Clinical trials: Atrial Fibrillation, Postoperative
Coronary Artery Bypass Grafting, Remimazolam
Remimazolam for Postoperative Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac severe arrhythmia globally and is associated with an increased risk of mortality and morbidity, with a loss of 6.0 million disability-adjusted life-years worldwide in 2017…
- Trial name
- RePAF (NCT05891145)
- Testing
- Remimazolam, midazolam
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yangzhou University
Arrhythmias, Cardiac, Cardiovascular Diseases
Randomized Clinical Trial PULVAB (Prophylactic Pulmonary Veins Ablation)
To compare prophylactic strategies of atrial fibrillation in patients with CAD and without AF.
- Conditions
- Arrhythmias, Cardiac, Cardiovascular Diseases, Postoperative Atrial Fibrillation, Myocardial Ischemia
- Trial name
- PULVAB (NCT03857711)
- Testing
- Conventional CABG, CABG+ PVI, CABG+ PVI+amiodarone
- Where
- 2 sites in Russia
- Volunteers
- 280 people
- Sponsor
- National Research Center of Surgery, Russia
Atrial Fibrillation
The Effect of Posterior Pericardiotomy on the Incidence of Atrial Fibrillation After Cardiac Surgery
The purpose of this study is to determine if preforming a posterior left pericardiotomy prevents atrial fibrillation after cardiac surgery.
- Trial name
- PALACS (NCT02875405)
- Testing
- Posterior left pericardiotomy
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Weill Medical College of Cornell University
Atrial Fibrillation
Spinal Cord Stimulation to Treat Post-operative Atrial Fibrillation
Patients will be randomized to control and spinal cord stimulation arm (SCS) to investigate the effect of SCS on the occurrence of post-operative atrial fibrillation in the five days after surgery.
- Trial name
- SCS-PAF (NCT02530203)
- Testing
- Spinal Cord Stimulation System, Holter Recording_ NEMon DR220 Holter Recorders
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Medtronic BRC
Postoperative Atrial Fibrillation
The Effect of Ligament of Marshall Excision During Minimally Invasive Cardiac Surgery-Coronary Artery Bypass Grafting (MICS-CABG) on the Prevention of Postoperative New-Onset Atrial Fibrillation: A Multicenter, Prospective, Randomized, Triple-Blinded Study
After heart bypass surgery, many patients develop a heart rhythm problem called postoperative atrial fibrillation, or POAF for short. This issue happens to 20%-40% of all bypass patients.
- Trial name
- NCT07755072
- Testing
- MICS-CABG combined with excision of the Ligament of Marshall
- Where
- China
- Volunteers
- 628 people
- Sponsor
- Peking University Third Hospital
Postoperative Atrial Fibrillation, Lung Surgery
Perioperative Statins to Prevent AFib After Lung Surgery
The goal of this clinical trial is to learn whether short-term treatment with atorvastatin can prevent new abnormal rapid heart rhythms after lung surgery in adults aged 60 years or older who are scheduled to have a lung segment…
- Trial name
- STAT-LUNG (NCT07727681)
- Testing
- Atorvastatin
- Where
- 2 sites in China
- Volunteers
- 540 people
- Sponsor
- Peking Union Medical College Hospital
Atrial Fibrillation, Atrial Arrhythmia
Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
The study aims to evaluate and compare the incidence of atrial arrhythmias (including Post-Operative Atrial Fibrillation (POAF), atrial flutter, and atrial tachycardia) stratified by baseline Utah fibrosis stages and overall…
- Conditions
- Atrial Fibrillation, Atrial Arrhythmia, Atrial Flutter, Atrial Tachycardia
- Trial name
- NCT05014802
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Tulane University
Post-operative Atrial Fibrillation
Preemptive Pharmacogenetic-guided Metoprolol Management for PostoperativeAtrial Fibrillation in Cardiac Surgery
Metoprolol is frequently administered to cardiac surgery patients to reduce the incidence of postoperative atrial fibrillation (PoAF).
- Trial name
- PREEMPTIVE (NCT03943927)
- Testing
- Guided Metoprolol Management
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation
Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery
In this study, the investigators aim to determine whether injecting botulinum toxin into epicardial fat pads is efficacious and safe for decreasing postoperative atrial fibrillation (POAF) after cardiac surgery.
- Trial name
- NCT02498769
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Joseph Mathew, M.D.
Atrial Fibrillation
Impact of Sodium-glucose Cotransporter 2 Inhibitors on Post-operative Atrial Fibrillation in Cardiothoracic Surgery
SGLT2 inhibitors are oral anti-diabetic medications that were found to improve cardiorenal outcomes in patients with type 2 diabetes mellitus (DM), chronic heart failure with reduced and preserved ejection fraction, and chronic…
- Trial name
- NCT06251453
- Testing
- SGLT2 inhibitor
- Where
- 2 sites in Qatar
- Volunteers
- 3,280 people
- Sponsor
- Hamad Medical Corporation
Atrial Fibrillation (AF), Catheter Ablation
PROMBot-HSM-FA: Protocol for a Feasibility Study of a Chatbot Platform to Collect Patient-reported Outcomes After AF Ablation
The goal of this clinical trial is to learn if using a WhatsApp-based chatbot called PROMBot-FA can help people recover after atrial fibrillation ablation.
- Trial name
- PROMBot-HSM-FA (NCT07237178)
- Testing
- PROMBot-FA Chatbot-Supported Follow-Up, Standard Care (in control arm)
- Volunteers
- 76 people
- Sponsor
- Ana Rita Londral, PhD
Coronary Heart Disease
Supplementation With Polyphenol-Rich Foods and Atrial Fibrillation After a Cardiac Surgery
Post-operative atrial fibrillation (POAF) is a major cause of morbidity and mortality after a cardiac surgery. Both systemic inflammation and oxidative stress play a role in the initiation of POAF after a cardiac surgery.
- Trial name
- Polyphemus (NCT02045134)
- Testing
- High-anthocyanin rich corn flour
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Neuromed IRCCS
Atrial Fibrillation
The Effect of Magnesium Therapy to Prevent Post-operative Atrial Fibrillation After Cardiac Surgery in Adults
It is well known that magnesium sulfate has a membrane stabilizing effect , and broad spectrum anti arrhythmic properties. In this trial, the investigators study its prophylactic effect against atrial fibrillation in…
- Trial name
- NCT02928315
- Testing
- Magnesium Sulfate, control
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Postoperative Atrial Fibrillation
The Effect of Intra Operative Dexmedetomidine in Prevention of Early Postoperative Atrial Fibrillation
The incidence of atrial fibrillation (AF) after lung resection varies between 12% and 30% after lobectomy and 23%-67% after pneumonectomy. The average time of onset of AF after lung resection is 2-3 days.
- Trial name
- NCT05320705
- Testing
- Intra Operative Dexmedetomidine
- Where
- Egypt
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction
- Trial name
- CABGGenomics (NCT01258231)
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation, Inflammation
Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, marked by an irregular and rapid heart rate, and associated with increased morbidity, longer hospital stays, and higher costs.
- Trial name
- NCT06475547
- Testing
- Descriptive
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Odense University Hospital
Atrial Fibrillation
The Safety of Non-vitamin K Oral Anticoagulants Compared to Warfarin Early After Cardiac Surgery
A small pilot study comparing different blood thinners (non-vitamin K oral anticoagulants [NOACs] and warfarin) will be conducted in people at risk for blood clots after open-heart surgery.
- Trial name
- NCT05006287
- Testing
- Non-vitamin K oral anticoagulants (NOACs), Warfarin
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Paul's Hospital, Canada
Atrial Fibrillation
Post-operative Corticosteroid Treatment After Mitral Valve Surgery
The aim of the study is to intestigate whether three days intravenous corticosteroid management prevent atrial fibrillations in adults after mitral valve surgery.
- Trial name
- MitralPOCS (NCT03682393)
- Testing
- Hydrocortisone
- Where
- Finland
- Sponsor
- Kuopio University Hospital
Coronary Artery Bypass Graft Surgery
Vitamin C in Cardiac Surgery Patients
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery that increases the incidence of stroke, kidney injury and death.
- Trial name
- NCT03123107
- Testing
- Ascorbic Acid
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Geisinger Clinic
AKI, Neurocognitive Disorders
El DORADO STUDY (Evaluation of Delivery of Oxygen on Renal, Arrhythmia and Delirium Outcomes Study)
The study aims to develop a novel perioperative noninvasive delivery of oxygen (DO2) and hemodynamic index in the prediction of postoperative outcomes including post-operative acute kidney injury (POAKI), perioperative…
- Conditions
- AKI, Neurocognitive Disorders, Atrial Fibrillation
- Trial name
- NCT04895384
- Testing
- Edwards ClearSight and Masimo SET
- Where
- 2 sites in Singapore
- Volunteers
- 600 people
- Sponsor
- National University Hospital, Singapore