Clinical trials: Atrial Fibrillation Ablation
Atrial Fibrillation
High Power vs Standard Power RF Ablation of Atrial Fibrillation in Conscious Patients
High RF energy ablation of atrial fibrillation is fast, safe, less painful and effective procedure.
- Trial name
- HPvSP-AF (NCT04250181)
- Testing
- RF ablation of atrial fibrillation
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Lublin
Atrial Fibrillation Recurrent
Pulmonary Vein (PV) Imaging by Intracardiac Echography (ICE) After Ablation
To test the hypothesis that structural changes documented by ICE after pulmonary vein deconnection by RF can predict AF recurrences
- Trial name
- NCT05781282
- Testing
- Atrial fibrillation ablation
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atrial Fibrillation, Atrial Flutter
Evaluation of the Amigo Robotic System for Ablation of the Cavo-Tricuspid Isthmus
The purpose of this study is to compare standard manual and robotically controlled catheter ablation of the cavo-tricuspid isthmus (CTI) as a treatment for atrial flutter.
- Trial name
- Amigo-AFL (NCT02467179)
- Testing
- Amigo™ Robotic Catheter Manipulation, Manual Catheter Manipulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Paroxysmal Atrial Fibrillation
Study of Statin for Reduction of Postoperative Paroxysmal Atrial Fibrillation
The study will select all recruited patients with paroxysmal atrial fibrillation will be randomly allocated to receive oral rosuvastatin 20mg/day or blank control from 7 days before ablation and last for 3 months.
- Trial name
- NCT02502110
- Testing
- rosuvastatin
- Volunteers
- 346 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Atrial Fibrillation Paroxysmal, Cardiac Ablation
NS-PFA Catheter Ablation of Paroxysmal Atrial Fibrillation With the Pulse Biosciences CellFX System
The objective of this study is to demonstrate the safety and effectiveness of the CellFX nano-second Pulsed Field Ablation (nsPFA) Cardiac Catheter Ablation System in treating recurrent, drug-resistant, symptomatic paroxysmal…
- Conditions
- Atrial Fibrillation Paroxysmal, Cardiac Ablation, Cardiac Arrhythmia
- Trial name
- NANOPULSE-AF (NCT07018596)
- Testing
- CellFX nsPFA Cardiac Catheter System
- Where
- Czechia
- Volunteers
- 215 people
- Sponsor
- Pulse Biosciences, Inc.
Ventricular Tachycardia, Atrial Fibrillation
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
To use programmed ventricular stimulation at the time of AF ablation to define the prevalence and mechanism of inducible ventricular tachycardia (VT); pace-mapping to define the site of origin of ventricular arrhythmias; and…
- Trial name
- NCT06647459
- Testing
- EP Study
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure, Atrial Fibrillation
Heart Rate Regularization in Atrial Fibrilation and Heart Failure
The PACE-FIB trial is a multicentre, randomised, open-label clinical trial. Patients older than 18 years, with permanent AF, LVEF>40%, average resting heart rate ≤ 110 beats per minute (bpm), at least one hospitalisation due to…
- Trial name
- PACE-FIB (NCT05029570)
- Testing
- Conduction System Pacing (pacemaker implantation)
- Where
- Spain
- Volunteers
- 334 people
- Sponsor
- Daniel Rodríguez Muñoz
Persistent Atrial Fibrillation
Using a Novel Balloon-shaped Large-Focal Pulsed Field Ablation Catheter in Persistent Atrial Fibrillation
This clinical trial aims to evaluate the safety and effectiveness of pulmonary vein isolation (PVI) and linear ablation using a large-focal pulsed field ablation (PFA) catheter in patients with persistent atrial fibrillation…
- Trial name
- PFApple-Per AF (NCT07294742)
- Testing
- a novel Balloon-shaped Large-Focal Pulsed Field Ablation Catheter
- Where
- China
- Volunteers
- 34 people
- Sponsor
- The Third People's Hospital of Chengdu
Persistent Atrial Fibrillation
Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
This is a pilot study to assess the usefulness of ECG mapping, and enhanced MRI and PET scan imaging in identifying atrial fibrosis and arrhythmia circuits involved in persistent atrial fibrillation and in guiding an innovative…
- Trial name
- COAST-AF (NCT02184013)
- Testing
- Catheter ablation
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation, Heart Failure
AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study
The purpose of this study is to determine whether early atrioventricular node (AVN) ablation with pacing device therapy will reduce death and hospitalization when compared to the conventional drug therapy in elderly patients with…
- Trial name
- PACIFIC (NCT00589303)
- Testing
- FDA approved rate and rhythm control drugs, AV Node ablation and device implant
- Where
- 6 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation, Thromboembolism
Investigation on Appropriate Duration of Dabigatran Use After Catheter Ablation for Paroxysmal Atrial Fibrillation in Patients With Low Thromboembolic Risk
The purpose of this study is to investigate the appropriate duration of dabigatran use after radiofrequency catheter ablation for paroxysmal atrial fibrillation in patients with low thromboembolic risk.
- Trial name
- NCT02313584
- Testing
- dabigatran
- Volunteers
- 464 people
- Sponsor
- Korea University
Atrial Fibrillation, Arrhythmias, Cardiac
Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people in the US and around the world. Over the last 20 years, catheter based AF ablation has been widely adopted offering improved symptom…
- Trial name
- PRECAF (NCT03646643)
- Testing
- Standard Atrial fibrillation ablation, Coronary sinus to left atrium connection elimination
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation
Long-Term Evaluation of TAILORED Vs Anatomical Ablation Strategy for Persistent Atrial Fibrillation
The TAILORED-LT study is conducted as an extension follow-up until 5 years of the initial TAILORED-AF study (NCT04702451), in order to demonstrate the long-term superiority in terms of freedom of atrial fibrillation (AF) of a…
- Trial name
- TAILORED-LT (NCT06825104)
- Testing
- Volta AF-Xplorer, Dispersion ablation + PVI, PVI
- Where
- 13 sites in France, Germany
- Volunteers
- 278 people
- Sponsor
- Volta Medical
Atrial Fibrillation, Atrial Fibrillation, Persistent
Left Roof Linear, Mitral Isthmus Linear and Left Anterior Septal Linear Ablation for Non-paroxysmal AF: PROMISED Trial.
The purpose of this prospective randomized study is to assess whether a new treatment strategy consisting of circumferential Pulmonary vein isolation (PVI), left ROof linear (RL), Mitral Isthmus linear (MIL), and left anterior…
- Trial name
- NCT06249347
- Testing
- PROMISED, CPVI and LAAC, Radiofrequency ablation catheter
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Atrial Fibrillation, Femoral Vein Injury
Haemostasis After Venous Access in Atrial Fibrillation Catheter Ablation: The HARNESS Trial
Atrial fibrillation (AF) is the most common heart rhythm disorder affecting adults in the United Kingdom. In patients with AF who continue to experience symptoms despite medications, catheter ablation is an established…
- Conditions
- Atrial Fibrillation, Femoral Vein Injury, Bleeding
- Trial name
- HARNESS (NCT06470555)
- Testing
- A figure-of-eight suture secured with a three-way tap, Shortened bed rest duration of 2-hours, Manual compression
- Where
- United Kingdom
- Volunteers
- 336 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation
Safety & Performance of the Centauri System for Patients With Atrial Fibrillation
This is a prospective, single-arm, open-label clinical study following patients to 1 year, to evaluate the safety and performance of the Centauri system for catheter ablation of atrial fibrillation (AF).
- Trial name
- SPACE AF (NCT04652778)
- Testing
- Pulsed Field Ablation (PFA) using the Centauri System
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Galaxy Medical, Inc.
Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction
CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction)
The clinical equipoise in the treatment of Atrial Fibrillation (AF) in patients with Heart Failure with mildly reduced Ejection Fraction/Heart Failure with Preserved Ejection Fraction (HFmrEF/HFpEF) reflects the scarcity of…
- Trial name
- NCT07254455
- Testing
- Catheter ablation
- Volunteers
- 900 people
- Sponsor
- Tulane University
Atrial Fibrillation (AF), Persistant Atrial Fibrillation
A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation
The purpose of this study is to establish the safety of the pulsed field ablation (PFA) therapy of Pulmonary Veins and Electrographic Flow (EGF) identified extra-PV sources of atrial fibrillation (PVI + EGF ablation of sources)…
- Trial name
- OPTIMIZE (NCT07187115)
- Testing
- FARAPOINT Pulsed Field Ablation System, OptiMap System (non-ablative), FARAPULSE Pulsed Field Ablation (PFA) System and Opal HDx Mapping System
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 699 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation (AF)
Tele-Rehabilitation After Catheter Ablation in Patients With Atrial Fibrillation
This study aims to investigate the effects of remotely supervised cardiac telerehabilitation in patients with atrial fibrillation who have undergone catheter ablation.
- Trial name
- NCT07808307
- Testing
- Remotely Supervised Cardiac Telerehabilitation, Usual Care and General Exercise Guidance
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Hande Cörüt
Atrial Fibrillation
RF Ablation of Atrial Fibrillation
This is an early feasibility trial designed to demonstrate whether a new ablation device can be used safely and effectively in treating atrial fibrillation.
- Trial name
- NCT00265629
- Testing
- RF catheter ablation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- C. R. Bard