Clinical trials: Asthma Exacerbation
Asthma Acute, Asthma Attack
Post Exacerbation Asthma Clinic Telecare Intervention to Reduce Recurrent Exacerbations
Asthma exacerbations leading to emergency department visits or hospitalization are associated with a high risk of recurrent exacerbations, poor disease control, and increased healthcare utilization in the months following…
- Trial name
- PACT (NCT07629830)
- Testing
- Follow-up in a remote flare-up clinic
- Where
- Israel
- Volunteers
- 220 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Asthma
Asthma/Steroid Withdrawal Study
The investigators propose to study the patterns of metabolite changes in subjects with asthma to determine if there is a predictable pattern prior to, and post, clinical exacerbation. Hypothesis: 1.
- Trial name
- NCT00395239
- Testing
- inhaled corticosteroid
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Status Asthmaticus
Effectiveness and Cost Study Comparing Two Ways to Deliver Albuterol for the Treatment of Asthma in the Hospital
This study will be conducted as a randomized, double blinded, controlled trial. The control group will receive albuterol delivered by a nebulizer along with placebo treatments delivered by a metered dose inhaler (MDI) with a…
- Trial name
- NCT00623688
- Testing
- Metered Dose Inhaler & Optichamber Advantage Valve Holding Chamber (VHC), Airlife Sidestream High Efficiency Nebulizer
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Akron Children's Hospital
COPD
High Risk Populations Among COPD Patients in Japan
The patients with complications of COPD and asthma have features mixed with two diseases, COPD and asthma. Therefore, the outcomes are worsened if the patients with COPD have symptoms overlapped with asthma, however, no…
- Trial name
- NCT02413359
- Where
- Japan
- Volunteers
- 1,016 people
- Sponsor
- AstraZeneca
Bronchial Asthma
Evaluation of Clinical Effect of Acupuncture on Acute Exacerbation of Bronchial Asthma
Based on the bioholographic theory, this study preliminarily explores the clinical efficacy of hand acupuncture in treating acute exacerbation of bronchial asthma and evaluates its immediate anti-asthmatic effect, so as to…
- Trial name
- NCT07632352
- Testing
- Acupuncture, Standard Western medicine treatment
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Asthma Attack, Asthma Control
Boosting Referrals to Asthma Specialists for Patients Seen at the Emergency Room for an Asthma Exacerbation
This study is testing a new way to help adults with asthma get follow up care after an emergency room (ER) visit for an asthma attack.
- Conditions
- Asthma Attack, Asthma Control, Asthma Exacerbations, Asthma
- Trial name
- NCT07396987
- Testing
- ER-Initiated Telehealth Referral
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Juan Carlos Cardet
Asthma, Asthma Attack
The Effect of Asthma Flare-up Clinic After Exacerbation
The goal of this interventional study is to examine the effect of asthma flare-up clinic follow-up in adult subjects after an asthma flare-up. This study aim to answer the following questions: 1.
- Trial name
- NCT06201728
- Testing
- Follow-up in a flare-up clinic
- Where
- Israel
- Volunteers
- 230 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Asthma
Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents
This is a multi-center, double-blind, placebo-controlled, randomized trial of dupilumab adjunctive therapy for prevention of asthma exacerbations in urban children and adolescents with T2-high exacerbation-prone asthma.
- Trial name
- PANDA (NCT05347771)
- Testing
- Dupilumab
- Where
- 8 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Benralizumab Exacerbation Study
This is an exploratory study, the focus of which is to understand the nature of asthma exacerbations that occur despite open label benralizumab therapy in severe eosinophilic asthma.
- Trial name
- BenRex (NCT04102800)
- Testing
- Benralizumab
- Where
- 15 sites in United Kingdom
- Volunteers
- 157 people
- Sponsor
- NHS Greater Glasgow and Clyde
Asthma in Children, Asthma Attack
Wearable Electronic Breath Sound Sensing Device
This study will assess the ability of a wearable stethoscope to monitor wheezing in high-risk asthma patients admitted at Children's Healthcare of Atlanta.
- Trial name
- WEBSS (NCT06734793)
- Testing
- Wearable stethoscope, Routine Clinical lung Auscultation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Asthma
A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype
This study will assess whether switching participants who have benefitted from mepolizumab or benralizumab to GSK3511294 (Depemokimab) is non-inferior to maintaining current treatment on the annualized rate of clinically…
- Trial name
- NIMBLE (NCT04718389)
- Testing
- GSK3511294 (Depemokimab), Mepolizumab, Benralizumab
- Where
- 397 sites in United States, Australia and 19 more
- Volunteers
- 1,717 people
- Sponsor
- GlaxoSmithKline
Asthma Exacerbation, Children
A Comparative Study of Adding Ipratropium to Salbutamol for the Treatment of Asthma Attack in Children
The goal of this clinical trial was to determine if adding ipratropium bromide to salbutamol improves asthma treatment in children.
- Trial name
- NCT06918418
- Testing
- Salbutamol (Ventolin®), salbutamol + ipratropium bromide nebules
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Asthma
House Dust Mite Treatment of Asthma. The MITRA Trial House Dust Mite Treatment of Asthma
The purpose of this trial is to investigate if treatment with house dust mite allergen immunotherapy tablet can reduce the risk of asthma exacerbation in subjects with house dust mite induced asthma.
- Trial name
- MITRA (NCT01433523)
- Testing
- ALK HDM AIT 6 DU, ALK HDM AIT 12 DU
- Where
- Germany
- Volunteers
- 834 people
- Sponsor
- ALK-Abelló A/S
Acute Asthma
Emergency Department (ED)-Directed Interventions to Improve Asthma Outcomes
The purpose of this study is to determine if evidence-based guidance on follow-up care and self-management provided to PCPs and patients, respectively, reduces relapses within 90 days for acute asthma (primary outcome).
- Trial name
- NCT01079000
- Testing
- Opinion Leader letter, Involvement of a care manager, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 367 people
- Sponsor
- University of Alberta
Asthma
Mechanisms of Acute Asthma Exacerbations Through Molecular Analysis of Airway Secretions and Tissues
The purpose of this study is to investigate mechanisms which cause acute asthma exacerbations by examining blood and airway secretions during an acute onset (sputum or tracheal aspirates).
- Trial name
- MAST-X (NCT00603629)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Francisco
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Childhood Asthma With Acute Exacerbation
Azithromycin Treatment of Hospitalized Children With Asthmatic Symptoms
The purpose of this double-blind, randomized, controlled clinical trial is to investigate the effect of a three-day azithromycin treatment versus placebo treatment in children aged 1-5 years who are hospitalized due to…
- Trial name
- COPSACazt (NCT05028153)
- Testing
- Azithromycin Oral Liquid Product
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Asthma Exacerbation
Asthma Exacerbation and Helium-3 MRI
The goal of this research is to use Helium-3 MRI to see the changes in airflow of the lungs at different times of an attack. These three stages are immediately after the attack, 1 month later and 4-6 months later.
- Trial name
- NCT00846014
- Testing
- Helium-3
- Where
- United States
- Sponsor
- University of Massachusetts, Worcester
Asthma, Asthma Attack
Optimisation of ASthma In Those With Uncontrolled Symptoms (OASIS)
A digital tool, called ReferID has been developed to facilitate the review of asthma patients. It aims to assist in the identification of patients with uncontrolled and/or severe asthma and to ensure a timely referral to…
- Conditions
- Asthma, Asthma Attack, Asthma Persistent, Covid19
- Trial name
- OASIS (NCT04941001)
- Testing
- ReferID
- Where
- United Kingdom
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Asthma
Repeated High-dose Inhaled Corticosteroids for Asthma
The purpose of this study is to to compare the effects of high-dose Inhaled Corticosteroids (ICS) vs. placebo in adults with chronic stable asthma.
- Trial name
- ReHICS (NCT00695604)
- Testing
- Fluticasone
- Where
- United States
- Sponsor
- University of Chicago