Clinical trials: Assisted Reproduction
Repeated IVF Failure, Microbiota
The Role of the Physiological Endometrial Microbiota in Assisted Reproduction Outcomes
The goal of this observational study is to investigate the influence and contribution of the normal composition and balance of the endometrial microbiota on the achievement of embryo implantation and the maintenance of pregnancy…
- Trial name
- no exist (NCT07606053)
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Assisting Nature
Infertility, Female, Mitochondrial
Automitochondrial Transplantation Improves Live Birth in Elderly Patients With Low Prognosis After Repeated IVF Failure
The goal to this clinical trial is to study the effectiveness and safety of automitochondrial transplantation of urine derived stem cells(USCs) in in elderly patients with low prognosis after repeated IVF failure.
- Conditions
- Infertility, Female, Mitochondrial, Elderly, Assisted Reproductive Technique
- Trial name
- ACTILB (NCT06020742)
- Testing
- Autologous USC mitochondrial oocyte transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Infertility
Gynecologists' Feedback on ART-Birth Rates
The investigators will examine the hypothesis that women who are given their personalized IVF-prognosis are less likely to overestimate their IVF-live birth rate, as compared to women who do not receive a personalized…
- Trial name
- GAB-RCT (NCT04169295)
- Testing
- Gynecologists' feedback on ART-Birth rates, Control group
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Non-viable Oocytes, Extra Spermatozoa
Evaluation of Discarded Laboratory Pathological Specimens and Media
The researchers propose to investigate the causes, incidence, and time-related events of chromosomal and physiologic abnormalities as they relate to patient diagnosis, fertility drugs utilized, and in vitro laboratory culture…
- Conditions
- Non-viable Oocytes, Extra Spermatozoa, Seminal Fluid, Granulosa Cells
- Trial name
- NCT01219439
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Fetal Cardiac Disorder
Fetal Cardiac Remodeling in Singleton Pregnancies Conceived by Assisted Reproductive Technology (Biopsied and Non-Biopsied ICSI) Versus Those Normally Conceived
The study aims to assess the presence of fetal cardiac remodeling and dysfunction in singleton pregnancies conceived by assisted reproductive technology (Biopsied and Non-Biopsied ICSI) as compared with those conceived…
- Trial name
- NCT05172336
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Wael Elbanna Clinic
Infertility Assisted Reproductive Technology
Artificial Shrinkage of Fresh Blastocysts
The aim of the study is to determine if collapsing an embryo (or making it fold compactly by taking away its fluid) before the transfer in the uterine cavity improves pregnancy rates in assisted reproductive technology (ART).
- Trial name
- BlastoCollapse (NCT02988544)
- Testing
- Artificial shrinkage
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Infertility, Sub-fertility
Human Papillomavirus and Rate of Pregnancy Achieved Via Medically Assisted Procreation
The main objective of this study is to investigate the association between the presence of HPV infection in one or both members of infertile/sub-infertile couples and the outcome of pregnancies obtained by assisted reproduction.
- Conditions
- Infertility, Sub-fertility, Papillomavirus Infections
- Trial name
- PAPILLO-PMA (NCT01894425)
- Where
- 4 sites in France
- Volunteers
- 700 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
HIV-1, Fertility
Intrauterine Insemination In HIV-Discordant Couples
This study aims to assess the feasibility of a novel standard of care technique for intrauterine insemination (IUI) in HIV-discordant couples in the United States.
- Conditions
- HIV-1, Fertility, Infertility
- Trial name
- ARTEMIS (NCT01173276)
- Testing
- Sperm Washing with Intrauterine Insemination (IUI)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Medical Center
Sterility, Infertility
Oral Versus Vaginal Progesterone in the Luteal Support in Cryo-warmed Embryo Transfer Cycles
In IVF/ICSI cycles, the progesterone levels induced by ovarian stimulation are low, therefore the luteal phase is supported by progesterone.
- Trial name
- NCT03619707
- Testing
- Progesterone
- Where
- Lebanon
- Volunteers
- 157 people
- Sponsor
- American University of Beirut Medical Center
Infertility
Psychosocial Determinants of Continuing or Discontinuing Infertility Treatment: A Psychological Analysis
The current study aims to explore and analyse the decision making process of couples in regards to continuing or discontinuing infertility treatment.
- Trial name
- NCT00974649
- Testing
- self-report questionnaire
- Where
- Belgium
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Infertility, Ovulation Induction
Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro Fertilization
This was a prospective, open-label, non-comparative, Phase IIIb trial to assess the convenience, safety and efficacy of the new Gonal-F fbm [recombinant follicle stimulating hormone (r-FSH)] liquid formulation, in common setting…
- Conditions
- Infertility, Ovulation Induction, In-Vitro Fertilization
- Trial name
- Prestyje (NCT01183143)
- Testing
- GONAL-f®
- Where
- Germany
- Volunteers
- 215 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ovarian Stimulation
Lutropin Alfa in Women at Risk of Poor Response
Evaluate the effectiveness of adding lutropin alfa (recombinant human luteinizing hormone [r-hLH]) in the middle of the follicular phase compared to no addition, in infertile women at risk of poor response stimulated with…
- Trial name
- NCT01112358
- Testing
- r-FSH, r-hLH, Analogous GnRH antagonist
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility
SIS Versus Office Hysteroscopy for Uterine Cavity Evaluation Prior to IVF
Saline infusion sonography (SIS) and hysteroscopy are commonly employed methods for uterine cavity evaluation. While hysteroscopy is regarded as the gold standard for diagnosis of intra-uterine pathology, it is not often used as…
- Trial name
- NCT04415489
- Testing
- Office hysteroscopy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Reproductive Techniques, Assisted
Endometrial Volume and Sub-endometrial Vascularity as Predictors of In-vitro Fertilization Success
100 patients aged 21-40 years old, diagnosed as primary or secondary infertility These patients are then assigned to receive ICSI treatment (ovulation induction, .
- Trial name
- NCT02381821
- Testing
- 3 D ultrasound and Doppler examination, GnRH agonist
- Volunteers
- 82 people
- Sponsor
- Cairo University
Embryo Hypoxia
Influence of Manipulation of Oocytes and Embryos in Low Oxygen Tension on Assisted Reproduction Technology Outcome
Nowadays, most assisted reproduction laboratories attempt to maintain as much as possible ex vivo culture conditions comparable to those in vivo.
- Trial name
- NCT04424784
- Testing
- 5% O2
- Where
- China
- Volunteers
- 1,160 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Infertility Assisted Reproductive Technology, Infertility (IVF Patients)
Blastocyst AI Assisted Morphokinetics in ART
The goal of this observational study is to learn if embryo characteristics obtained via the recording of real-time embryo activity via 30-seconds video capture (e.g.: Embryo Morphokinetics) can correlate with known embryo outcome…
- Trial name
- AIM (NCT07611448)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Viable Biosciences
In Vitro Fertilization
EXpression PRofile Endometrium Samples Study
This is a Phase IV, pilot, open-label, national, multi-centric study planned to determine the gene expression profiles and histologic changes of the endometrial tissue before and after stimulation with Gonal-f®.
- Trial name
- EXPRESS (NCT01210144)
- Testing
- Gonal -f® [r-hFSH], Ovitrelle® [r-hCG alfa], Gonadotropin-releasing hormone (GnRH) Agonist
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, Female
Effects of Pentoxifylline and Vitamin E on Pregnancy Rate in Infertile Women Treated by ICSI:
Our findings will provide preliminary clinical evidence to suggest the new experimental treatment approaches, toward female factor infertility treatment with pentoxyfylline.
- Trial name
- NCT03476564
- Testing
- pentoxifylline, Vit E
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Benha University
Infertility, Female, Intracytoplasmic Sperm Injections
Piezo-ICSI to Improve the Developmental Potential of Fertilized Oocytes in Aged Infertility Women With Assisted Reproductive Technology
The goal of this clinical trial is to test Piezo-ICSI on improving oocyte fertilization and embryo development in elderly infertile patients undergoing intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT06459778
- Testing
- Piezo-ICSI
- Where
- China
- Volunteers
- 147 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School