Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation (AF), Arrhythmia
Relaxin Therapy for Atrial Fibrillation
Atrial fibrillation (AF) is the most common heart rhythm disorder. The presence of AF increases the risk of death and is associated with a 5-6-fold increase in stroke incidence, due almost exclusively to thrombus formation in the…
- Conditions
- Atrial Fibrillation (AF), Arrhythmia, Oxidative Stress, Stroke
- Trial name
- Relax-in-AF (NCT07359872)
- Testing
- Relaxin
- Volunteers
- 208 people
- Sponsor
- Deeptankar DeMazumder
Atrial Fibrillation
Isolation of Pulmonary Veins With the Aid of Magnetic Resonance Imaging
The ALICIA-FA study will elucidate whether targeting atrial myocardial fibrosis identified by late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) improves atrial fibrillation (AF) ablation outcomes.
- Trial name
- ALICIA (NCT02698631)
- Testing
- Conventional AF ablation, LGE-MRI guided AF ablation
- Where
- 2 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Hospital Clinic of Barcelona
Pericardial Effusion
Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion
The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.
- Trial name
- NCT02260206
- Testing
- Colchicine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yong Seog Oh
Atrial Fibrillation
Impact of Anxiety on Cardiac Substrate Modification in Women With Atrial Fibrillation Undergoing Catheter Ablation
This pilot study aims to assess the impact of anxiety on the cardiac substrate remodeling in female patients with paroxysmal and persistent atrial fibrillation (AF).
- Trial name
- AWARE (NCT02547584)
- Testing
- Catheter ablation
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation, Insulin Resistance
Insulin Resistance as a Predictor of Pulsed Field Ablation Success in Atrial Fibrillation (HOMA-PULSE)
This study investigates whether insulin resistance, a metabolic condition where the body's cells respond poorly to insulin, can predict the success of atrial fibrillation (AF) ablation using pulsed field ablation (PFA)…
- Conditions
- Atrial Fibrillation, Insulin Resistance, Catheter Ablation, Artificial Intelligence
- Trial name
- HOMA-PULSE (NCT07551947)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Persistent Atrial Fibrillation
The Study for Evaluate of Safety and Efficacy of Vein of Marshall RF Ablation
The goal of this clinical trial is to evaluate the initial safety and effectiveness of an investigational medical device. Electrode catheter ablation of the Marshall vein is performed using TIRA, a clinical trial medical device…
- Trial name
- NCT05854238
- Testing
- TIRA-VoM
- Where
- 2 sites in South Korea
- Volunteers
- 4 people
- Sponsor
- Tau-MEDICAL Co., Ltd.
Atrial Fibrillation, Pulsed Field Ablation
A Registry on the FARAVIEW Technology of the OPAL HDx Mapping System When Used With the FARAWAVE NAV Ablation Catheter in the Treatment of Atrial Fibrillation
The study is designed to collect data on the acute and long-term (1 year) safety and effectiveness outcome when an ablation procedure is performed in a commercial and standard of care setting with the FARAPULSE™ Pulsed Field…
- Conditions
- Atrial Fibrillation, Pulsed Field Ablation, FARAPULSE
- Trial name
- OPALISE (NCT06808217)
- Testing
- FARAPULSE Pulsed Field Ablation System
- Where
- 22 sites in Austria, France and 8 more
- Volunteers
- 550 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation (AF), Atrial Tachycardia
Conduction Breakthrough in the Coronary Sinus Post Endocardial Mitral Isthmus Ablation
The goal of this observational study is to learn more about how doctors can create a complete electrical block in the heart during catheter ablation procedures used to treat certain abnormal heart rhythms.
- Conditions
- Atrial Fibrillation (AF), Atrial Tachycardia, Paroxysmal AF, Persisent Atrial Fibrillation
- Trial name
- COSMIC (NCT07889440)
- Volunteers
- 50 people
- Sponsor
- Sebastien Knecht
Atrial Fibrillation, Aldosterone
Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study)
Atrial fibrillation (AF) is the most common cardiac arrhythmias with a constantly growing prevalence. Two main techniques are used today to restore sinus rhythm: electrical cardioversion and radiofrequency ablation.
- Trial name
- ALDO-AF (NCT02804321)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Caen
Chronic Atrial Fibrillation, Persistent Atrial Fibrillation
Comparison of Two Pulmonary Vein Ablation Techniques for Persistent AF
Investigator initiated, randomized controlled trial of two radiofrequency (RF)ablation protocols currently performed in the electrophysiology lab, but have not been studied prospectively to identify which, if either technique, is…
- Trial name
- NCT03295422
- Testing
- RF ablation PVI alone, RF ablation PVI plus LPAW
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Sequoia Hospital
Atrial Fibrillation
PROSPective Evaluation of Outcome After CatheTer Ablation in Atrial Fibrillation
Atrial fibrillation ablation is the most common intervention performed worldwide. Up to 20 to 45% of patients show recurrence of AF within 12 month after catheter ablation, however its determinant are incompletely understood.
- Trial name
- PROSPECT-AF (NCT05009797)
- Testing
- atrial fibrillation catheter ablation
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Lille
Paroxysmal Atrial Fibrillation
EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation
Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).
- Trial name
- EXCLAMATORY (NCT06212791)
- Testing
- Self- Report Evaluation-Duke Activity Status Index, Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire, Cardiopulmonary exercise test (CPET)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Atrial Fibrillation
Effects of Fish Oil on Post Ablation Arrhythmias
To determine if peri-operative treatment with omega-3 fatty acids is associated with a decrease in the incidence of early recurrences of atrial arrhythmias (within 30 days) and an improvement in probability of long-term…
- Trial name
- NCT00791089
- Testing
- LOVAZA Omega 3-acid ethyl esters, LOVAZA
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Persistent Atrial Fibrillation
Catheter Ablation Therapy for Persistent Atrial Fibrillation
Use of catheter ablation for persistent atrial fibrillation (PerAF) remains controversial due to unsatisfactory long-term success rates (15% - 28.4%).
- Trial name
- CLEAR-AF (NCT02892162)
- Testing
- Additional LAAW linear ablation
- Where
- China
- Volunteers
- 214 people
- Sponsor
- China National Center for Cardiovascular Diseases
Vagal Nerve Stimulation, Autonomic Nervous System
Vagal Response and Cardiac Autonomic Modulation. Insides From Cryoballoon Ablation
The investigators sought to evaluate the incidence and influence of vagal response observed during cryoballoon-based pulmonary vein isolation on the cardiac autonomic nervous system (CANS) and ablation outcomes in paroxysmal…
- Conditions
- Vagal Nerve Stimulation, Autonomic Nervous System, Catheter Ablation
- Trial name
- NCT04896424
- Testing
- cryoballoon-based pulmonary veins isolation
- Volunteers
- 296 people
- Sponsor
- Pomeranian Medical University Szczecin
Atrial Fibrillation
Catheter Ablation Versus Antiarrythmic Drugs for Atrial Fibrillation in China
The mainstay of treatment for atrial fibrillation remains pharmacological;however,catheter ablation has increasingly been used over the last decades. The relative merits of each strategy have not been extensively studied.
- Trial name
- NCT01341353
- Testing
- catheter ablation, Digaoxin,amiodarone,β receptor antagonist, Calcium Antagonists
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Wuhan University
Coagulation; Intravascular
Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation
Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important. Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial…
- Trial name
- COHERE (NCT01935557)
- Testing
- Continuous heparin infusion, Intermittent heparin infusion
- Where
- South Korea
- Volunteers
- 296 people
- Sponsor
- Yong Seog Oh
Atrial Fibrillation, Fibrosis
Efficacy of Delayed Enhancement MRI-Guided Ablation vs Conventional Catheter Ablation of Atrial Fibrillation
This proposal is aiming at modifying and improving persistent AF management guidelines by evaluating targeting DE-MRI detected atrial fibrosis during AF ablation and its related effect on procedural outcome.
- Trial name
- DECAAFII (NCT02529319)
- Testing
- MRI-Guided Ablation, Conventional Ablation
- Where
- United States
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Medicine
Atrial Fibrillation
Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation
There is a need to compare the efficacy of PVI versus PVI plus catheter ablation, which includes ablation of complex fractionated atrial electrograms (CFAE) and linear lesions in the same procedure.
- Trial name
- NCT03115554
- Testing
- PVI Plus Catheter Ablation, PVI Alone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Persistent Atrial Fibrillation
Feasibility Study of the FARAPULSE™ Cardiac Ablation System Plus in the Treatment of Persistent Atrial Fibrillation(PersAFOne II)
The objective of this safety and feasibility study is to assess whether the endocardial creation of electrically nonconductive lesions via PEF catheter ablation applied using the FARAPULSE Cardiac Ablation System Plus is a…
- Trial name
- PersAFOne II (NCT05152966)
- Testing
- Ablation
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Boston Scientific Corporation