Clinical trials: Atherosclerosis, Cerebral
Cardiovascular Diseases, Atherosclerosis
Inflammatory Genomics in Human Carotid Artery Disease
To investigate the relationship between genetic variation in genes for inflammation and carotid artery atherosclerosis.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Carotid Artery Diseases, Inflammation
- Trial name
- NCT00070668
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myocardial Infarction, Severe Periodontitis
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental…
- Conditions
- Acute Myocardial Infarction, Severe Periodontitis, Carotid Atherosclerosis
- Trial name
- PAROCARD (NCT04046237)
- Testing
- Periodontal treatment
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Atherosclerosis
PET Detection of CCR2 in Human Atherosclerosis
: Use of novel radio-pharmaceutical 64CUDOTA-ECL1i to evaluate arterial atherosclrosis
- Trial name
- NCT04537403
- Testing
- Group 1-64CU-DOTA-ECL1i (radioactive imaging medicine), Group 2 64CU-DOTA-ECL1i (radioactive imaging medicine)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Carotid Stenosis, Cardiovascular Disease
Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization
The combination of aspirin and dipyridamole, two antiplatelet drugs, is approved in Italy for the secondary prevention of cerebral embolism in patients with carotid atherosclerosis.
- Conditions
- Carotid Stenosis, Cardiovascular Disease, Atherosclerosis, Stroke
- Trial name
- ICAR (NCT02630862)
- Testing
- Aspirin, aspirin plus dipyridamole
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- University of Roma La Sapienza
Carotid Atherosclerosis, Carotid Artery Stenosis Asymptomatic
PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Multisite)
The goal of this clinical trial is to evaluate the feasibility of imaging atherosclerosis by 64Cu-NODAGA-CANF PET-MR in a pilot study of patients with asymptomatic carotid artery stenosis (ACAS).
- Conditions
- Carotid Atherosclerosis, Carotid Artery Stenosis Asymptomatic, Asymptomatic Carotid Artery Stenosis
- Trial name
- NCT07916883
- Testing
- 64Cu-NODAGA-CANF
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Atherosclerosis, Cardiovascular Diseases
Beijing Hospital Atherosclerosis Study
The Beijing Hospital Atherosclerosis Study (BHAS) is a prospective, single-center, observational cohort study performed at the Beijing Hospital in Beijing, China.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia
- Trial name
- BHAS (NCT03072797)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Atherosclerosis
Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging
The goal of this study is to assess a slimy substance that settles/deposits along blood vessel wall. This slimy substance is called plaque. Plaque could be made up of fat, calcium or both. Plaque deposition narrows the vessels.
- Trial name
- NCT02114697
- Testing
- Statin therapy, Lifestyle modification
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Emory University
Stroke, Intracranial Atherosclerosis
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
This will be a randomized double blind placebo-controlled pilot study using a repeated measures design in which participants with acute ischemic stroke and intracranial atherosclerotic disease are randomized to either drug or…
- Conditions
- Stroke, Intracranial Atherosclerosis, Intraplaque Hemorrhage
- Trial name
- PINNACLE (NCT03507374)
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Carotid Atherosclerosis
Carotid Atherosclerosis and Vascular Events in People With Diabetes
Diabetes is a risk factor for carotid atherosclerotic whose progression is associated with an increased risk of vascular events.
- Trial name
- PROCAVE-D (NCT02929355)
- Testing
- carotid assesment by duplex ultrasonography
- Where
- France
- Volunteers
- 731 people
- Sponsor
- Hospices Civils de Lyon
Atherosclerosis Cerebral Infarction
Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject
Randomized, control, open label, multicentre clinical study. The patient who are in accordance with subject inclusion and exclusion criteria will be randomized to A group: Routine treatment B group: Routine treatment+ Cilostazol…
- Trial name
- NCT00823875
- Testing
- Cilostazol group, Probucol group, Cilostazol + Probucol group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Otsuka Beijing Research Institute
Atherosclerosis, Ischemic Stroke
A Phase I Study to Evaluate Safety and Pharmacokinetics of Escalating Single Doses and Multiple Doses of SP-8356
This is a 2-part, single-centre, randomised study in healthy males. Part 1 is a double-blind, randomised, placebo-controlled, single ascending dose (SAD) study in healthy males.
- Trial name
- NCT05574166
- Testing
- SP-8356
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Carotid Stenosis
Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.
- Trial name
- NCT00670202
- Testing
- Fasudil Hydrochloride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Risk Factors, Coronary Artery Disease
Correlation of Artherosclerotic Plaque Volume and Intima Media Thickness With Soluble P-selectin
The proposed project is a prospective observational, single-center cohort study aimed to examine the progression of atherosclerotic alterations of the carotid arteries (IMT, plaque volume) during a follow-up of up to four years…
- Conditions
- Cardiovascular Risk Factors, Coronary Artery Disease, Cerebrovascular Disease, Peripheral Artery Disease
- Trial name
- NCT01895725
- Where
- Austria
- Volunteers
- 443 people
- Sponsor
- Medical University Innsbruck
Carotid Stenosis
Paraoxonase and LDL Oxidation in Carotid Artery Disease
Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism.
- Trial name
- NCT00011258
- Testing
- Paraoxonase
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- US Department of Veterans Affairs
Carotid Atherosclerosis
Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques
Sonodynamic therapy (SDT) is a new treatment for carotid atherosclerotic plaque. The aim of this study is to assess the safety and efficacy of this technique.
- Trial name
- SMART-C (NCT03382249)
- Testing
- Sonodynamic therapy (SDT), pseudo-SDT
- Where
- China
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Carotid Artery Disease, Atherosclerosis
Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
In this proposal, the investigators will demonstrate the feasibility and noninferiority of telerobotic ultrasonography as compared to traditional manual acquisition in performing a limited carotid Duplex examination and in…
- Conditions
- Carotid Artery Disease, Atherosclerosis, Atheromatous Plaques, Arteriosclerosis
- Trial name
- NCT05654935
- Testing
- Ultrasound for Carotid Arteries, Telerobotic Ultrasound for Carotid Arteries
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Atherosclerotic Carotid Disease, Atheroma
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
A new way of scanning narrowing in the arteries (main blood vessels) caused by fatty deposits known as plaques has been developed. Heart attacks and strokes occur when plaques become inflamed, depending on the artery affected.
- Conditions
- Atherosclerotic Carotid Disease, Atheroma, Atherosclerosis
- Trial name
- NCT00368589
- Testing
- atorvastatin
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Hypercholesterolemia, Hypercholesterolemia, Familial
PET Imaging of Inflammation and Lipid Lowering Study
While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has been used as an early marker of drug efficacy in numerous clinical cardiovascular drug trials, as a glucose analog, its signal in the vasculature…
- Conditions
- Hypercholesterolemia, Hypercholesterolemia, Familial, Atherosclerosis, Carotid Artery Plaque
- Trial name
- PIILL (NCT04073797)
- Testing
- Inclisiran, 68Ga-DOTATATE PET-MRI, Colchicine
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Cambridge
Cardiovascular Diseases, Carotid Artery Diseases
Carotid Atherosclerosis Follow-up Study
To determine whether the degree of carotid artery atherosclerosis, as measured by B-mode ultrasound, predicts the development of myocardial infarction, stroke, and all-cause mortality in patients with angiographically defined…
- Conditions
- Cardiovascular Diseases, Carotid Artery Diseases, Myocardial Infarction, Coronary Disease
- Trial name
- NCT00005189
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Artery Disease
Self Selected Exercise Intensity in PAD Patients
Although the benefits of supervised walking training in patients with peripheral arterial disease (PAD) and symptoms of intermittent claudication (IC) are well established, one of the main problems found in this type of protocol…
- Trial name
- NCT04333615
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Nove de Julho