Clinical trials: Aspiration, Respiratory
Moderated-high Risk of Postoperative Pulmonary Complication, Abdominal Surgery Expected More Than Two Hours
Individualized Perioperative Open Lung Ventilatory Strategy
The purpose of this study is to determine whether individualized ventilatory management combining the use of low tidal volumes, alveolar recruitment maneuvers, individually titrated positive end-expiratory pressure and…
- Trial name
- iPROVE (NCT02158923)
- Testing
- Alveolar recruitment maneuver, Calculation of optimal PEEP, Postoperative CPAP
- Where
- 7 sites in United States, Argentina and 2 more
- Volunteers
- 920 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Flail Chest, Ventilation
Trial of Operative Fixation of Fractured Ribs in Patients With Flail Chest
Background: Fracture of several ribs in more than one place as the result of trauma, leads to paradoxical movement of the chest wall and ventilatory failure.
- Trial name
- NCT00298259
- Testing
- operative fixation of fractured ribs
- Where
- Australia
- Volunteers
- 48 people
- Sponsor
- The Alfred
Secretion Removal Above ETT Cuff
Evaluation of Above the Cuff Suctioning During General Anesthesia
The aim of this prospective, randomized, pilot study is compare ease of tracheal intubation, amount of microaspiration and efficacy of secretion removal using three FDA (Food and Drug Administration)-cleared endotracheal tubes…
- Trial name
- NCT01386879
- Testing
- methylene blue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Respiration Disorders
Respiratory Monitoring System That Detects & Predicts OIRD
This study is being conducted to evaluate the ability of the Respiratory Monitoring System (RMS) to detect and predict opioid induced respiratory depression (OIRD) in post-operative surgical patients managed with opioid…
- Trial name
- RTM-NIH-SBIR-2 (NCT07217197)
- Testing
- Study to evaluate a Respiratory Monitoring System (RMS) with a Tracheal Sound Sensor (TSS) for detecting and predicting opioid induced respiratory Depression (OIRD).
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Cancer Uterus Cervix
Respiration After Robot Assisted Laparoscopic Hysterectomy
The study will investigate how respiratory function is affected by robot-assisted surgery. Previous studies have investigated the impact after open and laparoscopic surgery, but there are no studies yet after robot-assisted…
- Trial name
- REHYR (NCT06806280)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Spinal Cord Injuries (SCI)
Hypoxia Pathways for Early Recovery After Spinal Cord Injury
Spinal cord injury (SCI) disrupts neural pathways to respiratory motor neurons, diminishing breathing capacity and airway defense (e.g., cough).
- Trial name
- HyPER-FLO (NCT07002437)
- Testing
- Augmented Acute Intermittent Hypoxia (aAIH), Acute Intermittent Hypercapnic-Hypoxia (AIHH)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Respiratory Complication, Respiration, Artificial
Ventilation in Cardiac Surgery
The purpose of this study is to evaluate prospectively ventilatory practices in the perioperative cardiac surgery period.
- Conditions
- Respiratory Complication, Respiration, Artificial, Anesthesia, General, Bypass, Cardiopulmonary
- Trial name
- VENICE (NCT03255356)
- Testing
- Survey
- Where
- 10 sites in Belgium, Brazil and 8 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Artificial Respiration, Consciousness Disorders
Evaluation of a New Mechanical Ventilation Weaning Strategy for Patients With Altered Level of Consciousness
The purpose of this study is to determine if a weaning strategy from artificial ventilation governs by respiratory behaviour status assessed by our method is safe enough.
- Conditions
- Artificial Respiration, Consciousness Disorders, Wearing Off Effect
- Trial name
- ORGAR (NCT00700869)
- Testing
- mechanical ventilation
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Foreign Body Aspiration
The Impact of Preoperative Nasal Capnography on Clinical Management in Patients Undergoing Diagnostic Bronchoscopy for Suspected Foreign Body Aspiration
Introduction Despite advances in medical care, foreign body aspiration remains a common and ongoing health concern in children. Diagnostic bronchoscopy is the gold standard for confirming the diagnosis and providing definitive…
- Trial name
- Capnography (NCT07870005)
- Testing
- Nasal capnographic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Mersin University
Pulmonary Embolism
Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism
To determine the safety and efficacy of the Indigo Aspiration System for aspiration mechanical thrombectomy in patients with acute pulmonary embolism (PE)
- Trial name
- EXTRACT-PE (NCT03218566)
- Testing
- Indigo Aspiration System
- Where
- 22 sites in United States
- Volunteers
- 119 people
- Sponsor
- Penumbra Inc.
Laparoscopic Nephrectomy
Comparison of Ventilation Distribution Between Tidal Volume 6ml/kgBW and 10ml/kgBW
This study aims to compare the ventilation Distribution between tidal Volume 6ml/kgBW and tidal volume 10ml/kgBW in laparoscopic nephrectomy patients
- Trial name
- NCT02834039
- Testing
- Tidal volume 6 ml/kgBW, Tidal volume 10 ml/kgBW
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Dysphagia, Critical Illness
Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial
This research study is investigating the efficacy and implementation of expiratory muscle strength training (EMST), standard of care dysphagia treatment, and intensive dysphagia treatment in critically ill adults in the acute…
- Trial name
- NCT07736105
- Testing
- Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Disabilities Multiple, Obstruction Airway
Training on the Heimlich Maneuver for Mothers of Children With Disabilities
Foreign body obstruction is one of the most common causes of medical emergencies, particularly in childhood, and can lead to fatal outcomes if not treated promptly and correctly.
- Conditions
- Disabilities Multiple, Obstruction Airway, Foreign Body Aspiration
- Trial name
- NCT07699341
- Testing
- Heimlich Maneuver training
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Respiratory Failure, Pneumothorax
Mechanical Ventilation During Cardiac Surgery
Background There is no unanimous opinion about a lung-protective strategy in cardiac surgery. Small randomized clinical and animals trials suggest that ventilation during cardio-pulmonary bypass (CPB) could be protective on the…
- Conditions
- Respiratory Failure, Pneumothorax, Atelectasis, Aspiration Pneumonia
- Trial name
- NCT02090205
- Testing
- Non-ventilation during CPB, Ventilation with CPAP, Ventilation with 5 act/minute
- Where
- 13 sites in Italy
- Volunteers
- 780 people
- Sponsor
- Ospedale San Raffaele
Parkinson's Disease
Expiratory Muscle Training in Patients With Parkinson's Disease
Respiratory difficulty is one of the primary factors leading to death in patients with Idiopathic Parkinson's Disease (IPD). The progressive degeneration of a family of segregated motor and non-motor circuits in the brain results…
- Trial name
- EMST (NCT00843739)
- Testing
- EMST - Active Treatment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Respiration, Artificial, Vascular Filling
Mitral Doppler as a Predictor of Respiratory Worsening After Vascular Filling
Interventional study of the accuracy of a non-invasive testing by echocardiography to predict respiratory worsening after vascular filling.
- Conditions
- Respiration, Artificial, Vascular Filling, Echocardiography
- Trial name
- EVALDM (NCT03447366)
- Testing
- mitral doppler
- Where
- 3 sites in France
- Volunteers
- 87 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Airway Management, Lung Diseases
Comparison of Supraglottic Airway Devices in EBUS
Supraglottic airway devices (SAD) provide ventilation of patients requiring respiratory support without tracheal intubation. Therefore, SAD is used to maintain airway during anesthesia in surgeries that do not require intubation.
- Trial name
- SAD-EBUS (NCT06177769)
- Testing
- LMA classic, LMA Proseal, I-gel
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Ankara Etlik City Hospital
Chronic Low-back Pain
Integrative Breathwork Intervention for Chronic Pain
The proposed research is to develop and refine a multicomponent breathwork intervention, Guided Respiration Mindfulness Therapy, and to iteratively evaluate its feasibility, acceptability, and plausibility for clinically…
- Trial name
- NCT06546956
- Testing
- Integrative Breathwork Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Respiratory Distress Syndrome, Prematurity
Influence of Flow Rate Change on CO2 Levels During High Flow Nasal Ventilation (HFNV) in Preterm Infants.
Background Preterm infants often need respiratory support. HFNV is a non-invasive method with benefits over CPAP, such as reduced nasal trauma and improved feeding. Aim Study the impact of low (2 LPM) vs.
- Conditions
- Respiratory Distress Syndrome, Prematurity, Non Invasive Ventilation
- Trial name
- NCT06622902
- Testing
- change flow from 6 to 2 LPM. Follow TcCO2 for 3 hours, change flow from 2 to 6 LPM. Follow TcCO2 for 3h
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Rambam Health Care Campus
Bradycardia, Hypoxemia
Nose-close and Abdomen-compression in Pediatric Flexible Bronchoscopy
The nasopharyngeal oxygen (NPO) with Nose-close (NC) and Abdomen-compression (AC) technique may use for support or rescue asphyxiated infants during Flexible bronchoscopy.
- Trial name
- NPO-NC-AC (NCT01629186)
- Testing
- NPO with Nose-close and Abdomen-compression
- Where
- Taiwan
- Volunteers
- 156 people
- Sponsor
- Cho-yu Chan, MD
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