Clinical trials: Aspiration, Respiratory
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
COPD
Efficacy of AZD3199 in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to investigate the efficacy, safety and tolerability of 4 weeks treatment with AZD3199 in moderate to severe COPD.
- Trial name
- GLAD (NCT00929708)
- Testing
- AZD3199, formoterol
- Where
- 38 sites in Bulgaria, Canada and 3 more
- Volunteers
- 329 people
- Sponsor
- AstraZeneca
Pulmonary Embolism
Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism
To determine the safety and efficacy of the Indigo Aspiration System for aspiration mechanical thrombectomy in patients with acute pulmonary embolism (PE)
- Trial name
- EXTRACT-PE (NCT03218566)
- Testing
- Indigo Aspiration System
- Where
- 22 sites in United States
- Volunteers
- 119 people
- Sponsor
- Penumbra Inc.
Asthma
Immunotherapy Administered Under the Tongue to Treat Dust Mite Allergy
This study will investigate sublingual immunotherapy (SLIT), a treatment involving antigens placement under the tongue to help asthma sufferers build a tolerance to the allergy-causing substances.
- Trial name
- NCT00200850
- Testing
- House Dust Mite SLIT, High dose SLIT
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Spinal Cord Injuries, Brown Sequard
Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury
Change to Reflect What Was Done and reason Changes Were Made. The purpose of this study is to determine (1) if a specific breathing treatment (intermittent hypoxia) can promote changes in breathing function and (2) if pairing…
- Conditions
- Spinal Cord Injuries, Brown Sequard, Central Cord Syndrome
- Trial name
- NCT01272011
- Testing
- Intermittent Hypoxia, Locomotor Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Ventilation, Reproducibility
Assessing Variability of the Ventilatory Response to Duffin's Rebreathing Procedure
This study will combine Duffin's rebreathing procedure with additional study procedures, such as quantitative pupillometry, that are planned for subsequent clinical studies in order to confirm feasibility and gather…
- Conditions
- Ventilation, Reproducibility, Physiology
- Trial name
- NCT05168501
- Testing
- Rebreathing procedure
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Chronic Obstructive Pulmonary Disease (COPD)
The Study Will Evaluate the Effect of AZD8683 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to investigate effects of inhaled AZD8683 compared to placebo in COPD patients.
- Trial name
- NCT01205269
- Testing
- AZD8683, 50 mcg, AZD8683, 200 mcg
- Where
- 4 sites in Poland
- Volunteers
- 28 people
- Sponsor
- AstraZeneca
Upper Airway Obstruction
Phamacological Reversal of Airway Instability During Sedation
The investigators are attempting to demonstrate a decrease in the frequency and severity of sedation-induced respiratory arrhythmias(central and obstructive apneas) with pharmacological pre-treatment in this pilot project and…
- Trial name
- PHYSO (NCT01171118)
- Testing
- Physostigmine, Oxygen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Respiratory Failure
Extubation With or Without Spontaneous Breathing Trial
Spontaneous breathing trial (SBT) has long been thought to be a essential process before extubation. In this study,the investigator hypothesized that SBT could be not essential during weaning from ventilator and investigated…
- Trial name
- SBT (NCT01020773)
- Testing
- spontaneous breathing trial
- Volunteers
- 67 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Paresis
Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function
Background: Outpatient continuous interscalene brachial plexus blocks are used to control pain after shoulder surgery, with infusions of 0.125% bupivacaine or 0.2% ropivacaine.
- Trial name
- NCT02059070
- Testing
- Ropivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Anesthesiology WSU/DMC-NorthStar
Oropharyngeal Dysphagia, Oropharyngeal Cancer
Respiratory-Swallow Training in Veterans With Oropharyngeal Cancer
Cancers of the head and neck require surgical, radiation, and chemotherapy treatments that are intended to cure the disease. These treatments have toxic effects on muscles and structures that are necessary to swallow safely and…
- Trial name
- RSPT (NCT01032928)
- Testing
- Respiratory-Swallow Phase training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- US Department of Veterans Affairs
Dysphagia
Aspiration in Acute Respiratory Failure Survivors
The purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.
- Trial name
- NCT02363686
- Testing
- FEES, BSE
- Where
- 3 sites in United States
- Volunteers
- 248 people
- Sponsor
- University of Colorado, Denver
Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants
Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Oral feeding of neonates while on nasal continuous positive airway pressure (NCPAP) is a common practice in many neonatal intensive care units (NICU) all over the country.
- Conditions
- Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants, Respiratory Aspiration, Newborn, Premature
- Trial name
- NCT02661256
- Testing
- NCPAP, Varibar® Thin Liquid Barium Sulfate for Suspension
- Volunteers
- 7 people
- Sponsor
- NYU Langone Health
Sedation, Respiration, Artificial
Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms
The primary objective of this study is to test the hypothesis that time on the ventilator and ICU length of stay will be shorter in TAA patients given postoperative sedation with dexmedetomidine compared to those given standard…
- Conditions
- Sedation, Respiration, Artificial, Length of Stay
- Trial name
- NCT00409344
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Vagus Nerve Stimulation: Integration of Behavior and Cardiac Modulation
This study characterized the impact of respiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry, vagal tone and depressed mood in patients with major depressive disorder…
- Trial name
- tVNS-MDD (NCT04467164)
- Testing
- exhalatory-gated transcutaneous vagus nerve stimulation (e-RAVANS), Inhalatory-gated transcutaneous vagus nerve stimulation (i-RAVANS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Respiratory Failure
Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
The aim of this study was to compare the indices of rapid shallow breathing, neuromechanical efficiency (NME), and neuroventilatory efficiency (NVE) between patients being successfully extubated and those who failed weaning.
- Trial name
- NCT01065428
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Southeast University, China
Asthma in Children, Pollution; Exposure
AIM to Improve Asthma: Airflow Improvements During Meal-Prep
The investigators propose a pilot trial of kitchen ventilation in the homes of children using a youth engaged research strategy.
- Trial name
- AIM (NCT04464720)
- Testing
- Cooking Ventilation Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, Berkeley
Substance Use Disorder
Project IMPACT: In-the-Moment Protection From Automatic Capture by Trigger
Despite conscious intentions to remain abstinent, persons with substance use disorders often find that negative emotions and environmental cues automatically "trigger" drinking and other substance use.
- Trial name
- NCT02579317
- Testing
- Resonance Breathing, Non-Resonance Breathing
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Rutgers, The State University of New Jersey
Meconium Aspiration
Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome
OBJECTIVES: Evaluate the safety and efficacy of lucinactant administered by bronchoalveolar lavage (BAL) in the treatment of meconium aspiration syndrome (MAS) in newborn infants.
- Trial name
- NCT00004500
- Testing
- Lucinactant, Standard Care
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Windtree Therapeutics