Clinical trials: Assessment Evaluation
Periodontal Diseases, Bone Resorption
Bioactive Glass and Platelet Rich Fibrin in Intrabony Defects
Background: Platelet-rich fibrin (PRF) and bioactive glass putty has been shown to be effective in promoting reduction in probing depth, gain in clinical attachment, and defect fill in intrabony periodontal defects.
- Trial name
- NCT02982681
- Testing
- Platelet rich fibrin, Bioactive Glass
- Volunteers
- 10 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Acute Myocardial Infarction
Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction
This study is a first-in-human assessment of safety of using UCMSC in patients with AMI via a combination of IC and IV stem cell administration.
- Trial name
- NCT04056819
- Testing
- Allogeneic umbilical cord mesenchymal stem cells
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Ever Supreme Bio Technology Co., Ltd.
Heart Failure
Heart Failure IDentification in a High Risk Cardiovascular OutpatiEnt Population (HIDE)
This is a pilot, multicenter, real-world, single-visit, low risk, phase IV interventional study to efficiently identify new cases of heart failure (HF) Stage C in subjects who are at risk of cardiovascular (CV) disease in…
- Trial name
- HIDE (NCT04143919)
- Testing
- NYHA assessment, Serum NT-proBNP concentration, Transthoracic Ecocardiogram
- Where
- 5 sites in Dominican Republic, El Salvador and 1 more
- Volunteers
- 317 people
- Sponsor
- Novartis Pharmaceuticals
Cocaine Dependence
Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of RTI-336 in Healthy, Male Subjects
This is the first study to be conducted in humans for RTI-336, a new chemical entity, with evaluations focusing on the safety, tolerability, and pharmacokinetics of RTI-336 following administration of single, oral doses.
- Trial name
- NCT00808119
- Testing
- RTI-336 (CTDP 31862)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- RTI International
Congenital Diaphragmatic Hernia
Measurement of Lung Area at Chest Radiography to Define the Prognosis in Newborns With CDH
CDH represents a malformative disorder characterized by an incomplete diaphragm formation. This results in poor lung development (pulmonary hypoplasia), associated with altered vascularization of the lung (pulmonary…
- Trial name
- NeoAPACHE (NCT04396028)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Caries,Dental
CARDEC-PEL: Comparison of Two Methods of Caries Risk Assessment in Children
The aim of the study was to compare dental caries treatment and follow-up based on an elaborate and individualized assessment of caries risk in children, to a simpler risk assessment strategy by means of a double-blind randomized…
- Trial name
- NCT03969628
- Testing
- ICCMS
- Where
- Brazil
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
A Study to Evaluate Safety, Tolerability, and Efficacy Profile of Rivoceranib With Paclitaxel in Advanced Gastric or Gastroesophageal Junction Cancer
This is an open-label, single-center, single-arm, dose escalation and dose expansion Phase I/IIa study designed to determine the recommended Phase 2 dose (RP2D) and the safety and tolerability profile along with preliminary signs…
- Trial name
- NCT03707028
- Testing
- Rivoceranib, Paclitaxel
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Elevar Therapeutics
Phantom Limb Pain, Phantom Pain
VR to Evaluate Phantom Limb Pain
The objective of this study is to develop a virtual rehabilitation system that can be used to effectively treat Phantom Limb Pain (PLP) within the research setting and for at-home use by individuals with upper and lower extremity…
- Conditions
- Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain
- Trial name
- NCT05915065
- Testing
- Coapt Phantom Limb Pain Management System
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Shirley Ryan AbilityLab
Hypertension
VALERIA: Valsartan in Combination With Lisinopril in Hypertensive Patients With Microalbuminuria
The purpose of this study is to compare if the combination of valsartan 320 mg/lisinopril 20 mg versus the monotherapies of lisinopril 40 mg or valsartan 320 mg will result in a greater decrease of urinary albumin excretion…
- Trial name
- NCT00171067
- Testing
- valsartan, lisinopril
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 134 people
- Sponsor
- Novartis
Coronavirus, Inflammation
Treatment of Patients With Mild Coronavirus-19 (COVID-19) Disease With Methotrexate Associated to LDL Like Nanoparticles (Nano-COVID19)
The investigators propose a prospective, randomized, double-blind, placebo-controlled study, conducted in two phases. The purpose of the study is to evaluate the safety and efficacy of methotrexate in a cholesterol-rich…
- Conditions
- Coronavirus, Inflammation, Covid19
- Trial name
- Nano-COVID19 (NCT04610567)
- Testing
- Methotrexate-LDE phase 1, Methotrexate-LDE phase 2
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus, Type 2
Safety Assessment of Lyxumia (Lixisenatide) and Sulfonylurea as Add-on Treatment to Basal Insulin in Uncontrolled Patients With Type 2 Diabetes Mellitus Who Elect to Fast During Ramadan
Primary Objective: To compare the safety, in terms of percentage of patients with symptomatic documented hypoglycemia during Ramadan fast, of lixisenatide versus sulfonylurea (SU).
- Trial name
- LixiRam (NCT02941367)
- Testing
- Lixisenatide (AVE0010), Sulfonylurea, metformin
- Where
- 16 sites in India, Israel and 2 more
- Volunteers
- 184 people
- Sponsor
- Sanofi
Cardiac Resynchronisation Therapy (CRT), Heart Failure
A Study Testing a New Heart Scan Method to Improve Pacemaker Treatment for Heart Failure
Cardiac resynchronization therapy (CRT) is a device treatment for patients with heart failure which cannot be managed by medications alone. CRT can help the heart contract more efficiently and improve the pumping function.
- Trial name
- EFFECT-CRT (NCT07084467)
- Testing
- EF1 guided CRT optimisation, Standard of Care (SOC)
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- King's College London
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04237467
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Generalized Anxiety Disorder
A 10-Week Study for Efficacy and Safety Study of Gabitril in the Treatment of Adults With Generalized Anxiety Disorder
The purpose of this study is to evaluate the safety and efficacy of an investigational anti-anxiety medication relative to placebo in patients with generalized anxiety disorder (GAD).
- Trial name
- NCT00236067
- Testing
- Gabitril
- Where
- 21 sites in United States
- Volunteers
- 440 people
- Sponsor
- Cephalon
TIA
SpecTRA; A Study of the Validation of Protein Biomarkers in Transient Ischemic Attack
A clinical decision support rule/tool for classification of TIA/mimic that will enable rapid detection of ACVS in hyper-acute settings is being developed.
- Trial name
- NCT03070067
- Testing
- Non-Interventional Study
- Where
- 2 sites in Canada
- Volunteers
- 1,150 people
- Sponsor
- Andrew Penn
Contraception
Comparative Cycle Control Europe
The aim of this study is to evaluate bleeding pattern, cycle control, and safety of this new four-phasic oral contraceptive in comparison to a reference OC.
- Trial name
- NCT00185367
- Testing
- EV/DNG (Qlaira, BAY86-5027, SH T00658K), SH D 593 B (Miranova)
- Where
- 34 sites in Czechia, France and 1 more
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- Bayer
Shock, Microcirculation
Brain Ultrasound With Contrast Microbubbles Injection in Shock Status
Alterations in the brain microcirculation may be involved in patients with shock. For a three-day period, we investigate the brain microcirculation using contrast-enhanced ultrasound with microbubble injection in patients with…
- Trial name
- NCT04290767
- Testing
- Sulphur hexafluoride microbubbles SONOVUE (BRACCO, Milan, Italy)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Osteo Arthritis Shoulders, Traumatic Arthritis
Clinical Evaluation of the Integra® Titan™ Modular Shoulder System Generation 2.5 for Primary Shoulder Joint Replacement
A post market, prospective, non-randomized, multi-center, open-label, clinical study using survivorship as the reference performance goal to study the safety and efficacy of the Titan Modular Shoulder System 2.5 when used for…
- Conditions
- Osteo Arthritis Shoulders, Traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT03250767
- Testing
- Integra Titan Modular Shoulder System 2.5
- Where
- 7 sites in United States
- Volunteers
- 58 people
- Sponsor
- Smith & Nephew, Inc.
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Evaluation of Remote Patient Monitoring.
Nottingham Primary Care Trust has launched telemonitoring to support: independent living and self-management ability of people with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and co-morbidities…
- Trial name
- NCT00789100
- Where
- United Kingdom
- Sponsor
- Brunel University
Diabetes
Ambulance 'Hypos Can Strike Twice' Study
This study will assess the effectiveness the "Hypos can strike twice" intervention on people with diabetes experiencing hypoglycaemia (or "hypo", meaning low blood sugar).
- Trial name
- Ambu-HS2 (NCT04243200)
- Testing
- Hypos can strike twice
- Where
- United Kingdom
- Volunteers
- 5,015 people
- Sponsor
- University of Lincoln
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