Clinical trials: Atrial Fibrillation and Flutter
Atrial Fibrillation, Atrial Flutter
Sodium Channel Splicing in Heart Failure Trial
The purpose of this research is to see if investigators can detect truncated mRNA splice variants of the cardiac voltage-gated sodium (Na+) channel gene, SCN5A, in patients with a weak heart (Heart Failure) with or without an…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Heart Failure
- Trial name
- SOCS-HEFT (NCT01185587)
- Where
- 2 sites in United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Stroke, Venous Thrombosis
Pharmacogenetic Dosing of Warfarin
Purpose: Warfarin is now the most commonly used oral anticoagulant. This drug has inter-individual variability due to the genetic polymorphisms in the warfarin metabolizing enzyme, CYP2C9 and warfarin target, VKORC1.
- Conditions
- Stroke, Venous Thrombosis, Atrial Fibrillation, Atrial Flutter
- Trial name
- NCT02065388
- Testing
- Standard of care dosing for warfarin, Genotype-guided dosingTaiwan algorithm for warfarin, Genotype-guided dosing IWPC algorithm for warfarin
- Where
- 3 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- Academia Sinica, Taiwan
Atrial Fibrillation, Atrial Flutter
Therapy of Atrial Flutter by Afib Ablation
Ablation of the cavotricuspid isthmus (CTI) in the right atrium is currently the therapy of choice for the treatment of typical atrial flutter (3,4). It is a curative approach and has a high success rate (5).
- Trial name
- TripleA (NCT02051621)
- Testing
- Antiarrhythmic drug, Cavo-tricuspid-isthmus-ablation, Pulmonary vein isolation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Rostock
Atrial Fibrillation, Atrial Flutter
Strategy of Early Detection and Active Management of Supraventricular Arrhythmia With Telecardiology (SETAM)
This study investigates if the early detection and treatment of supraventricular arrhythmia (SVA) may help to prevent the progression of the arrhythmia and improve the clinical outcome.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Atrial Tachycardia
- Trial name
- SETAM (NCT01108692)
- Testing
- Telecardiology
- Where
- 57 sites in France
- Volunteers
- 602 people
- Sponsor
- Biotronik France
Atrial Fibrillation, Inflammation
Markers of Oxidative Stress Present in Blood in Patients With Atrial Fibrillation
Atrial fibrillation is an abnormal heart beat that starts in the upper parts of the heart and can cause stroke or death, if untreated.
- Conditions
- Atrial Fibrillation, Inflammation, Atrial Flutter
- Trial name
- NCT00142194
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Emory University
Atrial Fibrillation, Atrial Flutter
Markers of Oxidative Stress Present in Left Atrial Appendage Tissue in Patients With Atrial Fibrillation
The purpose of the study is to look at the differences between people who have irregular heart beats coming from the upper chamber of the heart (atrial fibrillation) compared to those who do not have these irregular beats.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Inflammation
- Trial name
- NCT00243802
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
Atrial Fibrillation, Atrial Flutter
A Retrospective Analysis of the Use of ACE-inhibitors and Angiotensin Receptor Blockers
It is well known that atrial fibrillation (AF) and atrial flutter occur frequently after most types of cardiac surgeries.(1-4) Postoperative AF is associated with significant morbidity, longer hospital stay, and higher related…
- Trial name
- NCT00321945
- Testing
- ACE-Inhibitors and Angiotensin Receptor Blockers
- Where
- 3 sites in United States
- Volunteers
- 546 people
- Sponsor
- Emory University
Atrial Fibrillation, Perimitral Flutter
Ablation of Perimitral Flutter Following Catheter Ablation of Atrial Fibrillation: Impact on Outcomes
This prospective, randomized study aims to compare the impact of ablation of perimitral flutter only versus cardioversion and repeat isolation of pulmonary veins with ablation of additional triggers, on procedure outcome.
- Trial name
- PROPOSE (NCT01173796)
- Testing
- catheter ablation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation, Atrial Flutter
Double Blind Placebo COntrolled Dose Ranging studY of the eFficacy and safEty of SSR149744c 300 or 600 mg for the Conversion of Atrial Fibrillation / fluttEr
Double blind study to assess versus placebo the efficacy of SSR149744C for the conversion of atrial fibrillation/flutter to sinus rhythm at the time of the planned electrical cardioversion.
- Trial name
- CORYFEE (NCT00232310)
- Testing
- CELIVARONE (SSR149744C)
- Where
- 9 sites in United States, Canada and 7 more
- Volunteers
- 150 people
- Sponsor
- Sanofi
Atrial Fibrillation, Atrial Flutter
Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 mg OD With Amiodarone as Calibrator for the Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/Flutter
Double blind study to evaluate the efficacy and tolerability of SSR149744C and select a dose to be further investigated in the maintenance of sinus rhythm after electrical, pharmacological or spontaneous conversion of AF/AFL.
- Trial name
- MAIA (NCT00233441)
- Testing
- CELIVARONE (SSR149744C)
- Where
- 17 sites in United States, Argentina and 15 more
- Volunteers
- 673 people
- Sponsor
- Sanofi
Pre-excitation Syndromes, Paroxysmal Tachycardia
Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG
Patients complaining of tachycardia but with a negative Holter ECG, are for a limited time period offered a simplified electrophysiological(EP) examination.
- Conditions
- Pre-excitation Syndromes, Paroxysmal Tachycardia, Atrial Fibrillation, Atrial Flutter
- Trial name
- NCT00251121
- Testing
- Mini-invasive electrophysiological study, Atrial pacing
- Where
- Norway
- Volunteers
- 51 people
- Sponsor
- Sykehuset Telemark
Arrhythmia, Atrial Fibrillation
Concentrations of Amiodarone in Fat Tissue During Chronic Treatment
The objective of this study is to determine if concentrations of amiodarone in fat tissue increases constantly over time during chronic treatment with this drug, and if blood concentrations reflect accurately the concentrations…
- Conditions
- Arrhythmia, Atrial Fibrillation, Atrial Flutter
- Trial name
- ATACA (NCT00313443)
- Testing
- Fat tissue needle aspiration
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hopital Lariboisière
Atrial Fibrillation, Atrial Flutter
American-Australian-African Trial With Dronedarone in Patients With Atrial Fibrillation or Atrial Flutter for the Maintenance of Sinus Rhythm
To assess the efficacy of dronedarone versus placebo for the maintenance of normal sinus rhythm after electrical, pharmacological or spontaneous conversion of atrial fibrillation/atrial flutter (AF/AFL).
- Trial name
- ADONIS (NCT00259376)
- Testing
- Dronedarone (SR33589)
- Where
- 5 sites in United States, Argentina and 3 more
- Volunteers
- 629 people
- Sponsor
- Sanofi
Atrial Fibrillation, Atrial Flutter
EURopean Trial In Atrial Fibrillation(AF) or Flutter (AFL) Patients Receiving Dronedarone for the maIntenance of Sinus Rhythm (EURIDIS)
To assess the efficacy of dronedarone versus placebo for the maintenance of normal sinus rhythm after electrical, pharmacological or spontaneous conversion of atrial fibrillation/atrial flutter (AF/AFL).
- Trial name
- EURIDIS (NCT00259428)
- Testing
- Dronedarone (SR33589)
- Where
- 12 sites in Belgium, Czechia and 10 more
- Volunteers
- 615 people
- Sponsor
- Sanofi
Atrial Fibrillation, Atrial Flutter
Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation
The purpose of this research study is to test an experimental drug ATI-5923 vs Coumadin. The study is intended to demonstrate ATI-5923 is superior to Coumadin for keeping INR values in the desired therapeutic range.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Venous Thromboembolic Disease, Myocardial Infarction
- Trial name
- EmbraceAC (NCT00691470)
- Testing
- ATI-5923, Coumadin (warfarin)
- Where
- 41 sites in United States
- Volunteers
- 600 people
- Sponsor
- ARYx Therapeutics
Atrial Fibrillation, Atrial Flutter
A Trial With Dronedarone to Prevent Hospitalization or Death in Patients With Atrial Fibrillation
To assess the efficacy of dronedarone in preventing cardiovascular hospitalization or death from any cause in a population of high-risk patients with atrial fibrillation/atrial flutter (AF/AFL).
- Trial name
- ATHENA (NCT00174785)
- Testing
- dronedarone (SR33589)
- Where
- 37 sites in United States, Argentina and 35 more
- Volunteers
- 4,628 people
- Sponsor
- Sanofi
Atrial Flutter, Atrial Fibrillation
Study to Determine the Response and Effectiveness of RSD1235 in Subjects With Atrial Fibrillation or Atrial Flutter
The purpose of this study is to demonstrate the effectiveness of RSD1235 compared with placebo, in the conversion of atrial fibrillation or atrial flutter to sinus rhythm.
- Trial name
- NCT00115791
- Testing
- RSD1235
- Where
- 54 sites in United States, Argentina and 5 more
- Volunteers
- 276 people
- Sponsor
- Astellas Pharma Inc
Atrial Fibrillation, Atrial Flutter
Response to RSD1235 Compared to Placebo in Subjects With Atrial Arrhythmia After Heart Surgery
The purpose of this study is to demonstrate the safety and efficacy of RSD1235 compared to placebo in the conversion of atrial arrhythmia to sinus rhythm in subjects following valvular and/or coronary artery bypass graft surgery.
- Trial name
- NCT00125320
- Testing
- RSD1235
- Where
- 22 sites in United States, Argentina and 4 more
- Volunteers
- 190 people
- Sponsor
- Astellas Pharma Inc
Heart Failure, Tachycardia
Safety and Efficacy Study of RENEWAL 4 AVT
The purpose of this study is to assess the safety and effectiveness of the CONTAK RENEWAL 4 AVT device.
- Conditions
- Heart Failure, Tachycardia, Atrial Fibrillation, Atrial Flutter
- Trial name
- NCT00180336
- Testing
- CRT-D
- Where
- Germany
- Volunteers
- 170 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
Amiodarone to Prevent Post-Operative Arrhythmias
Rapid heart rhythms originating from the upper heart chambers (atrial tachyarrhythmias) are very common after open-heart surgery.
- Trial name
- NCT00251706
- Testing
- amiodarone
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of Calgary