Clinical trials: Atheroscleroses, Cerebral
Carotid Atherosclerosis
The Study of Blood Pressure Variability to Impact Arterial Stiffness and Carotid Atherosclerosis
The purpose of this study is to investigate whether and what extent blood pressure variability is associated with arterial stiffness and carotid atherosclerosis, furthermore to compare the difference in the relationship of the…
- Trial name
- NCT01466699
- Volunteers
- 1,235 people
- Sponsor
- Yan Li
Abdominal Aortic Aneurysm, Carotid Atherosclerosis
Preconditioning Shields Against Vascular Events in Surgery
Major vascular surgery involves operations to repair swollen blood vessels, clear debris from blocked arteries or bypass blocked blood vessels.
- Conditions
- Abdominal Aortic Aneurysm, Carotid Atherosclerosis, Critical Lower Limb Ischaemia
- Trial name
- SAVES (NCT01691911)
- Testing
- Remote preconditioning
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Atherosclerosis, Carotid Stenosis
Classification of Carotid Plaque With Computed Tomography With Fast kVp (Kilovolt Peak)-Switching Technique
Classification of carotid plaque vessel wall changes in carotid stenosis accordingly to AHA classification (American Heart Association)- comparison between histology and CT.
- Trial name
- NCT02436967
- Testing
- Carotid endarterectomy in clinical healthcare.
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska Institutet
Stroke, Ischemic
Effect of Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke
The goal of this clinical trial is to explore the influence of chronic RIC on collateral status evaluated by DSA in ischemic stroke patients with LAA etiology.
- Trial name
- RICAS (NCT06170944)
- Testing
- Remote ischemic preconditioning
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Transient Ischemic Attack
Prospective Evaluation of Carotid Free-floating Thrombus
Hardened plaque located in the carotid arteries can cause stroke or transient ischemic attack (TIA). This type of plaque is linked to unstable free-floating thrombi (FFT).
- Trial name
- NCT02405845
- Testing
- Computed Tomographic Angiogram
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiovascular Disease, Hypertension
Stop Atherosclerosis in Native Diabetics Study
Compared to standard treatment goals achieving lower targets for LDL cholesterol (bad cholesterol) and blood pressure in people with diabetes will slow the progression of atherosclerosis as measured by carotid artery thickness…
- Conditions
- Cardiovascular Disease, Hypertension, Hyperlipidemia, Diabetes
- Trial name
- SANDS (NCT00147251)
- Testing
- FDA approved drugs to treat blood pressure and cholesterol
- Where
- 4 sites in United States
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Cynthia West
Intracranial Atherosclerosis, Optical Coherence Tomography
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis
To evaluate the clinical significance of optical coherence tomography (OCT) in interventional treatment of intracranial atherosclerotic stenosis (ICAS).
- Conditions
- Intracranial Atherosclerosis, Optical Coherence Tomography, Plaque, Atherosclerotic, Artery Stenosis
- Trial name
- OCT-ICAS (NCT05550077)
- Testing
- Optical Coherence Tomography, Percutaneous transluminal angioplasty and stenting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- jiaoliqun
Cardiovascular Diseases, Heart Diseases
Adipose Distribution and Atherosclerosis
To relate distribution of adipose tissue measured by a then new imaging technique, Magnetic Resonance Imaging (MRI) to extracranial carotid atherosclerosis, cardiovascular disease risk factors, and to more conventional measures…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Carotid Stenosis
- Trial name
- NCT00005348
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Intracranial Atherosclerosis
Post Market Surveillance Study of the Wingspan Stent System
The primary objective of this study is to evaluate the rate of stroke and/or death in patients treated with the Wingspan Stent System, according to the Indications for Use, within 72 hours post procedure.
- Trial name
- WEAVE (NCT02034058)
- Testing
- Wingspan Stent System
- Where
- 26 sites in United States
- Volunteers
- 152 people
- Sponsor
- Stryker Neurovascular
Ischemic Stroke
Balloon Angioplasty for Minor Unstable Stroke With IntraCranial Atherosclerosis Stenosis (BAMUS-ICAS)
Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, especially in East and South Asia, and is significantly associated with stroke recurrence and early neurological deterioration (END) despite aggressive…
- Trial name
- BAMUS-ICAS (NCT06763458)
- Testing
- Submaximal balloon angioplasty
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Shenyang Military Region
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Atherosclerosis, Cardiovascular Diseases
Epidemiology of Vascular Inflammation & Atherosclerosis
To investigate the relationship of vascular cell phenotypes to atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis
- Trial name
- NCT00087893
- Volunteers
- 931 people
- Sponsor
- University of Vermont
Carotid Stenosis, Carotid Artery Diseases
Embolic Signals Detection Study (Esds) in Candidates for Surgical Carotid Revascularisation
About 20% of strokes are caused by emboli deriving from a carotid plaque. In symptomatic patients with carotid stenosis grater than 70% the Carotid Endarterectomy (CEA) reduces stroke risk by about 75% and is generally accepted…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- NCT05134493
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Peripheral Artery Disease
Self Selected Exercise Intensity in PAD Patients
Although the benefits of supervised walking training in patients with peripheral arterial disease (PAD) and symptoms of intermittent claudication (IC) are well established, one of the main problems found in this type of protocol…
- Trial name
- NCT04333615
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Nove de Julho
Carotid Atherosclerosis
Carotid Atherosclerosis and Vascular Events in People With Diabetes
Diabetes is a risk factor for carotid atherosclerotic whose progression is associated with an increased risk of vascular events.
- Trial name
- PROCAVE-D (NCT02929355)
- Testing
- carotid assesment by duplex ultrasonography
- Where
- France
- Volunteers
- 731 people
- Sponsor
- Hospices Civils de Lyon
Stroke, Atherosclerosis
Comparison of the Improvement and Safety of the Ankle Brachial Arterial Pressure Index of Sarpogrelate and Clopidogrel in Stroke Patients With Decreased Ankle Brachial Arterial Pressure Index and Intermittent Claudication of Lower Limb Vascular Atherosclerosis.
The clinical trial aims to confirm the improvement effect of the ankle brachial index and the safety of sarpogrelate administration compared to clopidogrel in stroke patients with decreased ankle brachial arterial pressure index…
- Trial name
- NCT06424548
- Testing
- Administration of Sarpogrelate, Traditional administration of Clopidogrel
- Volunteers
- 100 people
- Sponsor
- Ewha Womans University Seoul Hospital
Stroke, Ischemic
BEACON-AA: Apixaban With or Without Clopidogrel in Stroke Patients With Atrial Fibrillation and Cerebral Atherosclerosis
This trial aims to compare the safety and efficacy of apixaban alone versus apixaban combined with clopidogrel in patients with acute ischemic stroke associated with non-valvular atrial fibrillation and concomitant symptomatic…
- Conditions
- Stroke, Ischemic, Atrial Fibrillation, Intracrnaial Arterioscelrosis
- Trial name
- NCT07237308
- Testing
- Apixaban, Clopidogrel
- Where
- South Korea
- Volunteers
- 586 people
- Sponsor
- Yonsei University
Type 2 Diabetes Mellitus, Microangiopathy
Changes in the Retinal and Carotid Microcirculation After Restoring Normoglycemia in Patients With Type 2 Diabetes
This is a prospective and observational study in patients with type two diabetes. The study hypothesis is that chronic hyperglycemia causes an increase in the microcirculation on the carotid artery wall and retina, evaluated by…
- Conditions
- Type 2 Diabetes Mellitus, Microangiopathy, Diabetic Retinopathy, Arteriosclerosis
- Trial name
- OCTAUS-T2D (NCT03594591)
- Testing
- Antidiabetic treatment by usual care
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Stroke, Ischemic, Atherosclerosis, Cerebral
The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques
Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is directly attributed to the progression or rupture of intracranial high-risk plaque in Asia.
- Trial name
- INSIST-HRMRI (NCT03753555)
- Testing
- Atorvastatin Calcium, Probucol, PCSK9 inhibitor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Shenyang Military Region
Artery Disease, Peripheral, Aortic Diseases
Relationship Between Morbimortality and Basal Activated Clotting Time (ACT) in Patients Undergoing Vascular Surgery
Check whether patients with higher comorbidity and risk of complication, estimated using the V (p) -POSSUM score, ACS NSQIP and the ASA classification, present higher baseline activated clotting time values.
- Conditions
- Artery Disease, Peripheral, Aortic Diseases, Carotid Artery Diseases, Other Disease
- Trial name
- NCT04703582
- Testing
- Activated clotting time
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau