Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation, Atrial Flutter
Feasibility Study for Optically Guided Radiofrequency Ablation Catheter
Clinical study intended to evaluate the feasibility of a new irrigated RF ablation catheter that allows the physiologist to perform a regular RF ablation procedure while it is being monitored through an imaging technique known as…
- Trial name
- NEOVIEW (NCT03589742)
- Testing
- AblaView® Ablation Catheter
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Medlumics
Atrial Fibrillation or Atrial Flutter
Multipolar Mapping and Atrial Arrhythmias
This clinical investigation utilizes the Constellation Full Contact Mapping catheter in the left and right atria to explore atrial signal characteristics that can guide atrial fibrillation and atrial flutter ablation procedures…
- Trial name
- NCT02307188
- Testing
- Constellation Full Contact Mapping Catheter
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Angelo Biviano
Atrial Fibrillation
Safety & Clinical Performance Study of Catheter Ablation With the Centauri System for Patients With Atrial Fibrillation
This study is a prospective, single-arm, open-label study following patients to 1 year, to evaluate the safety and performance of the Centauri System for catheter ablation of atrial fibrillation (AF).
- Trial name
- ECLIPSE AF (NCT04523545)
- Testing
- cardiac ablation
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Galaxy Medical, Inc.
Atrial Fibrillation
Characterization and Elimination of Mother Rotors
Recent clinical studies have shown that atrial fibrillation (AF) in humans might be sustained by localized sources called "mother rotors" which exhibit persistent, fast, and well organized activity during AF and play an important…
- Trial name
- CENTRA-AF (NCT01924377)
- Testing
- standard circumferential pulmonary vein isolation by radiofrequency ablation catheter, CPVI + rotors' identification and ablation
- Where
- Italy
- Sponsor
- Maria Cecilia Hospital
Persistent Atrial Fibrillation
Norwegian Study of Persistent Atrial Fibrillation Treatment: Cryoballoon Versus Radiofrequency Catheter Ablation
This study will compare efficacy and safety of pulmonary vein isolation using a cryoballoon catheter versus a radiofrequency ablation with a contact force sensing catheter for treatment of patients with persistent or longstanding…
- Trial name
- NO PERS-AF (NCT03008811)
- Testing
- Pulmonary vein isolation with cryoballoon catheter., Pulmonary vein isolation with radiofrequency ablation.
- Where
- 3 sites in Norway
- Volunteers
- 101 people
- Sponsor
- Haukeland University Hospital
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Outcomes of an Optimized Workflow With PulseSelect Pulsed Field Ablation (PFA) System in Paroxysmal and Persistent Atrial Fibrillation
The NEXT PULSE study is a pre-market, prospective, multi-center, non-randomized, interventional clinical study. Adult subjects with symptomatic paroxysmal or persistent AF who provided consent will be enrolled and treated with…
- Trial name
- NEXT PULSE (NCT07575828)
- Testing
- PulseSelect Pulse Field Ablation (PFA) System
- Volunteers
- 320 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation (AF)
Feasibility, Safety, Cost-effectiveness, and Environmental Impact of Reprocessed Ablation Catheters in PVI
This study evaluates whether re-sterilized (reprocessed) ablation catheters are as effective and safe as new ablation catheters when used for pulmonary vein isolation in patients with atrial fibrillation.
- Trial name
- RE-USE PVI (NCT07389434)
- Testing
- Participants will undergo pulmonary vein isolation using pulsed field ablation (PFA). The intervention consists of the use of either a reprocessed electroporation ablation catheter or a new electropor
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University Hospital Dubrava
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF)
Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure
Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardiovascular epidemics, individually impairing quality of life and cardiac performance, as well as increasing the risk of hospitalisation and mortality.
- Trial name
- OPTIMal AF-HF (NCT07238452)
- Testing
- Pulmonary Vein Isolation, Pharmacological Rate Control
- Volunteers
- 1,050 people
- Sponsor
- University of British Columbia
Atrial Fibrillation
Exercise-based Cardiac Rehabilitation for Atrial Fibrillation
The investigators aim to conduct a pilot randomised controlled trial (RCT) with embedded feasibility study to evaluate an exercise-based cardiac rehabilitation (ExCR) programme when delivered to patients with atrial fibrillation…
- Trial name
- ExCR-AF (NCT06401148)
- Testing
- Cardiac rehab intervention group
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Liverpool John Moores University
Persistent Atrial Fibrillation
Individualised Mapping in Persistent AF Ablation
A clinical randomised trial to compare strategies for ablation in persistent and long-standing persistent atrial fibrillation comprising of two arms: pulmonary veins isolation (PVI) only and PVI + individualised mapping-guided…
- Trial name
- IMAGE AF (NCT05065112)
- Testing
- Pulmonary veins isolation + Cartofinder-guided ablation, Pulmonary veins isolation
- Volunteers
- 212 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Persistent Atrial Fibrillation
Left Atrial Isolation by Catheter Ablation in Persistent Atrial Fibrillation With Severe Atrial Fibrosis
This is a single-arm clinical trial evaluating the efficacy and safety of left atrial isolation achieved by catheter ablation in patients with persistent atrial fibrillation with severe atrial fibrosis.
- Trial name
- NCT05173779
- Testing
- Left atrial isolation by catheter ablation
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System
This is a prospective, multicenter, randomized clinical evaluation of the Sphere-9 Mapping and Ablation Catheter with the Affera Mapping and Ablation System.
- Trial name
- SPHERE Per-AF (NCT05120193)
- Testing
- Mapping and Ablation
- Where
- 23 sites in United States, Czechia and 1 more
- Volunteers
- 477 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Migraine, Atrial Fibrillation
Effect of Catheter Ablation on Clinical Course of Migraine in AF Patients With or Without Previous History of Migraine
The purpose of this prospective study is to evaluate the effect of catheter ablation on incidence, prevalence and disease-severity of migraine in AF patients undergoing ablation, with or without a history of migraine.
- Trial name
- CONFIRM (NCT01391091)
- Testing
- Radiofrequency catheter ablation
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation (AF)
Assessment of Pulmonary Vein Isolation Using a Balloon Catheter With Pulsed Field Energy in Atrial Fibrillation
The goal of this clinical trial is to evaluate whether pulsed field ablation (PFA) using the novel VOLT catheter is as safe and effective as conventional thermal ablation (radiofrequency or cryotherapy) for the treatment of…
- Trial name
- ILLUMINATE-AF (NCT07156877)
- Testing
- Pulsed Field Ablation (PFA) with VOLT Catheter, Thermal Ablation (Radiofrequency or Cryoablation)
- Where
- 2 sites in Belgium
- Volunteers
- 136 people
- Sponsor
- Sebastien Knecht
Atrial Fibrillation
Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF
Atrial fibrillation (AF) is a very common arrhythmia causing many symptoms resulting in numerous hospitalizations. Catheter ablation is a technique that has evolved significantly to improve symptomatic recurrences, but does not…
- Trial name
- SMAC AF (NCT00438113)
- Testing
- Aggressive Blood Pressure control
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Nova Scotia Health Authority
Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent
Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation
A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrium; Fibrillation, Atrial Arrhythmia
- Trial name
- CLIP-AF (NCT06165510)
- Testing
- Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device., Standard Endocardial Catheter Ablation
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
Randomised Comparison of the Octaray and Pentaray Catheters
In this study we aim to compare the mapping performance in the left atrium of the established Pentaray catheter to the newer Octaray catheter.
- Trial name
- COPEC (NCT05988424)
- Testing
- Left atrial mapping
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Paroxysmal Atrial Fibrillation
Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Virtual Rotor Mapping and Catheter Ablation
Radiofrequency catheter ablation is effective in the treatment of patients with paroxysmal atrial fibrillation. In order to reduce the recurrence rate after catheter ablation, the investigators propose to apply 'virtual' ablation…
- Trial name
- CUVIA-AF II (NCT02558699)
- Testing
- physician's personal experience, Virtual rotor mapping
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Safety and Performance of the SpherePVI™ Catheter to Treat Paroxysmal Atrial Fibrillation
A prospective, single-arm, single-center study to evaluate the safety, performance, and effectiveness of the SpherePVI™ Catheter for treating paroxysmal AF.
- Trial name
- SpherePVI (NCT05144503)
- Testing
- SpherePVI™ Catheter
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Persistent Atrial Fibrillation Longstanding
Multitarget Pulse Field Ablation Guided by Endocardial and Non-invasive Atrial Driver Mapping (PFA+ADM) Pilot Study. Development of an Ablation Strategy to Improve the Efficacy of Long Standing Atrial Fibrillation Ablation in Patients With High Comorbidity Burden or Heart Failure
To assess the efficacy and safety of a percutaneous ablation strategy that targets multiple extrapulmonary structures as the Cox-Maze IV.
- Trial name
- PFA+ADM (NCT07118488)
- Testing
- Multitarget PFA Ablation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Innovacion en Biomedicina (FIBMED)