Clinical trials: Atherosclerosis
Atherosclerosis
Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes
The purpose of this study is to test the safety and effectiveness of rosiglitazone against a sulfonylurea in reducing or slowing the development of atherosclerosis in the blood vessels of the heart.
- Trial name
- NCT00116831
- Testing
- Glipizide, rosiglitazone maleate
- Where
- 156 sites in United States, Argentina and 18 more
- Volunteers
- 672 people
- Sponsor
- GlaxoSmithKline
Atherosclerosis
Trial of Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial)
The purpose of this study is to determine whether the combination of clopidogrel with aspirin prevents the development of blockages (atherosclerosis) in vein grafts one year after coronary artery bypass surgery (CABG) compared to…
- Trial name
- CASCADE (NCT00228423)
- Testing
- Clopidogrel 75 mg daily, water pill daily
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Peripheral Arterial Disease
Pantheris Atherectomy Treatment of In-Stent Restenosis In Lower Extremity Arteries
A prospective, non-randomized, international, multi-center study to evaluate the safety and effectiveness of the Pantheris OCT-Imaging System to perform atherectomy in In-Stent Restenotic (ISR) lesions in lower extremity arteries.
- Trial name
- INSIGHT (NCT03192696)
- Testing
- Atherectomy Catheter
- Where
- 12 sites in United States
- Volunteers
- 127 people
- Sponsor
- Avinger, Inc.
Cardiovascular Diseases, Heart Diseases
Strong Heart Study Analyses Obesity and Lipoproteins
To examine the relationship of obesity and body fat distribution to lipoprotein concentrations in members of the Strong Heart Study.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Obesity
- Trial name
- NCT00005510
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Artery Disease
Clinical Outcomes of Three Different Percutaneous Revascularization Strategies for the Treatment of Lifestyle Limiting Claudication: A Retrospective Analysis
To determine the effect of three different percutaneous revascularization strategies (Balloon Cryoplasty vs. Stent Placement vs. Atherectomy) in the treatment of lifestyle limiting lower extremity claudication
- Trial name
- FIX-IT Retro (NCT00512720)
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- Corewell Health West
Critical Limb Ischemia
To Evaluate the Safety and Efficacy of IM and IV Administration of Autologous ADMSCs for Treatment of CLI
Various preclinical animal studies have shown the potential of stem cells in re-vascularising ischemic limbs and promoting collateral vessel formation.
- Trial name
- NCT02145897
- Testing
- Autologous Stromal Vascular Fraction (SVF), Autologous Adipose Derieved MSCs, Control
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Kasiak Research Pvt. Ltd.
Cardiovascular Disease
Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study
Evaluate the effect of olpasiran administered subcutaneously (SC) compared with placebo, on percent change from baseline in lipoprotein(a) (Lp[a]).
- Trial name
- NCT04270760
- Testing
- Olpasiran
- Where
- 36 sites in United States, Australia and 5 more
- Volunteers
- 281 people
- Sponsor
- Amgen
Peripheral Arterial Disease
BIOLUX P-IV CHINA ( BIOTRONIK )
Prospective, multi-center, non-randomized clinical trial with follow-up investigations at 1, 6 and 12 months. To confirm safety and efficacy of Passeo-18 Lux DCB in new and non-stented re-stenotic lesions in the superficial…
- Trial name
- NCT02912715
- Testing
- Paclitaxel releasing angioplasty balloon
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Biotronik (Beijing) Medical Device Ltd.
Peripheral Arterial Disease (PAD)
Evaluation of WIRION™ EPS in Lower Extremities Arteries
Demonstrate the safety and performance of the WIRION™ EPS in subjects undergoing lower extremity atherectomy for the treatment of Peripheral Arterial Disease (PAD)
- Trial name
- WISE-LE (NCT02780349)
- Testing
- WIRION
- Where
- 10 sites in United States, Germany
- Volunteers
- 103 people
- Sponsor
- Gardia Medical
Critical Limb Ischemia, Atherosclerosis
Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells
The purpose of this study is to determine the safety and efficacy of G-CSF-mobilized autologous peripheral blood mononuclear cell injection to ischemic limbs of patients with critical limb ischemia.
- Conditions
- Critical Limb Ischemia, Atherosclerosis, Ischemic Ulcer, Gangrene
- Trial name
- NCT01833585
- Testing
- Peripheral blood mononuclear cell
- Where
- Thailand
- Volunteers
- 8 people
- Sponsor
- Mahidol University
Peripheral Arterial Disease
To Evaluate the Introduction of a Public Health Approach to Peripheral Arterial Disease (PAD) Using National Centre for Sport and Exercise Medicine Facilities.
The aim of the project is to investigate the clinical and patient centred outcomes of people with Peripheral Arterial Disease (PAD) attending a podiatry led integrated care pathway, utilising advice on diet, activity and smoking…
- Trial name
- PodPAD (NCT02901847)
- Testing
- PAD tailored care
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Systemic Lupus Erythematosus, Lupus
Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE)
The purpose of this study is to find the best way to prevent heart disease and stroke in people with lupus (systemic lupus erythematosis, or SLE).
- Trial name
- NCT00054938
- Testing
- pravastatin, aspirin, ramipril
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes
Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes
Diabetes is associated with dyslipidaemia leading to generalized atherosclerosis, cardiovascular disease (CVD) and nephropathy. Osteoprotegerin (OPG), a glycoprotein involved in bone homeostasis, has been implicated in the…
- Trial name
- NCT00471549
- Testing
- Statin (simvastatin)
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
Peripheral Arterial Disease, Endothelial Dysfunction
Effects of Combined Aerobic and Resistance Training in Patients With Intermittent Claudication
Exercise training improves walking capacity and regional perfusion in patients with Intermittent Claudication (IC). Endothelial Progenitor Cells (EPCs) and Endothelial Microparticles (EMPs) could play an important role in this…
- Trial name
- NCT04302571
- Testing
- combined aerobic and resistance physical activity
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Atherosclerosis, Peripheral Arterial Disease
The Effects of Allicor on Patients After Revascularization Treatment During a Year
A significant challenge in medical care is atherosclerotic occlusion of peripheral arteries, such as lower extremities and brachiocephalic arteries, which can eventually lead to loss of limbs or fatal ischemic strokes.
- Trial name
- TEA-PARTY (NCT05813171)
- Testing
- Allicor
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
Hypertension
LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED)
The primary objective of this study is to evaluate efficacy, arterial stiffness measured by Pulse Wave Velocity (PWV) of Losartan potassium group compared to Carvedilol group after 24 weeks of treatment in patients with the…
- Trial name
- NCT00496834
- Testing
- losartan potassium, Comparator: carvedilol, Comparator: losartan (+) hydrochlorothiazide (HCTZ)
- Volunteers
- 201 people
- Sponsor
- Organon and Co
Thyroid Dysfunction, Atherosclerosis
The TRUST Study - CardioVascular Imaging IMT
Coronary heart disease (CHD) are the leading causes of mortality and morbidity, particularly with the current context of an aging population.
- Conditions
- Thyroid Dysfunction, Atherosclerosis, Heart Failure
- Trial name
- NCT02832934
- Testing
- Levothyroxine
- Where
- 3 sites in Switzerland
- Volunteers
- 184 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Periodontitis, Atherosclerotic Cardiovascular Disease
Short-term Changes on C-Reactive Protein (CRP) Levels After Non-surgical Periodontal Treatment
The hypotheses tested were that levels of C-Reactive Protein (CRP) would be higher in patients with chronic periodontitis in comparison with those without periodontal disease and that the non-surgical periodontal treatment would…
- Trial name
- NCT01433744
- Testing
- Non-surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- State University of Maringá
Familiar Hypercholesterolemia
High Intensity Interval Training in the Treatment of Familial Hypercholesterolemia (UPPA-FH)
This study has one main objective: a) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia…
- Trial name
- UPPA-FH (NCT06833944)
- Testing
- HIIT intervention program, MICT intervention program
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Peripheral Artery Disease
PREDICT-PVI Understanding Peripheral Restenosis: Genomic and Proteomic Determinants of Vascular Intervention
The overall goal of this multicenter collaborative research study is to identify genetic, proteomic, and/or lipidic (lipidomic) biomarkers associated with the outcomes of lower extremity revascularization in patients with…
- Trial name
- NCT02180373
- Where
- 4 sites in United States
- Volunteers
- 67 people
- Sponsor
- Vascular Cures