Clinical trials: Atrioventricular Heart-block
Atrial Fibrillation, Atrioventricular Block, Second and Third Degree
Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG
During the preoperative examination, in addition to the standard examination recommended before high-risk cardiac surgeries, a digital single-lead ECG is recorded using portable CardioQUARK devices.
- Conditions
- Atrial Fibrillation, Atrioventricular Block, Second and Third Degree, Sinus Node Dysfunction, Ventricular Tachycardia (VT)
- Trial name
- NCT07348991
- Testing
- digital single-channel ECG recording
- Volunteers
- 300 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Bradycardia, Conduction Block, Atrioventricular
LLL vs. SDL for LBBP: A Non-inferiority RCT
Left Bundle Branch Pacing (LBBP) has emerged as one of the most commonly used physiological pacing modalities in clinical practice.
- Trial name
- NCT07378124
- Testing
- SDL implantation, LLL implantation
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Ningbo No.2 Hospital
Left Bundle-Branch Block, Aortic Stenosis
Study on Heart Block Risks Using Outcome-Based Modeling
This study developed a prediction model for high-grade atrioventricular block (AVB) and complete left bundle branch block (CLBBB) following transcatheter aortic valve replacement (TAVR) in Chinese patients with aortic stenosis…
- Trial name
- SAVIOR (NCT07065123)
- Testing
- The population undergoing TAVR for aortic valve stenosis with outcomes of permanent pacemaker implantation and complete left bundle branch block after surgery
- Volunteers
- 112 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Bradycardia, Atrioventricular Block
Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up
The goal of this observational post-market clinical Follow-up study is to learn about the long-term safety, performance, and clinical benefits of pacing the left bundle branch area (LBBAP) using the INGEVITY+ pacemaker lead in…
- Conditions
- Bradycardia, Atrioventricular Block, Sinus Node Dysfunction, Bundle-Branch Block
- Trial name
- SEPTA PMCF (NCT07209852)
- Testing
- Pacemaker lead
- Where
- 13 sites in Belgium, France and 5 more
- Volunteers
- 140 people
- Sponsor
- Boston Scientific Corporation
Lupus Erythematosus, Systemic, Atrioventricular Block
Systemic Lupus Erythematous and Heart Conduction Disorders
Connective tissue diseases have been related to heart conduction disorders. The anti-Ro/SSA antibodies are thought to have a pathogenic role, and they most prevalent in systemic lupus erythematous (SLE).
- Conditions
- Lupus Erythematosus, Systemic, Atrioventricular Block, Sudden Death
- Trial name
- NCT02162992
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 151 people
- Sponsor
- Germans Trias i Pujol Hospital
Atrioventricular Block
Impact of Right Ventricular Pacing Determined by Electrocardiography
Typically pacemaker electrode has been attached to the right ventricular apex. This method lead to Non-physiological Ventricular contraction. It has been reported to cause by ventricular dysfunction.
- Trial name
- RVpacing (NCT01922518)
- Testing
- Septal pacing, Apex pacing
- Where
- South Korea
- Volunteers
- 233 people
- Sponsor
- Yong Seog Oh
Cardiac Pacemaker, Arrythmia
Aveir DR Real-World Evidence Post-Approval Study
The purpose of this post-approval study is to evaluate the long-term safety of the dual-chamber Aveir DR leadless pacemaker using real-world evidence methods.
- Conditions
- Cardiac Pacemaker, Arrythmia, Bradycardia
- Trial name
- NCT05935007
- Testing
- Aveir DR Leadless Pacemaker System
- Where
- United States
- Volunteers
- 1,805 people
- Sponsor
- Abbott Medical Devices
Heart Block AV
Micra AV Tracking During Exercise Testing
The purpose of this study is to determine the effectiveness of the Micra AV 2.0 device during exercise or elevated heart rates. Participation in research studies is voluntary.
- Trial name
- NCT05966168
- Testing
- Medtronic Micra AV Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
High Degree AV-block, Left Bundle Branch Block
QT Interval in Patients With Pacemaker Dependency
The aim of this study is to examine a correction term for an adapted QT interval during ventricular pacing (right, left and biventricular pacing) to obtain valid formulae correcting for the QT intervals in various pacing…
- Trial name
- QT-TENDENCY (NCT01694550)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University of Magdeburg
Sick Sinus Syndrome, Complete Atrioventricular Block
Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation
This study is intended to compare the feasibility, safety and efficacy of Ensite-NavX zero-fluoroscopic navigation system to conventional fluoroscopic X-ray approach as to performing double-chamber pacemaker implantation.
- Conditions
- Sick Sinus Syndrome, Complete Atrioventricular Block, High Degree Second Degree Atrioventricular Block (Disorder), Bradycardia
- Trial name
- ZF-PMDC (NCT03118427)
- Testing
- zero-fluoroscopy 3D navigation, conventional x-ray navigation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Conduction Block, Atrioventricular, Bundle-Branch Block
Novel Approach to Conduction System Pacing With Use of Ultrasound
Each year, over one million pacemakers are implanted globally using x-rays. Recent developments have been aimed at determining which area of the heart is the best option for lead placement.
- Trial name
- CONDUCT USe (NCT06815783)
- Testing
- Ultrasound guidance, Fluoroscopy guided
- Where
- 2 sites in Canada
- Volunteers
- 152 people
- Sponsor
- Habib Khan
Sinus Node Dysfunction, Atrioventricular Block
Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode
Observational study on long PR interval using the SafeR mode in bradycardia patients.
- Trial name
- PRECISE (NCT02586480)
- Testing
- dual chamber pacemaker with SafeR algorithm
- Where
- 58 sites in France
- Volunteers
- 848 people
- Sponsor
- LivaNova
Bradycardia, Sinus Node Dysfunction
Left Bundle Area Versus Selective His Bundle Pacing
This is a voluntary research study to find out which location in the heart a pacemaker wire is the most efficient for a patient's heart and for battery life.
- Conditions
- Bradycardia, Sinus Node Dysfunction, Atrioventricular Block
- Trial name
- LEFTBASH (NCT04093414)
- Testing
- Select Secure pacing lead
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- David Haines, MD
Atrioventricular Block, Left Bundle Branch Area Pacing
Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block)
This is a multicenter, randomized controlled study. The aim of this study is to compare the impact of LBBAP on left ventricular function as compared with traditional right ventricular pacing in patients with atrioventricular…
- Conditions
- Atrioventricular Block, Left Bundle Branch Area Pacing, Right Ventricular Pacing, Heart Failure
- Trial name
- LEAP-Block (NCT04730921)
- Testing
- Left bundle branch area pacing, Right ventricular pacing
- Where
- 8 sites in China
- Volunteers
- 486 people
- Sponsor
- Fu Wai Hospital, Beijing, China
AVB - Atrioventricular Block, Fetal AVB
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
Fetal complete (i.e., third degree, 3°) atrioventricular block (AVB), identified in the 2nd trimester of pregnancy in an otherwise normally developing heart, is almost universally associated with maternal anti-Ro autoantibodies…
- Trial name
- NCT04474223
- Testing
- Dexamethasone, IVIG
- Where
- 24 sites in United States, Canada
- Volunteers
- 1,300 people
- Sponsor
- NYU Langone Health
Bradycardia, Heart Failure
LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy
LEAP-CAR will evaluate the benefit of left bundle branch area pacing (LBBAP), comparing to conventional right ventricular pacing (RVP), in preventing pacing-induced cardiomyopathy (PICM) in patients undergoing pacemaker implant…
- Conditions
- Bradycardia, Heart Failure, Pacemaker-Induced Cardiomyopathy, Conduction Block, Atrioventricular
- Trial name
- LEAP-CAR (NCT05910866)
- Testing
- Left bundle branch area pacing (LBBAP), Right ventricular pacing (RVP)
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
AV Block Complete, AV Block-2Nd Degree-Type 1
Efficacy and Safety of Micra AV2 Transcatheter Pacing System
A third generation, Micra AV2 is now available and proposes increased automaticity and improved AV synchrony algorithms based on computing model.
- Conditions
- AV Block Complete, AV Block-2Nd Degree-Type 1, AV Block
- Trial name
- EMAV2 (NCT07356505)
- Testing
- Implant procedure of a Micra AV2 leadless pacemaker (Medtronic)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atrioventricular Block
Ventricular Pacing Site Selection (V-PASS)
The purpose of this study is to determine whether there is a relationship between ventricular lead position and the incidence of heart failure and atrial fibrillation in patients with indication for permanent pacemaker…
- Trial name
- NCT00292383
- Testing
- Leads to be implanted according randomization on specified sites. Vitatron pacemakers to be implanted: T60 DR, T70 DR, T20 SR, C60 DR
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Medtronic BRC
Arrhythmias, Cardiac, Atrial Fibrillation
enHEART - Exploring Full Content of Optical Signals to Enhance Cardiac Arrhythmia Screening
This research will investigate the PPG signal morphology related to physiological and non- physiological changes in arrhythmia-related heart rate as well as the performance of the PPG-based features previously developed within…
- Conditions
- Arrhythmias, Cardiac, Atrial Fibrillation, Atrial Flutter, Atrioventricular Block
- Trial name
- enHEART (NCT04884100)
- Testing
- Validating and improving PPG-based algorithms
- Where
- Switzerland
- Volunteers
- 95 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sinus Node Dysfunction, Bradycardia
BIOTRONIK Conduction System Pacing With the Solia Lead - Solia CSP S
The purpose of the BIO-CONDUCT study is to demonstrate the safety and effectiveness of the BIOTRONIK Solia CSP S pacing lead when implanted in the left bundle branch area (LBBA).
- Conditions
- Sinus Node Dysfunction, Bradycardia, Atrioventricular Block
- Trial name
- BIO-CONDUCT (NCT06540079)
- Testing
- Solia CSP S lead
- Where
- 10 sites in United States
- Volunteers
- 192 people
- Sponsor
- Biotronik, Inc.