Clinical trials: Atelectasis
Obesity (Body Mass Index >30 kg/m2), Atelectasis, Postoperative
Dynamic Compliance-Guided Personalized PEEP During Laparoscopic Bariatric Surgery: Effects on Intraoperative Respiratory Parameters
Atelectasis may be encountered in the patient population aged 18-65 years undergoing elective laparoscopic bariatric surgery under general anesthesia with endotracheal intubation.
- Conditions
- Obesity (Body Mass Index >30 kg/m2), Atelectasis, Postoperative, PEEP With Dynamic Compliance, Individualized PEEP
- Trial name
- NCT07345650
- Testing
- Individualized approach
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yeditepe University
Respiratory Distress Syndrome, Preterm Birth
LISA vs INSURE in Extremely Low Birth Weight Infants. A Manikin Study
This is an unblinded, randomized, controlled, crossover (AB/BA) trial of surfactant treatment with LISA vs. INSURE in a manikin simulating an extremely low birth weight infant.
- Conditions
- Respiratory Distress Syndrome, Preterm Birth, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT04944108
- Testing
- LISA approach, Insure approach
- Where
- 2 sites in Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Respiratory Distress Syndrome (Neonatal), Surfactant
Surfactant Using a Supraglottic Airway Device in Late Preterm to Early Term Infants
The purpose of this research is to learn new information that may help other infants that have respiratory distress syndrome and need breathing support after birth.
- Trial name
- SPLASH (NCT07176117)
- Testing
- Surfactant Administration Through Laryngeal or Supraglottic Airway (SALSA), Continuous Positive Airway Pressure (CPAP)
- Where
- 3 sites in United States
- Volunteers
- 422 people
- Sponsor
- Sharp HealthCare
Dyspnea, Respiratory Rate
Evaluating the Effectiveness of Incentive Spirometry
Post-operative pulmonary complications (PPCs) have a major impact on patients and healthcare expenses. The goal of perioperative respiratory therapy is to improve airway clearance, increase lung volume, and mitigate atelectasis.
- Conditions
- Dyspnea, Respiratory Rate, Oxygen Saturation, Oxygen Requirements
- Trial name
- NCT02952027
- Testing
- Use-recording, patient-reminder alarm for incentive spirometry
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Lifespan
Infants Aged 0 Days to 13 Months Scheduled for Elective Surgery
Effect of Pressure Support Ventilation During Anesthetic Emergence on Postoperative Atelectasis in Infant
Atelectasis occurs in patients of all ages who receive mechanical ventilation under general anesthesia, and although fatal cases are rare, it is known as a cause of postoperative hypoxia or fever.
- Trial name
- NCT05373589
- Testing
- conventional ventilation, group C, pressure support, group PS
- Where
- South Korea
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Morbid Obesity, Obesity
Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients
Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse.
- Conditions
- Morbid Obesity, Obesity, Respiratory Failure, Atelectasis
- Trial name
- NCT07542093
- Volunteers
- 45 people
- Sponsor
- Assiut University
Atelectasis
Peroperative Use of Positive End-expiratory Pressure Prevents Formation of Atelectasis as Studied by Computerised Tomography at End of Surgery
Atelectasis is common during and after general anaesthesia and a number of interventions have been suggested in order to prevent their formation.
- Trial name
- NCT02548416
- Testing
- Positive end-expiratory pressure, Control group, zero PEEP
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Västmanland
Pulmonary Atelectasis
Ventilator Hyperinflation and Manual Rib Cage Compression
This is a randomized crossover trial to evaluate the effects of thoracic compression applied alone or in association with hyperinflation maneuver with the ventilator.
- Trial name
- NCT03630484
- Testing
- Expiratory Rib Cage Compression, Compression + Ventilator Hyperinflation
- Volunteers
- 30 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
Tracheomalacia, Bronchopulmonary Dysplasia (BPD)
Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention
Children with lung and airway malformations or early structural lung damage face significant challenges, often leading to recurrent respiratory infections, hospitalizations, and decreased quality of life.
- Conditions
- Tracheomalacia, Bronchopulmonary Dysplasia (BPD), Vascular Ring, Cystic Lung Disease
- Trial name
- TRALULALA-AZI (NCT06409299)
- Testing
- Azithromycin 40 MG/ML
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pediatric Surgery
Determination of Best PEEP (Positive End-expiratory Pressure) in Anesthetized Infants in Terms of Prevention of Atelectasis
Purpose of research; to determine the appropriate positive end-expiratory pressure to minimize atelectasis during general anesthesia in infants.
- Trial name
- NCT03969173
- Testing
- applying PEEP3, applying PEEP6, applying PEEP9
- Where
- South Korea
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Infant, Premature, Diseases, Respiratory Distress Syndrome
Pain Assessment During Less-Invasive-Surfactant-Administration
Primary aims of the study are to evaluate the feasibility of Skin conductance (SC) measurements and its correlation to Neonatal Pain and Distress Scale (N-PASS) - scores during the Less-Invasive-Surfactant-Administration…
- Conditions
- Infant, Premature, Diseases, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Pain
- Trial name
- PALISA (NCT06150586)
- Testing
- Skin Conductance (SC) Measurement, Video Recording
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University of Zurich
Atelectasis
Role of Lung Ultrasound Imaging for Intraoperative Monitoring of Atelectasis During Laparoscopic Surgery
General anesthesia results in the development of atelectasis in the dependent areas of the lungs exposing patients to an increased risk of hypoxemia.
- Trial name
- NCT01749436
- Testing
- Lung ultrasound imaging examinations
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Atelectasis, Compliance, Patient
Restoration of Pulmonary Compliance After Laparoscopic Gynaecologic Surgery Using a Recruitment Maneuver
To investigate the hypothesis that an alveolar recruitment maneuver after the release of pneumoperitoneum would restore the lung compliance to the baseline values after a laparoscopic gynaecologic surgery.
- Trial name
- NCT06203665
- Testing
- Recruitment Maneuver
- Where
- Greece
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Panagiota Griva
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Respiratory Failure, Respiratory Infection
Avoiding Neuromuscular Blockers to Reduce Complications
The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.
- Conditions
- Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis
- Trial name
- NCT03962725
- Testing
- Neuromuscular Blocking Agents, Anesthetic Adjuncts
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Neonatal Respiratory Distress
DIaphragmatic Swing According to Cpap Flow Output in NEOnates (DISCONEO)
The hypothesis behind the study is that the performance of constant flow CPAP (Continuous Positive Airway Pressure) devices (CF-CPAP) is not inferior to that of variable flow CPAP devices (VF-CPAP) in terms of respiratory efforts…
- Trial name
- NCT07513051
- Testing
- CF-CPAP; CF-CPAP; VF-CPAP; VF-CPAP, VF-CPAP; VF-CPAP; CF-CPAP; CF-CPAP, CF-CPAP; VF-CPAP; VF-CPAP; CF-CPAP
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Atelectasis
Effect of Hyperoxia and Hypergravity on Lung Ventilation and Perfusion
The primary aim of this project is to get further knowledge on the effects of + Gz accelerations and hyperoxia on lung ventilation in humans.
- Trial name
- NCT01993394
- Testing
- hypergravity, gas mixture
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Postoperative Complications, Cancer
Predictive Value of Ariscat Index In The Development of Pulmonary Complication After Major Abdominal Cancer Surgery
The term postoperative pulmonary complication is the development of any complications affecting the respiratory system after anesthetic and surgery procedures.
- Conditions
- Postoperative Complications, Cancer, Pulmonary Complication, Atelectasis
- Trial name
- NCT04663958
- Testing
- Detection / Screening
- Where
- Turkey (Türkiye)
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Apnea, Anesthesia
Functional Residual Capacity Under Apnoeic Oxygenation with Different Flow Rates in Children
During induction of general anaesthesia physiological breathing stops and needs to be artificially established with facemask ventilation, and finally tracheal intubation or placement of a supraglottic airway.
- Conditions
- Apnea, Anesthesia, Intubation Complication, Children, Only
- Trial name
- FUTURE (NCT05672329)
- Testing
- 0.2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 4 L/kg/min, FiO2 1.0 + continuous jaw thrust
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- Thomas Riva
Neonatal Respiratory Distress
Effectiveness of Bubble Nasal Continuous Positive Airway Pressure (bCPAP) in Neonatal Respiratory Distress
The objective of study is to determine the effectiveness of bubble Continuous Positive Airway Pressure (bCPAP) in neonates presenting with respiratory distress as compared to the control group ( using oxygen via nasal cannula).
- Trial name
- bCPAP (NCT04401696)
- Testing
- Bubble CPAP, Nasal Oxygen
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- King Edward Medical University