Clinical trials: Atrial Appendage
Atrial Fibrillation, GI Bleeding
Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry
The GI-FLX Registry is intended to create a registry of patients with a history of Atrial Fibrillation (AF) and Gastrointestinal (GI) bleed who will receive Left Atrial Appendage Closure (LAAC) with WATCHMAN FLX device and…
- Trial name
- NCT06052358
- Testing
- LAAC with Watchman FLX device
- Where
- 4 sites in United States
- Volunteers
- 73 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Atrial Fibrillation, Atrial Fibrillation, Persistent
Left Roof Linear, Mitral Isthmus Linear and Left Anterior Septal Linear Ablation for Non-paroxysmal AF: PROMISED Trial.
The purpose of this prospective randomized study is to assess whether a new treatment strategy consisting of circumferential Pulmonary vein isolation (PVI), left ROof linear (RL), Mitral Isthmus linear (MIL), and left anterior…
- Trial name
- NCT06249347
- Testing
- PROMISED, CPVI and LAAC, Radiofrequency ablation catheter
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cardiology
Comprehensive CT-guided vs Echo-fluoroscopy-guided Strategy in the Left Atrial Appendage Occlusion
Percutaneous left atrial appendage occlusion (LAAO) is an increasingly used alternative to oral anticoagulation in patients with nonvalvular atrial fibrillation (AF).
- Trial name
- NCT04913207
- Testing
- method of device size selection
- Where
- China
- Volunteers
- 310 people
- Sponsor
- RenJi Hospital
Heart Failure, Left Atrial Appendage Occlusion
Left Atrial Appendage Occlusion Study III Extended Follow Up
LAAOS III Extension is a longer term follow-up of an international cohort study of patients who were enrolled in the Left Atrial Appendage Occlusion Study (LAAOS III) trial.
- Trial name
- LAAOSIIIX (NCT05399342)
- Testing
- No Intervention
- Sponsor
- Population Health Research Institute
Left Atrial Appendage Occlusion
Use of Intracardiac Echocardiography or Left Atrial Appendage Radiography to Guide Implantation of a Left Atrial Appendage Occlusion Device
A total of 40 patients with atrial fibrillation were scheduled to receive left atrial appendage occlusion, which were divided into two groups.
- Trial name
- NCT04524741
- Testing
- intracardiac echocardiography
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Second Hospital of Hebei Medical University
Stroke Prevention, Atrial Fibrillation
Stand-alone Totally Thoracoscopic Left Atrial Appendage Occlusion Using AtriClip® Device in Non-valvular Atrial Fibrillation.
Polish multicenter registry to assess safety and durability of totally thoracoscopic left atrial appendage occlusion for stroke prevention in atrial fibrillation.
- Conditions
- Stroke Prevention, Atrial Fibrillation, Safety Issues
- Trial name
- THORACS-LAAO (NCT03838341)
- Testing
- AtriClip™ LAA Exclusion System, Oral anticoagulation therapy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Atrial Fibrillation, Heart Diseases
Left Atrial Appendage Occlusion With WATCHMAN® Device in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic Kidney Disease on Hemodialysis
Atrial fibrillation (AF) is more common in patients with renal disease compared to the general population an risk increase to as much as 10 times in patients on hemodialysis (HD).
- Conditions
- Atrial Fibrillation, Heart Diseases, Renal Disease, Bleeding
- Trial name
- WATCH-HD (NCT03446794)
- Testing
- Non Intervention
- Where
- 20 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Fundación EPIC
Atrial Fibrillation
Post-approval Study of Percutaneous Left Atrial Appendage Closure ( FLAAC-2 )
Patients with atrial fibrillation are at significant risk of thrombus formation in the left atrial appendage, which can lead to a stroke or systemic embolism.
- Trial name
- FLAAC-2 (NCT03434015)
- Where
- France
- Volunteers
- 1,051 people
- Sponsor
- French Cardiology Society
Left Atrial Appendage Thrombosis, Stroke, Ischemic
RF Applications for Residual LAA Leaks
Although the clinical impact of residual left atrial appendage (LAA) leaks still requires confirmation, its patency resulting from incomplete LAA closure may promote blood stagnation and thrombus formation, and increase the risk…
- Conditions
- Left Atrial Appendage Thrombosis, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- REACT (NCT04726943)
- Testing
- Radiofrequency Energy Applications
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation, Atrial Appendage
AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE
The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Atrial Appendage, Anticoagulants, Stroke
- Trial name
- APPENDAGE (NCT04796714)
- Testing
- Double antiplatelet therapy, Aspirin, Brain MRI
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Neurobehavioral Manifestations, Atrial Fibrillation
Frontal Cognitive Control Functions Before and After Percutaneous Catheter Procedures in Treatment of Atrial Fibrillation
Atrial fibrillation is a common arrythmia. It is an independent risk factor for stroke. There for anticoagulation therapy is used for atrial fibrillation patients.
- Trial name
- NCT02306460
- Where
- Finland
- Volunteers
- 17 people
- Sponsor
- Tampere University Hospital
LAAO With Amplatzer Amulet
Preprocedural Assessment of Anatomy and Device Sizing With CT and 3D Simulation in Left Atrial Appendage Occlusion.
The objectives of the current proposal are to analyse to what extend: 1. The use of 3D in silico simulation by FEops HEARTguide improves of influences the pre-procedural assessment and device size selection and to what extend it…
- Trial name
- PRECISE LAAO (NCT04640051)
- Testing
- LAAO
- Where
- 6 sites in Belgium
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- AZ Sint-Jan AV
Atrial Fibrillation, Coronary Artery Disease
LAAO With DAPT Versus Antithrombotic Therapy
This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation…
- Trial name
- NCT03310801
- Testing
- ACP or Watchman
- Volunteers
- 480 people
- Sponsor
- Korea University Anam Hospital
Nonvalvular Atrial Fibrillation
TEE-Guided Versus CCTA-Guided Preprocedural Imaging for Left Atrial Appendage Closure
This prospective, open-label, multicenter randomized controlled trial will compare two preprocedural imaging assessment strategies in adults with nonvalvular atrial fibrillation who are scheduled to undergo percutaneous left…
- Trial name
- PEARL-LAAC (NCT07815119)
- Testing
- Transesophageal Echocardiography-Guided Preprocedural Assessment, Cardiac Computed Tomography Angiography-Guided Preprocedural Assessment
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Shanghai Zhongshan Hospital
Left Atrial Appendage Thrombosis, Thrombi
Clinical Outcomes Between Anticoagulation and DAPT Therapy in AF Patients Successfully Undergoing LAAO
The objective of this study is to assess the efficacy and safety different dosage of rivaroxaban application versus dual antiplatelet therapy after successful closure of left atrial appendage using the LAMBRE device.
- Conditions
- Left Atrial Appendage Thrombosis, Thrombi, Stroke
- Trial name
- NCT04135677
- Testing
- Rivaroxaban, DAPT
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Shanghai Zhongshan Hospital
Nonvalvular Atrial Fibrillation
First in Man Study of Left Atrial Appendage Pulsed Field Ablation Occluder
This is the first in man study of E-SeaLATM developed and manufactured by Hangzhou Dinova EP Technology Co., Ltd, which can achieve pulsed field ablation and mechanical closure of the Left Atrial Appendage simultaneously, this…
- Trial name
- NCT05731882
- Testing
- E-SeaLA, CardioPulse PFA system
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- Hangzhou Dinova EP Technology Co., Ltd
Atrial Fibrillation, Stroke
Aspirin Discontinuation After Left Atrial Appendage Occlusion in Atrial Fibrillation
The ASPIRIN LAAO trial is a prospective, multi-center, randomized, double blinded, placebo-controlled study aiming at investigating the safety of terminating the use of aspirin after left atrial appendage occlusion (LAAO).
- Conditions
- Atrial Fibrillation, Stroke, Bleeding
- Trial name
- ASPIRIN-LAAO (NCT03821883)
- Testing
- Aspirin Tablet
- Where
- China
- Volunteers
- 1,120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation
Left Atrial Appendage Occlusion Registry (LAAO Registry)
The Left Atrial Appendage Occlusion Registry (LAAO Registry™) is designed to assess the prevalence, demographics, management, and outcomes of patients undergoing percutaneous and epicardial based left atrial appendage occlusion…
- Trial name
- NCT02699957
- Testing
- Left Atrial Appendage Occlusion
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- American College of Cardiology
Atrial Fibrillation, Ischemic Stroke, Acute
Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry
This study is intended to assess the incidence and correlation to the development of peri-device leaks (PDLs), device related thrombosis (DRTs) and cerebral vascular accident (CVA)/transient ischemic attacks (TIAs) in association…
- Trial name
- NCT06075628
- Testing
- Left Atrial Appendage Occlusion
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, PFA Ablation and LAAC Procedures
Left Atrial Appendage Closure With Versus Without Pulsed Field Ablation in Atrial Fibrillation Patients With Mild Symptoms and High Stroke Risk
This study is a prospective, multicenter, single-blinded, randomized controlled trial to investigate whether concomitant left atrial appendage closure (LAAC) and pulsed field ablation (PFA) is more effective than LAAC alone in…
- Trial name
- REVERSE-OPTION (NCT07453940)
- Testing
- LAAC plus PFA for persistent AF with high risk of stroke, LAAC for persistent AF with high risk of stroke
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital