Clinical trials: Asymptomatic Condition, open to volunteers
Heart Failure, Ventricular Dysfunction, Left
ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era
Asymptomatic left ventricular systolic dysfunction (ALVSD), identified as a key component of stage B heart failure (HF) by AHA/ACC guidelines, is a common precursor to clinically overt HF.
- Conditions
- Heart Failure, Ventricular Dysfunction, Left, Artificial Intelligence, Early Diagnosis
- Trial name
- ELEGANT (NCT06968533)
- Testing
- AI-ECG guided diagnosis
- Where
- Taiwan
- Volunteers
- 13,350 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Cardiomyopathy, Dilated
Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial)
Prospective, multicenter, randomized, placebo-controlled, double-blind clinical trial to evaluate safety and efficacy of candesartan in the prevention of the development of Dilated Cardiomyopathy (DCM) in genetic carriers of a…
- Trial name
- EARLY-GENE (NCT05321875)
- Testing
- Candesartan
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Cristina Avendaño Solá
Hyperuricemia or Gout
Clinical Efficacy Trial of Burdock Root Extract in Patients With Asymptomatic Hyperuricaemia
Multicentre, double-blind, randomized, placebo-controlled trial of the clinical efficacy of burdock root extract in patients with asymptomatic hyperuricemia, with the primary objective to assess the efficacy of the use of burdock…
- Trial name
- NCT07002762
- Testing
- Burdock ( Arctium lappa L.) root extract in a form of a nutritional additive
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- OMNIFARMA LLC
Spine Metastases
Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease
Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation…
- Trial name
- PROMISSeD (NCT05534321)
- Testing
- Prophylactic Radiotherapy, Standard of care systemic therapy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Baptist Health South Florida
Monoclonal Gammopathy of Undetermined Significance, Smoldering Plasma Cell Myeloma
Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies
This study examines the quality of life in patients with monoclonal gammopathy of unknown significance and smoldering multiple myeloma.
- Trial name
- NCT05136807
- Testing
- Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- M.D. Anderson Cancer Center
Aortic Stenosis
Remote Monitoring for Patients With Aortic Stenosis
Remote-AS aims to develop a remote digital monitoring cohort of people with AS and use these data to establish a digital twin intervention to personalise risks and benefits, and optimise the time of surgical or transcatheter…
- Trial name
- Remote-AS (NCT07690748)
- Volunteers
- 160 people
- Sponsor
- Baker Heart and Diabetes Institute
Covert Brain Infarction
A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)
Magnetic resonance imaging (MRI) is commonly used in healthcare, and sometimes it shows small areas of brain damage called Covert Brain Infarcts (CBIs).
- Trial name
- EURO-CBI (NCT07012629)
- Testing
- acetylsalicyclic acid (ASA), Clopidogrel, Rosuvastatin
- Where
- 14 sites in Denmark, Germany and 3 more
- Volunteers
- 1,652 people
- Sponsor
- Aarhus University Hospital
Femoroacetabular Impingement
Biomechanical Investigation of Symptomatic FAI and Two Groups of Asymptomatic Controls
Femoroacetabular impingement (FAI) is an orthopaedic condition that is primarily characterized by the presence of anatomic bony abnormalities in the femoral head and/or the acetabulum resulting in an abnormal contact between the…
- Trial name
- CAM-FAI adult (NCT06272292)
- Testing
- EOS, 3D motion lab analysis
- Where
- Belgium
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Waldenstrom Macroglobulinemia
Spanish Registry of Patients With IgM Monoclonal Gammopathies
Waldenström's macroglobulinemia (WM) is a B-cell lymphoproliferative disorder which is defined by bone marrow infiltration by small lymphocytes, lymphoplasmacytoid and plasma cells together with the presence of a detectable…
- Trial name
- PRAME (NCT05093153)
- Where
- 51 sites in Spain
- Volunteers
- 1,000 people
- Sponsor
- Fundación Española de Hematología y Hemoterapía
COVID-19
A Follow-up Study of Asymptomatic Infections and Diagnosed Patients With Covid-19 in Shanghai
This study is to clarify the distribution characteristics, host and clinical characteristics, disease outcome and risk factors, changes of multiple organs such as cardiopulmonary function and changes in social and psychological…
- Trial name
- NCT05387304
- Where
- China
- Volunteers
- 250,000 people
- Sponsor
- Ruijin Hospital
Asymptomatic Atrial Fibrillation
Subclinical Atrial Fibrillation Home Monitoring in Hypertensive Patients
Atrial fibrillation is a highly prevalent and incidental arrhythmia, often asymptomatic, and frequently detected incidentally or in association with a stroke.
- Trial name
- NCT07058831
- Testing
- Home ECG monitoring
- Where
- Argentina
- Volunteers
- 499 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Research Center Rosario British Sanatorium
Cardiovascular Diseases in Pregnancy
Prospective Pakistan Registry of Echocardiographic Screening in Asymptomatic Pregnant Women
Consecutive obstetric patients attending routine antenatal visits were enrolled in this ongoing registry. A standardized 2D transthoracic echocardiogram (TTE) protocol was employed.
- Trial name
- PRESAP (NCT06004544)
- Where
- Pakistan
- Volunteers
- 10,000 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
Evaluation of Balloon Guide Catheter as Proximal Protection During Carotid Artery Stenting (EMBO-PROTECT)
Carotid angioplasty and stenting (CAS) is an effective treatment for carotid artery stenosis but carries a risk of cerebral embolization.
- Trial name
- EMBO-PROTECT (NCT07576790)
- Testing
- balloon guide catheter, No Proximal Protection Group
- Volunteers
- 126 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Colonization, Asymptomatic, Colonisation
Encapsulated Probiotics & Gut Microbiota
The aim of this study is to determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotics (NCT07439978)
- Testing
- probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Cryptococcal Meningitis
Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia
This will be a randomized controlled trial of asymptomatic (Cryptococcal Antigen test)CrAg positive persons in Uganda. Patients will be randomized to receive preemptive treatment with 1 dose of liposomal amphotericin (10mg/kg) in…
- Trial name
- ACACIA (NCT03945448)
- Testing
- Single dose liposomal Amphotericin and Fluconazole, Fluconazole
- Where
- Uganda
- Volunteers
- 356 people
- Sponsor
- Makerere University
Lung Cancers
Identification and Validation of Blood-Based Biomarkers for Early Detection of Asymptomatic Lung Cancer in High-Risk Heavy Smokers
The goal of this observational study is to develop and evaluate a blood test for asymptomatic heavy smokers to screen for those at highest risk of developing lung cancer.
- Trial name
- NCT06816121
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Everest Detection, Inc.
Melanoma, Brain Metastases
Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases
This is a multicenter, phase II trial of relatlimab (rela), nivolumab (nivo), and ipilimumab (ipi) in patients with asymptomatic and symptomatic melanoma brain metastases.
- Trial name
- NCT06712927
- Testing
- Ipilimumab, Nivolumab + Relatlimab FDC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS)
Peripersonal Space Representation in Upper Limb Segmental Exclusion
This study aims to evaluate the representation of action peripersonal space (PPS) in subjects suffering from unilateral segmental exclusion syndrome of the upper limb compared to healthy control subjects.
- Conditions
- Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS), Upper Limb Neglect (Peripheral)
- Trial name
- NCT07349173
- Testing
- Reachability Judgment Task in VR.
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Metastatic Castration-resistant Prostate Cancer
The COSMYC Trial (COmbined Suppression of MYC)
This research is being done to determine if receiving the combination of testosterone and ZEN-3694 followed by the combination of enzalutamide plus ZEN-3694 will decrease the size of tumors in patients with prostate cancer that…
- Trial name
- NCT06922318
- Testing
- ZEN-3694, Testosterone cypionate, Enzalutamide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Type2 Diabetes, Coronary Heart Disease
Coronary Artery Calcium-guided Primary Prevention of Major Coronary Heart Disease in Asymptomatic Diabetes
To evaluate benefits of primary prevention of major coronary heart disease for asymptomatic coronary artery disease in type 2 diabetes mellitus based on the coronary artery calcium score Our proposal 1.
- Trial name
- NCT05267990
- Testing
- Multi-Detector Computed Tomography
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- JuFeng, Hsiao