Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation, Paroxysmal Arrhythmia
NAVISTAR® THERMOCOOL® SF Catheter: Observational Study
This is a prospective, interventional, observational, unblinded, single-arm, multicenter registry of younger and older subjects with drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation.
- Trial name
- SFAF (NCT01585961)
- Testing
- Catheter Ablation (NAVISTAR® THERMOCOOL® SF Catheter)
- Where
- 45 sites in United States
- Volunteers
- 511 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
Left Atrium Substrate Based Ablation Plus Circumferential Pulmonary Vein Isolation to Treat Chronic Atrial Fibrillation
The purpose of this study is to determine whether left atrium substrate based ablation plus circumferential is effective in the treatment of persistent and long-standing atrial fibrillation.
- Trial name
- NCT01716143
- Testing
- radiofrequency catheter ablation
- Where
- China
- Volunteers
- 87 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation
PVAC GOLD Versus Irrigated RF Single Tip Catheter With Contact FORCE Ablation of the Pulmonary Veins for Treatment of Drug Refractory Symptomatic Paroxysmal and Persistent Atrial Fibrillation
The GOLD FORCE trial investigates the differences between treatment with a Contact Force single-tip catheter against the PVAC GOLD multielectrode catheter in cardiac ablation procedures in patients with paroxysmal atrial…
- Trial name
- GOLD-FORCE (NCT02463851)
- Testing
- PVAC GOLD multielectrode catheter, Contact Force single-tip ablation catheter
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 212 people
- Sponsor
- L.V.A. Boersma
Atrial Arrhythmia
Relationship Between the Posterior Atrial Wall and the Esophagus: Esophageal Position and Temperature MEasurement During Atrial Fibrillation Ablation.
A multimodal strategy integrating esophageal visualization with the multidetector computed tomography (MDCT) and simultaneous temperature monitoring has never been put into practice.
- Trial name
- AWESOME-AF (NCT04394923)
- Testing
- Modification of the pulmonary vein ablation line, Regular PVI ablation
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Centro Medico Teknon
Atrial Fibrillation
Assess Differences in Pain Following Cryo and Radiofrequency Atrial Fibrillation Ablation
The primary objective is to assess any differences in patient quality of life between Cryo Balloon ablation and Radiofrequency ablation in the treatment of atrial fibrillation.
- Trial name
- NCT03148392
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Sumit Verma, MD
Atrial Fibrillation, Arrhythmia
A Randomized Trial of the Ostial Versus the Extra-Ostial Ablation Strategy for Atrial Fibrillation
Both segmental, ostial and circumferential, extra-ostial pulmonary vein (PV) isolation have been proven effective in the treatment of atrial fibrillation.
- Trial name
- NCT00192972
- Testing
- Catheter ablation (pulmonary vein isolation)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Atrial Fibrillation
Catheter Ablation of Atrial Fibrillation Using Hansen Medical Robotic Navigation
Atrial fibrillation (AF) affects as many as 1 in 100 people and reduces the quality of life of large numbers of people in the UK and around the world.
- Trial name
- Hansen (NCT01037296)
- Testing
- catheter ablation
- Where
- United Kingdom
- Volunteers
- 166 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation, Atrial Flutter
Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System for Treatment of Atrial and Ventricular Arrhythmias
A prospective, single-arm, multi-center, safety and performance assessment of the Sphere-9™ Catheter and the Affera Mapping and RF Ablation System to treat Atrial Arrhythmias
- Conditions
- Atrial Fibrillation, Atrial Flutter, Ventricular Tachycardia
- Trial name
- NCT04211441
- Testing
- Catheter mapping and ablation with the Sphere-9 Catheter and Affera Mapping and Ablation System
- Where
- 2 sites in Czechia
- Volunteers
- 74 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation
320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.
This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation.
- Trial name
- NCT06308094
- Testing
- CT
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Persistent Atrial Fibrillation
FIH Study of PFLotus in Persistent Atrial Fibrillation
Single-shot pulsed-field ablation (PFA) catheters maximize pulmonary vein isolation (PVI) efficiency but are limited for focal or linear ablation.
- Trial name
- PFLotus- FIH (NCT07301190)
- Testing
- Pulse field ablation with the PFLotus catheter
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Third People's Hospital of Chengdu
Atrial Fibrillation Recurrent, Pulmonary Venous Isolation
Dapagliflozin to Prevent Atrial Fibrillation Recurrence After Transcatheter Pulmonary Venous Isolation.
Transcatheter left atrial antral ablation, aiming at complete electrical isolation of the pulmonary veins (PVI), has become mainstay in atrial fibrillation (AF) treatment.
- Conditions
- Atrial Fibrillation Recurrent, Pulmonary Venous Isolation, Catheter Ablation, Sodium-glucose Co-transporter 2 Inhibitors
- Trial name
- NCT04780438
- Testing
- Dapagliflozin
- Where
- 2 sites in Greece
- Volunteers
- 350 people
- Sponsor
- G.Gennimatas General Hospital
Atrial Fibrillation, Atrial Remodeling
High-density Mapping-guided bOx Isolation and subsTrate Ablation
This study evaluates the efficacy of high-density mapping guided atrial substrate ablation for persistent atrial fibrillation. 1/5 of the patients with persistent atrial fibrillation undergo pulmonary veins isolation, 2/5 of them…
- Trial name
- HOT (NCT03998956)
- Testing
- CPVI, CPVI+BOX, CPVI+BOX+SUB
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Persistent Atrial Fibrillation
PFLotus With the DePolar Mapping System in Patients With Persistent Atrial Fibrillation
This clinical trial aims to evaluate the safety and efficacy of pulmonary vein isolation (PVI), focal, and linear ablation in patients with persistent atrial fibrillation (PersAF) using a novel shape-adaptive pulsed field…
- Trial name
- NCT07321002
- Testing
- Ablation with the PFLotus catheter and Depolar system
- Volunteers
- 35 people
- Sponsor
- The Third People's Hospital of Chengdu
Paroxysmal Atrial Fibrillation
IMPACT: A Safety and Feasibility Study of the IOWA Approach Cardiac Ablation System
IMPACT is a prospective, single-arm, multi-center, safety and feasibility study evaluating the IOWA Approach Cardiac Ablation System (FARAPULSE, Inc.) for the treatment of paroxysmal atrial fibrillation.
- Trial name
- IMPACT (NCT03700372)
- Testing
- IOWA Approach Cardiac Ablation System
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Boston Scientific Corporation
Arterial Hypertension, Atrial Fibrillation
Combined Treatment of Arterial Hypertension and Atrial Fibrillation
The purpose of this study is the comparative evaluation of systolic blood pressure (SBP) lowering, atrial fibrillation (AF) recurrence and clinical data in patients with paroxysmal/persistent AF and resistant/non-resistant…
- Trial name
- NCT01897545
- Testing
- Circumferential PV isolation, PV isolation+renal denervation
- Where
- 3 sites in United States, Greece and 1 more
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation
The Automated Calculation of AF Cycle Length and Complexity Using a Novel EP Recording System
Collect electrophysiological data during atrial fibrillation (AF) ablation procedures to assess the performance of a Signal Complexity Visualization algorithm designed to be integrated into the CathVision ECGenius® System.
- Trial name
- NCT05477602
- Testing
- Cardiac Ablation for the treatment of persistent Atrial Fibrillation
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- CathVision ApS
Heart Diseases, Arrhythmia
NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation
This trial compares the safety and effectiveness of catheter ablation for PAF with antiarrhythmic drug therapy. The investigational catheter being studied is the NAVISTAR® THERMOCOOL® irrigated-tip catheter.
- Conditions
- Heart Diseases, Arrhythmia, Atrial Fibrillation
- Trial name
- Afib IDE (NCT00116428)
- Testing
- NAVISTAR® THERMOCOOL® Catheter, Antiarrhythmic drug
- Where
- 17 sites in United States, Brazil and 3 more
- Volunteers
- 167 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
A New Theory of Electrophysiological Mechanism of Atrial Fibrillation
The electrophysiological mechanisms of atrial fibrillation remain disagreements. The goal of this clinical trail is to propose a new electrophysiological mechanism hypothesis of atrial fibrillation（AF）,meanwhile, the…
- Trial name
- ANTEMAF (NCT05845034)
- Testing
- PVI + SPEs ablation, PVI ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Atrial Fibrillation, Radiofrequency Catheter Ablation
Use of Radiofrequency Ablation to Eliminate Continuous Atrial Fibrillation in Patients Undergoing Mitral Valve Surgery
The aim of this prospective randomized clinical trial was to evaluate the early and late outcome following left atrial radiofrequency ablation during MV surgery for the treatment of continuous atrial fibrillation and to assess…
- Trial name
- NCT00238706
- Testing
- Radiofrequency ablation
- Sponsor
- University Hospitals, Leicester
Paroxysmal Atrial Fibrillation
THERMOCOOL SMARTTOUCH®SF Catheters With Ablation Index Study
A single-center, real word study of consecutive subjects who undergo radiofrequency ablation for paroxysmal AF using THERMOCOOL SMARTTOUCH®SF (STSF) Catheter guiding by Ablation Index (AI).
- Trial name
- STSF (NCT03963349)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Biosense Webster, Inc.