Clinical trials: Atrial Fibrillation Catheter Ablation
Long Standing Persistent Atrial Fibrillation
Long-term Outcomes in Long Standing Persistent Atrial Fibrillation
Atrial fibrillation (AF) is a condition detected as an irregular heartbeat. It is the most common rhythm disturbance worldwide which can lead to significant symptoms and serious health problems (stroke and heart failure).
- Trial name
- LoTO_CASA_AF (NCT04280042)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Persistent Atrial Fibrillation
Catgut Embedding in Acupoints on Treating Persistent Atrial Fibrillation After Catheter Ablation
This is a multi-center, 2-arm, assessor and statistician blinded, pilot randomized controlled trial, to evaluate the effect of catgut embedding in acupoints of Neiguan and Zusanli in reducing early recurrence and improving…
- Trial name
- NCT05125042
- Testing
- Amiodarone hydrochloride tablet + acupoint catgut embedding, Amiodarone hydrochloride tablet
- Volunteers
- 120 people
- Sponsor
- Shanghai Chest Hospital
Arrhythmias, Cardiac, Heart Failure, Systolic
Reasons for Variations in Health Related Quality of Life and Symptom Burden in Patients With Atrial Fibrillation
Atrial fibrillation is the most common cardiac arrhythmia. There is a large variation in symptoms; from almost none to severe but the reason for this is unclear.
- Conditions
- Arrhythmias, Cardiac, Heart Failure, Systolic, Atrial Fibrillation
- Trial name
- SMURF (NCT01553045)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Atrial Fibrillation
Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.
Brief summary: The objective of this study is to compare two different ablation strategies in participants with persistent atrial fibrillation and fibrotic areas in the left atrium.
- Trial name
- IDEAL-AF (NCT04377594)
- Testing
- Radio frequency ablation
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Atrium; Fibrillation, Atrium; Flutter
Refralon in Patients With Recurrence Paroxysmal and Persistent Forms of Atrial Fibrillation Who Underwent Catheter Ablation
It is planned to evaluate the efficacy and safety of the class III antiarrhythmic drug refralon as a drug for pharmacological cardioversion in patients with recurrent atrial fibrillation (AF) and atrial flutter (AFL) after…
- Trial name
- NCT05456204
- Testing
- Pharmacological cardioversion with Refralon
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Atrial Fibrillation
Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Prospective Randomized Study
Radiofrequency catheter ablation is highly effective in the treatment of patients with persistent atrial fibrillation. In order to decrease the recurrence rate after catheter ablation, the investigators propose to apply 'virtual'…
- Trial name
- NCT02171364
- Testing
- Virtual ablation in based 3D CT of patient who diagnosed AF, conventional ablation based on physician's personal experience
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Heart Failure
Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure
Heart failure (HF) with preserved left ventricular function (pEF) is difficult clinical syndrome to treat effectively with few evidence based therapies.
- Conditions
- Atrial Fibrillation, Heart Failure, Diastolic Heart Failure
- Trial name
- TAP-CHF (NCT04160000)
- Testing
- Catheter ablation, Rate or Rhythm control antiarrhythmic drugs for atrial fibrillation, Insertion of CardioMems Hemodynamic monitor
- Where
- 9 sites in United States, Germany and 1 more
- Volunteers
- 360 people
- Sponsor
- Electrophysiology Research Foundation
Atrial Fibrillation
Electrophysiological Effects of NACOS and AVK on Pulmonary Veins and Left Atrium in Paroxysmal AF Catheter Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmias with a constantly growing prevalence AF. The purpose of paroxysmal AF processing is to control outbreaks from these pulmonary veins, medicated way (antiarrhythmic)…
- Trial name
- NACO-VP (NCT02814955)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Femoral Vein Injury
Haemostasis After Venous Access in Atrial Fibrillation Catheter Ablation: The HARNESS Trial
Atrial fibrillation (AF) is the most common heart rhythm disorder affecting adults in the United Kingdom. In patients with AF who continue to experience symptoms despite medications, catheter ablation is an established…
- Conditions
- Atrial Fibrillation, Femoral Vein Injury, Bleeding
- Trial name
- HARNESS (NCT06470555)
- Testing
- A figure-of-eight suture secured with a three-way tap, Shortened bed rest duration of 2-hours, Manual compression
- Where
- United Kingdom
- Volunteers
- 336 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation Paroxysmal
FOCALFLEX (CE Mark) Study
This clinical investigation is intended to demonstrate safety and effectiveness of the TactiFlex™ Ablation Catheter Sensor Enabled™, the Volt™ Pulse Field Ablation (PFA) Generator, and EnSite™ X EP System with EnSite™ Pulsed…
- Trial name
- NCT06271967
- Testing
- TactiFlex™ Ablation Catheter Sensor Enabled™
- Where
- 24 sites in Australia, Austria and 9 more
- Volunteers
- 150 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
CPVI Alone Versus. CPVI Plus Electrophysiological Substrate Ablation in the LA During SR for the Treatment of Non-PAF
The primary objective of this investigation is to compare the efficacy of two different AF ablation strategies in patients with non-paroxysmal AF: CPVI plus electrophysiologic substrate ablation in the left atrium during sinus…
- Trial name
- STABLE-SR_II (NCT03448562)
- Testing
- CPVI, STABLE-SR
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation
ECG-I Targeted Ablation for Persistent AF Not Responding to Pulmonary Vein Isolation Results of a Two Staged Strategy.
Atrial Fibrillation (AF) is a irregular heart rhythm associated with significant morbidity and mortality. Catheter ablation is a treatment where catheters are passed through the veins in the leg into the left atrium of the heart…
- Trial name
- TARGET-AF2 (NCT04633265)
- Testing
- ECG-I Mapping of Atrial Fibrillation
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
Hybrid Staged Operating Room and Interventional Catheter Ablation for Atrial Fibrillation
Prospective, multi-center, investigator-driven trial. This study hypothesizes that combining surgical endoscopic and transcatheter techniques in a staged fashion provides superior clinical outcomes than isolated surgical/EP…
- Trial name
- HISTORIC-AF (NCT01622907)
- Where
- 10 sites in France, Germany and 3 more
- Volunteers
- 100 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Atrial Fibrillation
Prophylactic Pulmonary Vein Isolation Study
This study is being done to learn the effects of the Pulmonary Vein Isolation in patients that are at high risk to developing, but do not have a documented history of atrial fibrillation.
- Trial name
- NCT00587899
- Testing
- Pulmonary Vein Isolation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation
Clinical Trial for Optimal Novel Oral Anticoagulant (NOAC) Schedule Immediate Before Catheter Ablation for Atrial Fibrillation
This study is to evaluated the interruption schedule of NOAC in patients who undergo atrial fibrillation ablation. The investigators will compare the bleeding complications were classified as major and minor bleeding…
- Trial name
- NCT02504177
- Testing
- novel oral anticoagulant for 30 days, novel oral anticoagulant for 24 hour
- Where
- South Korea
- Volunteers
- 433 people
- Sponsor
- Yonsei University
Paroxysmal AF
Durability of Pulmonary Vein Isolation Using a Variable-Loop Biphasic Pulsed Field Ablation Catheter in Patients With Paroxysmal Atrial Fibrillation
The VARIFY study is designed to find out how durable pulmonary vein isolation (PVI) is after treatment with the VARIPULSE pulsed field ablation (PFA) system in patients with paroxysmal atrial fibrillation (AF).
- Trial name
- VARIFY (NCT07236619)
- Testing
- Pulmonary vein isolation with the VariPulse catheter
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Atrial Fibrillation, Thoracoscopic Ablation
Thoracoscopic Versus Catheter Ablation in Persistent Atrial Fibrillation With Enlarged Left Atrium
This is a prospective, single-center, open-label, randomized controlled trial comparing thoracoscopic surgical ablation with percutaneous endocardial catheter ablation as the first rhythm-control procedure in patients with…
- Conditions
- Atrial Fibrillation, Thoracoscopic Ablation, Endocardial Ablation
- Trial name
- NCT07783984
- Testing
- Thoracoscopic ablation, Percutaneous catheter ablation
- Where
- South Korea
- Volunteers
- 194 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation (AF), Ventricular Tachycardia (VT)
Complex Arrhythmia Registry
This is a prospective, non-randomized, multicenter observational registry study designed to systematically evaluate the long-term efficacy and safety of catheter ablation for treating atrial fibrillation (AF) and ventricular…
- Trial name
- CAR (NCT07024927)
- Testing
- AF ablation, VT ablation
- Where
- 2 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Heart Failure
Catheter Ablation vs. Standard Conventional Treatment in Patients With LV Dysfunction and AF
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. The incidence and prevalence of AF increase exponentially with increasing age and AF is associated with higher mortality, more frequent…
- Trial name
- CASTLE-AF (NCT00643188)
- Testing
- Radiofrequency ablation, Conventional treatment
- Where
- 32 sites in Australia, Austria and 6 more
- Volunteers
- 398 people
- Sponsor
- Biotronik SE & Co. KG
Atrial Fibrillation
PV-Isolation With the Cryoballoon Versus RF:a Randomized Controlled Prospective Non-inferiority Trial (FreezeAF)
This study is designed as a randomized, controlled, prospective, non-inferiority clinical trial, where the efficacy and safety of the cryoballoon ablation system (CE certificated) will be compared to the standard ablation…
- Trial name
- FreezeAF (NCT00774566)
- Testing
- PV-Isolation RF, PV-Isolation Cryo
- Where
- Germany
- Volunteers
- 322 people
- Sponsor
- Staedtisches Klinikum Karlsruhe