Clinical trials: Atheromatous Plaques
Atherosclerosis, Coronary, Emotional Stress
Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability
Emotional stress is associated with future cardiovascular events. However, the biological interconnection between brain emotional neural activity and acute plaque instability is not fully understood.
- Conditions
- Atherosclerosis, Coronary, Emotional Stress, Inflammation, Hematopoiesis
- Trial name
- NCT04853511
- Testing
- OCT-FLIM (optical coherence tomography-fluorescence life time)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Atheroma, Cardiac Disease
Early Detection of Cardiovascular Disease
The investigators plan to evaluate the correlation between carotid plaque enhancement on Contrast-enhanced ultrasound (CEUS), significant coronary artery disease (CAD), and cardiovascular (CV) outcomes in a systematic manner.
- Conditions
- Atheroma, Cardiac Disease, Vascular Diseases, Atherosclerosis
- Trial name
- VIBE (NCT03466255)
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 610 people
- Sponsor
- Dr. Amer Johri
Acute Coronary Syndrome
18F-NaF-PET for Identification of TCFA
Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies.
- Trial name
- NaF-PET (NCT02388412)
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Seoul National University Hospital
Atherosclerosis
The Influence of Dietary Plant Sterols and Plant Stanols on Cholesterol and Plant Sterol Levels in Atheromatous Plaques
This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheromatous plaques.
- Trial name
- NCT00737919
- Testing
- Plant Stanol, Plant Sterol
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Coronary Stenosis, Acute Coronary Syndrome
Coronary Plaque Geometry and Acute Coronary Syndromes
The aim of GEOMETRY study is to investigate the correlation between coronary plaque geometric modifications and lesion vulnerability in patients with suspected coronary artery disease referred for cardiac computed tomography…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atherosclerosis
- Trial name
- NCT03702764
- Testing
- CCTA
- Where
- Romania
- Volunteers
- 1,000 people
- Sponsor
- Cardio Med Medical Center
Coronary Artery Disease, Hypercholesterolemia
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
The main aim of this trial is to demonstrate that Evolocumab plus routine lipid management is superior to routine lipid management alone in modifying plaque (non-calcified) volume as measured by Artificial Intelligence-enabled…
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Atheroma, Atherosclerotic Plaque
- Trial name
- NCT07803679
- Testing
- Evolocumab, Routine Lipid Management, Autoinjector
- Volunteers
- 308 people
- Sponsor
- Amgen
Arteriosclerosis
Detection of Enterovirus RNA in Atheromatous Lesions
Atherosclerosis is one of the first causes of morbidity-mortality in industrialized countries. Numerous works suggest that some infectious agents could be involved in the inflammatory process leading to the development of this…
- Trial name
- ATH-ENTE (NCT00674531)
- Testing
- Artery resection
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Carotid Stenosis, Carotid Artery Diseases
Ultrafast Ultrasound Imaging Assesment of Carotid Plaque Neovascularization
Stroke is the second leading cause of death in the Western world and the leading cause of major lifelong disability. About 15% of strokes are secondary to thrombosis or embolization of an unstable atheromatous carotid plaque.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- ULTRA-VASC (NCT04470687)
- Testing
- contrast enhanced ultrafast ultrasound imaging
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Endarterectomy
Impact of an Optimized Formulation of Omega 3 on the Composition of Atheromatous Plaques in Patients Requiring Carotid Endarterectomy
Determining whether treatment with an optimized formulation of omega 3 for 6 weeks causes a 40% decrease in the average concentration of total microparticles (MPs) in the atheromatous plaque.
- Trial name
- POMEGA (NCT02582710)
- Testing
- VASCAZEN
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Strasbourg, France
Thromboangiitis Obliterans, Atheromatous Arteritis
ADDICTAO: Psychological and Addictive Profile of Patients With Buerger's Disease
Background: Buerger's disease (thromboangiitis obliterans or TAO) is a rare disease (1/ 10 000) characterized by the development of segmental thrombotic occlusions of the medium and small arteries of the extremities.
- Trial name
- ADDICTAO (NCT01064206)
- Where
- 16 sites in France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Lille
Atheromatous
Prospective Evaluation of Femoral Tripod Eversion Technique
Endarteriectomy is considered as the first line treatment of femoral bifurcation atheromatous lesions. Eversion technique, similar to that used for carotid bifurcation, is safe and possible for the majority of the femoral tripod…
- Trial name
- Eversion (NCT03357185)
- Testing
- Femoral eversion
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Hôpital NOVO
Atheroma; Heart
Assessment of GARP Expression in Acute and Chronic Coronary Syndrome
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions.
- Trial name
- GARP-CS (NCT07384910)
- Testing
- Arterial blood sample
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- Université Catholique de Louvain
Coronary Artery Disease
Statin and Atheroma Vulnerability Evaluation
The purpose of this study is to evaluate the effect of statin therapy on the modification of atherosclerotic plaque composition and vulnerability in non-intervened coronary arteries with mild to moderate stenosis using VH-IVUS…
- Trial name
- STABLE (NCT00997880)
- Testing
- Rosuvastatin calcium 40mg, Rosuvastatin calcium10mg
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- Seung-Jung Park
Stroke, Thrombolysis
Efficacy and Safety of Intravenous Thrombolysis in Branch Atheromatous Disease
Rationale and Relevance: Branch Atheromatous Disease (BAD) describes an atherosclerotic occlusion of one of the deep penetrating cerebral arteries, including the lenticulostriate artery (LSA), paramedian pontine artery (PPA), and…
- Conditions
- Stroke, Thrombolysis, DAPT(Dual Antiplatelet Therapy), SAPT(Single Antiplatelet Therapy)
- Trial name
- NCT07299994
- Where
- 8 sites in Austria, Germany and 1 more
- Volunteers
- 462 people
- Sponsor
- Sigmund Freud PrivatUniversitat
Femoropopliteal Atheromatous Lesions
The DETECT Project
This study aims to assess the all-cause mortality at 2 years of patients treated by a paclitaxel drug-eluting devices or non-drug-eluting devices after an endovascular femoropopliteal artery revascularization based on the French…
- Trial name
- DETECT (NCT05254106)
- Testing
- Lower limb artery revascularization with paclitaxel-eluting device
- Where
- France
- Volunteers
- 250,000 people
- Sponsor
- Nantes University Hospital
Atherosclerosis
Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes
The purpose of this study is to test the safety and effectiveness of rosiglitazone against a sulfonylurea in reducing or slowing the development of atherosclerosis in the blood vessels of the heart.
- Trial name
- NCT00116831
- Testing
- Glipizide, rosiglitazone maleate
- Where
- 156 sites in United States, Argentina and 18 more
- Volunteers
- 672 people
- Sponsor
- GlaxoSmithKline
Coronary Stenosis, Periodontal Diseases
Periodontal Disease, Inflammation and Acute Coronary Syndromes
Recent studies have shown that the systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and development of acute coronary…
- Conditions
- Coronary Stenosis, Periodontal Diseases, Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction
- Trial name
- ATHERODENT (NCT03395041)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Cardio Med Medical Center
Coronary Stenosis, Acute Coronary Syndrome
Systemic, Pancoronary and Local Coronary Vulnerability
The aim of the VIP study is to investigate the impact of vulnerability markers (inflammatory serum biomarkers for systemic vulnerability, coronary shear stress and vulnerability mapping for pancoronary vulnerability, and…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- VIP (NCT03606330)
- Testing
- Cardiac imaging tests, Venous blood sample collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Coronary Artery Disease, Coronary Atheroscleroses
Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - IV
This study is a single-center, prospective cohort study. The study is designed to identify novel circulating biomarkers for early prediction of high-risk coronary plaques.
- Conditions
- Coronary Artery Disease, Coronary Atheroscleroses, Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
- Trial name
- RECOGNIZE-IV (NCT06793787)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Branch Atheromatous Disease
Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction
Perforating artery territorial infarction (PAI) refers to a single ischemic lesion in a single perforating arterial territory and branch atheromatous disease (BAD) is an important type.
- Trial name
- STRATEGY (NCT05310968)
- Testing
- Tirofiban hydrochloride sodium chloride injection, Aspirin
- Where
- 37 sites in China
- Volunteers
- 970 people
- Sponsor
- Beijing Tiantan Hospital