Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation
Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation
There is a need to compare the efficacy of PVI versus PVI plus catheter ablation, which includes ablation of complex fractionated atrial electrograms (CFAE) and linear lesions in the same procedure.
- Trial name
- NCT03115554
- Testing
- PVI Plus Catheter Ablation, PVI Alone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation
Coronary Computed Tomography AngioGraphy Prior to Catheter Ablation in Patients With Atrial FIBrillation
The purpose of this randomized, controlled trial is to investigate whether coronary computed tomography (CT) angiography prior to catheter ablation and derived treatment (medical anti-ischemic and multimodality treatment and/or…
- Trial name
- FIBCAG (NCT05978388)
- Testing
- Analysis of coronary CT Angiography and CAC scoring at the time of catheter ablation
- Where
- Denmark
- Volunteers
- 852 people
- Sponsor
- Tor Biering-Sørensen
Atrial Fibrillation
Evaluation of the CIRCA Monitoring System in Prevention of Esophageal Lesions Following RFCA
The purpose of this study is to determine if the use of Circa™ temperature monitoring system during ablation procedures will reduce the risk of esophageal lesions or damage.
- Trial name
- CIRCA-EGD (NCT02467166)
- Testing
- Circa™ Probe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Atrial Fibrillation
First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study)
The purpose of this study is to determine whether catheter-based pulmonary vein isolation is superior to antiarrhythmic drugs as first line therapy in patients with symptomatic paroxysmal recurrent atrial fibrillation not…
- Trial name
- RAAFT (NCT00392054)
- Testing
- Pulmonary Vein Isolation performed by Catheter Ablation, Conventional Antiarrhythmic Drug Therapy
- Where
- 16 sites in United States, Canada and 3 more
- Volunteers
- 127 people
- Sponsor
- Population Health Research Institute
Atrial Fibrillation
Interventional Strategies in Treatment of Atrial Fibrillation: Percutaneous Closure of the Left Atrial Appendage Versus Catheter Ablation
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with an increased risk of morbidity and mortality1.
- Trial name
- ISAR-AF (NCT01363895)
- Testing
- Percutaneous closure of LAA, Catheter ablation of AF
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Arrhythmia, Atrial Fibrillation
Arterial Embolism After Catheter Ablation of Atrial Fibrillation. ATRIAL FIBRILLATION
The EMBOL-AF is a multicenter, international, observational study designed as a retrospective registry that will investigate the characteristics of systemic arterial embolic events after treatment of atrial fibrillation by…
- Conditions
- Arrhythmia, Atrial Fibrillation, Ablation, Stroke, Acute
- Trial name
- EMBOL-AF (NCT06134739)
- Testing
- No intervention.
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitario La Paz
Atrial Fibrillation
Clinical Study for Workflow and Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System for Treating Symptomatic Paroxysmal AF (QDOT-Micro)
The QDOT-Micro study is a prospective, multi-center, non-randomized, interventional clinical study.
- Trial name
- NCT02944968
- Testing
- THERMOCOOL SMARTTOUCH® SF-5D catheter
- Volunteers
- 51 people
- Sponsor
- Biosense Webster, Inc.
Paroxysmal Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
Pulsed Field Ablation of SVC and PV in Paroxysmal Atrial Fibrillation (PASPA Study)
The PASPA study is a multicenter, randomized trial comparing Pulmonary Vein Isolation (PVI) alone versus PVI plus Superior Vena Cava Isolation (SVCI) using Pulsed Field Ablation (PFA) in patients with paroxysmal atrial…
- Trial name
- PASPA (NCT07191626)
- Testing
- PFA - PV + SVCI, PFA - PVI only
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Symptomatic Paroxysmal Atrial Fibrillation (PAF)
FIRE AND ICE: Comparative Study of Two Ablation Procedures in Patients With Atrial Fibrillation
Comparing efficacy and safety of isolation of the pulmonary veins (PV) using a Cryoballoon catheter versus a radiofrequency ablation with a ThermoCool catheter in patients with paroxysmal atrial fibrillation.
- Trial name
- NCT01490814
- Testing
- Electrical isolation of the pulmonary veins, Electrical isolation of pulmonary veins
- Where
- 19 sites in Czechia, France and 6 more
- Volunteers
- 769 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Thromboembolism
Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation
This study aims to explore the risk of periprocedural thromboembolic events in continuous versus interrupted Coumadin therapy in a large, randomized high-risk patient population undergoing radio-frequency catheter ablation for…
- Trial name
- COMPARE (NCT01006876)
- Testing
- Coumadin
- Where
- United States
- Volunteers
- 1,584 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation, Persistent
Thoracoscopic Surgical Versus Catheter Ablation Approaches for Primary Treatment of Persistent Atrial Fibrillation
Rationale: Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia. AF is classified as paroxysmal or persistent AF, based on the duration and persistency of the arrhythmia.
- Trial name
- APPROACH AF (NCT04715425)
- Testing
- Thoracoscopic pulmonary vein isolation without additional lesion + left atrial appendage exclusion/amputation, Catheter pulmonary vein isolation without additional lesions
- Where
- 3 sites in Netherlands
- Volunteers
- 170 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Persistent Atrial Fibrillation
AF Substrate Mapping and Guided Ablation
In this study, the investigators aim to identify and characterize, by means of an EnSite Velocity Research Software, the electrophysiological characteristics of substrates that sustain AF in patients with persistent AF and to…
- Trial name
- NCT02571218
- Testing
- Substrate+mCPVA, mCPVA
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
Pulsed-field Ablation Vs. Sham Ablation to Treat AF
The study is planned as a single-blind, multicenter, prospective, randomized study. Sixty sbjects will be randomized 1:1 to either: (i) EP study + PFA, or (ii) EP study + Sham ablation control.
- Trial name
- NCT05717725
- Testing
- Pulsed-field ablation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation
Re-Ablation Using a Tailored Approach Targeting EGM-Dispersion
Multi-center, international, non-randomized clinical trial evaluating the use of Volta's VX1 algorithm as used in combination with repeat catheter ablation after AF recurrence after previous catheter ablation.
- Trial name
- RESTART (NCT05477147)
- Testing
- Catheter Ablation
- Where
- 19 sites in United States, Belgium and 2 more
- Volunteers
- 96 people
- Sponsor
- Volta Medical
Persistent Atrial Fibrillation, Catheter Ablation
Persistent Atrial Fibrillation Without the Evidence of Low-voltage Areas
An effective therapy of persistent atrial fibrillation beyond pulmonary vein isolation remains unsatisfactory. Targeting endocardial low-voltage areas represents an approach of substrate modification.
- Conditions
- Persistent Atrial Fibrillation, Catheter Ablation, Low Voltage Areas
- Trial name
- NCT06124690
- Testing
- Catheter ablation
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Robert Bosch Medical Center
Atrial Fibrillation
Radiofrequency vs Cryoballoon Ablation for Atrial Fibrillation Assessed by Implantable Cardiac Monitor
The study is a prospective randomized comparison of two methods of catheter ablation of atrial fibrillation: Radiofrequency ablation which is the standard of care will be compared to Cryoballoon ablation to perform pulmonary vein…
- Trial name
- RACE-AF (NCT03805555)
- Testing
- Radiofrequency ablation, Cryoballoon ablation
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Catheter Ablation, Radiofrequency, Atrial Fibrillation
Impact of a New Ablation Tracking Tool in Paroxysmal Atrial Fibrillation Ablation With Contact Force Technology
Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. A novel technology was recently developed to allow an automatic points annotation when indirect parameters of lesion formation reach…
- Trial name
- VISITALY (NCT02681926)
- Testing
- VISITAG
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Giulio Zucchelli
Persistent Atrial Fibrillation, Catheter Ablation
Left Atrial Function Analysis for Patients With Persistent Atrial Fibrillation Undergoing Pulmonary Vein Isolation
This prospective observational study is designed to describe the factors determining the success of pulmonary vein isolation (PVI) for patients with persistent atrial fibrillation (AF).
- Trial name
- LAMPP (NCT03242694)
- Testing
- LA pressure, voltage map, strain, scar-map, blood sampling, pulmonary vein isolation
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Atrial Fibrillation (AF), Stroke
Comparative Evaluation of the Efficacy and Safety of High-Power Short-Duration Radiofrequency Ablation and Standard Low-Power Ablation in Catheter Treatment of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and represents one of the leading causes of cardiovascular morbidity and mortality.
- Conditions
- Atrial Fibrillation (AF), Stroke, Acute Cerebrovascular Accident, Atrial Fibrillation Recurrent
- Trial name
- NCT07728539
- Testing
- Technique of radiofrequency ablation using very high-power short-duration ablation parameters, Technique of radiofrequency ablation using low-power settings
- Where
- Russia
- Volunteers
- 196 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Atrial Fibrillation
Lesion Formation With Pulsed Field Versus Cryobaloon Ablation as Assessed by Cardiac Magnetic Resoncance
This randomised study will compare pulsed field ablation and cryoballoon ablation with respect to ablation lesion quality as assessed by late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) at 3 months…
- Trial name
- PULSED-ICE-CMR (NCT06220006)
- Testing
- Pulmonary vein isolation
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Clinic of Barcelona