Clinical trials: Aspiration Pneumonitis
Aspiration Pneumonias
Continuous Supraglottic Aspiration in Intubated and Mechanically Ventilated Patients: the "SUPRAtube" Device
Purpose of the trial: Evaluate the efficacy and safety of the device of self-invention of continuous oropharyngeal aspiration denominated "SUPRAtube" in patients with orotracheal intubation and mechanical ventilation.
- Trial name
- Supratube (NCT03573635)
- Testing
- Supratube, Reference
- Where
- Colombia
- Volunteers
- 38 people
- Sponsor
- Fundación Cardiovascular de Colombia
Pneumonia, Aspiration Pneumonia
Community Acquired Pneumonia in Older Adults
This study will utilize diagnostic imaging and salivary biomarkers to estimate the prevalence of aspiration in older adults with suspected community-acquired bacterial pneumonia (CABP).
- Trial name
- NCT04709978
- Testing
- Videofluoroscopic Swallowing Study, Nuclear medicine pulmonary aspiration study, TOR-BSST and 3 oz Water Swallow
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Wisconsin, Madison
Aspiration Pneumonia
Dynamic Laryngotracheal Separation for Aspiration
People who aspirate after neurologic insults such as stroke often develop fatal pneumonia. This study examines the effects of dynamic vocal cord closure on swallowing.
- Trial name
- NCT00580346
- Testing
- Placement of laryngeal implant
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Aspiration Pneumonia
Eating Rehabilitation Training for Timely Removal of Nasogastric Tube in Elderly Patients
Aspiration pneumonia is a common complication in senior patients with high morbidity and mortality rate. The decline of physical function among elders can easily lead to swallowing disorders, and nasogastric (NG) tube insertion…
- Trial name
- NCT05810688
- Testing
- eating rehabilitation training
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Early Aspiration Pneumonia
Bronchial Alpha Amylase as a Marker for Early Aspiration Pneumonia in Therapeutic Hypothermia.
Early Aspiration Pneumonia is a frequent and dreadful complication in survivors of cardiac arrest. Therapeutic Hypothermia widely used in Intensive Care Unit for its benefice on post cardiac arrest syndrome may otherwise hide…
- Trial name
- NCT03007862
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Esophageal Motility Disorders, Gastric Motor Dysfunction
Gastrointestinal Dysmotility on Aspiration Risk
The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment.
- Conditions
- Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux
- Trial name
- NCT05455359
- Testing
- Prucalopride, Famotidine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Aspiration Pneumonia
Functionality and Accuracy of the smART System in Real-Life ICU Settings
Total participants in the "Functionality and Accuracy of the smART System in Real-Life ICU Settings" are 10 participants - in the current Jefferson study site there were 8 participants and in the Sheba study site (identifier…
- Trial name
- NCT03198988
- Testing
- smART Feeding Tube System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- ART Medical Ltd.
Aspiration Pneumonia
Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
The two most common consequences resulting from aspiration are chemical pneumonitis and bacterial aspiration pneumonia. Both entities present with comparable clinical signs and symptoms.
- Trial name
- APAPI (NCT03763799)
- Testing
- PCR-based microbiological diagnosis strategy, Standard microbiological diagnosis strategy
- Where
- 2 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Lille
Pneumonia, Aspiration, Gastric Content
Point-of-care Gastric Ultrasound for Fracture Surgery
Although there are fasting guidelines offered by the American Society of Anesthesiology (ASA) for managing preoperative patient assessment, some patients may need to be more cautious about the risk of aspiration.
- Conditions
- Pneumonia, Aspiration, Gastric Content, Fractures, Bone
- Trial name
- NCT05728242
- Testing
- Gastric ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Haseki Training and Research Hospital
Aspiration Pneumonia, Bronchoscopy
FBS-ASaP: Fibrobronchoscopy in ASpiration Pneumonia in the Emergency Department
Non-Profit Prospective Observational Pilot Study The study will have an overall duration of 3 years, with patient enrollment starting after ethical committee approval.
- Trial name
- FBS-ASaP (NCT06511583)
- Testing
- Laryngotracheal Aspiration Procedure Using a Probe in the Emergency Department, Aspiration Procedure Using Fibrobronchoscopy in the Emergency Department
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Inhalation Pneumonia
Effect of Diluent Volume on Colistin Inhalation Therapy
The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy.
- Trial name
- NCT06230614
- Testing
- Colistin 1 MU in normal saline 1 ml, Colistin 1 MU in normal saline 2 ml
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University
ICU Patients, Under Mechanical Ventilation
Syndrome and Aspiration Pneumonia in Intensive Care
Inhalation is a common condition in patients with impaired their awareness requiring protection of the upper airway by endotracheal intubation. This inhalation may lead to chemical pneumonitis and/or bacterial pneumonia.
- Conditions
- ICU Patients, Under Mechanical Ventilation, In State of Coma (Define by Glasgow ≤ 8), No Antibiotic Treatment
- Trial name
- SPIRE (NCT01881672)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Head and Neck Cancer
Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Head and Neck Cancer to Prevent Aspiration Pneumonia
Patients with locally advanced head and neck cancer treated with chemo-radiotherapy have (during and shortly after this treatment) a high risk of developing pneumonia by aspiration.
- Trial name
- PANTAP (NCT01598402)
- Testing
- amoxicillin/clavulanic acid suspension
- Where
- 6 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Aspiration Pneumonia, Tracheostomy Complication
Intra-laryngeal Implant for Treatment of Chronic Aspirations
This study evaluates the medical device Newbreez LD is designed to protect the lower airways from saliva, liquids and food aspirations in tracheotomized patients suffering from chronic aspirations that require specific care and…
- Trial name
- NCT03325725
- Testing
- NewBreez LD intra-laryngeal implant
- Where
- 2 sites in France
- Sponsor
- ProTiP Medical
Aspiration, Aspiration Pneumonia
Early Antibiotics After Aspiration in ICU Patients
The purpose of this study is to evaluate the use of early antibiotics in ICU patients who appear to have aspirated, to help determine whether this improves outcomes by reducing the later incidence of pneumonia and other negative…
- Trial name
- NCT05079620
- Testing
- Ceftriaxone, Amoxicillin clavulanic acid, Cefepime
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UConn Health
Aspiration Pneumonias, Tube Feeding
Percutaneous Endoscopic Gastrostomy Versus Percutaneous Endoscopic Gastrostomy With Jejunal Extension
The goal of this clinical trial is to learn if placing a feeding tube with a small bowel extension (called Percutaneous Endoscopic Gastrostomy With Jejunal Extension [PEG-J]) is better at preventing pneumonia than a standard…
- Conditions
- Aspiration Pneumonias, Tube Feeding, Enteral Feeds
- Trial name
- NCT06717321
- Testing
- (Arm 1): PEG, (Arm 2): PEG-J
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Jerry Dang
Chronic Obstructive Bronchopneumopathy, Infectious Pneumonia
Study of Collagen IV and XIX in Bronchoalveolar Lavage, Pulmonary Aspiration and Bronchial Biopsies
Collagens are proteins present in all tissues. Besides their structural role, recent data showed that they were able to regulate many cellular functions.
- Conditions
- Chronic Obstructive Bronchopneumopathy, Infectious Pneumonia, Pneumonitis, Lung Cancer
- Trial name
- BRONCOLL (NCT02788643)
- Testing
- biological fluids (serum, bronchoalveolar lavage and pulmonary aspiration) and bronchial biopsies collection
- Where
- France
- Volunteers
- 51 people
- Sponsor
- CHU de Reims
Aspiration Pneumonia, Malnutrition
Nutrition Monitoring and Feeding Optimization With the smART+ System - Comparative Study
The smART+ is a comprehensive modular patient care system intended for ICU patients. The main purpose of the study is the optimization of the delivery of nutrition.
- Trial name
- NCT04098224
- Testing
- smART+ System
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- ART Medical Ltd.
Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications
Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in…
- Conditions
- Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications, Postoperative Respiratory Failure, Postoperative Bronchospasm
- Trial name
- NCT07186933
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras
Inhalation Pneumonia, Risk Factor
Study of Risk Factors for Developing Inhalation Pneumonia After Inhalation
Inhalation pneumonia (PI) is common in clinical practice but is rarely studied. For example, there are no data on the incidence of pneumonia after inhalation and risk factors or protective factors to develop one since it is known…
- Trial name
- PrevAsPI-Obs (NCT03108430)
- Testing
- Risk factors and incidence of IP after inhalation
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens