Clinical trials: Atrial Fibrillation Catheter Ablation
Arrhythmias, Cardiac, Paroxysmal Atrial Fibrillation
InsightPFA Trial of the LotosPFA Catheter
This trial aims to determine whether the InsightPFA for PVI is as effective and safe as standard RFA in the treatment of symptomatic paroxysmal AF.
- Trial name
- InsightPFA (NCT06014996)
- Testing
- Pulsed Field Ablation (PFA) Therapy, Radiofrequency Ablation（RAF）Therapy
- Where
- 10 sites in China
- Volunteers
- 292 people
- Sponsor
- Insight Medtech Co., Ltd.
Atrial Fibrillation, Stroke
Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial
This trial is comparing medical approaches for stroke prevention in people who have atrial fibrillation (AF) and have undergone a successful procedure called ablation to eliminate or substantially reduce the arrhythmia.
- Trial name
- OCEAN (NCT02168829)
- Testing
- Rivaroxaban, Acetylsalicylic acid
- Where
- 55 sites in Australia, Belgium and 4 more
- Volunteers
- 1,284 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Real-world Experience of Catheter Ablation Using Novel Ablation Technologies for the Treatment of Atrial Fibrillation
The primary purpose of this registry is to obtain real-world clinical experience for the latest and future ablation technologies when used in conjunction with the Carto system in the treatment of patients with atrial fibrillation…
- Trial name
- NOVEL AF (NCT05006456)
- Testing
- Catheter ablation
- Volunteers
- 4,000 people
- Sponsor
- Beijing Anzhen Hospital
Esophageal Diseases
Improving Oesophageal Protection During AF Ablation
Catheter ablation is an established treatment for atrial fibrillation (AF). For those with the more longstanding form of the condition and are graded as longstanding persistent AF, catheter ablation techniques often involve an…
- Trial name
- IMPACT (NCT03819946)
- Testing
- esophageal cooling device (Attune Medical, Chicago, IL), Standard esophageal temperature probe
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- St. George's Hospital, London
Atrial Fibrillation
RandOmised Controlled Trial of STAR Mapping™ Guided Ablation for AF.
Atrial fibrillation (AF) is the most common arrhythmia with an expected rise in prevalence over the next decade. Beyond causing troublesome symptoms AF is associated with increased mortality and morbidity.
- Trial name
- ROC-STAR (NCT04442113)
- Testing
- Pulmonary vein isolation plus ablation guided by novel STAR mapping™, Pulmonary vein isolation
- Sponsor
- Rhythm AI Ltd
Persistent Atrial Fibrillation
Catgut Embedding in Acupoints on Treating Persistent Atrial Fibrillation After Catheter Ablation
This is a multi-center, 2-arm, assessor and statistician blinded, pilot randomized controlled trial, to evaluate the effect of catgut embedding in acupoints of Neiguan and Zusanli in reducing early recurrence and improving…
- Trial name
- NCT05125042
- Testing
- Amiodarone hydrochloride tablet + acupoint catgut embedding, Amiodarone hydrochloride tablet
- Volunteers
- 120 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation (AF)
Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation
The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF).
- Trial name
- DESTINATION (NCT06615596)
- Testing
- discontinue anticoagulation therapy, Anticoagulant drugs, Catheter Ablation
- Where
- 12 sites in United States, China
- Volunteers
- 3,160 people
- Sponsor
- China National Center for Cardiovascular Diseases
Paroxysmal Atrial Fibrillation
Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation
This prospective, multicenter, randomized, controlled, noninferiority trial will compare local anesthesia with conscious sedation and general anesthesia in patients undergoing pulsed field ablation for paroxysmal atrial…
- Trial name
- PULSE-SED (NCT07877519)
- Testing
- Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System
- Where
- China
- Volunteers
- 390 people
- Sponsor
- China National Center for Cardiovascular Diseases
Persistent Atrial Fibrillation, Heart Failure With Reduced Ejection Fraction
AF Ablation for HF With Reduced EF
This is an open label, multi-center, randomized parallel control clinical trial, to examining thethe clinical outcomes of AF ablation on HFrEF patients with persistent atrial fibrillation.
- Trial name
- NCT05827172
- Testing
- AF ablation, medical therapy
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Pulmonary Vein Isolation Guided by Ablation Index (Ablation Index Registry Study)
This is a prospective, multi-center, research study designed to evaluate the acute achievement of pulmonary vein (PV) isolation with ThermoCool SmartTouch (ST) and ThermoCool SmartTouch SF (STSF) catheter using the Ablation Index…
- Trial name
- AIR (NCT03277976)
- Testing
- PVI using ThermoCool® SmartTouch® Catheter, PVI using ThermoCool® SmartTouch SF® Catheter
- Where
- Italy
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Clinica Mediterranea
Atrial Fibrillation, Persistent
Thoracoscopic Ablation Versus Catheter Ablation in Patients With Atrial Fibrillation
Despite good progress in the management of patients with atrial fibrillation (AF), this arrhythmia remains one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity in the world.
- Trial name
- TACAAF (NCT04237389)
- Testing
- Ablation Index Guided endocardial catheter radiofrequency ablation, minimally invasive thoracoscopic surgical epicardial ablation.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- National Research Center of Surgery, Russia
Atrial Fibrillation
Ground-Breaking Electroporation-based Intervention for PERSistent Atrial Fibrillation Treatment (BEAT PERS-AF)
BEAT AF is a randomized controlled trial aiming to assess the efficacy and the safety of pulsed field energy in persistent AF ablation
- Trial name
- BEAT PERS-AF (NCT05418725)
- Testing
- PVI and Linear lesion using PEF, PVI and Linear lesion using CFRF
- Where
- 9 sites in Austria, Belgium and 3 more
- Volunteers
- 83 people
- Sponsor
- University Hospital, Bordeaux
Atrial Flutter, Atrial Fibrillation
Cryoballoon Pulmonary Venous Isolation in Patients Referred for Typical Atrial Flutter Ablation
Background: Atrial fibrillation is frequently associated with typical atrial flutter in clinical practice. If the radical treatment of atrial flutter by radiofrequency catheter is achieved in most cases without recurrence, it…
- Trial name
- PAF CRIOBLAF (NCT01521988)
- Testing
- Atrial flutter ablation, Atrial flutter ablation and pulmonary vein isolation
- Where
- 15 sites in France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Rouen
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Reducing Recurrence of Symptomatic Atrial Fibrillation After Catheter Ablation by App-based Mental Training
Atrial fibrillation (AF) is one of the most common heart rhythm disorders and it is associated with a variety of symptoms leading to a considerable deterioration in quality of life.
- Conditions
- Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Meditation
- Trial name
- Mental-AF (NCT04067427)
- Testing
- Mental training
- Where
- Germany
- Volunteers
- 183 people
- Sponsor
- Helios Health Institute GmbH
Paroxysmal Atrial Fibrillation
Study of Statin for Reduction of Postoperative Paroxysmal Atrial Fibrillation
The study will select all recruited patients with paroxysmal atrial fibrillation will be randomly allocated to receive oral rosuvastatin 20mg/day or blank control from 7 days before ablation and last for 3 months.
- Trial name
- NCT02502110
- Testing
- rosuvastatin
- Volunteers
- 346 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Atrial Fibrillation
Safety and Performance of the SpherePVI™ Catheter to Treat Paroxysmal Atrial Fibrillation
A prospective, single-arm, single-center study to evaluate the safety, performance, and effectiveness of the SpherePVI™ Catheter for treating paroxysmal AF.
- Trial name
- SpherePVI (NCT05144503)
- Testing
- SpherePVI™ Catheter
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation (AF)
Extended Ablation Versus Pulmonary Vein Isolation to Treat Persistent Atrial Fibrillation
The aim is to determine the effect of extended ablation (pre-specified linear PF/RF lesion set) in addition to PVI in symptomatic persistent AF patients on AF/AT/AFL recurrence.
- Trial name
- EXTEND-PVI (NCT07424326)
- Testing
- PVI-plus, PVI-only
- Where
- 4 sites in Czechia
- Volunteers
- 450 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation
Pulsed-field Ablation Vs. Sham Ablation to Treat AF
The study is planned as a single-blind, multicenter, prospective, randomized study. Sixty sbjects will be randomized 1:1 to either: (i) EP study + PFA, or (ii) EP study + Sham ablation control.
- Trial name
- NCT05717725
- Testing
- Pulsed-field ablation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation
Randomized Trial of Two Ablation Catheters in Paroxysmal Atrial Fibrillation
Atrial fibrillation (AF) is a chaotic heart rhythm of the top chambers of the heart. AF occurs in up to 10% of the population over the age of 60.
- Trial name
- NCT00678340
- Testing
- WACA and PVI, PVAC
- Where
- United Kingdom
- Volunteers
- 178 people
- Sponsor
- Pier Lambiase
Atrial Fibrillation Ablation, Persistent Atrial Fibrillation
Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation
The goal of this clinical trial is to determine whether tirzepatide can reduce atrial fibrillation (AF) burden after catheter ablation in overweight or obese patients with persistent AF.
- Conditions
- Atrial Fibrillation Ablation, Persistent Atrial Fibrillation, Obesity & Overweight
- Trial name
- TREAT-AF (NCT07382024)
- Testing
- Tirzepatide, Standard Care (in control arm)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital