Clinical trials: Aspiration, Respiratory
Quality of Life, Behavior
Breathing and Decision-Making
The study aims to investigate how slow breathing with prolonged exhalation (i.e., ProlEx breathing) modulates decision-making under risk in healthy participants.
- Conditions
- Quality of Life, Behavior, Stress, Psychological
- Trial name
- ProlEx-MRI (NCT05936684)
- Testing
- Breathing with prolonged exhalation (ProlEx) during risky decision-making, Normal breathing (Eupnea/Control) during risky decision-making
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Bariatric Surgery Candidate, Mechanical Ventilation
Comparison of Two Mechanical Ventilation Modes on Oxygenisation
Comparison the effect of two different mechanical ventilation modes on tissue oxygenization.
- Conditions
- Bariatric Surgery Candidate, Mechanical Ventilation, Hypoxia, Tissue Damage
- Trial name
- NCT04389047
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 1 of 7)
NOTE: This is the first of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882516
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Obstructive Sleep Apnea, Hypertension
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure.
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases, Stroke
- Trial name
- NCT01280006
- Testing
- Intermittent hypoxia, Indomethacin, Celecoxib
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hypnotic; Withdrawal State With Delirium, Neurological Disorder
Efficacy of BIS Monitoring in Deep Hypnotic State
Determining the efficacy of the BIS monitor in monitoring deep hypnotic states as well as intra- and post-operative outcomes in neurosurgery patients
- Conditions
- Hypnotic; Withdrawal State With Delirium, Neurological Disorder, Postoperative Delirium, Postoperative Confusion
- Trial name
- NCT06177847
- Testing
- BIS
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Respiration
Optical Breath-hold Control System for Image-guided Procedures
The objective or our study is to test the feasibility of a new optical-based breath-hold control (OBC) system for monitoring breath-hold levels and providing patient feedback during CT-guided biopsies of the lung and upper…
- Trial name
- OBC (NCT01062789)
- Testing
- Optical breath-hold control system (OBC)
- Where
- United States
- Sponsor
- Mayo Clinic
Enteral Nutrition, Critical Care
"Efficacy of Intermittent Enteral Nutrition Versus Continuous Administration in Intensive Care"
The goal of this clinical trial is to Determine efficacy of intermittent enteral nutrition vs continuous enteral nutrition in adults patients with a nasogastric tube in a intensive care unit.
- Conditions
- Enteral Nutrition, Critical Care, Feeding Methods, Gastric Feeding Tube
- Trial name
- ENINCO (NCT05879263)
- Testing
- INTERMITTENT ENTERAL NUTRITITION (IEN), CONTINUOS ENTERAL NUTRITITION (CEN)
- Where
- Spain
- Volunteers
- 190 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Cardiac Arrest
Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial
When the heart stops pumping during cardiac arrest, cardiopulmonary resuscitation (CPR) is used to continue pushing blood and providing oxygen to vital organs.
- Trial name
- OPTIVO (NCT07479836)
- Testing
- Low Volume Ventilation, High Volume Ventilation
- Where
- Canada
- Volunteers
- 1,656 people
- Sponsor
- Sunnybrook Health Sciences Centre
Deglutition Disorder, Healthy
Electrical Muscle Stimulation to Aid Swallowing in Dysphagia
The purpose of this study is to determine the feasibility of using extrinsic laryngeal muscle stimulation to elevate the larynx in a manner similar to that which occurs during normal swallowing.
- Trial name
- NCT00001936
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Covid19
Efficacy and Safety Evaluation of Inhaleen Inhalation in Hospitalized COVID-19 Patients
The current study will investigate the tolerability and efficacy of inhaled Carragelose® versus saline in hospitalized COVID-19 patients.
- Trial name
- NCT04793984
- Testing
- Carragelose, NaCl
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Marinomed Biotech AG
Respiration, Artificial, Critical Care
Pressure Support During Chest Wall Compression
The purpose of this study is to compare two physiotherapy techniques: chest wall compression versus chest wall compression plus increase of 10 cmH2O in inspiratory pressure.
- Trial name
- NCT01155648
- Testing
- Chest wall compression plus increase of 10 cmH2O in inspiratory pressure during Pressure Support Ventilation for ten minutes in chest., Chest wall compression for ten minutes in chest
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COPD Asthma, Asthma-COPD Overlap Syndrome
Evaluation of Inhalation Technique in Patients With COPD, Asthma or ACOS Using a Dry Powder Device (DPI)
This study analyzes the prevalence of patients using inhalation devices via incorrect technique and access the adherence of patients to correct inhalation technique when taught along with their subjective improvement of symptoms.
- Conditions
- COPD Asthma, Asthma-COPD Overlap Syndrome, Inhalation
- Trial name
- NCT03275935
- Where
- Nepal
- Volunteers
- 307 people
- Sponsor
- Kathmandu University School of Medical Sciences
Chronic Neck Pain, Healthy (Controls)
Accessory Inspiratory Muscles in Chronic Neck Pain
This cross-sectional case-control study aims to investigate the ultrasonographic structural and functional characteristics of accessory inspiratory muscles in individuals with chronic non-specific neck pain and compare them with…
- Trial name
- AIM-CNP (NCT07782099)
- Testing
- Diaphragm Ultrasonography, Anterior Scalene Muscle Ultrasonography, Upper Trapezius Muscle Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kocaeli Sağlık ve Teknoloji Üniversitesi
Chronic Critical Illness, Prolonged Mechanical Ventilation
Prediction of Functional Outcomes From Chronic Critical Illness
The purpose of the study is to establish clinical determinants of poor cognitive and physical functional outcome of CCI patients so that the investigators may develop and validate a multi-dimensional clinical prediction model to…
- Trial name
- NCT03159208
- Where
- 6 sites in United States
- Volunteers
- 589 people
- Sponsor
- University of North Carolina, Chapel Hill
Pulmonary Disease, Chronic Obstructive
ADVAIR® DISKUS® Inhaler (Fluticasone Propionate/Salmeterol) Versus SEREVENT® DISKUS® Inhaler (Salmeterol) For The Treatment Of Chronic Obstructive Pulmonary Disease Exacerbations. ADVAIR® DISKUS® Inhaler and SEREVENT® DISKUS® Inhaler Are Trademarks of the GSK Group of Companies.
This study evaluates the effect of two medicines on COPD (Chronic Obstructive Pulmonary Disease) exacerbations. This study will last up to 56 weeks, and subjects will visit the clinic 10 times.
- Trial name
- NCT00144911
- Testing
- Salmeterol, Fluticasone Propionate/Salmeterol Combination Product
- Where
- 97 sites in United States, Canada
- Volunteers
- 740 people
- Sponsor
- GlaxoSmithKline
Renal Function After Partial Nephrectomy
PaNeX: Partial Nephrectomy Under Xenon
Purpose of this study is to determine whether Xenon - as compared to Isoflurane - shows a nephroprotection after partial nephrectomy.
- Trial name
- PaNeX (NCT01839084)
- Testing
- Xenon, Isoflurane
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- RWTH Aachen University
Ventilator Acquired Pneumonia, Aspiration
Comparison of Two Strategies of Oropharyngeal and Tracheal Suctioning in Mechanically Ventilated Patients
The purpose of this study is to evaluate the impact of an optimized suctioning procedure on the risk of endotracheal microaspiration, measured by tracheal to oropharyngeal ratio of amylase enzymatic activity.
- Trial name
- AMYLASPI (NCT01807884)
- Testing
- Optimized oral care, Routine oral care
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bordeaux
Critically Ill, H1N1/Influenza Infection
Collaborative H1N1 Adjuvant Treatment Pilot Trial
Study Design: A, multinational, double blind, placebo-controlled pilot RCT involving 80 patients in the general ICUs of 30 centres.
- Trial name
- CHAT (NCT01033955)
- Testing
- Rosuvastatin
- Where
- 9 sites in Canada
- Volunteers
- 8 people
- Sponsor
- Canadian Critical Care Trials Group
Aspiration, Respiratory
Continuous Supraglottic pH Monitoring in Prolonged Intubated Intensive Care Patients and High Risk Aspiration Intraoperative Patients
This is a pilot prospective cohort study of the incidence of supraglottic pH readings.
- Trial name
- NCT02604043
- Testing
- pH monitoring, accelerometer monitoring
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University
Asthmatic
Effects of Costovertebral Joint Mobilization on Respiratory Function in Asthmatic Patients
The aim of this randomized controlled trial is to determine the effectiveness of costovertebral joint mobilization on lung function in asthmatics.
- Trial name
- NCT06133985
- Testing
- Costovertebral mobilizations + Conventional PT, Conventional treatment
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
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