Clinical trials: Atrial Function, open to volunteers
Atrial Fibrillation and Flutter, Heart Failure
Multimodal Cardiac Imaging Registry in Patients with Atrial Fibrillation
The goal of this observational registry is to collect a curated dataset of multimodal imaging data that will serve for development of artificial-intelligence based solutions for prediction of risk and outcomes in patients with…
- Conditions
- Atrial Fibrillation and Flutter, Heart Failure, Artificial Intelligence (AI), Echocardiography
- Trial name
- IMAGE-AF (NCT06584266)
- Testing
- Transoesophageal echocardiography, Catheter ablation
- Where
- 7 sites in Czechia, Poland
- Volunteers
- 3,000 people
- Sponsor
- University in Zielona Góra
Atrial Fibrillation (AF)
LA Function After PFA in Paroxysmal AF
A prospective study that investigates the changes in LA echocardiographic parameters after PFA for paroxysmal AF.
- Trial name
- NCT07439016
- Testing
- LA and LAA function measurements
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation
Repeatable Evaluation of Functional Intra-procedural Signals for Effect in Pulsed Field Ablation REFINE-PFA
The study is a prospective, exploratory observational study with the ECGenius® System and the PFAnalyzer software module in PFA cases using the FaraPulse PFA system.
- Trial name
- REFINE-PFA (NCT07275151)
- Testing
- Pulmonary vein isolation ablation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- CathVision ApS
Lipoprotein Disorder, Arterial Stiffness
The Effect of Lipoprotein (a) on Arterial Stiffness, Endothelial Function and Myocardial Deformation
1. Introduction Lipoprotein(a), or Lp(a), is a type of lipoprotein that is structurally similar to LDL (low-density lipoprotein) but carries an additional protein called apolipoprotein (a). 2.
- Conditions
- Lipoprotein Disorder, Arterial Stiffness, Endothelial Dysfunction
- Trial name
- Lpa_endo (NCT07324902)
- Where
- 2 sites in Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Athens
Atrial Fibrillation (AF), Stroke
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
The aim is to investigate whether screening with long-term ECG monitoring in individuals with elevated NT-proBNP leads to a lower incidence of ischeamic stroke and death from vascular causes.
- Conditions
- Atrial Fibrillation (AF), Stroke, NT-pro-BNP, Cognitive Function and Well-Being
- Trial name
- PAFS-Tromsø (NCT07343895)
- Testing
- Long term heart rythm monitoring by ECG247
- Where
- 2 sites in Norway
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Paroxysmal Atrial Fibrillation, Pulsed Field Ablation
Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: Clinical Efficacy and Left Atrial Function Protection
This is a prospective clinical study aiming to evaluate the clinical efficacy and safety of a novel domestic pulsed field ablation (PFA) system in the treatment of paroxysmal atrial fibrillation (PAF), and to specifically assess…
- Conditions
- Paroxysmal Atrial Fibrillation, Pulsed Field Ablation, Catheter Ablation, Left Atrial Function
- Trial name
- NCT07865221
- Testing
- Novel Pulsed Field Ablation System, Radiofrequency Ablation Catheter
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Tianjin Medical University General Hospital
Atrial Fibrillation, Functional Mitral Regurgitation
Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation
A prospective, observational cohort study designed to identify clinical phenotypes and evaluate predictors \& outcomes of functional mitral and tricuspid valve regurgitation in patients with atrial fibrillation.
- Conditions
- Atrial Fibrillation, Functional Mitral Regurgitation, Functional Tricuspid Regurgitation
- Trial name
- NCT05920824
- Testing
- Echocardiogram
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation (AF), Hypertension
SGLT2i Improve Left Atrial Function in Patients With Paroxysmal Atrial Fibrillation, Hypertension and Abnormal Glucose Metabolism
Heart failure is the most important clinical endpoint event in atrial fibrillation (AF). Patients with AF complicated by heart failure have a significantly higher risk of all-cause mortality and cardiovascular mortality compared…
- Trial name
- NCT07482020
- Testing
- SGLT-2 inhibitors
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Huashan Hospital
Atrial Functional Mitral Regurgitation, Atrial Fibrillation (AF)
Ablation With Transcatheter Edge-to-edge Repair for Atrial Functional Mitral Regurgitation and Atrial Fibrillation
This trial is a randomized study for patients with significant atrial functional mitral regurgitation (AFMR) and atrial fibrillation (AF).
- Trial name
- ATTRACTION (NCT07744035)
- Testing
- Transcatheter edge to edge repair, Catheter ablation
- Volunteers
- 384 people
- Sponsor
- Mao Chen
Hypertension, Cardiovascular Diseases
Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce CVD events, including incident HF. SGLT2 is a glucose transport protein in the kidneys. Inhibition of this protein results in glucosuria and lower serum blood sugar.
- Trial name
- NCT06507657
- Testing
- empagliflozin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Atrial Fibrillation (AF), Heart Failure (HF)
Effects of Enhanced External Counterpulsation Combined With Cardiac Rehabilitation in Patients With Atrial Fibrillation
This is a prospective randomized controlled trial designed to evaluate the effectiveness of enhanced external counterpulsation (EECP) combined with cardiac rehabilitation in patients with atrial fibrillation.
- Conditions
- Atrial Fibrillation (AF), Heart Failure (HF), Cardiac Rehabilitation
- Trial name
- EECP AF CR (NCT07058987)
- Testing
- Cardiac Rehabilitation Combined With EECP, Routine Medical Care
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Lanzhou University Second Hospital
Atrial Fibrillation
Progression of Atrial Fibrillation in the Young
The purpose of this study is to investigate the presence and magnitude of structural changes of the heart and their long-term development in young patients with atrial Fibrillation (AF), studied by echocardiographic measurements…
- Trial name
- PRAY (NCT05080712)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Atrial Fibrillation (AF), Catheter Ablation
Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial
Atrial fibrillation (AF) leads to atrial functional mitral regurgitation (MR) through mechanisms including mitral annular dilatation, systolic leaflet motion distance alteration, and contractility decrease.
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Atrial Functional Mitral Regurgitation
- Trial name
- ELEVATE-AF (NCT06883864)
- Testing
- Catheter ablation plus medication, Medication, (ELEVATE-AF X) experimental group
- Where
- 17 sites in China
- Volunteers
- 146 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Valve Regurgitation, Mitral Valve Regurgitation
Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse…
- Conditions
- Aortic Valve Regurgitation, Mitral Valve Regurgitation, Left Ventricle Dilated, Left Atrium Dilated
- Trial name
- ORMIX (NCT06805253)
- Testing
- Not applicable - observational study
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Atrial Fibrillation
Hidden Slow Conduction Ablation for Recurrent Atrial Fibrillation: Unmasking the Arrhythmogenic Substrate (Unmask-AF)
Over recent years, pulmonary vein isolation (PVI) procedures have demonstrated progressively enhanced efficacy and safety, resulting in a substantial increase in the number of atrial fibrillation ablations, not only as a…
- Trial name
- NCT06657170
- Testing
- Pulmunary veins reconnection plus hidden slow conduction ablation, Pulmunary veins (PV) reconnection ablation only
- Volunteers
- 212 people
- Sponsor
- Centro Medico Teknon
Atrial Fibrillation (AF), Physical Exercise
Concurrent Training in Patients Undergoing Atrial Fibrillation Ablation.
Atrial fibrillation (AF) is an irregular and often very fast heart rhythm, is considered the most common sustained cardiac arrhythmia in adults worldwide, and its incidence and prevalence are increasing.
- Conditions
- Atrial Fibrillation (AF), Physical Exercise, Physical Activity, Physical Fitness
- Trial name
- NCT06832033
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Marcos Echevarría
Heart Failure (HF), Atrial Fibrillation (AF)
Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation
Heart failure and atrial fibrillation are two of the most common heart diseases globally. Nearly half of all patients with heart failure also have atrial fibrillation.
- Trial name
- HFcAF (NCT07436299)
- Where
- 15 sites in United States, Belgium and 8 more
- Volunteers
- 400 people
- Sponsor
- Oslo University Hospital
PreDiabetes, Insulin Resistance
Disease Prevention in Clinical Practice Base on Patient Specific Physiology
It is well known that the Type 2 diabetes and vascular disease are preceded by over ten years by metabolic dysfunction and anatomic changes that can be quantified.
- Conditions
- PreDiabetes, Insulin Resistance, Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis
- Trial name
- STOPDISEASE (NCT03308773)
- Testing
- Lifestyle modification in routine care of patients
- Volunteers
- 5,000 people
- Sponsor
- Pacific Coast Family Medical Group
AF Ablation Patients With Moderate+ FMR and Persistent AF
Catheter Ablation for Functional Mitral Regurgitation in Persistent Atrial Fibrillation: Development and Validation of a Predictive Model-A Multicenter Prospective Cohort Study
Mitral Regurgitation (MR) is the most prevalent type of valvular heart disease in clinical practice, with an average prevalence of approximately 1% in populations with moderate-to-severe or worse MR, which increases significantly…
- Trial name
- NCT07096219
- Testing
- Catheter Ablation, ultrasonic cardiography (UCG)
- Where
- 2 sites in China
- Volunteers
- 556 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cognitive Function Abnormal, Atrial Fibrillation (AF)
Low-frequency Electrical Stimulation for Cognitive Enhancement in Atrial Fibrillation
Cognitive function in patients with atrial fibrillation (AF) is often impaired due to the complex influence of various factors (cerebral hypoperfusion, neurodegeneration, microemboli, hypertension, chronic inflammation).
- Trial name
- LESCAF (NCT07063381)
- Testing
- tVNS
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery