Clinical trials: Assisted Reproductive Technology
Fertilization
Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART
Oocyte activation is an imperative stage in the initiation of embryo development during the fertilization. Indeed, the entrance of sperm into the oocyte causes sequences of calcium oscillations in its cytoplasm, regulating a…
- Trial name
- NCT04519918
- Testing
- AOA
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Infertility
A Non-interventional Study to Identify the Patients With Severe Luteinizing Hormone Deficiency in the Daily Practice
This non-interventional study is planned to identify the subjects with severe luteinizing hormone (LH) deficiency in the daily practice.
- Trial name
- NCT01112618
- Where
- Germany
- Volunteers
- 3,247 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ectopic Pregnancy; Assisted Reproductive Technology
Risk Factors for Ectopic Pregnancy: Comparison of Fresh and Warmed Transfers. Analysis of a 10 Years, a Single Center Experience.
Ectopic pregnancy (EP) is a leading cause of maternal death during the first trimester of pregnancy. Previous studies have reported an increased incidence of EP in Assisted reproductive technologies techniques (ART) (Clayton et…
- Trial name
- NCT04325854
- Testing
- I and II level ART procedure
- Volunteers
- 27,377 people
- Sponsor
- Istituto Clinico Humanitas
Infertility
To Investigate REKOVELLE in Chinese Women Undergoing Assisted Reproductive Technologies: Effectiveness, Safety, and Patterns of Use in Real-world Practice
This is a multi-centre prospective non-interventional trial to assess the pattern of use of REKOVELLE® in Women Undergoing In Vitro Fertilisation (IVF) or Intracytoplasmic Sperm Injection (ICSI) Procedures in Routine Clinical…
- Trial name
- LYCHEE (NCT07029451)
- Where
- 28 sites in China
- Volunteers
- 2,549 people
- Sponsor
- Ferring Pharmaceuticals
Vitrification, Egg Donor
Validation of Donor Oocytes Semi-automated Vitrification
Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that…
- Conditions
- Vitrification, Egg Donor, Fertility, Assisted Reproductive Technology
- Trial name
- GAVIDO (NCT06238570)
- Testing
- Gavi, Merck® (automated vitrification instrument), Vitrolife system
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Children Born After Assisted Reproductive Technologies, Health Status
Health Status of Children Born After Assisted Reproductive Technologies
The goal of this observational study is to study the features of psychophysical development and the morbidity patterns of children born after assisted pregnancy, and to identify the connection with the health status of mothers…
- Conditions
- Children Born After Assisted Reproductive Technologies, Health Status, Child Development
- Trial name
- NCT06094998
- Testing
- hemogram examination
- Where
- Kazakhstan
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Kazakhstan's Medical University "KSPH"
Female Urogenital Diseases
The Effect of Laser-assisted Zona Thinning on the Implantation Rate in the Women of Advanced Age
The purpose of this study is to determine whether laser-assisted zona thinning improve the implantation rate of the women of advanced age in the first IVF/ICSI cycles
- Trial name
- NCT01765322
- Testing
- ZILOS-TK IVOS Analyzer
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanxi Provincial Maternity and Children's Hospital
Endometriosis, Omics
SH-SDU Shandong Endometriosis Reproductive Cohort
Endometriosis (EMs) is a chronic, estrogen-dependent, multi-systemic disease that affects approximately 190 million women worldwide.
- Conditions
- Endometriosis, Omics, Assisted Reproductive Technology
- Trial name
- NCT07558629
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Shandong University
Infertility
A Randomized, Multicentre, Open Label, Evaluator Blinded Study to Evaluate Safety and Efficacy of Folitime® of Gemabiotech S.A., Versus Gonal-f ® of Merck Serono, in Patients With Infertility Undergoing ART
This is an open-label, Phase 3, randomized, two arms, multicenter, prospective, experimental study of Folitime® (a new biosimilar formulation of r-hFSH, follitropin alfa) versus the original one (Gonal-f ®).
- Trial name
- NCT02454556
- Testing
- FOLITIME®, Gonal-F®
- Where
- Argentina
- Volunteers
- 106 people
- Sponsor
- Gema Biotech S.A.
POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology
Impact of Day 2 Versus Day 3 Fresh Embryo Transfer on Live Birth Rate in Poor-Prognosis Patients
This study aimed to compare the efficacy (live birth rate) of fresh embryo transfer on Day 2 versus Day 3 in POSEIDON Group 4 patients, and to determine the optimal timing of embryo transfer for this population.
- Conditions
- POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology, Female Infertility Due to Diminished Ovarian Reserve
- Trial name
- NCT07533695
- Testing
- Day 2 Fresh Embryo Transfer
- Volunteers
- 470 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Reproductive Techniques, Assisted
Study to Evaluate if the Addition of r-hLH (Luveris®) to FSH From Day 8 of Ovarian Stimulation is Able to Decrease Total FSH Dose and to Improve Cycle Outcome in Infertile Women Undergoing ART, Who Required High FSH Dose in a Previous Cycle
The present study was designed to investigate, in hyporesponder subjects, that required in a previous assisted reproductive technologies (ART) cycle follicle stimulating hormone (FSH) >3500 International Unit (IU), the…
- Trial name
- Luveris in ART (NCT01071200)
- Testing
- Recombinant human Follicle Stimulating Hormone (r-hFSH) and Recombinant human Luteinizing Hormone (r-hLH), r-hFSH
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Adenomyosis, Assisted Reproductive Technology
Low Molecular Weight Heparin on the Adenomyosis Patients'IVF-ET Outcome
In assisted reproductive technology, adenomyosis patients are characterized by lower clinical pregnancy rate, lower implantation rate and higher abortion rate.
- Trial name
- NCT04741295
- Testing
- Low molecular weight heparin
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Nanjing University
Infertility/Sterility
Positive Adjustment Coping Intervention
Involuntary childlessness is experienced as emotionally stressful, however psychosocial counseling is not always available on the spot.
- Trial name
- PACI (NCT03118219)
- Testing
- Positive adjustment coping intervention, Brainteaser
- Where
- Germany
- Volunteers
- 401 people
- Sponsor
- University Hospital Heidelberg
Infertility
3D Ultrasound Measurement of Junctional Zone Thickness and Its Relation to Implantation Success
100 patients aged 21-40 years old, diagnosed as primary or secondary infertility . These patients are then assigned to receive fertility treatment (ovulation induction, ICSI, intrauterine insemination and IVF).
- Trial name
- NCT02362061
- Testing
- 3D ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Infertility
Evaluation of IMSI to Treat Male Infertility
Intracytoplasmic Morphologically Selected Sperm (IMSI) is a modification of IntraCytoplasmic Sperm Injection (ICSI) with a choice of the spermatozoon to be injected done at a 6000x magnification instead of 400x commonly used in…
- Trial name
- PHRC-IMSI (NCT01780649)
- Testing
- IMSI, ICSI
- Where
- 9 sites in France
- Volunteers
- 255 people
- Sponsor
- University Hospital, Toulouse
Ectopic Pregnancies
Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology
The purpose of this study is to determine the predictive value of a single serum determination of activin A and inhibin A for the prognosis of ectopic pregnancy after in Vitro Fertilization (IVF) cycles, in both native and…
- Trial name
- NCT01589016
- Where
- Spain
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Adenomyosis, Infertility
Adenomyosis and Pregnancy Outcomes in Women Undergoing Assisted Reproductive Technology Treatment
Rationale: A rising number of adenomyosis cases are being diagnosed in women in the age group of 30 to 40 years. This is due to a combination of better diagnostic imaging techniques and a higher number of women delaying the…
- Conditions
- Adenomyosis, Infertility, ART, Pregnancy Loss
- Trial name
- AdAPT-ART (NCT05418140)
- Testing
- Ultrasound diagnosis of adenomyosis
- Where
- 9 sites in United Kingdom
- Volunteers
- 828 people
- Sponsor
- CARE Fertility UK
Assisted Reproductive Technology, Antibiotic Prophylaxis
Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT
The objective of this study is to determine the impact on clinical pregnancy rate of withholding routine prophylactic antibiotic therapy during IVF.
- Conditions
- Assisted Reproductive Technology, Antibiotic Prophylaxis, Embryo Transfer
- Trial name
- PAPET (NCT03386227)
- Testing
- Withholding antibiotic prophylaxis
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Infertility
Platelet-Rich Protein and the Endometrium
Platelet-rich plasma (PRP) may promote the endometrial growth and improve pregnancy outcome of patients with thin endometrium undergoing ART treatments.
- Trial name
- NCT02973555
- Testing
- PRP injection
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Cesarean Section, ART
Cesarean Section Scar Niche: The Impact on ART Outcome
To evaluate the impact of the presence of cesarean section niche and its characteristics on the outcome of ART cycles.
- Trial name
- NCT05358678
- Testing
- cs niche group
- Where
- Egypt
- Volunteers
- 266 people
- Sponsor
- Rahem Fertility Center