Clinical trials: Aspiration, Respiratory
Fasting, Delayed Gastric Emptying
Gastric Assessment of Pediatric Patients Undergoing Surgery
The goal of this pilot prospective cohort study is to examine the reproducibility of gastric volume and emptying as measured by gastric ultrasound and its correlation to a gold-standard test for gastric emptying in the…
- Conditions
- Fasting, Delayed Gastric Emptying, Aspiration Pneumonia, Respiratory Aspiration of Gastric Content
- Trial name
- NCT05674643
- Testing
- Gastric Ultrasound Baseline Scans, Acetaminophen Absorption Test (AAT), Gastric Ultrasound Serial Scans
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Healthy
Effects of Breathing Patterns on Post-prandial Vascular Function
The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.
- Trial name
- NCT04864184
- Testing
- Normal physiologic rate breathing, Slow breathing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Texas State University
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Low Back Pain
Low Back Pain and Breathing Pattern Dysfunction
The goal of this study is to identify if there is a significant prevalence of abnormal respiratory patterns in a sample of patients with low back pain (LBP), and if the presence of abnormal respiratory patterns are predictive of…
- Trial name
- LBP&BPD (NCT02429752)
- Testing
- Inspiratory muscle training
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Miami
Meconium Aspiration Syndrome, Infant, Newborn, Disease
Time of Positive Pressure Ventilation in Non-vigorous Infants Born Through Meconium-stained Amniotic Fluid
Background: Meconium stained amniotic fluid (MSAF) complicates 3 to 14% of pregnancies, causing meconium aspiration syndrome (MAS) in 5-10% of neonates born.
- Conditions
- Meconium Aspiration Syndrome, Infant, Newborn, Disease, Neonatal Resuscitation
- Trial name
- MASTIME (NCT04076189)
- Testing
- Endotracheal suctioning, No endotracheal suctioning
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University Hospital Padova
Respiratory Complication, Respiration, Artificial
Ventilation in Cardiac Surgery
The purpose of this study is to evaluate prospectively ventilatory practices in the perioperative cardiac surgery period.
- Conditions
- Respiratory Complication, Respiration, Artificial, Anesthesia, General, Bypass, Cardiopulmonary
- Trial name
- VENICE (NCT03255356)
- Testing
- Survey
- Where
- 10 sites in Belgium, Brazil and 8 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Asthma
Immunotherapy Administered Under the Tongue to Treat Dust Mite Allergy
This study will investigate sublingual immunotherapy (SLIT), a treatment involving antigens placement under the tongue to help asthma sufferers build a tolerance to the allergy-causing substances.
- Trial name
- NCT00200850
- Testing
- House Dust Mite SLIT, High dose SLIT
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Cystic Fibrosis
A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
This is a Phase 1/2 multicenter, open-label, single dose trial of SP-101 investigational gene therapy in adults with CF who are ineligible for or intolerant to CFTR modulator therapy.
- Trial name
- SAAVe (NCT06526923)
- Testing
- SP-101 and doxorubicin Cohort 1, SP-101 and doxorubicin Cohort 2
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Spirovant Sciences, Inc.
Respiration, Artificial
Patient-ventilator Asynchrony During Mechanical Invasive Assisted-ventilation in Pediatric Patients
The purpose of this study is to document the prevalence and type of asynchronies incidence during invasive mechanical ventilation in pediatric patients breathing under pressure support.
- Trial name
- NavPed-Inv (NCT01193023)
- Testing
- Pressure Support, NAVA
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Geneva
Meconium Aspiration Syndrome
Interleukin-6 in the Development of Meconium Aspiration Syndrome in Newborn
This trial is intended to assess the serum levels of interleukin-6 as a predictive factor for the occurrence of meconium aspiration syndrome in infants born with MSAF.
- Trial name
- NCT07394322
- Testing
- serum interleukin 6
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Multiple Sclerosis (MS)
Avonex®: Safety, Blood Levels and Effects
The primary objective was to determine the tolerability of a new inhaled formulation of interferon beta-1a when given as a single dose, when given once per week for 4 weeks, and compared with standard intramuscular (IM) AVONEX®…
- Trial name
- C-851 (NCT01863069)
- Testing
- Interferon beta 1a, (IM) AVONEX®
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Trio Medicines Ltd.
Obesity, Ventilation
Non-invasive Ventilation Following Extubation (Prophylactic) to Prevent Extubation Failure in Critically Obese Patients
Mechanical ventilation is the first artificial support used in intensive care. After a period of invasive mechanical ventilation, patients should be separated from the ventilator (weaning period of mechanical ventilation).
- Conditions
- Obesity, Ventilation, Intensive Care Unit
- Trial name
- EXTUB-OBESE (NCT04014920)
- Testing
- Oxygen group, NIV Group
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Quality of Life
Effect of Breathıng Exercıse Applıed to Indıvıduals Wıth Copd on Respıratory Functıon, Dyspnea and Qualıty of Lıfe
Purpose of the research This research was designed to determine the effect of breathing exercise applied to individuals diagnosed with COPD on respiratory function, dyspnea and quality of life.
- Trial name
- NCT06706297
- Testing
- pranayama breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ondokuz Mayıs University
Airway Complication of Anaesthesia, Healthy
The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
The investigators hypothesize that propofol, when compared to sevoflurane, causes the upper airway to collapse more easily and causes less activity in the tongue muscle.
- Trial name
- NCT01557920
- Testing
- Propofol, Sevoflurane
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Cortical Pharyngeal Area: Excitability, Facilitation and Plasticity in Healthy Subjects
The aims of this study are in four experimental sessions. The aims are: to characterize the excitability of the cortical pharyngeal area with pharyngeal pressure and electromyograms (EMGs), at rest, in awake healthy subjects; to…
- Trial name
- NCT00213382
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Stroke
Reflexive Coughing Force in Severe Aspirators
To assess coughing force during reflex coughing test in those with severe dysphagia and severe aspiration and compare them to than those with stroke patients with no signs of dysphagia/aspiration.
- Trial name
- NCT02080988
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Stage 1 Hypertensives
Additional Effect of Coherent Breathing With Aerobic Exercise on Cardiopulmonary Parameters and Quality of Life in Stage 1 Hypertensive Individuals
This study will use a randomized controlled trial to evaluate the added effects of coherent breathing combined with aerobic exercise versus aerobic exercise alone in 40 adults aged 30-65 with stage 1 hypertension.
- Trial name
- NCT07573683
- Testing
- Coherent Breathing., Aerobic Exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Pneumothorax
Chest Tube Drainage or Thoracoscopic Surgery for Failed Aspiration of Spontaneous Pneumothorax
We hypothesize that VATS is more effective than CTD for management of primary spontaneous pneumothorax with aspiration failure. To this end, we will compare two groups of patients who had experienced unsuccessful aspiration of…
- Trial name
- NCT00713362
- Testing
- Video-assisted thoracoscopic surgery, chest tube drainage
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation, Respiratory Failure
Impact of PEEP on Respiratory Effort During Assisted Ventilation
Assisted mechanical ventilation is widely used to preserve diaphragmatic activity and improve lung aeration in patients with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Respiratory Failure, Effort
- Trial name
- PEEP-EFFORT (NCT07437846)
- Testing
- PEEP Level Adjustment
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiratory Failure, Cardiac Failure
Mechanical Ventilation Controlled by the Electrical Activity of the Patient's Diaphragm - Effects on Cardiac Performance
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assist to spontaneous breathing based on the detection of the electrical activity of the diaphragm.
- Trial name
- NCT00647361
- Testing
- Neurally adjusted ventilatory assist (NAVA) provided by a commercially available mechanical ventilator (Servo i, Maquet Critical Care, Solna, Sweden).
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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