlipressin + albumin).
- Conditions
- Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury, Ascites Hepatic
- Trial name
- Liver-HERO (NCT05346393)
- Testing
- TIPS, Standard of Care
- Where
- 14 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Jena University Hospital
End Stage Liver Disease
End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA)
The purpose of this research study is to see how effective bioelectric impedance analysis (BIA) is in determining body composition (the amount of fat versus muscle in the body) and nutritional status in patients with End Stage…
- Trial name
- NCT00374582
- Testing
- Bodystat Quadscan 4000, bodystat quadscan 400
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Ascites Hepatic, Cirrhosis and Chronic Liver Disease
Evaluation of 'Melody' Paracentesis Device for Ascites Therapy
Ascites is the accumulation of fluid inside the abdomen. This can happen when the liver fails due to a substantial amount of scarring (cirrhosis).
- Trial name
- EMPATHY (NCT03191851)
- Testing
- standard device, Melody Device, Melody Device with Pump
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- University of Nottingham
Ascites, Hepatectomy
Portal Venous Hemodynamic Changes After Hepatectomy
The aim of this study is to investigate the pathophysiological mechanisms underlying the formation of posthepatectomy ascites with a focus on the significance of changes in portal venous hemodynamics after hepatic resection.
- Trial name
- NCT01073345
- Testing
- Portal venous pressure, Portal venous flow, Hepatic artery flow
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Heidelberg University