Clinical trials: Assessment Evaluation
Temporomandibular Disorder
Investigation and Modulation of the Mu-opioid Mechanisms in TMD (in Vivo)
In this study, this team of researchers will investigate the impact of chronic temporomandibular disorder suffering on the endogenous μ-opioid system in vivo, arguably one of the principal endogenous pain modulatory systems in…
- Trial name
- NCT03724032
- Testing
- HD-tDCS*
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Salivary Gland Dysfunction, Xerostomia
Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy
This early phase 1 trial studies the use of everolimus in restoring salivary gland function in participants with locally advanced head and neck cancer after concurrent chemoradiation or radiation therapy alone.
- Conditions
- Salivary Gland Dysfunction, Xerostomia, Head and Neck Cancer
- Trial name
- NCT03578432
- Testing
- Everolimus, Laboratory Biomarker Analysis, Survey Administration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Arizona
Gingivitis, Plaque, Dental
Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash
Qualified subjects will be enrolled and randomized to either one of the two study groups described above based on their initial modified gingivitis and plaque scores.
- Trial name
- NCT07263698
- Testing
- cetylpyridinium chloride (CPC), zinc lactate and sodium fluoride Mouthwash, sodium fluoride Mouthwash
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Externalized Conductors, Visual Lead Anomalies
St.Jude Medical Cardiac Lead Assessment Study
The Cardiac Lead Assessment Study (CLAS) is designed as a prospective, non-randomized, multi-center, international postmarket surveillance study under 522 Order PS120111 (August 16, 2012).
- Conditions
- Externalized Conductors, Visual Lead Anomalies, Electrical Dysfunction
- Trial name
- CLAS (NCT01507987)
- Testing
- Implanted with one or more of the following SJM leads: Riata leads, RiataST leads, Durata leads, and QuickSite/QuickFlex leads
- Where
- 45 sites in United States, Canada and 1 more
- Volunteers
- 2,216 people
- Sponsor
- Abbott Medical Devices
Solid Tumor, Adult
Tolerability and Safety of HF1K16 Injection in Patients With Refractory Solid Tumors
HF1K16 is an investigational pegylated liposome formulation of All-Trans Retinoic Acid (ATRA) for the induction of remission in patients with acute promyelocytic leukemia (APL) and for the treatment of solid tumors through…
- Trial name
- NCT05388487
- Testing
- HF1K16 /Arm 45 mg/m², HF1K16 /Arm 90 mg/m², HF1K16 /Arm 120 mg/m²
- Where
- 7 sites in China
- Volunteers
- 54 people
- Sponsor
- HighField Biopharmaceuticals Corporation
Skin and Subcutaneous Tissue Bacterial Infections, Gram-Positive Bacterial Infections
TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection
The purpose of this study is to evaluate safety, tolerability, pharmacokinetic characteristics and efficacy of TNP-2092 in adults with ABSSSI suspected or confirmed to be caused by gram-positive pathogens.
- Trial name
- P2_ABSSSI (NCT03964493)
- Testing
- TNP-2092, Vancomycin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- TenNor Therapeutics Limited
Rhinitis, Allergic, Perennial
A Clinical Study With Fluticasone Furoate Nasal Spray And Vehicle Placebo For The Treatment Of Perennial (Year-round) Allergic Rhinitis
The purpose of this study is to assess long-term ocular safety of fluticasone furoate nasal spray in adult and adolescent subjects diagnosed with perennial allergic rhinitis.
- Trial name
- NCT00682643
- Testing
- fluticasone furoate nasal spray
- Where
- 56 sites in United States
- Volunteers
- 550 people
- Sponsor
- GlaxoSmithKline
Niemann-Pick Type C Disease, GM1 Gangliosidosis
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
An 18-month double-blind, randomized, placebo-controlled, multicenter, Phase 3 study to evaluate the safety and efficacy of oral nizubaglustat (AZ-3102) in late-infantile and juvenile forms of Niemann-Pick type C disease and in…
- Conditions
- Niemann-Pick Type C Disease, GM1 Gangliosidosis, GM2 Gangliosidosis
- Trial name
- NCT07054515
- Testing
- AZ-3102
- Where
- 39 sites in United States, Argentina and 15 more
- Volunteers
- 147 people
- Sponsor
- Azafaros B.V.
Birt-Hogg-Dube Syndrome
Assessment of Safety of Air Travel in Patients With Birt-Hogg-Dube Syndrome
The aim of this study is to conduct survey-based assessments for the safety of air travel in patients with Birt-Hogg-Dube syndrome (BHD).
- Trial name
- NCT03040115
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Cincinnati
Visual Acuity
2-week Evaluation of Marketed Silicone Hydrogel Contact Lenses in Indian Population
The primary objective of this study is to evaluate the clinical performance of two marketed silicone hydrogel contact lenses in an Indian population in the following areas: physiological characteristics, comfort characteristics…
- Trial name
- NCT02394808
- Testing
- senofilcon A, lotrafilcon B
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Opioid Use
Investigation of the Effect of Intravenous Lidocaine Infusion on Postoperative Pain Treatment and Bowel Function in Robotic Bowel Surgery
Single center double blind randomised controlled trial. 60 subjects. Giving lidocaine IV or saline to patients due to robot assisted colorectal surgery. Primary outcome is cumulative morphine consumption at 24 hours.
- Trial name
- NCT03044808
- Testing
- Lidocaine, Saline
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Venous Ulcers
Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers
The purpose of this study is to determine whether nitric oxide (NO)gas is effective in the treatment of venous ulcers of the lower leg.
- Trial name
- NCT00613808
- Testing
- Nitric Oxide 200ppm Group B
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Nitric BioTherapeutics, Inc
Healthy Participants
A Study Assessing the Drug Levels, Drug Effects, and Safety of BMS-986322 in Healthy Participants
A Study assessing the drug levels and drug effects of variable doses of BMS-986322 in Healthy Participants compared to a placebo. The study also assesses how BMS-986322 affects the body with food and its acidity levels.
- Trial name
- NCT04175925
- Testing
- BMS-986322, famotidine
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Male Infertility Due to Azoospermia
Male Factor Infertility Across India Using Aphrodite Criteria
Study Purpose: The purpose of this study is to conduct an observational cross-sectional analysis of male factor infertility across diverse regions of India utilizing the Aphrodite Criteria.
- Trial name
- APHR (NCT06911840)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Pain, Acute, Analgesia
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
Using a retrospective review of records, we will conduct a multivariate analysis to examine the relationship between exposure to ketamine, as an analgesic agent in combat related trauma care, the use of additional opioid pain…
- Conditions
- Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder
- Trial name
- NCT04057989
- Testing
- ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Chronic Kidney Disease, Chronic Kidney Disease, Stage 3 (Moderate)
Study to Assess PK, Safety and Tolerability in Patients With DM and CKD
An open-label, phase IB, multi-center study evaluating DM199 in subjects with Type 1 Diabetes or Type 2 Diabetes and Stage 3 or 4 Chronic Kidney Disease.
- Conditions
- Chronic Kidney Disease, Chronic Kidney Disease, Stage 3 (Moderate), Chronic Kidney Disease, Stage 4 (Severe), Diabetes
- Trial name
- NCT03795389
- Testing
- DM199
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- DiaMedica Therapeutics Inc
Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension
Chinese PE Multimodality Imaging Artificial Intelligence Study
The CHinese pulmOnary Embolism Multimodality Imaging-artifiCial intelligencE Study (CHOICE) is a prospective observational multi-center study that will collect imaging text data and raw data of patients with pulmonary embolism…
- Conditions
- Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Disease
- Trial name
- NCT06526468
- Testing
- Artificial Intelligence
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- China-Japan Friendship Hospital
Bipolar Disorder
A Study of Olanzapine in Participants With Bipolar Disorder.
This study aimed to identify treatment patterns in patients with bipolar disorder receiving olanzapine according to demographic and clinical characteristics and to evaluate the effectiveness of education on weight gain, a side…
- Trial name
- NCT07263191
- Testing
- Olanzapine
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Oral Hygiene Education, Oral Hygiene Education Methods
The Effects of Different Oral Hygiene Instructions
The aim of this study is to evaluate the effects of verbal and video-based oral hygiene instructions on the oral health parameters in patients of different age groups.
- Trial name
- NCT06449950
- Testing
- Behavioral: Verbal Oral Hygiene Instructions, Behavioral: Video-Based Oral Hygiene Instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Ankara University
Deep Brain Stimulation
Evaluation of Advanced Imaging and Visualization for Clinical Deep Brain Stimulation
The objective of this project is to evaluate next generation visualization tools and surgical targeting models for clinical deep brain stimulation (DBS).
- Trial name
- NCT06191874
- Testing
- Standard-of-care (SOC) surgery plan, HoloDBS hypothetical surgery plan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
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