Clinical trials: Asherman Syndrome
Infertility, Female, Infertility of Uterine Origin
Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures
Investigators will examine safety and efficiency of the cell product of autologous bone marrow-derived mesenchymal stem cells (MSC) for patients with repeated IVF failures and hypoplastic or/and fibrosis process of endometrium
- Conditions
- Infertility, Female, Infertility of Uterine Origin, Asherman Syndrome
- Trial name
- NCT03166189
- Testing
- bone marrow-derived MSC and HRT, hormonal replacement therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Asherman Syndrome, Intrauterine Adhesion
PREvention of Intrauterine Adhesion After Adhesiolysis With Novel Tri-block deGradable Polymer Film.
PREG2 is a randomized controlled trial that aims to evaluate efficacy in preventing intrauterine adhesion recurrence after hysteroscopic adhesiolysis of a novel intrauterine barrier film named Womed Leaf
- Trial name
- PREG2 (NCT04963179)
- Testing
- Womed Leaf
- Where
- 15 sites in Belgium, China and 5 more
- Volunteers
- 160 people
- Sponsor
- Womed
Intrauterine Adhesion
The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03351205
- Testing
- disposable balloon uterine stent, dried biological amnion graft, estradiol valerate tablets+dydrogesterone tablets
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Symptomatic Submucosal Myoma
Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility
Since the development in the last few years of the bipolar energy in the surgery by hysteroscopy, the hysteroscopic treatment of the submucosal uterine myoma can be performed by use of either monopolar or bipolar current.
- Trial name
- NCT02661087
- Testing
- Hysteroscopic resection with bipolar energy, Hysteroscopic resection with monopolar energy
- Where
- 2 sites in Belgium, France
- Sponsor
- Brugmann University Hospital
Intrauterine Adhesion
The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis
The purpose of this study is to investigate the efficacy of Granulocyte Colony Stimulating Factor(G-CSF) on decreasing adhesion reformation and improving fertility outcomes after hysteroscopic adhesiolysis in patients with…
- Trial name
- NCT02855632
- Testing
- G-CSF, Normal saline, hormone therapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Sir Run Run Shaw Hospital
Endometrium; Atrophy, Intrauterine Synechiae
AD-SVF Therapy for Refractory Endometrial Infertility
The purpose of this study is to initially explore the efficacy of adipose-derived stromal vascular fraction (AD-SVF) therapy in the treatment of refractory endometrial infertility.
- Trial name
- NCT07230600
- Testing
- AD-SVF
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Asherman Syndrome
Pre-clinical Endometrial Tissular Renovation Study
The endometrium is a tissue with high capacity of renewal ("self-renewal"). This process is regulated by stem cells. Recent studies have shown that bone marrow-derived stem cells (BMDSCs) contribute to tissues and organs…
- Trial name
- PreENTIRE (NCT03665649)
- Testing
- CD133+ cells isolation
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Asherman Syndrome, Endometrial Atrophy
Use of PRP in Endometrial Reconstruction
Infertility, which affected 48.5 million couples worldwide in 2010 alone, has many causes; some causes result from issues related to the endometrium.
- Trial name
- NCT03249415
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Fundación IVI
Intrauterine Abnormalities in Infertility, Asherman Syndrome
Safety and Performance of the Semical Adhesion Barrier Gel for Prevention of Intra-uterine Adhesion
The aim of this study was to obtain short- and long-term performance and safety data of cross-linked hyaluronic acid-based adhesion barrier gel used to prevent intrauterine adhesion formation.
- Conditions
- Intrauterine Abnormalities in Infertility, Asherman Syndrome, Intra-uterine Adhesions, Postoperative Adhesion of Uterus
- Trial name
- SEMFERTIL (NCT07160764)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semikal Technology
Asherman Syndrome, Atrophic Endometrium
Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
This study will assess the use of autologous bone marrow stem cells mobilization using 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane (PLERIXAFOR) as an effective medical therapy for the treatment of…
- Conditions
- Asherman Syndrome, Atrophic Endometrium, Recurrent Implantation Failure
- Trial name
- NCT05343572
- Testing
- Plerixafor
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hugh Taylor
Asherman's Syndrome
Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions
The purpose of this study is to compare the outcome of loop intrauterine contraceptive device and heart-shaped intrauterine balloon for the adjunctive treatment of severe intrauterine adhesions in patients with infertility.
- Trial name
- ROABTIPWSIUA (NCT02708277)
- Testing
- loop-shaped intrauterine contraceptive device, intrauterine balloon (Cook Medical)
- Volunteers
- 93 people
- Sponsor
- Yuqing Chen
Infertility, Asherman's Syndrome
Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair
Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant…
- Trial name
- PRP-E (NCT02825849)
- Testing
- Intrauterine infusion of platelet rich plasma
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Asherman Syndrome
CURENDO (Cord-blood Uterine Regeneration Endometrium): Platelet-rich Plasma Therapy Derived From Umbilical Cord Blood for the Treatment of Endometrial Pathologies (Asherman Syndrome / Endometrial Atrophy / Thin Endometrium)
In recent years, platelet-rich plasma (PRP) has emerged as a promising alternative for treating endometrial pathologies that affect the endometrial lining.
- Trial name
- CURENDO (NCT07697924)
- Testing
- Umbilical cord platelet-rich plasma (hUC-PRP)
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Fundación IVI
Asherman Syndrome
Estrogen in the Prevention of Adhesion Reformation
Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium.It seems that the role of postoperative estrogen therapy in the prevention of recurrence of IU adhesions is still controversial.
- Trial name
- NCT03620929
- Testing
- Estradiol Valerate
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Intrauterine Adhesion
The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03330873
- Testing
- disposable balloon uterine stent, Foley catheter
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Asherman Syndrome
Effects of Platelet Rich Plasma on Endometrium
Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period.
- Trial name
- NCT04424160
- Testing
- PRP injection in the endometrium
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Acibadem University
Asherman Syndrome, Endometrial Atrophy
Umbilical Cord Plasma for Treating Endometrial Pathologies (Thin Endometrium / Asherman's Syndrome/ Endometria Atrophy)
In the last years, platelet-rich plasma (PRP) has emerged as a promising alternative to treat endometrial pathologies affecting the endometrial lining.
- Trial name
- hSCU-PRP (NCT05095597)
- Testing
- Injection of hUC-PRP by hysteroscopy, Oestraclin, Umbilical cord blood collection
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación IVI
Asherman's Syndrome, Endometrium; Atrophy, Cervix
Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy
The purpose of this study is to determine whether Bone Marrow Stem Cell transplantation may improve Assisted Reproduction Techniques (ART) outcomes in refractive Asherman's Syndrome or Atrophic Endometrium.
- Trial name
- BMSCT (NCT02144987)
- Testing
- Bone Marrow CD133+ Stem Cell Transplantation
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Myoma
Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel
The purpose of this study is to evaluate the intrauterine adhesion rate after the application of HYALOBARRIER Gel at the end of hysteroscopic myomectomy. Secondary endpoints were tolerance and side effect and subsequent fertility.
- Trial name
- HYGEM (NCT01412489)
- Testing
- HYALOBARRIER Gel
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intrauterine Adhesion
Autologous Platelet-Rich Plasma in the Management of Asherman Syndrome
The aim of the study is to find out the benefit of the platelet-rich plasma in preventing reformation of intrauterine adhesions after adhesiolysis in cases of Asherman syndrome
- Trial name
- NCT04308811
- Testing
- platelet rich plasma, amniotic membrane graft group, Intrauterine balloon
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University