Clinical trials: Atrial Fibrillation (AF)
Atrial Fibrillation (AF)
Pulsed-Field Ablation vs. Radiofrequency Ablation CombIned With Vein of Marshall Ethanol Ablation on Mitral Isthmus Block and Clinical Outcomes in Persistent Atrial Fibrillation
Atrial fibrillation (AF) is one of the most common clinical arrhythmias, and catheter ablation serves as a critical therapeutic approach.
- Trial name
- PRIME-AF (NCT06866704)
- Testing
- catheter ablation
- Volunteers
- 154 people
- Sponsor
- lingzhiyu
Atrial Fibrillation (AF)
Developing MRI Technologies for Atrial Fibrillation
To measure image quality of damaged areas of the heart in patients with Atrial fibrillation using the contrast Gadopiclenol vs conventional Gadolinium-based contrast agents(GBCA)
- Trial name
- NCT07083115
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Cardiac Arrhythmias, Atrial Fibrillation and Flutter
Increasing Detection of Sub-Clinical Atrial Fibrillation in Defibrillator Patients With the Use of a VDD-ICD Lead
This study aims to compare the Dx-ICD system (experimental) to standard VVI-ICD (control) on the ability to diagnose silent AF in patients without prior AF receiving an ICD for standard indications.
- Conditions
- Cardiac Arrhythmias, Atrial Fibrillation and Flutter, Cardiovascular Diseases, Implantable Cardioverter-Defibrillators
- Trial name
- Dx-AF (NCT03110627)
- Testing
- VDD ICD (experimental group), Single chamber VVI ICD (control group)
- Where
- 9 sites in Canada
- Volunteers
- 188 people
- Sponsor
- Unity Health Toronto
Atrial Fibrillation New Onset, Embolic Stroke of Undetermined Source
PFO Occlusion and Atrial Fibrillation
Interventional closure of patent foramen ovale (PFO) associates with reduced risk of stroke recurrence in patients with cryptogenic ischemic stroke as reported in the recent CLOSE and REDUCE trials.
- Conditions
- Atrial Fibrillation New Onset, Embolic Stroke of Undetermined Source, Patent Foramen Ovale
- Trial name
- NCT04898361
- Testing
- PFO closure
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital, Saarland
Atrial Fibrillation (AF)
Sex-Based Differences of LA: Impact on AF Ablation.
The aim of the study is to assess sex-related differences in patients who underwent a first ablation procedure for paroxysmal or persistent AF, guided by the personalized ablation strategy of the BY-LAWT protocol.
- Trial name
- NCT07159685
- Testing
- Atrial fibrillation ablation
- Where
- Spain
- Volunteers
- 700 people
- Sponsor
- Centro Medico Teknon
AF - Atrial Fibrillation, HTN-Hypertension
Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Atrial Fibrillation (AF) and Hypertension (HTN)
The close relationship between the increase of sympathetic tension, AF, and HTN cannot be ignored. In addition, the significant failure rate of PVI (20-50%) in the treatment of AF makes it very necessary to explore the effect of…
- Trial name
- NCT05841615
- Testing
- Renal Denervation operation, Pulmonary vein isolation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Atrial Fibrillation (AF), Arrhythmia
Computed Tomography of Pulse-Field Ablation
Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) reduces left atrial (LA) volume post-ablation, a phenomenon termed reverse atrial remodeling, indicative of successful reversal of atrial cardiomyopathy…
- Trial name
- CT-PFA (NCT07395089)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation (AF), Cardiac Surgery
Isolation of Pulmonary Veins Using the Box Technique in Patients Undergoing Sternotomy
Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide, affecting approximately 2.8% of the population, with prevalence increasing with age.
- Trial name
- BoxTer (NCT07312149)
- Testing
- Collection of study data from patient records
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
Atrial Fibrillation
Propagation ANalysis for Arrhythmogenic Conduction Elimination to Prevent Atrial Flutter and Fibrillation (PANACEA-AF)
The purpose of this study is to perform ultra-high density mapping of the left atrium (a chamber of the heart) using the the Rhythmia Mapping System and to determine whether additional ablation in areas of wavefront…
- Trial name
- PANACEA-AF (NCT03737838)
- Testing
- Atrial fibrillation ablation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Chicago
Atrial Fibrillation
Electrophysiological Effects of NACOS and AVK on Pulmonary Veins and Left Atrium in Paroxysmal AF Catheter Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmias with a constantly growing prevalence AF. The purpose of paroxysmal AF processing is to control outbreaks from these pulmonary veins, medicated way (antiarrhythmic)…
- Trial name
- NACO-VP (NCT02814955)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Hypertension
Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation
The objective of this trial is to determine the role of renal sympathetic denervation in the prevention of atrial fibrillation (AF) recurrence in patients with hypertension for whom a catheter-based AF ablation procedure is…
- Trial name
- ERADICATE--AF (NCT01873352)
- Testing
- catheter ablation, renal sympathetic denervation
- Where
- 2 sites in United States, Russia
- Volunteers
- 302 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation
Tracking Results of Ablations to Combat AF Registry Generation 2
The primary objective of the TRAC-AF Registry is to capture real-world safety and effectiveness data on AtriCure devices used to conduct open concomitant and/or hybrid ablation, and management of the LAA concomitant to a cardiac…
- Trial name
- TRAC-AF (NCT05111015)
- Testing
- Open Concomitant Surgical Ablation Procedures, Hybrid (Convergent) Ablation Procedures, AtriCure Hybrid Totally Thoracoscopic Ablation Procedures
- Where
- 29 sites in United States, Austria and 1 more
- Volunteers
- 10,000 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation, Paroxysmal, Atrial Fibrillation, Persistent
MultiPulse Therapy (MPT) for AF
Assess the clinical safety and feasibility of MultiPulse Therapy (MPT) electrical stimulation waveform sequence in terminating paroxysmal and persistent atrial fibrillation.
- Conditions
- Atrial Fibrillation, Paroxysmal, Atrial Fibrillation, Persistent, Atrial Fibrillation
- Trial name
- NCT04206917
- Testing
- Multi Pulse Therapy
- Where
- 6 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Cardialen, Inc.
Atrial Fibrillation
Strategies in Patients Undergoing Repeat AF Ablation
The aim of the proposed research project is to compare the efficacy of three different ablation strategies in patients with atrial fibrillation (AF) who are undergoing their first repeat catheter ablation for recurrent AF.
- Trial name
- TRAP-AF (NCT05185310)
- Testing
- Ablation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation, Arterial Hypertension
Comparison of Redo PVI With vs. Without Renal Denervation for Recurrent AF After Initial PVI
The objective of this study is to compare the elimination of atrial fibrillation in patients with recurrent atrial fibrillation despite prior pulmonary vein isolation (PVI) when undergoing repeat PVI (control) vs repeat PVI plus…
- Trial name
- NCT01959997
- Testing
- Redo PVI, PVI + RDN
- Where
- 2 sites in United States, Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Heart Failure, Coronary Heart Disease (CHD)
Reliability of Multiple-Repetition-Maximum Tests in Patients With Cardiovascular Disease or Risk Factors
Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important.
- Conditions
- Heart Failure, Coronary Heart Disease (CHD), Atrial Fibrillation (AF), Diabetes Mellitus
- Trial name
- NCT06796582
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Atrial Fibrillation, Cerebrothromboembolus
Anticoagulation in AF Ablation and Effects on Neurocognitive Function
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States, and treatment by AF ablation is quickly becoming the favored definitive therapy.
- Conditions
- Atrial Fibrillation, Cerebrothromboembolus, Neurocognitive Function
- Trial name
- NCT02120560
- Testing
- Atrial Fibrillation Ablation
- Where
- United States
- Sponsor
- University of California, San Francisco
Atrial Fibrillation
Does VoltagE Guided Additional Ablation Improve Procedural Outcome of Atrial Fibrillation Ablation?
This study is designed to investigate whether pulmonary vein isolation(PVI) plus stepwise additional ablation approach based on the degree of low voltage area versus PVI only can improve procedure outcome in persistent atrial…
- Trial name
- NCT03377751
- Testing
- Additional posterior wall isolation, Voltage-guided substrate homogenization, PVI only group
- Where
- 3 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Korea University Guro Hospital
Cardiovascular Diseases, Coronary Artery Disease
AI-Powered Electrocardiography for Diagnosis and Prognostic Prediction in Cardiovascular Disease (AI-CVD): Multicenter Retrospective Study
This multicenter retrospective study aims to develop, validate, and clinically apply an artificial intelligence (AI)-powered electrocardiography (ECG) algorithm for the diagnosis and prognostic prediction of cardiovascular…
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Heart Failure, Atrial Fibrillation (AF)
- Trial name
- AI-CVD (NCT07856472)
- Testing
- Retrospective ECG Data Analysis
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Inha University Hospital
Atrial Fibrillation (AF), Stroke (in Patients With Atrial Fibrillation)
DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial
People with atrial fibrillation who have a stroke while receiving a DOAC are at increased risk of experiencing another stroke. Physicians do not know the best medication to prevent another stroke in this group of people.
- Trial name
- SWITCH-AF (NCT07011095)
- Testing
- VKA, Direct Oral Anticoagulant (DOAC)
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute