Clinical trials: Aspiration, Respiratory
Pneumonia, Ventilator-Associated, Critical Illness
Intubation and Extubation Over 48 Hours Mechanical Ventilation
The purpose of this study is to determine how often ventilator associated pneumonia happens in the current intensive care units, and how types of endotracheal tube affect its occurrence.
- Trial name
- INDEX48 (NCT01123681)
- Testing
- Choice of endotracheal tube
- Where
- 6 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Okayama Research Investigator Organizing Network
Critical Illness, Respiration, Artificial
Conservative Versus Conventional Oxygen Administration in Critically Ill Patients
Oxygen supplementation in the inspired mixture is commonly used in critically ill patients and observational studies highlight that those patients remain hyperoxemic for substantial periods during Intensive Care Unit stay.
- Conditions
- Critical Illness, Respiration, Artificial, Hyperoxia, Hyperoxemia
- Trial name
- NCT04198077
- Testing
- Oxygen
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Modena and Reggio Emilia
Cystic Fibrosis
Evaluation of the Safety and Tolerability of Inhaled Nitric Oxide to Subjects With Cystic Fibrosis
Cystic Fibrosis is defined as a genetic disorder affecting approximately 100,000 individuals worldwide. CF is caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene.
- Trial name
- NCT01958944
- Testing
- Nitric oxide
- Where
- 2 sites in Israel
- Volunteers
- 9 people
- Sponsor
- Beyond Air Inc.
Cardiovascular Diseases
Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
Fluid responsiveness is difficult to assess at the bedside. The accuracy of published techniques to detect preload-dependent patients have many pitfalls and limitations.
- Trial name
- NCT03693365
- Testing
- PEEP trial
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Pleural Effusion
Comparing Active Versus Passive Aspiration in Therapeutic Thoracentesis: Efficacy, Procedure Time, and Patient Safety
This single-blind randomized controlled trial (RCT) aims to compare the efficacy and safety of active manual aspiration versus passive gravity drainage during therapeutic thoracentesis for large symptomatic pleural effusions.
- Trial name
- Thoracentesis (NCT07184736)
- Testing
- Active Manual Syringe Aspiration, Passive Gravity Drainage
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Adolescent Idiopathic Scoliosis, Diaphragmatic Manual Techniques
Three-Dimensional Scoliosis Exercises and Diaphragmatic Manual Techniques in Adolescents With Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine that emerges during growth and is characterized by lateral curvature, vertebral rotation, and trunk asymmetry.
- Conditions
- Adolescent Idiopathic Scoliosis, Diaphragmatic Manual Techniques, Schroth Exercises
- Trial name
- NCT07683533
- Testing
- Diaphragmatic manual techniques, Schroth exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Akdeniz University
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Chronic Obstructive Pulmonary Disease, Lung Disease Causing Persistent Narrowing of the Airways
AZD2115 Single Ascending Dose Study
AZD2115 Single Ascending Dose Study
- Trial name
- NCT01283984
- Testing
- AZD2115
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Intellivent ASV in Chronic Obstructive Pulmonary Disease Patients in the ICU
This study will evaluate the effect of a fully closed loop ventilation mode (Intellivent ASV) on the duration of ventilation compared to conventional modes in COPD patients.
- Trial name
- NCT02651935
- Testing
- Intellivent ASV
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Idiopathic Pulmonary Fibrosis
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of SM04646 Inhalation Solution in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
SM04646-IPF-03 is a Phase 2a, multi-center, open-label study evaluating the safety and efficacy of a single inhaled, nebulized dose of SM04646 solution over a 12-week treatment regimen in subjects with mild to moderate IPF.
- Trial name
- NCT03591926
- Testing
- SM04646
- Where
- 6 sites in Australia, New Zealand
- Sponsor
- Biosplice Therapeutics, Inc.
Pulmonary Nodule, Pneumothorax
Safety And Recovery Of Tubeless Strategy In Uniportal VATS Wedge Resection
Brief Summary The goal of this clinical trial is to evaluate the safety and recovery outcomes of different tubeless strategies in adult patients undergoing uniportal video-assisted thoracoscopic (VATS) wedge resection who are…
- Conditions
- Pulmonary Nodule, Pneumothorax, Postoperative Complications
- Trial name
- NCT07395349
- Testing
- Conventional Chest Tube Drainage, Single Intraoperative Aspiration Tubeless, Double Intraoperative Aspiration Tubeless
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome
Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.
The purpose of this study is to analyze whether the treatment of metabolic alkalosis with acetazolamide in intubated patients with chronic obstructive pulmonary disease (COPD) or with obesity hypoventilation syndrome (OHS)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome, Metabolic Alkalosis
- Trial name
- TRAMA (NCT01499485)
- Testing
- Acetazolamide
- Where
- 8 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Hospital Son Llatzer
Airway Obstruction, Sedation Complication
Medical Device for Airway Patency During Sedation
OVERALL SYNOPSIS PART A: Systematic evaluation in spontaneously breathing healthy volunteer study participants of cumulative duration of manual measures for airway patency and for mask ventilation with airway device prototype…
- Conditions
- Airway Obstruction, Sedation Complication, Perioperative Complication
- Trial name
- STAIRWAY-2 (NCT06270212)
- Testing
- STAIRWAY, NO DEVICE
- Where
- Sweden
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Stairway Medical AB
Coronary Artery Disease
Continued Ventilation During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.
- Trial name
- NCT01627756
- Testing
- Lung Ventilation, Non-ventilated Group
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Non Small Cell Lung Cancer, Non Small Cell Lung Cancer (NSCLC)
Liquid Biopsy Assay of EBUS-TBNA Supernatant Fluid for Diagnosing Lung Cancer
Background and aim: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the gold standard of lung cancer staging, yet up to 15% of procedures produce inadequate samples for definite diagnosis or…
- Conditions
- Non Small Cell Lung Cancer, Non Small Cell Lung Cancer (NSCLC), Lung Cancer (NSCLC), Lung Cancer - Non Small Cell
- Trial name
- NCT06889467
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Barzilai Medical Center
Aged, Neoplasms
Impact of Anesthesia Maintenance Methods on 5-year Survival After Surgery
Surgery is one of the major treatment methods for patients with solid organ cancer. And, alone with the ageing process, more and more elderly patients undergo surgery for cancer.
- Conditions
- Aged, Neoplasms, Surgical Procedure, Operative, Anesthesia, Inhalation
- Trial name
- NCT05343260
- Testing
- Sevoflurane, Propofol
- Where
- 15 sites in China
- Volunteers
- 1,228 people
- Sponsor
- Peking University First Hospital
Stage 1 Hypertensives
Additional Effect of Coherent Breathing With Aerobic Exercise on Cardiopulmonary Parameters and Quality of Life in Stage 1 Hypertensive Individuals
This study will use a randomized controlled trial to evaluate the added effects of coherent breathing combined with aerobic exercise versus aerobic exercise alone in 40 adults aged 30-65 with stage 1 hypertension.
- Trial name
- NCT07573683
- Testing
- Coherent Breathing., Aerobic Exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Pneumonia, Aspiration
The Clinical Application Value of "Showering Cells" in the Diagnosis of Aspiration Pneumonia
Based on our team's previous discovery of a unique type of squamous epithelial cell in the bronchoalveolar lavage fluid (BALF) of patients with aspiration pneumonia (AP) using microbiological rapid on-site evaluation (M-ROSE)…
- Trial name
- NCT07395310
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Chinese PLA General Hospital
Apnea
Laryngeal Mask Ambu Aura Once vs. Supreme in Children
The purpose of this study is determine safety and efficiency of mechanical ventilation in children with two different types of single use laryngeal masks (Ambu AuraOnce vs. LMA Supreme).
- Trial name
- NCT01718782
- Testing
- laryngeal mask Ambu AuraOnce, laryngeal mask LMA Supreme
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma, Lung Cancer
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Using a 22 vs 25-Gauge Needle
The goal of this clinical research study is to compare the effectiveness of a smaller, 25-gauge needle when used in an endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) instead of a standard 22-gauge…
- Trial name
- NCT03004586
- Testing
- 25-Gauge Needle, 22-Gauge Needle, Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- M.D. Anderson Cancer Center