Clinical trials: Aspiration, Respiratory
Pulmonary Disease, Chronic Obstructive
A Study To Investigate Safety, Blood Levels And Effects Of Giving GW642444, By Mouth, By Inhalation & By Injection
This study will involve the use of a new medicine called GW642444 being developed for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00711126
- Testing
- GW642444
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Respiratory Distress
Efficacy and Safety of Gastric Suctioning During Neonatal Resuscitation
The stomach of the newborn baby is often emptied soon after birth to prevent breathing problems (respiratory distress). Babies born with meconium-stained amniotic fluid and those with increased secretions associated with birth by…
- Trial name
- NCT00729989
- Testing
- Gastric suctioning
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Benjamin T. Stevens
Pulmonary Disease, Chronic Obstructive
Safety, Tolerability and Pharmacokinetics (PK) Study of GSK2269557 in Healthy Subjects
GSK2269557 is being developed as an anti-inflammatory and anti-infective agent for the treatment of inflammatory airways diseases.
- Trial name
- NCT03189589
- Testing
- GSK2269557 500 µg, GSK2269557 750 µg
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obstructive Sleep Apnea
Airway Muscle Training for Obstructive Sleep Apnea
The purpose of this research study is to determine if muscle training will improve snoring and obstructive sleep apnea. Subjects will receive a sleep study to determine the severity of their apnea.
- Trial name
- OSA (NCT02259660)
- Testing
- Respiratory muscle strength training
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Florida
Critical Illness
Early Passive Verticalization in Critically Ill Patients
In the critically patient bed rest and inmovilization are some of the responsable of the development of respiratory complications.
- Trial name
- TILT (NCT02270762)
- Testing
- Rest in bed, Passive verticalization
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Breathing
Training of the Inspiratory Musculature in the Improvement of Inspiratory Strength and Muscle Recovery in Soccer Players
Soccer requires the activation of aerobic and anaerobic metabolism. The increase of the ventilatory demand stimulates the increase of the neural impulse to the respiratory muscles, increasing the mechanical power of the…
- Trial name
- NCT04286074
- Testing
- 50% resistance, 10% resistance
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Nasal Congestion, Nursing
Effects of Different Nasal Irrigation Methods on Pain Level, Crying and Procedure Times in Nasal Congestion in Infants
This study aimed to evaluate the effects of different nasal irrigation (NI) methods for relieving nasal obstruction on pain, crying and procedure times, and physiologic parameters in infants with acute upper respiratory tract…
- Trial name
- NCT06691620
- Testing
- Nasal irrigation with isotonic saline, Nasal irrigation with hypertonic saline, Nontraumatic nasopharyngeal aspiration
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Pneumonia
Phase I Single-blind Clinical Trial to Evaluate the Safety and Local Immune Activation of a Toll-like Receptor 5 Agonist (FLAMOD) Administered by Aerosol
This is a single-blind, randomized, placebo-controlled, dose-escalation phase I monocentric trial assessing a single administration of FLAMOD by aerosol in healthy subjects.
- Trial name
- NEBUFLAG (NCT06681402)
- Testing
- FLAMOD
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke, Rehabilitation
The Efficacy of Bedside Respiratory Muscle Training in Stroke Patients
Objectives: To investigate the efficacy of bedside respiratory muscle training on pulmonary function and stroke-related disabilities in stroke patients.
- Conditions
- Stroke, Rehabilitation, Breathing Exercise, Pneumonia
- Trial name
- NCT03153345
- Testing
- bedside respiratory muscle training, conventional stroke rehabilitation program
- Volunteers
- 40 people
- Sponsor
- Korea University Anam Hospital
Anesthesia
Ambu AuraGain and Teleflex LMA Protector Fiberoptic Assessments in Elective Patients
Participant is being asked to take part in this study because participant is going to have surgery that requires general anesthesia (in which participant is unconscious for the procedure).
- Trial name
- NCT02724956
- Testing
- Ambu AuraGain, Teleflex LMA Protector, Ambu aScope
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Respiratory Insufficiency
Respiratory Mechanics and Patient-ventilator Asynchrony Index in Patients With Invasive Mechanical Ventilation
The objective of the study is to estimate the incidence of asynchrony and to assess its relationship with respiratory mechanics. This will be a prospective cohort study, including patients under invasive mechanical ventilation.
- Trial name
- EpiSync (NCT02687802)
- Testing
- mechanical ventilation
- Where
- Brazil
- Volunteers
- 103 people
- Sponsor
- University of Sao Paulo General Hospital
Respiratory Distress Syndrome, Adult
Pilot Study of Positive-End Expiratory Pressure in Acute Respiratory Distress Syndrome
Randomized controlled pilot trial in 70 patients with Acute Respiratory Distress Syndrome (ARDS) ventilated with low tidal volumes and limitation on airway pressure at 35 centimeters of water (cmH2O), to compare two different…
- Trial name
- PEEP-HUPA (NCT01119872)
- Testing
- Positive End-expiratory Pressure (PEEP)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitario Principe de Asturias
Amateur Athletes
Inspiratory Muscle Training in Amateur Athletes
The main objective of the study is to study the changes in FEV1 with the introduction of the specific inspiratory muscle training programme in the training programme of the popular athletes included.
- Trial name
- NCT06611969
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Lung Cancer
Electromagnetic Navigation Versus CT Guided TTNA in the Diagnosis of Early Peripheral Lung Cancer
The purpose of this study is to compare Electromagnetic navigation guided with CT-guided transthoracic needle aspiration (TTNA) in the diagnosis of pulmonary peripheral nodule.
- Trial name
- NCT03802266
- Testing
- Electromagnetic Navigation guided transthoracic needle aspiration, CT-guided Transthoracic Needle Aspiration
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Shanghai Chest Hospital
Healthy Adult Participants
Validity and Reliability of the Turkish Version of the 'Breathing Vigilance Questionnaire'
In the literature, assessment questionnaires related to dyspnea measure beliefs about breathing-related symptoms but do not directly measure breath awareness.
- Trial name
- Breathe-VQ (NCT07544472)
- Testing
- Survey using a questionnaire.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kutahya Health Sciences University
Anesthetics, Inhalation, Neuromuscular Blockade
Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children
Sugammadex is the first selective relaxant binding agent approved to reverse certain non-depolarizing neuromuscular drugs in patients 2 years old and above.
- Conditions
- Anesthetics, Inhalation, Neuromuscular Blockade, Anesthesia, General
- Trial name
- NCT03795259
- Testing
- Rocuronium, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Respiratory Function
Effect of a Respiratory Training Program on Woodwind and Brass Players
This project will study the effect of a respiratory training program on woodwind and brass players, using an inspiratory muscle training equipment.
- Trial name
- NCT06175286
- Testing
- POWERBreath Plus Medium Resistance training device
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Pneumonia, Pneumocystis Carinii, HIV Infections
Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy
To compare the use of pentamidine aerosol (inhaled mist) with the standard intravenous method of administration in patients with AIDS related Pneumocystis carinii pneumonia (PCP), to measure the amount of pentamidine aerosol that…
- Trial name
- NCT00000722
- Testing
- Pentamidine isethionate
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ventilator Weaning, Hand Strength
Handgrip Strength Value in Predicting Mechanical Ventilation Weaning
The purpose of this study is to test the association between ICU acquired weakness as evaluated by dominant handheld dynamometry (handgrip) and the mechanical ventilation weaning outcome
- Conditions
- Ventilator Weaning, Hand Strength, Respiration
- Trial name
- GRIPWEAN (NCT02946502)
- Testing
- Handheld dynamometry (handgrip strength)
- Where
- France
- Volunteers
- 261 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Airway Management, Lung Diseases
Comparison of Supraglottic Airway Devices in EBUS
Supraglottic airway devices (SAD) provide ventilation of patients requiring respiratory support without tracheal intubation. Therefore, SAD is used to maintain airway during anesthesia in surgeries that do not require intubation.
- Trial name
- SAD-EBUS (NCT06177769)
- Testing
- LMA classic, LMA Proseal, I-gel
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Ankara Etlik City Hospital
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