Clinical trials: Atrial Fibrillation Catheter Ablation
Permanent Atrial Fibrillation
Atrioventricular Junction Ablation and Biventricular Pacing for Atrial Fibrillation and Heart Failure
There is evidence of superiority of AV junction ablation strategy over pharmacological therapy only for symptoms of atrial fibrillation, but not for heart failure, hospitalization, morbidity and mortality.
- Trial name
- APAF-CRT (NCT02137187)
- Testing
- AV junction ablation, CRT, Optimized drug therapy
- Where
- Italy
- Volunteers
- 1,830 people
- Sponsor
- Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella
Atrial Fibrillation, Left Atrial Appendage
Left Atrial Appendage Electrical Isolation in Persistent Atrial Fibrillation
This project intends to enroll patients with persistent atrial fibrillation who are planning to undergo catheter ablation of atrial fibrillation.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage, Left Atrial Appendage Occlusion, Catheter Ablation
- Trial name
- NCT04897204
- Testing
- Catheter ablation and left atrial appendage occlusion, Additional left atrial appendage electrical isolation combined with catheter ablation and left atrial appendage occlusion
- Volunteers
- 120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation (AF), Catheter Ablation
Effects of Music During Atrial Fibrillation Ablation Under Conscious Sedation
I. Background Atrial fibrillation, a common type of arrhythmia, is often treated with radiofrequency catheter ablation, a minimally invasive procedure that helps restore a normal heart rhythm.
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Pain Management
- Trial name
- NCT06953752
- Testing
- Music intervention, Control
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shaoxing People's Hospital
Atrial Fibrillation (AF)
Procedural Mitral Isthmus Block Durability After Pulsed-Field Ablation in Patients with Non-Paroxysmal Atrial Fibrillation
Mitral isthmus is one of the targets for the catheter ablation of non-paroxysmal atrial fibrillation (AF), in which pulmonary veins isolation alone is not deemed sufficient.
- Trial name
- FARA Block (NCT06803238)
- Volunteers
- 40 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation (AF), Cardiac Arrhythmias
Anesthetic Safety of High-Frequency, Very-Low Tidal Volume Ventilation With Controlled Peak Pressure During Atrial Fibrillation Ablation
This prospective, observational, within-subject crossover pilot study evaluates the impact of a high-frequency, very-low tidal volume ventilation strategy with controlled peak inspiratory pressure (HFvLTV-cPP) on…
- Trial name
- HFvLTVcPPSAFE (NCT07402798)
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Centro Medico Teknon
Atrial Fibrillation
Apixaban Evaluation of Interrupted Or Uninterrupted Anticoagulation for Ablation of Atrial Fibrillation
The purpose of the prospective, randomized cohort in this study is to assess the safety and efficacy of 2 apixaban treatment strategies (uninterrupted versus interrupted) in subjects planned to undergo catheter ablation for the…
- Trial name
- AEIOU (NCT02608099)
- Testing
- Interrupted apixaban, Uninterrupted apixaban
- Where
- 19 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baim Institute for Clinical Research
Atrial Fibrillation
Reversal of Atrial Substrate to Prevent Atrial Fibrillation Pilot Study
This is a pilot study to assess feasibility to conduct a multi-center, randomized trial to examine the effect of aggressive risk factor control and arrhythmia trigger-based intervention on the atrial substrate, which is involved…
- Trial name
- RASTA-AF (NCT03186976)
- Testing
- Aggressive Risk Factor Control, Standard of Care
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Nova Scotia Health Authority
Paroxysmal Atrial Fibrillation (PAF)
Sphere-9 PAF China Study
The goal of this clinical trial is to find out if the Sphere-9 Catheter and Affera Integrated Mapping and Ablation System is safe and works to treat recurrent symptomatic paroxysmal atrial fibrillation (PAF) in adults who have…
- Trial name
- NCT07789925
- Testing
- Catheter ablation using Sphere-9™ Catheter and Affera™ Integrated Mapping and Ablation System
- Where
- 10 sites in China
- Volunteers
- 180 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Paroxysmal Atrial Fibrillation
Atrial Fibrillation Force Contact Ablation Study
This study will be divided into two phases. The purpose of the Phase I registry is to assess the current force being used for ablation of symptomatic paroxysmal AF in a wide range of operators in different Canadian centres with…
- Trial name
- CAFCAS (NCT01693107)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Atrial Fibrillation
Ten-year Outcomes After AF Ablation
Ablation of atrial fibrillation (AF) using pulmonary vein isolation is employed when patients do not respond favorably to medical therapy.
- Trial name
- NCT01867099
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- Valley Health System
Atrial Fibrillation
Feasibility of Ethanolization of Vein of Marshall With Specific Catheter in Atrial Fibrillation Ablation
In patients with persistent AF (PsAF), ablation limited to pulmonary vein (PV) isolation is the most straightforward approach, but results only in 50% of arrhythmia freedom at 1 year follow-up.
- Trial name
- Innov Marshall (NCT05427435)
- Testing
- Marshall ethanolisation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Ventricular Tachycardia, Atrial Fibrillation
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
To use programmed ventricular stimulation at the time of AF ablation to define the prevalence and mechanism of inducible ventricular tachycardia (VT); pace-mapping to define the site of origin of ventricular arrhythmias; and…
- Trial name
- NCT06647459
- Testing
- EP Study
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
AF - Atrial Fibrillation, Atrial Tachycardia
Non-fluoroscopy Ablation of AF/AT
Atrial fibrillation is the most common arrhythmia but can be treated by a catheter procedure where specialized wires (so-called catheters) are inserted in the left upper heart chamber.
- Trial name
- ZERO-AF (NCT03750435)
- Testing
- AF ablation or left-sided AT ablation
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Comparative Intra-procedural Evaluation of Farapulse and FARAWAVE Nav Catheters
The FARAPULSE PFA catheter (Boston Scientific), a first-generation Pulsed Field Ablation (PFA) tool, has demonstrated good performance in isolating pulmonary veins (PV).
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Pulsed Field Ablation
- Trial name
- NCT07130773
- Testing
- Second-generation FARAWAVE Nav catheter without the use of pre-ablation CT, FARAPULSE with pre-ablation CT
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- Cardiocentro Ticino
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Real-world Experience of Catheter Ablation Using Novel Ablation Technologies for the Treatment of Atrial Fibrillation
The primary purpose of this registry is to obtain real-world clinical experience for the latest and future ablation technologies when used in conjunction with the Carto system in the treatment of patients with atrial fibrillation…
- Trial name
- NOVEL AF (NCT05006456)
- Testing
- Catheter ablation
- Volunteers
- 4,000 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF)
Efficacy and Safety of Intravenous + Oral Vs. Oral Amiodarone in Preventing Recurrence After Catheter Ablation in Patients with Persistent Atrial Fibrillation
This study aims to investigate the efficacy and safety of intravenous combined with oral amiodarone in preventing atrial fibrillation (AF) recurrence after catheter ablation in patients with persistent atrial fibrillation.
- Trial name
- NCT06742866
- Testing
- Amiodarone Injection, Sodium Chloride Injection 0.9%
- Where
- China
- Volunteers
- 418 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation, Esophageal Fistula
Retracting the Esophagus During AF Ablation
This Study is designed to determine the outcome and effect of implementation of Esophageal Stylet as a strategy to minimize the risk of esophageal injury during the atrial fibrillation catheter ablation procedure.
- Conditions
- Atrial Fibrillation, Esophageal Fistula, Cardiac Arrhythmia
- Trial name
- EsoSure (NCT02665442)
- Testing
- Esophageal Stylet - EsoSure
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northeast Scientific, Inc.
Atrial Fibrillation
Effect of Structural Remodeling on Scar Formation as Assessed by DE-MRI of the Left Atrium
The purpose of this study is to evaluate the impact of pre-ablation fibrosis on scar formation in the left atrium of the heart. This will be assessed by delayed enhancement magnetic resonance imaging and will be looked at in…
- Trial name
- RADAR (NCT01187914)
- Volunteers
- 40 people
- Sponsor
- University of Utah