Clinical trials: Aspiration
Acute Respiratory Distress Syndrome, ARDS
Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome
Doctors follow a standard ventilator management strategy when making adjustments to the breathing machine to optimize the amount of oxygen into the lungs.
- Trial name
- NCT03793842
- Testing
- Usual care, PEEP titration by EIT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Michigan
Respiratory Failure
Extubation With or Without Spontaneous Breathing Trial
Spontaneous breathing trial (SBT) has long been thought to be a essential process before extubation. In this study,the investigator hypothesized that SBT could be not essential during weaning from ventilator and investigated…
- Trial name
- SBT (NCT01020773)
- Testing
- spontaneous breathing trial
- Volunteers
- 67 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Bronchopulmonary Dysplasia
Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Very premature infants often cannot breathe on their own and require assistance with a respirator. Conventional respirators deliver air or oxygen via a breathing tube placed through the mouth to the airway (endotracheal tube).
- Trial name
- NCT01440647
- Testing
- Extubation to NIPPV, Extubation to CPAP
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Obesity, Laparoscopic Gastric Bypass Surgery
CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
The purpose of this study is to investigate if a deep neuromuscular block with a continuous infusion of rocuronium titrated to a post-tetanic count (PTC) of 1-2 responses combined with reversal of neuromuscular blockade with…
- Conditions
- Obesity, Laparoscopic Gastric Bypass Surgery, Surgical Conditions, Respiratory Function
- Trial name
- CURES (NCT01748643)
- Testing
- deep neuromuscular blockade with rocuronium, reversal with sugammadex, normal neuromuscular blockade reversal with rocuronium, reversal with neostigmine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
Intraoperative Ventilation
A Comparison of Different Ventilation Strategies in Children Using the Proseal™ Laryngeal Mask Airway
The purpose of this research study is to compare difference between breathing by oneself or with the partial help from an anesthesia machine in children under general anesthesia.
- Trial name
- NCT00966433
- Testing
- Spontaneous ventilation, Pressure support Ventilation, Pressure control ventilation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
Pancreatic Masses, Lymph Nodes
Comparing a 25G EUS Fine Needle Aspiration (FNA) Device With a 20G EUS
The aim of this study is to compare the diagnostic accuracy of two EUS-guided tissue acquisition devices; the 25G Echotip Ultra Fine Needle Aspiration (FNA) device and the 20G Echotip ProCore Fine Needle Biopsy (FNB) device.
- Trial name
- ASPRO (NCT02167074)
- Testing
- 25G FNA needle, 20G ProCore FNB needle
- Where
- 13 sites in United States, Australia and 8 more
- Volunteers
- 615 people
- Sponsor
- Foundation for Liver Research
Chronic Hepatitis C
Evaluating Fine Needle Aspiration to Measure Hepatic Vaniprevir (MK-7009) Concentrations in Participants With Chronic Hepatitis C (MK-7009-048)
This study will evaluate the technical feasibility of using fine needle aspiration (FNA) of liver tissue to obtain vaniprevir (MK-7009) liver pharmacokinetic (PK) data, working towards identifying a minimally invasive…
- Trial name
- NCT01678131
- Testing
- Vaniprevir 600 mg, Peg-IFN alfa-2b, Ribavirin
- Volunteers
- 31 people
- Sponsor
- Merck Sharp & Dohme LLC
Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants
Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Oral feeding of neonates while on nasal continuous positive airway pressure (NCPAP) is a common practice in many neonatal intensive care units (NICU) all over the country.
- Conditions
- Deglutition Disorders, Respiratory Distress Syndrome In Premature Infants, Respiratory Aspiration, Newborn, Premature
- Trial name
- NCT02661256
- Testing
- NCPAP, Varibar® Thin Liquid Barium Sulfate for Suspension
- Volunteers
- 7 people
- Sponsor
- NYU Langone Health
Ventilation
A Comparison of Different Ventilation Strategies in Infants Using the PLMA™
The purpose of this research study is to compare difference between breathing by oneself or with the partial help from an anesthesia machine in infants under general anesthesia.
- Trial name
- NCT03235817
- Testing
- Spontaneous ventilation, Pressure support ventilation, Pressure control ventilation
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Wake Forest University
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Obesity
Pivotal Aspiration Therapy With Adjusted Lifestyle Therapy Study
This research study is being performed to find out if a new device, AspireAssist Aspiration Therapy System, can help people with obesity to lose weight without causing too many side effects.
- Trial name
- PATHWAY (NCT01766037)
- Testing
- Aspiration Therapy (AspireAssist), Lifestyle Therapy
- Where
- 10 sites in United States
- Volunteers
- 171 people
- Sponsor
- Aspire Bariatrics, Inc.
Breast Cancer Diagnosis
Automated Method for Breast Cancer Detection
Participants with suspicious breast lesions by mammography will undergo fine needle aspiration (FNA) under ultrasound guidance. The FNA will be read by the cytopathologist and analyzed in the breast cancer detection cartridge.
- Trial name
- NCT03863522
- Testing
- Fine needle aspiration, Cancer Detection cartridge
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pulmonary Arterial Hypertension
Safety Evaluation of Inhaled Treprostinil Administration Following Transition From Inhaled Ventavis in Pulmonary Arterial Hypertension (PAH) Subjects
This is a 24-month, multi-center, prospective, open-label, safety evaluation in PAH subjects following transition from a stable dose of inhaled iloprost (Ventavis).
- Trial name
- NCT00741819
- Testing
- Inhaled treprostinil
- Where
- 15 sites in United States
- Volunteers
- 73 people
- Sponsor
- United Therapeutics
Paresis
Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function
Background: Outpatient continuous interscalene brachial plexus blocks are used to control pain after shoulder surgery, with infusions of 0.125% bupivacaine or 0.2% ropivacaine.
- Trial name
- NCT02059070
- Testing
- Ropivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Anesthesiology WSU/DMC-NorthStar
Meconium Aspiration
Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome
OBJECTIVES: Evaluate the safety and efficacy of lucinactant administered by bronchoalveolar lavage (BAL) in the treatment of meconium aspiration syndrome (MAS) in newborn infants.
- Trial name
- NCT00004500
- Testing
- Lucinactant, Standard Care
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Windtree Therapeutics
Sedation, Critical Illness
Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
This randomized clinical trial evaluates the effects of a musical intervention on hormonal and inflammatory biomarkers in sedated adult patients undergoing invasive mechanical ventilation in an intensive care unit.
- Conditions
- Sedation, Critical Illness, Respiration, Artificial, Inflammation
- Trial name
- NCT06120660
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Oviedo
Infertility
Aspiration of Limited Number of Follicles to Prevent Severe Ovarian Hyperstimulation Syndrome
The purpose of this study is to evaluate the effect of single ovarian puncture to retrieve 7eggs only in prevention of severe ovarian hyperstimulation syndrome.
- Trial name
- NCT02635425
- Testing
- 7 eggs collection, Full eggs collection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ahmad Hussieny Salama
Upper Airway Obstruction
Phamacological Reversal of Airway Instability During Sedation
The investigators are attempting to demonstrate a decrease in the frequency and severity of sedation-induced respiratory arrhythmias(central and obstructive apneas) with pharmacological pre-treatment in this pilot project and…
- Trial name
- PHYSO (NCT01171118)
- Testing
- Physostigmine, Oxygen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Orthopedic Surgery, Ventilation
Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project
The objective is to determine the optimal intraoperative ventilation strategy among the chosen tidal volume and positive end-expiratory pressure (PEEP) levels, and standardize it in an enhanced recovery pathway for orthopedic…
- Trial name
- NCT03657368
- Testing
- Low tidal Volume, High tidal Volume, Low PEEP
- Where
- United States
- Volunteers
- 2,860 people
- Sponsor
- The Cleveland Clinic
Critical Illness
Gastric Ultrasound in Tube Fed Intubated Patients
This study will use point of care (POC) gastric ultrasound to confirm that nasojejunal tube (NJ) feeds result in minimal to no gastric content and therefore are low risk for aspiration and should be allowed at the very least to…
- Trial name
- NCT04612348
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Joseph D. Tobias