Clinical trials: Asthma Exacerbations
Asthma in Children
High-dose Vitamin D Supplement for the Prevention of Acute Asthma-like Symptoms in Preschool Children
To investigate whether high-dose vitamin D supplementation may have a beneficial effect on secondary prevention in preschool children (1-5 years of age), with respiratory infections being the primary cause of acute exacerbations…
- Trial name
- COPSACvitd (NCT05043116)
- Testing
- Cholecalciferol D3
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Acute Asthma
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms
The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic…
- Trial name
- NCT01016444
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- MetroHealth Medical Center
Asthma
Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Project Aim: To determine if intramuscular epinephrine is an effective adjunct to inhaled bronchodilators (β2 agonists) for children with severe asthma exacerbation.
- Trial name
- NCT01705964
- Testing
- IM epinephrine 1:1000, No intervention
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Louisville
Asthma Exacerbation
Reduction in Clinical Variance Using Targeted Design Changes in Computerized Provider Order Entry Order (CPOE) Sets
Selective redesign of order sets using different ways to frame the order and physician decision-making in a computerized provider order entry system could increase adherence to evidence-based care and reduce population-specific…
- Trial name
- NCT00952471
- Testing
- Evidence Based Intervention to order set
- Where
- United States
- Volunteers
- 458 people
- Sponsor
- Brian Jacobs
Asthma Control
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called "remission") when given earlier in their disease, before asthma becomes severe.
- Trial name
- HOTHOT (NCT07309614)
- Testing
- Dupilumab Prefilled Syringe
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 150 people
- Sponsor
- Université de Sherbrooke
Asthma Attack
Asthma: Phenotyping Exacerbations 3
Exacerbations of asthma (asthma attacks) are very common in the UK. They are frightening for patients, expensive for the health service, and occasionally lead to avoidable deaths.
- Trial name
- APEX3 (NCT05446090)
- Testing
- Spirometry including peak flow, Fractional Exhaled Nitric Oxide (FeNO), Forced Oscillation Technique (FOT)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Nottingham
Asthma
Retrospective Review on Patients With Recurrent Asthmatic Attacks Requiring Hospitalizations
Asthma is a common respiratory disease. around the world. Asthma exacerbation is one of the major sequelae and associated with various morbidity and mortality.
- Trial name
- NCT04479501
- Testing
- Asthma exacerbation related hospitalization
- Where
- Hong Kong
- Volunteers
- 2,280 people
- Sponsor
- Chinese University of Hong Kong
Asthma Brittle
Exploring Asthma Exacerbations in Mepolizumab Treated Patients
This is a multicentre, observational study focusing on exacerbation events in patients with severe eosinophilic asthma on Mepolizumab.
- Trial name
- NCT03324230
- Where
- 4 sites in United Kingdom
- Volunteers
- 146 people
- Sponsor
- Queen's University, Belfast
Asthma, Atopy
Imaging Study of the Lungs During an Allergic Asthma Attack
Asthma is a disease of rapidly increasing incidence that already affects more than 17 million people in the United States alone.
- Trial name
- NCT01547286
- Testing
- Standardized Cat Allergen Extract and Standardized Dust Mite Allergen, Computed Tomography imaging, functional Positron Emission Tomography imaging, Nebulized methacholine inhalation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Asthma Exacerbations, Biomarkers / Blood
Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)
The aim of this study is to evaluate usual care versus biomarker-directed care (using blood eosinophil counts) for the management of asthma patients in primary care setting.
- Conditions
- Asthma Exacerbations, Biomarkers / Blood, Eosinophil Blood Count
- Trial name
- BEAM (NCT07486401)
- Testing
- Biomarker-directed treatment for asthma management, Usual Care
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- National Healthcare Group Polyclinics
Asthma
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms
This is a clinical study that is designed to study the effects of the supplemental intake of enriched omega-3 polyunsaturated fatty acids (fish oil) in patients with moderate to severe asthma.
- Trial name
- NCT00621829
- Testing
- EPA enriched fish oils
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
COPD
Respiratory Pathogens of Patients With Asthma and COPD Exacerbations
To assess the infective etiologies by quantitative polymerase chain reaction (qPCR) of acute exacerbation of COPD and asthma who required hospitalization.
- Trial name
- NCT02866357
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Asthma
Nebulized Magnesium Sulfate as an Adjunct to Standard Therapy in Asthma Exacerbation
The purpose of this study is to investigate the effectiveness of nebulized magnesium sulfate in patient with moderate to severe asthma exacerbation in pediatric emergency
- Trial name
- NCT02584738
- Testing
- Nebulized Magnesium Sulfate, Nebulized isotonic saline, Nebulized Salbutamol
- Where
- Mexico
- Volunteers
- 152 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Asthma
Fluctuation of Airway Function in Children With Asthma
It is increasingly recognised that asthma is not a single disease but that there are many different phenotypes. Much of the work that we have previously carried out has focussed on differentiating children with difficult asthma…
- Trial name
- NCT02252289
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Imperial College London
Asthma (Diagnosis)
Longitudinal Phenotyping and Endotyping Study in Adult Patients With Mild, Moderate, or Severe Asthma
Background and study aims: The purpose of this research registry is to understand how asthma varies from person to person and monitor changes that may occur over time.
- Trial name
- MAPLE-UK (NCT07189806)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Hvivo
Acute Asthma
Magnesium Nebulization Utilization in Management of Pediatric Asthma
Acute asthma is the most common cause of pediatric hospitalizations. While the investigators know that repeat inhalations of ß2 agonists and ipratropium with early oral steroids substantially reduce hospitalizations, many…
- Trial name
- MAGNUMPA (NCT01429415)
- Testing
- Magnesium Sulfate Sandoz, Sodium Chloride , USP PPC
- Where
- 7 sites in Canada
- Volunteers
- 818 people
- Sponsor
- The Hospital for Sick Children
Severe Asthma
The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab: The TezEx Study
Tezepelumab is a treatment that is approved by NICE (National Institute for Health and Care Excellence, https://www.nice.org.uk/) for patients with severe asthma, that remains poorly controlled despite high dose inhaled…
- Trial name
- TezEx (NCT06666504)
- Testing
- Prospective Data Analysis
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Childhood Asthma With Acute Exacerbation
Antibiotic Treatment of Recurrent Episodes of Asthma in Children
Copsac has discovered that asthmatic exacerbations are as closely linked to bacterial as to viral infection. The current study will examine whether treatment of asthmatic exacerbations with macrolide antibiotics - in the abscence…
- Trial name
- AB-studie (NCT01233297)
- Testing
- Azithromycin
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Asthma Acute, COPD Exacerbation Acute
Rademikibart IV for Acute Asthma and COPD Exacerbation
A Phase 2, open-label, single-arm trial to evaluate IV rademikibart as an add-on treatment for acute exacerbation in participants with asthma or COPD with type 2 inflammation
- Trial name
- NCT07705737
- Testing
- Rademikibart
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Connect Biopharm LLC
Asthma
Creation of Home-based Asthma Real-World Measures With Mobile Health Study
Four novel biologic therapies (benralizumab, dupilumab, mepolizumab, reslizumab) have been recently approved for moderate-to-severe, eosinophilic or oral steroid-dependent asthma.
- Trial name
- CHARM (NCT04462224)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Jewish Health