Clinical trials: Aspiration, Respiratory
Asthma
Clinical Pharmacology Study of CHF1535 pMDI 50/6 µg Versus The Free Combination In Asthmatic Children 5-11 Years Old
The rationale is to investigate the systemic availability of BDP/B17MP and formoterol after single oral inhalation of CHF 1535 50/6 pMDI vs the free combination of approved BDP and Formoterol pMDIs, in asthmatic children (5 to 11…
- Trial name
- PAED1 (NCT01848769)
- Testing
- CHF1535 pMDI + AC Plus, BDP + AC Plus, Formoterol + AC Plus
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pulmonary Emphysema, COPD
AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation
The purpose of this study is to characterize the safety and efficacy of the AeriSeal System in patients with advanced upper lobe predominant emphysema and significant collateral ventilation as determined by the Chartis System.
- Conditions
- Pulmonary Emphysema, COPD, Lung Diseases
- Trial name
- CV+ (NCT01460108)
- Testing
- AeriSeal System
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Ventilation, Functional Residual Capacity
Functional Residual Capacity (FRC) Guided Alveolar Recruitment Strategy
In ventilated patients open endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements.
- Trial name
- NCT00779090
- Testing
- Alveolar recruitment manoeuvre
- Volunteers
- 59 people
- Sponsor
- University of Luebeck
Respiration, Artificial, Respiratory Insufficiency
Tracheobronchial Secretion Removal
Patients undergoing intubation and mechanical ventilation require removal of secretion by means of trachoebronchial suctioning. Timing of the procedure is mainly based on clinical parameters.
- Trial name
- NCT00932776
- Testing
- TBA care device, Control
- Where
- Italy
- Sponsor
- University of Milano Bicocca
Respiration and the Airways With Laryngeal Masks
Blind Tracheal Intubation Through Supraglottic Airway Devices
Tracheal intubation is considered the gold standard for protecting the airway. As the supraglottic airway devices (SADs) could be inserted without laryngoscopy, so that SADs with different designs and safety issues could be used…
- Trial name
- NCT05624073
- Testing
- Air-QTM Blocker, LarySealTM Pro
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tuberculosis
A Phase I Study Investigating the Local Tolerability and Pharmacokinetics of Isoniazid (INH) Inhalation by Wet Nebulization in Patients With Tuberculosis
Rationale: To halt the global tuberculosis (TB) crisis, and particular the ongoing threat of drug-resistant TB (DR-TB), it is essential to reduce transmission.
- Trial name
- INHalation-01 (NCT07708779)
- Testing
- Isoniazid
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- University Medical Center Groningen
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Out-of-Hospital Cardiac Arrest, Pulmonary Ventilation
CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study
The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS).
- Trial name
- CAvent (NCT04237727)
- Testing
- Fluxmed GrH portable pneumotachograph
- Where
- 5 sites in Netherlands, Sweden
- Volunteers
- 241 people
- Sponsor
- Uppsala University
Covid19
Inhalation of KELEA Excellerated Water in Covid-19 Infected Individuals
Preliminary reports have been received from several sources that the periodic inhaling of the nebulized mist from water that has a heightened level of kinetic activity has quickly (less than 2 days) lessened the severity of…
- Trial name
- NCT04490824
- Testing
- KELEA Excellerated Water, Water Without an Elevated Level of KELEA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Institute of Progressive Medicine
Morbid Obesity
Laryngeal Masks for Bariatric Surgery
Obese people pose specific problems as far as the management of airway during surgery. The study aims to compare efficacy and safety of two LMA devices.
- Trial name
- NCT01724970
- Testing
- ProSeal, Supreme LMA
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Padova
Hypertension, Pulmonary
Inhaled Iloprost (Ventavis): Efficacy, Safety, and Pharmacokinetics (PK) Confirmation Study
This study is to investigate the efficacy, safety, and Pharmacokinetics (PK) of Inhaled Iloprost (Ventavis) therapy in Japanese pulmonary arterial hypertension (PAH) patients in Main Treatment Phase (12 weeks) and to investigate…
- Trial name
- IBUKI (NCT01469169)
- Testing
- Iloprost (Ventavis inhaled, BAYQ6256)
- Where
- 18 sites in Japan
- Volunteers
- 27 people
- Sponsor
- Bayer
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Infant, Newborn, Infant, Low Birth Weight
Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants
This multi-site, randomized trial was conducted to determine the safety and effectiveness of a higher dose of vitamin A and determine if this would increase the rate of survival without bronchopulmonary dysplasia (BPD) and reduce…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Vitamin A (NCT01203488)
- Testing
- Vitamin A
- Where
- 11 sites in United States
- Volunteers
- 807 people
- Sponsor
- NICHD Neonatal Research Network
Healthy Volunteers
AZD5423 Single Ascending Dose Study
The aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD5423 following single ascending dose administrations in healthy male subjects.
- Trial name
- NCT00963183
- Testing
- AZD5423
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Feeding Behavior
New Chicco Bottles Study
Breastfeeding is recommended as the ideal form of nutrition for newborns and infants at least for the first 6 months of life by several Institutions such as the American Academy of Pediatrics (AAP) and the World Health…
- Trial name
- Step-Up (NCT03311282)
- Testing
- infants bottles
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Sprim Advanced Life Sciences
Pneumonia, Aspiration, Gastric Content
Point-of-care Gastric Ultrasound for Fracture Surgery
Although there are fasting guidelines offered by the American Society of Anesthesiology (ASA) for managing preoperative patient assessment, some patients may need to be more cautious about the risk of aspiration.
- Conditions
- Pneumonia, Aspiration, Gastric Content, Fractures, Bone
- Trial name
- NCT05728242
- Testing
- Gastric ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Haseki Training and Research Hospital
Lung Cancer
EBUS/Spectrum Analysis
To evaluate the clinical benefit of spectrum analysis of endobronchial ultrasound images of lymph nodes during EBUS TBNA for lymph node staging in patients with lung cancer.
- Trial name
- NCT01972386
- Testing
- Spectrum Image Analysis using a Linear Array Ultrasound Bronchoscope
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- University Health Network, Toronto
Lung Cancer With Mediastinal Lymph Node Involvement
Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging
A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by…
- Trial name
- NCT01653002
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Essen
Pregnancy
Changes in Ventilation Inhomogeneity and Respiratory Function Following Elective Caesarean Section Under Regional Anaesthesia
Pregnancy is associated with physiological changes affecting the cardiorespiratory system as a consequence of an increase in both cardiac output and intra-abdominal pressure.
- Trial name
- VIRCA (NCT02714556)
- Testing
- Physiologic measures of lung function
- Where
- Switzerland
- Sponsor
- Walid HABRE
Perinatal Morbidity
Post Term Pregnancy - Induction of Labor or Monitoring of Pregnancy
Post term pregnancy is a risk pregnancy. Aim of the study was to investigate whether induction of labor at gestational age 289(41 weeks+2 days) reduces neonatal morbidity compared to expectant management.
- Trial name
- NCT00385229
- Testing
- induction of labor
- Where
- Norway
- Volunteers
- 508 people
- Sponsor
- St. Olavs Hospital
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