Clinical trials: Assessment Evaluation
Pediatric Cancer, Quality of Life
Enabling Symptom Identification and Tracking in Children Receiving Cancer Treatment
Children with cancer and hematopoietic stem cell transplant (HSCT) recipients suffer from severe and bothersome symptoms because treatments are intense.
- Conditions
- Pediatric Cancer, Quality of Life, Symptom Screening
- Trial name
- NCT03495518
- Testing
- Symptom feedback to Health Care Provider, Standard of care
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Hemophilia A
Evaluation of SCT800 in Prophylaxis Therapy on Previous Treated Patients With Severe Hemophilia A
This study is a multi-center, open-label, single-arm trial to evaluate the efficacy,safety and pharmacokinetics of SCT800 in regular prophylaxis and perioperative treatment in patients (≥12 years old) with severe hemophilia A who…
- Trial name
- NCT03815318
- Testing
- Recombinant Human Coagulation FVIII
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Sinocelltech Ltd.
Assisted Reproductive Techniques
Gamete Donation Conception and Disclosure to Children : Towards an Evaluation of the Practices (AMP)
Assisted reproductive techniques (ART) is very framed in France by principles initially stated by the french CECOS Federation of (Centre d'Etude et de Conservation des Oeufs et du Sperme) and then included in the bioethic law.
- Trial name
- AMP (NCT03801018)
- Testing
- Questionnary and Interviews
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Prostate Cancer
Darolutamide+ADT Post-RP w/o ePLND in hrPC: Briganti 2019
The goal of this clinical trial is to evaluate whether adjuvant darolutamide plus androgen-deprivation therapy (ADT) can reduce post-operative recurrence and improve disease control in high-risk prostate cancer patients-defined…
- Trial name
- NCT07282197
- Testing
- Darolutamide (BAY 1841788)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University First Hospital
COPD
Placebo Controlled Evaluation of Sedation and Physiological Response to Intranasal Dexmedetomidine in Severe COPD
A variety of medications have been used to treat the anxiety, discomfort, and fear associated with continuous and sudden episodic breathlessness in patients with advanced respiratory disease.
- Trial name
- NCT02773797
- Testing
- IN-DEX 1.0 mcg/kg, intranasal saline, IN-DEX 1.5 mcg/kg, intranasal saline
- Where
- United States
- Sponsor
- Dayton VA Medical Center
Depression, Psychological Distress
German Evaluation of the Effectiveness of the Psychological Intervention Managing Cancer and Living Meaningfully (CALM)
Purpose of this randomized controlled trial is to test the efficacy of the individual psychotherapeutic intervention Managing Cancer and Living Meaningfully (CALM) in a German sample of patients with advanced cancer.
- Trial name
- NCT02051660
- Testing
- Manualized CALM intervention, Non-manualized supportive intervention.
- Where
- 2 sites in Germany
- Volunteers
- 206 people
- Sponsor
- University of Leipzig
Choroidal Neovascularization (CNV)
Assess the Efficacy/Safety of Intravitreal Ranibizumab in Patients With Vision Loss Due to Choroidal Neovascularization.
This study was conducted to evaluate the efficacy and safety of 0.5 mg ranibizumab in adult and adolescent patients with visual impairment due to choridal neovascularization (CNV).
- Trial name
- NCT01840410
- Testing
- Ranibizumab
- Where
- 59 sites in Australia, Canada and 19 more
- Volunteers
- 183 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson's Disease
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with…
- Trial name
- PARAISO (NCT07174310)
- Testing
- Prasinezumab
- Where
- 192 sites in United States, Australia and 15 more
- Volunteers
- 900 people
- Sponsor
- Hoffmann-La Roche
Resectable HER2-positive Breast Cancer
A Phase III Study of KN026 in Combination With HB1801 as Adjuvant Therapy for Resectable HER2-Positive Breast Cancer
This is a randomized, controlled, open-label, multicenter, Phase Ⅲ clinical study designed to compare the efficacy and safety of KN026 combined with HB1801 and chemotherapy versus trastuzumab combined with pertuzumab and…
- Trial name
- NCT07441460
- Testing
- KN026, HB1801, Trastuzumab
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Shanghai JMT-Bio Inc.
Neoplasm Malignant
First-in-human Single Agent Study of SAR442257 in RRMM and RR-NHL
Primary Objective: To determine the maximum tolerated dose (MTD) of SAR442257 administered as a single agent in patients with relapsed and refractory multiple myeloma (RRMM) and relapsed and refractory non-Hodgkin lymphoma…
- Trial name
- NCT04401020
- Testing
- SAR442257
- Where
- 16 sites in United States, Czechia and 3 more
- Volunteers
- 47 people
- Sponsor
- Sanofi
Diabetic Retinopathy
A Study to Evaluate the Efficacy of Oral AKST4290 in Participants With Moderately Severe to Severe Diabetic Retinopathy (CAPRI)
A Double-Masked, Placebo-Controlled Study to Evaluate the Efficacy of Oral AKST4290 in Participants with Moderately Severe to Severe Diabetic Retinopathy (CAPRI).
- Trial name
- NCT05038020
- Testing
- AKST4290
- Where
- 17 sites in United States
- Volunteers
- 3 people
- Sponsor
- Alkahest, Inc.
Bipolar Disorder I, Bipolar Disorder II
PSYCHE (Personalised Monitoring SYstems for Care in Mental Health)
For the moment, the detection of a mood episode in Bipolar Disorder (BD) relies on the appearance of the first clinical signs that the clinician detect or that the patient becomes aware of and reports to the clinician.
- Conditions
- Bipolar Disorder I, Bipolar Disorder II, Rapid Cycling Bipolar Disorder(DSM-IV-TR)
- Trial name
- PSYCHE (NCT01879982)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Strasbourg, France
Traumatic Brain Injury
Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study
Excitatory amino acids may be involved in secondary neuronal damage after traumatic brain injury. The amount of microglia activation is an indirect measure of neuronal damage.
- Trial name
- NCT00205582
- Testing
- Positron Emission Tomography
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Covid19, Cognitive Impairment
Assessment of Executive Functions After Covid-19
As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.
- Trial name
- NCT04771624
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Total Hip Arthroplasty (THA), Postoperative Pain Management After Total Hip Arthroplasty
MRI-Based Assessment of Local Anesthetic Spread in the PENG Block Compartment
This study uses MRI imaging to evaluate the spread of local anesthetic following the administration of a pericapsular nerve group (PENG) block.
- Trial name
- MRI-PENG (NCT07040423)
- Testing
- PENG Block, Magnetic resonance imaging
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Campus Bio-Medico University
Congenital Cytomegalovirus Infection
Diagnosis of Congenital CMV Infection in Neonates Who Failed Newborn Hearing Screening
Universal hearing screening at birth by use of otoacoustic emission (OAE) is now offered in most maternities in France to detect symptomatic hearing impairment at birth but screening of cCMV infection is not coupled with this…
- Trial name
- CYMEAUDIT (NCT02139423)
- Testing
- CMV PCR
- Where
- France
- Volunteers
- 235 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ulcerative Colitis
A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis
This is a study to learn if the experimental medicine (called PF-07054894) is safe, effective, and how it is processed in adult people with ulcers in the colon.
- Trial name
- NCT05549323
- Testing
- PF-07054894
- Where
- 17 sites in United States, Germany and 1 more
- Volunteers
- 44 people
- Sponsor
- Pfizer
Stroke
Acupuncture and Computer-based Training to Improve Attention Deficits in Patients After Stroke
The purpose of this study is to determine whether acupuncture and computer-based attention training can be combined for more effective post-stroke attentional deficits.
- Trial name
- ACoTrain (NCT02324959)
- Testing
- RehaCom, Acupuncture
- Where
- 3 sites in China, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- Fujian University of Traditional Chinese Medicine
Prostate Cancer
A Non-Interventional Study to Evaluate Time to Event and Healthcare Resource Utilisation for Prostate Cancer Participants Throughout the Disease Trajectories Until Progression or Death
Primary objective of this study is to describe the time in each prostate cancer stage from non-metastatic Hormone Sensitive Prostate Cancer (m0HSPC), metastatic Hormone Sensitive Prostate Cancer (m1HSPC), non-metastatic…
- Trial name
- NCT03619980
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 6,908 people
- Sponsor
- Astellas Pharma Europe Ltd.
Cochlear Implant Recipients, Hearing Loss, Cochlear
An Investigation to Evaluate Sound Coding Enhancements in Adult Cochlear Implant Recipients
This study will evaluate a range of experimental sound coding strategies that may improve hearing for cochlear implant recipients.
- Trial name
- SONORA-MU (NCT06867380)
- Testing
- Investigational sound coding strategy A, Cochlear default sound coding strategy A, Investigational sound coding strategy B
- Where
- 2 sites in Australia
- Volunteers
- 120 people
- Sponsor
- Cochlear
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