Clinical trials: Aspiration, Respiratory
Healthy
Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With A Reference Product
The purpose of this study is to compare the absorption of four different inhalation products with the reference product in healthy volunteers.
- Trial name
- NCT03155204
- Testing
- tiotropium pMDI
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Lung Injury, Acute
Effects of Oxygen on Lung Tissue During Anesthesia
Collect exhaled breath condensates from patients scheduled for a routine surgical procedure before, during, and after surgery for measurements of IsoFs Draw blood from patients scheduled for a routine surgical procedure before…
- Trial name
- NCT00715338
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University
Acute Respiratory Distress Syndrome
Open Suction vs. Closed Suction in ARDS
The alveoli tend to collapse in patients with ARDS. Endotracheal aspiration may increase alveolar collapse by decreasing the end-expiratory lung volume.
- Trial name
- NCT05537974
- Testing
- Endotracheal aspiration
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Non-cystic Fibrosis Bronchiectasis
Inhalations of Ultra-low Doses of Melphalan for the Treatment of Non-cystic Fibrosis Bronchiectasis
This non-randomised open-label prospective pilot study evaluates the safety and efficacy of inhalations of ultra-low doses of alkylating drug melphalan for the treatment of non-cystic fibrosis bronchiectasis.
- Trial name
- SEADIB1 (NCT04278040)
- Testing
- Melphalan
- Where
- Russia
- Volunteers
- 7 people
- Sponsor
- Federal State Budgetary Institution, Pulmonology Scientific Research Institute
Pregnancy, Respiratory Aspiration of Gastric Content
Intra- and Interrater Reliability of Quantitative Ultrasound Assessment of Gastric Content in Term Parturients Before Elective Caesarean Delivery
The presence of solid food or fluid residue in the stomach is always a major concern when patients require medical procedures under sedation or general anesthesia, due to the high risk of pulmonary aspiration of the stomach…
- Trial name
- NCT05946447
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Cystic Fibrosis (CF)
Exercises' Effect on Muscle Strength, Aerobic Capacity and Respiratory Functions in Cystic Fibrosis
This research aims to evaluate the effects of upper and lower limb exercises on muscle strength and pulmonary function in children diagnosed with CF.
- Trial name
- NCT07508904
- Testing
- Arm Cycle Ergometry, Leg Cycle Ergometry
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines
To evaluate the impact of enteral nutrition on microaspiration of gastric content and pharyngeal secretions
- Trial name
- NCT03411447
- Testing
- Parenteral nutrition, Enteral nutrition
- Where
- 6 sites in France
- Volunteers
- 139 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Bruxism, Respiratory Function
Investigation of Respiratory Functions, Respiratory Muscle Strength, Balance and Sleep Quality in Patients With Bruxism
It has been reported that patients with bruxism frequently present with upper respiratory tract symptoms such as rhinitis, sinusitis, and mouth breathing.
- Conditions
- Bruxism, Respiratory Function, Sleep Quality, Balance
- Trial name
- NCT07294833
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gazi University
Severe Community-acquired Pneumonia
Amoxicillin/Clavulanic Acid Susceptibility in Acute Community-acquired Pneumonia Requiring Intensive Care Management
Severe community-acquired pneumonia (CAP) and community-acquired aspiration pneumonia (CAAP) are common reasons for adult emergency department visits and subsequent admission to the intensive care unit (ICU).
- Trial name
- CAP-ICU (NCT07322549)
- Testing
- Susceptibility to AMC, Susceptibilty to 3GC
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Hemiplegia, Respiratory Function Loss
Effect of Transcutaneous Auricular Vagus Nerve Stimulation Application on Respiratory Functions in Stroke Patients
The purpose of this study is to evaluate the effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (TAVSS) in improving respiratory muscle strength and function in chronic stroke patients.
- Trial name
- TAVNS (NCT06793800)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Fenerbahce University
Congestive Heart Failure
Study for Breathing Interventions in Congestive Heart Failure
Slow breathing may reduce stress. Adults with congestive heart failure have higher stress than the general population. This study will examine if using slow breathing is feasible among adults with heart failure.
- Trial name
- NCT03449121
- Testing
- Slow breathing techniques
- Sponsor
- Vanderbilt University Medical Center
Glucose Homeostasis, Protein Metabolism
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Background: Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress.
- Conditions
- Glucose Homeostasis, Protein Metabolism, Lipid Metabolism, Respiratory Function
- Trial name
- NCT01143493
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Respiratory Distress Syndrome
Effect of Different Ventilatory Strategies on Cardiac Function in Patients With Acute Respiratory Failure
Mechanical ventilation with low tidal volume (about 6 ml.kg-1) reduces mortality in ALI/ARDS patients respect to high tidal volume ventilation (about 12 ml.kg-1).
- Trial name
- VITALI (NCT00713713)
- Testing
- Mechanical ventilation with low and high tidal volume
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
ALS, Respiratory Insufficiency
Combined Respiratory Training in Persons With ALS
The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1.
- Conditions
- ALS, Respiratory Insufficiency, Dysphagia
- Trial name
- NCT05913882
- Testing
- Respiratory Muscle Strength Training (LVR+EMST)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Nova Southeastern University
Covid19, Infective Pneumonia
The Effect of Inspiratory Muscle Training in Post COVID-19 Patients
The COVID-19 infection, which is considered as a pandemic by the World Health Organization, affects the whole world. COVID-19 is an infectious respiratory disease caused by SARS-CoV-2.
- Trial name
- NCT04811859
- Testing
- Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istinye University
Immunity, Cellular
Analysis of Antigen Specific B Cell Responses to Immunization With Influenza Virus Vaccine
Immunization with the inactivated influenza vaccine with blood samples collected at 7 visits (baseline, day 7, 14, 28, 60, 90 and 180, fine needle aspiration (FNAs) from axillary lymph nodes at baseline, days, 4, 14, 28, 60 and…
- Trial name
- NCT03748524
- Testing
- Influenza Vaccine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pneumonia
Prevention of Pneumonia Comparing Ceftriaxone With Subglottic Aspiration
The primary purpose of the trial is to compare the efficacy and safety of two measures which claim to prevent early-onset ventilator-associated pneumonia.
- Trial name
- NCT00374959
- Testing
- ceftriaxone, Endotracheal tube for aspiration of subglottic secretions.
- Where
- 3 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Universitario Principe de Asturias
Pelvic Floor, Respiration
Pelvic Floor Activity and Breathing in Women
The pelvic floor and diaphragm work together in many different functions. Two important functions are breathing and continence. The pelvic floor muscles have to lift and squeeze to maintain continence.
- Trial name
- NCT01694979
- Testing
- Minimum expiration effort, Moderate expiration effort, Maximum expiration effort
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kitani, Lenore, PT
Respiration, Artificial, Laparoscopy
Hemodynamic Effects of Ventilation Modes
Different ventilation modes can be used in laparoscopic surgeries. These surgeries are performed in steep Trendelenburg position with serious hemodynamic disturbances.
- Conditions
- Respiration, Artificial, Laparoscopy, Hemodynamics
- Trial name
- NCT03684291
- Testing
- Mode of Mechanical Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ufuk University
Upper Airway Obstruction
Phamacological Reversal of Airway Instability During Sedation
The investigators are attempting to demonstrate a decrease in the frequency and severity of sedation-induced respiratory arrhythmias(central and obstructive apneas) with pharmacological pre-treatment in this pilot project and…
- Trial name
- PHYSO (NCT01171118)
- Testing
- Physostigmine, Oxygen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
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