Clinical trials: Asthma Acute
Asthma, Status Asthmaticus
Study Evaluating the Safety and Effects of MN-221 in Subjects Experiencing an Acute Exacerbation of Asthma
The objective of this clinical study is to examine the safety and effectiveness of intravenous MN-221 compared to placebo when administered as an adjunct to standard therapy in subjects experiencing an acute exacerbation of…
- Trial name
- NCT00683449
- Testing
- Dose Group 1, Dose Group 2, Dose Group 3
- Where
- 9 sites in United States
- Volunteers
- 29 people
- Sponsor
- MediciNova
COPD, Asthma
Health Effects of Secondhand Smoke Exposure in Outdoor Smoking Areas in Patients With COPD and Asthma ( TackSHSWP5 )
Within the TackSHS project (H2020 project grant agreement No 681040), we will conduct a clinical research study, aiming at: i) to measure respiratory health effects when exposed to secondhand smoke (SHS) in patients with asthma…
- Conditions
- COPD, Asthma, Second Hand Tobacco Smoke
- Trial name
- TackSHSWP5 (NCT03074734)
- Testing
- Exposure to secondhand tobacco smoke
- Volunteers
- 60 people
- Sponsor
- Institut Català d'Oncologia
Asthma
Positive Expiratory Pressure for the Treatment of Acute Asthma in Children
Asthma is a leading cause of emergency department (ED) visits for children. A novel way of treating asthma is the use of positive expiratory pressure (PEP).
- Trial name
- NCT02494076
- Testing
- EzPAP, Standard Care
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Sickle Cell Disease, Vitamin D Deficiency
Vitamin D for Sickle-cell Respiratory Complications
This study aims to answer the question whether oral vitamin D supplementation can decrease lung complications in children and adolescents with sickle cell disease.
- Conditions
- Sickle Cell Disease, Vitamin D Deficiency, Acute Chest Syndrome, Asthma
- Trial name
- NCT01443728
- Testing
- Experimental: Vitamin D3 100,000 IU, Active Comparator: Vitamin D3 12,000 IU
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Gary M Brittenham, MD
Asthma
Study of Budesonide as an Addition to Standard Therapy in Adult Asthmatics in the Emergency Room.
To determine whether adding nebulized inhaled steroids to the standard care of acutely ill ED patients with refractory acute asthma helps improve forced expiratory volume at one second (FEV1) and decrease the need for…
- Trial name
- NCT00588406
- Testing
- Budesonide, albuterol, Ipratropium bromide
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- Northwell Health
Asthma
Study of MK-0476 in Adult Patients With Acute Asthma (0476-334)
The study estimates the efficacy and safety of MK0476 and aminophylline intravenous administration in adult participants with acute asthma.
- Trial name
- NCT00442338
- Testing
- montelukast sodium, aminophylline hydrate
- Volunteers
- 91 people
- Sponsor
- Organon and Co
Asthma
Examining Changes in Nasal IL-1 During Acute Asthma Exacerbation in Adolescents
To study the change from baseline in IL-1β (interleukin 1 beta) concentrations in the nasal airway during acute asthma exacerbation, specifically to measure the degree of change and identify the timing of peak IL-1β…
- Trial name
- Attack Asthma (NCT04748055)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Asthma
Interactive Acute Smooth Muscle Effects of Salmeterol and Fluticasone in the Airway
The addition of an inhaled long-acting beta-adrenergic agonist to an inhaled glucocorticosteroid improves disease control in persistent asthma.
- Trial name
- NCT01231230
- Testing
- fluticasone, Salmeterol, fluticasone/salmeterol
- Volunteers
- 14 people
- Sponsor
- University of Miami
Asthma
Albuterol Versus Xopenex in Treatment of Acute Asthma in the Emergency Department (ED)
The purpose of this study is to determine in a large, double-blind, randomized, prospective pediatric clinical trial whether the use of continuous levalbuterol (Xopenex) in addition to standard emergency department treatment for…
- Trial name
- Xopenex (NCT00585039)
- Testing
- xopenex
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Phoenix Children's Hospital
Acute Asthma
A Pilot Study to Determine the Most Effective Dose of Arformoterol for Treating Acute Asthmatic Patients
The purpose of this study is to determine the best dose of nebulized arformoterol, a quick onset but long acting beta agonist, for use in treating acute bronchospasm in asthmatics presenting to the the Emergency Department.
- Trial name
- NCT00819637
- Testing
- arformoterol (RR formoterol), levalbuterol
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Henry Ford Health System
Asthma
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide
Glucocorticosteroids recently have been shown to have non-genomic actions that are plasma membrane-mediated and do not require gene transcription and translation.
- Trial name
- NCT01219738
- Testing
- Budesonide 360ug, Budesonide 720ug, Budesonide 1440ug
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Sickle Cell Disease, Anemia, Sickle Cell
Daily Vitamin D for Sickle-cell Respiratory Complications
This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease.
- Conditions
- Sickle Cell Disease, Anemia, Sickle Cell, Anemia, Hemolytic, Congenital, Respiratory Tract Diseases
- Trial name
- ViDAS-2 (NCT04170348)
- Testing
- Daily oral vitamin D3, 3,333 IU, Monthly oral vitamin D3, 100,000 IU
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Columbia University
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh
Asthma
Nebulized Fluticasone Propionate VS Oral Prednisone in Chinese Pediatric and Adolescent Subjects With an Acute Exacerbation of Asthma
This is a multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study to determine the efficacy and safety of nebulized fluticasone propionate 1mg twice daily compared with oral prednisone…
- Trial name
- NCT01687296
- Testing
- fluticasone propionate inhalation solution, oral prednisone, salbutamol
- Where
- 11 sites in China
- Volunteers
- 261 people
- Sponsor
- GlaxoSmithKline
Asthma
Neurostimulation for the Relief of Acute Bronchoconstriction
The goal of this study is to validate design for the Resolve™ Stimulator and Proximity Electrode and the associated procedure to quickly and safely place an electrode into the neck, in the vicinity of the vagus nerve by a…
- Trial name
- NCT00762931
- Testing
- Resolve Stimulator and Proximity Lead
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- ElectroCore INC
Asthma, Children
Efficacy and Safety of Increasing Doses of Inhaled Albuterol in Children With Acute Wheezing Episodes
Metered dose inhalers with spacers are devices capable of providing higher rates of lung deposition of drugs such as beta agonists when compared to conventional nebulizers, but there is no consensus about the optimal dose when…
- Trial name
- NCT01323010
- Testing
- Albuterol - Experimental, Albuterol - Control
- Where
- Brazil
- Volunteers
- 119 people
- Sponsor
- University of Sao Paulo
Asthma
A Study of an Intravenous Drug in Pediatric Patients With Acute Asthma (0476-301)
This study will attempt to find out if the addition of an intravenous form of a drug that is already used for treating asthma in children will help resolve asthma attacks faster than using the current standard care alone.
- Trial name
- NCT00117338
- Testing
- montelukast sodium
- Volunteers
- 276 people
- Sponsor
- Organon and Co
Asthma
A Study of Levalbuterol Tartrate HFA Inhalation Aerosol Metered Dose Inhaler (MDI) in Pediatric Subjects
This is a study of levalbuterol tartrate HFA inhalation aerosol MDI in pediatric subjects birth to ≤ 48 months of age who go to the Emergency Department (ED) or their physician's office with an acute bronchospasm.
- Trial name
- NCT02150499
- Testing
- levalbuterol tartrate HFA inhalation aerosol
- Where
- 17 sites in United States
- Volunteers
- 18 people
- Sponsor
- Sumitomo Pharma America, Inc.
Acute Bronchial Obstruction, Asthma
Efficacy of Formoterol vs Ipatropioum Bromide Plus Fenoterol in Children (5-<12 Years) With Acute Bronchial Obstruction
To determine efficacy and tolerability of inhaled Formoterol vs nebulized Ipatropioum Bromide plus Fenoterol in cumulative sequential doses in asthmatic children (5-<12 years) with acute bronchial obstruction attending emergency…
- Trial name
- NCT00460577
- Testing
- Formoterol fumerate, fenoterol/ipratropium bromide
- Where
- 2 sites in Venezuela
- Volunteers
- 60 people
- Sponsor
- Novartis
Status Asthmaticus
Heliox-Powered Albuterol Therapy in the Treatment of Children Admitted With Acute Asthma Exacerbation
The purpose of this study is to investigate whether heliox-powered albuterol nebulizer therapy will result in reduced inpatient length of stay in children hospitalized with acute asthma exacerbations.
- Trial name
- NCT00410150
- Testing
- Helium-oxygen-driven albuterol nebulizer, Oxygen
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati